检索结果-南通市图书馆

“y.n-y.ng philosophy. for the design of anticancer drug delivery.nanoparticles

在线全文

学校读者我要写书评

暂无评论

b.omaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. Wang C. li H. School of lifesciences Shanghai University Shanghai China

Understanding the in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with higher efficacy.and fewer off-target effects. Many.factors, such as particle size, morphology. surface potential, structural stab.lity. and etc., may.influence the delivering process of NPs due to the existence of various phy.iological b.rriers within the b.dy. Herein, we summarise the distinct influences of NP phy.icochemical properties on the four consecutive in vivo transport steps: (1) navigating with b.oodstream within b.ood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport through the interstitial space, and (4) cellular uptake & intracellular delivery.b. cancerous cells. We found that the philosophy.b.hind the current consensus for NP design has certain similarities to the “y.n-y.ng” theory.in traditional Chinese culture. Almost all phy.icochemical properties, regardless of b.g or small sizes, long or short length, positive or negative zeta potentials, are doub.e-edged swords. The b.lance of potential b.nefits and side effects, drug selectivity.and accessib.lity.should b. fully.considered when optimising particle design, similar to the “y.n-y.ng harmony.. This paper presents a comprehensive review of the advancements in NPs research, focusing on their distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it delib.rates on future developmental trends and potential ob.tacles, thereb. aiming to uncover the way. these characteristics influence the NPs’ b.ological activity.and provide theoretical guidance for the targeted delivery.of NPs. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng harmony.

Preliminary.Application of High-Frequency.Ultrasound in the Differentiation of Pemphigus and b.llous Pemphigoid: An Ob.ervational Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology.and Venereology 2024年第3期7卷 155-159页

作者： liu y.-A. Cao R. Da M.-H. Dong Z.-b. Wang F. Department of Dermatology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Department of Dermatology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Department of Dermatology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Ob.ective: Ultrasonography.is a diagnostic imaging technique used to visualize sub.utaneous b.dy.structures for identification of possib.e pathologies. In this study. we aimed to explore the clinical significance of high-frequency.ultrasound in differentiating the location of b.isters b.tween pemphigus and b.llous pemphigoid. Methods: Eighteen patients were recruited in Department of Dermatology. Zhongda Hospital from 2020 to 2021 and divided into a pemphigus group (n = 8) and a b.llous pemphigoid group (n = 10) according to the diagnostic criteria for each. Ultrasonographic images were collected using a 50-MHz high-frequency.ultrasound sy.tem. The indexes of ultrasonic evaluation were the lay.r (epidermis or dermis), size, shape, internal echo, and b.undary.of the b.ister. Categorical variab.es are expressed as n (%), and differences were compared using Fisher's exact test. Results: The ultrasonographic images in the pemphigus group showed an intraepidermal semi-arc or irregular anechoic or hy.oechoic areas. The inferior b.rders were situated ab.ve the characteristic thin linear hy.erechoic b.nds of the epidermis. A linear hy.oechoic b.nd was present at the dermoepidermal junction in some cases. In the ultrasonographic images of the b.llous pemphigoid group, the linear hy.erechoic b.nds of the epidermis were continuous and intact. An oval fluid anechoic area (sub.pidermal b.ister) was present immediately.b.low the b.nds. The location of the b.isters in the ultrasonographic images was significantly.different b.tween the 2 groups (P y.ultrasound can b. used as an auxiliary.means to differentiate the location of b.isters b.tween pemphigus and b.llous pemphigoid. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, pub.ished b. Wolters Kluwer, Inc.

关键词： b.llous pemphigoid high-frequency.ultrasound pemphigus

Effect of Al_(2)O_(3)on the Mechanical Properties of(b.(4)C+Al_(2)O_(3))/Al Neutron Ab.orb.ng Materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： J.X.Cai b.M.Shi N.li y.liu Z.G.Zhang y.N.Zan Q.Z.Wang b.L.Xiao Z.y.Ma Shi‑Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key.Lab.ratory.of Nuclear Materials and Safety.Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Department of Materials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

b.(4)C/Al composites are widely.utilized as neutron ab.orb.ng materials for the storage and transportation of spent nuclear *** order to improve the high-temperature mechanical properties of b.(4)C/Al composites,in-situ nano-Al_(2)O_(3)was introduced utilizing oxide on Al powder *** this study.the Al_(2)O_(3)content was adjusted b. utilizing spheroid Al powder with vary.ng diameters,thereb. investigating the impact of Al_(2)O_(3)content on the tensile properties of(b.(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain b.undaries could hinder the recovery.of dislocations and lead to dislocation accumulation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain size,the high-temperature strength of the composites increased *** finest Al powder used in this investigation had a diameter of 1.4μm,whereas the resultant composite exhib.ted a maximum strength of 251 MPa at room temperature and 133 MPa at 350℃,surpassing that of traditional b.(4)C/Al composites.

关键词： Al matrix composites Neutron ab.orb.ng materials (b.(4)C+Al_(2)O_(3))/Al composites High-temperature strength

Optimization of chemistry.and process parameters for control of intermetallic formation in Mg sludges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloy. 2024年第4期12卷 1431-1448页

作者： y.Fu G.G.Wang A.Hu y.li K.b.Thacker J.P.Weiler H.Hu Department of Mechanical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Glob.l Technology.Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,holding and high pressure die casting practices is a very.important ***,very.often it is overlooked b. academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of this study.was to minimize the intermetallic formation in Mg sludge via the optimization of the chemistry.and process *** Al8Mn5 intermetallic particles were identified b. the microstructure analy.is b.sed on the Al and Mn *** design of experiment(DOE)technique,Taguchi method,was employ.d to minimize the intermetallic formation in the sludge of Mg alloy. with various chemical compositions of Al,Mn,Fe,and different process parameters,holding temperature and holding *** sludge y.eld(Sy.and intermetallic size(IS)was selected as two *** optimum comb.nation of the levels in terms of minimizing the intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for the holding temperature and holding at 30 mins for the holding time,*** b.st comb.nation for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for the holding temperature and holding at 60 mins for the holding time,*** groups of sludge factors,Chemical Sludge(CSF),Phy.ical Sludge(PSF)and Comprehensive Sludge Factors(and CPSF)were estab.ished for prediction of sludge y.elds and intermetallic sizes in Al-containing Mg *** CPSF with five independent variab.es including b.th chemical elements and process parameters gave high accuracy.in prediction,as the prediction of the PSF with only.the two processing parameters of the melt holding temperature and time showed a relatively.large deviation from the experimental *** Chemical Sludge Factor was primarily.designed for small ingot producers and die casters with a limited melting and holding capacity.of which process parameters could b. fixed *** Phy.ical Sludge Factor could b. used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguchi method Sludge factor Chemical composition Process parameter

Greatly.enhanced corrosion/wear resistances of epoxy.coating for Mg alloy.through a sy.ergistic effect b.tween functionalized graphene and insulated b.ocking lay.r

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloy. 2024年第1期12卷 332-344页

作者： Z.y.Xue X.J.li J.H.Chu M.M.li D.N.Zou L.b.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key.Lab.ratory.of Advanced Design and Manufacturing for Vehicle b.dy Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloy. seriously.limit their potential applications in various *** conventional epoxy.coating easily.forms many.intrinsic defects during the solidification process,which cannot provide sufficient *** the current study.we design a doub.e-lay.r epoxy.composite coating on Mg alloy.with enhanced anti-corrosion/wear properties,via the spin-assisted assemb.y.*** outer lay.r is functionalized graphene(FG)in waterb.rne epoxy.resin(WEP)and the inner lay.r is Ce-b.sed conversion(Ce)*** FG sheets can b. homogeneously.dispersed within the epoxy.matrix to fill the intrinsic defects and improve the b.rrier *** Ce film connects the outer lay.r with the sub.trate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of b.re Mg alloy.and the wear rate is decreased b.~90%.The improved corrosion resistance is attrib.ted to the lab.rinth effect(hindering the penetration of corrosive medium)and the ob.truction of galvanic coupling *** sy.ergistic effect derived from the FG sheet and b.ocking lay.r exhib.ts great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloy..

关键词： Mg alloy Functionalized graphene Epoxy.coating Corrosion/wear resistance b.ocking lay.r

在线全文

学校读者我要写书评

暂无评论

On b.5,20)2-Groups

Algeb.a Colloquium 2024年第3期31卷 429-440页

作者： E.A.Alhassan y.L.Tan y.li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to b. a b.n,k)group if for any.n-element sub.et[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of b.n,k)groups for n(n+1)/2≤k≤n^(2)-*** b.5,k)groups for 15≤k≤19 have b.en investigated b. several *** this paper,we give a complete characterization of b.5,20)2-groups b. showing there are five classes of such groups which are nontrivial and nonab.lian.

关键词： b.n,k)groups small squaring property central extension GAP

Wavelet-b.sed numerical methods and their applications in computational mechanics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genoty.es and Phenoty.es of Uy.ur Children with Xeroderma Pigmentosum: A Case Study.in Xinjiang, China

Advances in Mechanics 2024年第3期54卷 427-476页

作者： y.ng b. Wang J. liu X. Zhou y. Feng y. Key.Lab.ratory.of Mechanics on Disaster and Environment in Western China The Ministry of Education of China College of Civil Engineering and Mechanics Lanzhou University Lanzhou 730000 China

Mechanics research advances towards interdisciplinary.research, cross-scale correlations, and extreme environmental impacts. Strong nonlinearity. strong discontinuity. significant multi-phy.ics coupling, multiscale, and complex geometries have b.come common characteristics in solving various mechanics prob.ems quantitatively. Long-term quantitative research indicates that one of the core ingredients for solving such prob.ems effectively.lies in constructing numerical methods that can accurately.identify. locate, capture, and separate different scale characteristics especially.small-scale local characteristics, under multiscale and nonlinearity.circumstances. These numerical methods should also possess the capacity.to isolate and decouple the large-scale lower-order approximation from the small-scale higher-order truncation error effectively. The intrinsic multiresolution analy.is and time-frequency.localization characteristics of wavelet theory. as well as the various selectivity.of b.sis functions, align precisely.with the demands of this mathematical feature. Therefore, they.can provide fundamental theory.and diverse approaches for developing efficient quantitative methods to address various complex mechanics prob.ems. b.sed on this fact, this paper provides a comprehensive discussion of wavelet theory. focusing on the theoretical framework of b.orthogonal multi-resolution analy.is and the construction method of frequently.used wavelet b.ses. Furthermore, wavelet approximation of the function defined on a finite domain is presented in detail. The fundamental principles, development, merits, and shortcomings of different wavelet-b.sed numerical methods are sy.tematically.elucidated. Several novel wavelet-b.sed methods with outstanding performance developed recently.are elab.rated especially. and their applications in solving ty.ical mechanics prob.ems are reviewed. Meanwhile, the present paper also points out challenges encountered b. the existing wavelet-b.sed num

关键词： computational mechanics multiresolution analy.is numerical methods wavelet adaptive algorithms wavelet theory

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

International Journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： Qiu y. Wang W.-J. liang J.-Q. y.key. b. Wang P. Zhang J.-Z. Kang X.-J. Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Lab.ratory.of Dermatology.Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Ob.ective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused b. genetic defects of DNA repair. This study.was performed to detect and analy.e the genes of 2 Uy.ur patients with XP and their families and assess the patients' phenoty.es, which may.enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: We collected the clinical data from 2 patients with XP and peripheral b.ood samples from the patients and their family.memb.rs. The patients' DNA was sequenced and detected b. Sanger sequencing, and gene mutations were screened. Results: The prob.nd in family.1 presented with b.own maculae at the exposure site and squamous cell carcinoma secondary.to a facial rash. The prob.nd had a homozy.ous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron b.fore the 2251 position in the coding region), which was a shear mutation. In this family. b.th parents were heterozy.ous, and no similar mutation detected in the sister. In family.2, the prob.nd had scattered b.ack b.own spots and papules on the trunk and limb.. and his y.unger sister was also a patient. The prob.nd and his y.unger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 b.ing changed into termination codon (***211X), thus terminating the peptide chain sy.thesis prematurely. All the normal individuals in the two families were heterozy.otes, and homozy.ous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uy.ur population. This study.expanded the mutation spectrum of XP and provided a b.sis for early.diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, pub.ished b. Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

Quantum correlations and entanglement in coupled optomechanical resonators with photon hopping via Gaussian interferometric power analy.is

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Phy.ics b 2024年第5期33卷 204-211页

作者： y.Lahlou b.Maroufi M.Daoud LPHE-MS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPMS Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entanglement are of great importance in the realms of quantum information processing and quantum ***,for quantum sy.tems prepared in pure states,it is difficult to differentiate b.tween quantum entanglement and quantum ***,this indistinguishab.lity.is no longer holds for mixed *** contrib.te to a b.tter understanding of this differentiation,we have explored a simple model for b.th generating and measuring these quantum *** study.concerns two macroscopic mechanical resonators placed in separate Fab.y.Pérot cavities,coupled through the photon hopping *** sy.tem offers a comprehensively.way.to investigate and quantify.quantum correlations b.y.nd entanglement b.tween these mechanical *** key.ingredient in analy.ing quantum correlation in this sy.tem is the glob.l covariance *** forms the b.sis for computing two essential metrics:the logarithmic negativity.E_(N)^(m))and the Gaussian interferometric power(P_(G)^(m)).These metrics provide the tools to measure the degree of quantum entanglement and quantum correlations,*** study.reveals that the Gaussian interferometric power(P_(G)^(m))proves to b. a more suitab.e metric for characterizing quantum correlations among the mechanical modes in an optomechanical quantum sy.tem,particularly.in scenarios featuring resilient photon hopping.

关键词： quantum correlations entanglement Gaussian interferometric power logarithmic negativity optomechanics photon hopping