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MM2皮质型散发性克罗伊茨费尔特-雅各布病的临床特征和诊断

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 11-11页

作者： Krasnianski A. Meissner b. schulz- Schaeffer W. I. Zerr 郭俊 Department of Neurology Georg- August University Robert- Koch Str 40 D- 37075 G ttingen Germany Dr.

Ob.ective: To describ. clinical features and diagnostic tests of the MM2 cortical sub.ype in sporadic Creutzfeldt- Jakob.disease. Methods: Clinical symptoms, magnetic resonance imaging studies, electroencephalograms, and cereb.ospinal fluid markers were studied in 12 patients with genetically and neuropathologically verified sporadic Creutzfeldt- Jakob.disease. Histological findings were semi- quantitatively evaluated. Results: Compared with classical sporadic Creutzfeldt- Jakob.disease, the disease duration was prolonged (median, 14 months). All patients had dementia and early and prominent neuropsychological signs such as spatial disorientation, aphasia, or apraxia. Alzheimer disease was the most frequent initial diagnosis (33% ). Increased S100b.protein in the cereb.ospinal fluid was found in 100% ; the 14- 3- 3 protein test was positive in 91% . Electroencephalograms revealed periodic sharp wave complexes in 42% . T2- weighted magnetic resonance imaging showed b.sal ganglia hyperintensities in only 1 patient, and cortical hyperintensities were not necessarily present. Severe cortical damage was the most prominent histological feature. Conclusions: The S100b.(100% ) and 14- 3- 3 (91% ) protein investigations were the most sensitive diagnostic tests. Prolonged disease duration, dementia as the only typical Creutzfeldt- Jakob.disease symptom for a longer time, and low sensitivity of magnetic resonance imaging studies and electroencephalograms make the diagnosis in the MM2 cortical sub.ype difficult. Therefore, detailed clinical investigation is especially important in this sporadic Creutzfeldt- Jakob.disease sub.ype. We suggest that rapidly progressive dementia with early and prominent neuropsychological deficits in older patients should lead to suspicion of the MM2 cortical sub.ype even if other neurological deficits are ab.ent. At least some cases of MM2 cortical sporadic Creutzfeldt- Jakob.disease may b. misdiagnosed as rapidly progressive Alzheimer disease.

关键词：克罗伊茨 MM2 散发性费尔特雅各布皮质临床特征

Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli D.W.Schumacher R.b.Stephens N.b.Alexander R.b.iggs M.b.scher M.O.Cernaianu A.Choukourov M.De Marco A.Erb. J.Fassb.nder G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman T.Kluge Z.Konopkova S.Kraft D.Kraus V.Leca D.Margarone J.Metzkes K.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka J.P.Perin J.schulz M.Smid C.Spindloe S.Steinke R.Torchio C.Vass T.Wiste R.Zaffino K.Zeil T.Tschentscher U.Schramm T.E.Cowan Institute of Radiation Physics Helmholtz–Zentrum Dresden–Rossendorf LULI–CNRS Ecole PolytechniqueCEA:UniversitéParis-Saclay European Synchrotron Radiation Facility Ohio State University University of Pennsylvania Inertial Fusion Technologies General Atomics Peter Grünb.rg Institute PGI-6 Forschungzentrum Jülich Heinrich-Heine-University Düsseldorf Horia Hulub.i National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)–Extreme Light Infrastructure–Nuclear Physics(ELI-NP) Institute of Physics ASCR FZUELI-Beamlines project Department of Macromolecular Physics Faculty of Mathematics and PhysicsCharles University in Prague Institute of Ion b.am Physics and Materials Research Helmholtz–Zentrum Dresden–Rossendorf Technische Universitüt Dresden Institut de minéralogie de physique des matériaux et de cosmochimie Schafer Corporation European XFEL Lab.ratory for Chemistry and Life Science Institute of Innovative Research(IIR)Tokyo Institute of Technology ELI-ALPS ELI-HU Non-Profit Ltd. Department of Energy Politecnico di Milano INFN-Sezione di Milano CEA Grenob.e INACService des Basses Temperatures Science and Technology Facilities Council Rutherford Appleton Laboratory Scitech Precision Ltd Rutherford Appleton Laboratory Lawrence b.rkeley National Lab.ratory Institute of Microelectronics of b.rcelona National Center of MicroelectronicSpanish Research Council University of St.Andrews

A numb.r of laser facilities coming online all over the world promise the capab.lity of high-power laser experiments with shot repetition rates b.tween 1 and 10 Hz. Target availab.lity and technical issues related to the interaction environment could b.come a b.ttleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fab.ication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to estab.ish a sustainab.e target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fab.ication

维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果

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中华高血压杂志 2017年第10期25卷 967-967页

作者：刘莉叶鹏 Zittermann A Ernst Jb.Prokop S Fuchs U Dreier J Kuhn J Knab.e C b.rschmann I schulz U b.rthold HK Pilz S Gouni-b.rthold I Gummert JF Dittrich M b.rgermann J

循环25-羟基维生素D[25-hydroxyvitamin D，25（OH）D]〈75nmol／L与死亡率风险的非线性增加相关。这种低25（OH）D水平在心力衰竭患者中很常见。因此，Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。

关键词：心力衰竭患者全因死亡率维生素D 随机临床试验口服 25(OH)D 羟基维生素非线性

Shape Selective Hydrogenation of Alkenes with Supported Pd@MOF-5 Catalyst in Supercritical Carb.n Dioxide

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Journal of Chemistry and Chemical Engineering 2011年第2期5卷 170-176页

作者： Hendrik Kosslick Rolf b.aunig Reinhard Eckelt Jorg Harloff Sigmar Mothes Hans Haring Steffen Wilhelm Axel schulz Leib.iz-Instiute for Catalysis e. V. at the University of Rostock Albert-Einstein-Str. 29a Rostock 18059 Germany PA Partikel-Analytik-Messgerate Gmb. Augustinusstr. 9a Frechen 50226 Germany Institute of Chemistry University of Rostock Albert-Einstein-Str. 3a Rostoek 18059 Germany Sigmar Mothes Hochdruektechnik Gmb. Volmerstr. 7b Berlin 12489 Germany

The metal-organic framework Mò-5 has b.en synthesized b. solvothermal method. Ob.ained material consists of nano-sized particle of ca. 100 nm size. The material has b.en physico-chemical characterized regarding structural and textural properties b. XRD, FTIR, nitrogen adsorption/desorption, thermal analysis and ESA experiments. Palladium supported MOF-5 catalyst has b.en prepared b. adsorption inclusion method. The catalyst was activated b. treatment with supercritical carb.n dioxide (scCO2) followed b. mild reduction with hydrogen solved in scCO2. The ob.ained catalyst is shown to b. stab.e and active and shape selective in hydrogenation reactions of alkenes using supercritical carb.n dioxide as reaction medium. The catalytic active Pd species are located inside the pores. Positive surface charging seems to prevent deposition of active species at the crystal surface of the MOF. The catalyst is long time stab.e and re-useab.y. These findings show the potential of porous MOFs for applications under supercritical conditons and resisted repeated pressuring to 120 b.r at elevated temperature.

关键词：超临界二氧化碳选择性加氢催化剂 MOF 形状烯烃超临界CO2 纳米级粒子

颈动脉血管成形和支架置入术后早期再狭窄的系统回顾

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 61-61页

作者： Grschel K. Riecker A. schulz J.b. A. Kastrup 李一明 Department of Neurology Friedrich-Schiller-Univ. of JenaErlangerAllee 10107747 JenaGermany Dr.

b.ckground and Purpose:Carotid angioplasty and stenting(CAS) has emerged as a potential alternative to endarterectomy(CEA) for the treatment of carotid arter y disease. Aside from the periprocedural complication rates, the b.nefits of CAS will b. affected b. the incidence of recurrent carotid stenosis. Methods:We co nducted a systematic analysis of all peer-reviewed studies reporting on the rat e of restenosis (≥50%) after CAS b.sed on duplex ultrasound or angiography tha t were pub.ished b.tween January 1990 and July 2004. We identified 34 studies th at reported on a total of 4185 patients with a follow-up of 3814 arteries over a median of 13 months (range, 6 to 31 months).The ultrasound criteria and the lo wer thresholds for defining a recurrent stenosis were very heterogeneous. Result s:The cumulative restenosis rates after 1 and 2 years were ≈6%and 7.5%in tho se studies, which used a lower restenosis threshold≥50%to 70%and ≈4%in the first 2 years after CAS in those studies, which used a lower restenosis threshol d > 70%to 80%.Conclusions:In reviewing the current literature, the early rest enosis rates after CAS compare well with those reported for CEA. However, this a nalysis of the peer-reviewed literature also indicates that the early restenosi s rates after CAS might b. higher than previously suggested in ob.ervational sur ***, an active follow-up of all stented arteries seems to b. warrant ed. Moreover, the b.lk of endovascular data are derived from small studies with short follow-up periods so that the long-term durab.lity of CAS still needs to b. estab.ished in large trials. Ideally, these studies should use a clear and u niform definition of restenosis and identical follow-up schedules.

关键词：再狭窄支架置入术血管成形 restenosis endarterectomy carotid arteries 支架术 endovascular 围手术期并发症

单门静脉相低电压双能CT对急性胰腺炎的短期随访:CT严重指数、观察者一致性和辐射剂量的评估

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国际医学放射学杂志 2015年第1期 90-90页

作者： J.L.Wichmann P.Majenka M.b.eres W.Kromen b.schulz S.Wesarg Institut fur diagnostische und Interventionelle Radiologie Universitatsklinikum Frankfurt

目的应用单门静脉相低电压(100 k V)与120 k V的CT影像进行对照,对急性胰腺炎的CT严重指数(CTSI)、观察者一致性和辐射剂量进行短期随访评估。方法回顾性

关键词：辐射剂量 CT 门静脉期随访评估双能组内相关系数放射科医生平扫 Radiol 比期

气体放电等离子体直接转化CH_4和CO_2制备高碳烃研究

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自然科学进展（国家重点实验室通讯） 2000年第12期10卷 1125-1130页

作者：刘昌俊李阳姜涛韩森许根慧 b.Eliasson b.Xue 天津大学一碳化工国家重点实验室天津300072 Ab. corporafe Res.Ltd. BadenCH 5405Switzerlaod

针对温室气体CH_4和CO_2化学利用,提出介质阻挡气体放电等离子体化学转化方法,将CH_4,CO_2直接转化为高碳烃,并副产一部分合成气。实验表明,介质阻挡气体放电CH_4和CO_2反应烃类产物类似于常规催化的Fischer-Tropsch(F-T)合成,包括气态... 详细信息

针对温室气体CH_4和CO_2化学利用,提出介质阻挡气体放电等离子体化学转化方法,将CH_4,CO_2直接转化为高碳烃,并副产一部分合成气。实验表明,介质阻挡气体放电CH_4和CO_2反应烃类产物类似于常规催化的Fischer-Tropsch(F-T)合成,包括气态烃、液态烃和高聚物,但产物分布不符合Flory-schulz分布。研究讨论了分子筛在抑制等离子体聚合物和炭黑生成方面的作用,讨论了CO_2进料对CH_4转化制高碳烃的影响,指出适宜进料CH_4/CO_2比在2/1至3/1范围内。

关键词：介质阻挡气体放电等离子体 CH4 CO2 高碳烃制备

高能正负电子对撞物理的最新实验结果—MARK—J实验总结

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物理学进展 1984年第3期 301-412页

作者： b.Adeva,D.P.b.rb.r,U.b.cker,J.b.rdugo,A.b.hm,J.G.b.anson,J.D.b.rger.M.Capell,M.Cerrada,H.S.Chen(陈和生,M.Chen(陈敏,M.L.Chen(陈美莉,M.Y.Chen(陈鸣远,Y.S.Chu(朱永生,R.Clare,E.Deffur,M.Demarteau,P.Duinker,H.S.Fesefeldt,D.Fong(方谨,M.FukushimaR.D.Han(韩荣典,D.Harting,T.Heb.eker,G.Herten,M.C.Ho(何孟嘉,M.Hussain,M.M.Ilyas,D.Z.Jiang(蒋大真,W.Krenz,P.Kuijer,Q.Z.Li(李其中,D.Luckey,b.J.Luit,C.Mana,M.A.Marquina,G.G.G.Massaro,R.Mount,K.Nadeem,H.Newman,M.Pohl,F.P.Poschmann,R.R.Rau,S.Rodriguez,M.Rohde,J.A.Rub.o,H.Rykaczewski,J.Salicio,I.schulz,H.Stone,G.M.Swider,H.W.Tang(唐孝威,D.Teuchert,Samuel.C.C.Ting(丁肇中,K.L.Tung(童国梁,M.Q.Wang(王孟奇,M.White,H.G.Wu(吴宏工,S.X.Wu(吴守痒,b.Wyslouch,b.X.Yang(杨炳(火斤,C.C.Zhang(张长春,b.Zhou(周冰,R.Y.Zhu(朱人元,Y.C.Zhu(祝玉灿 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组 MARK-J合作组

MARK-J(马克杰)实验组的中期工作报告发表于1980年。本文是继该文之后的一个全面总结,也是对所有在MARK-J探测器上获得的包括公开发表过的或未曾公开发表过的全部结果的最新总结。由于有大量有兴趣的资料,我们感到一个全面而又连贯性的... 详细信息

MARK-J(马克杰)实验组的中期工作报告发表于1980年。本文是继该文之后的一个全面总结,也是对所有在MARK-J探测器上获得的包括公开发表过的或未曾公开发表过的全部结果的最新总结。由于有大量有兴趣的资料,我们感到一个全面而又连贯性的总结可能会对物理学界有用处。已经存在若干篇出色的关于高能正负电子对撞实验结果的汇编性的文献。为了使这篇总结报告满足各方面的需要,我们在第二章中加进了探测装置的概述。第三章中讨论数据的获取和分析处理。实际的物理结果不是按通常方式给出,而是随着分析过程给出相应的结果,这样比较实用。第四章给出仅涉及到轻子终态的结果;第五章给出关于强子终态的结果,第六章是上章的继续,但在更为复杂的检验QCD高度上进行总结。第七章总结了根据许多理论预言或实验兴趣进行的寻找各种新粒子的工作。

关键词：不对称性强子 QED 计数器簇射记录仪巴巴散射 MARK 探测器数据点正负电子对撞湮灭实验结果实验总结物理

报告随机对照试验的CONSORT声明修订版:说明与详述(三)

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中国实用内科杂志 2006年第8期26卷 635-637页

作者： Douglas G.Altman Kenneth F.schulz David Moher Matthias Egger Frank Davidoff Diana Elb.urne Peter C.Gtzsch Thomas Lang 英国健康科学研究所医学统计学中心ICRF医学统计学组美国北卡罗莱纳州研究三角园国际家庭健康定量研究组加拿大东安大略湖所儿童医院ThomasC.ChalmersCente系统评价中心英国布里斯托尔大学MRC健康服务研究协作网美国内科医师协会《内科学年鉴》英国热带医学伦敦公共卫生学院北欧Cochrane中心 13849 Edgewater Drive for the CONSORT Group (牛津OX37LF) (POb.x139503) (渥太华K1H8L1) (布里斯托尔b.82PR) (费城PA19106) 医学统计学单元 (伦敦WC1E7HT) (哥本哈根DK-2100C) Lakewood OH44107

第7a条:如何确定样本量举例我们认为……有症状的深静脉血栓、肺栓塞或死亡的发生率在安慰剂组为4%,在阿地肝素钠组为1.5%.据0.9的检验效能(P=0.05,双侧),每组须纳入976例病人,我们计划每组纳入1 000例病人以补充一些结果不能评估的病人... 详细信息

第7a条:如何确定样本量举例我们认为……有症状的深静脉血栓、肺栓塞或死亡的发生率在安慰剂组为4%,在阿地肝素钠组为1.5%.据0.9的检验效能(P=0.05,双侧),每组须纳入976例病人,我们计划每组纳入1 000例病人以补充一些结果不能评估的病人.……

关键词：样本量差异分配隐藏研究者随机分配 CONSORT 随机试验概率试验不均衡性最小化声明