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A facile s.rategy for tuning the dens.ty of s.rface-grafted b.omolecules.for melt extrus.on-b.s.d additive manufacturing applications

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b.o-Des.gn and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.b.eren G.Dos.s.ntos.P.J.Dijks.ra C.Mota J.b.uer H.Ferreira Rui L.Reis.N.Neves.s.Camarero-Es.inos. M.b.b.ker L.Moroni Department of Complex Tis.ue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3b.s.Res.arch Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVs.3b.s.PT Government As.ociate Lab.ratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERb.s.UE Basque Foundation for Science48009 BilbaoSpain

Melt extrus.on-b.s.d additive manufacturing(ME-AM)is.a promis.ng technique to fab.icate porous.s.affolds.for tis.ue engi-neering ***,mos. s.nthetic s.micrys.alline polymers.do not pos.es. the intrins.c b.ological activity required to control cell *** of b.omolecules.on polymeric s.rfaces.of AM s.affolds.enhances.the b.oactivity of a cons.ruct;however,there are limited s.rategies.availab.e to control the s.rface ***,we report a s.rategy to tune the s.rface dens.ty of b.oactive groups.b. b.ending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups.with an unfunctionalized high molecular weight PCL75k at different *** porous.three-dimens.onal(3D)s.af-folds.were then fab.icated us.ng a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept tes.,we prepared films.of three different mas. ratios.of low and high molecular weight polymers.with a thermopres. and reacted with an alkynated fluores.ent model compound on the s.rface,yielding a dens.ty of 201-561 pmol/cm^(2).s.b.equently,a b.ne morphogenetic protein 2(b.P-2)-derived peptide was.grafted onto the films.compris.ng different b.end compos.tions.and the effect of peptide s.rface dens.ty on the os.eogenic differentiation of human mes.nchymal s.romal cells.hMs.s.was.*** two weeks.of culturing in a b.s.c medium,cells.expres.ed higher levels.of b.P receptor II(b.PRII)on films.with the conjugated *** addition,we found that alkaline phos.hatas. activity was.only s.gnificantly enhanced on films.contain-ing the highes. peptide dens.ty(i.e.,561 pmol/cm^(2)),indicating the importance of the s.rface *** together,thes. res.lts.emphas.ze that the dens.ty of s.rface peptides.on cell differentiation mus. b. cons.dered at the cell-material ***,we have pres.nted a viab.e s.rategy for ME-AM community that des.res.to tune the b.lk and s.rface functionality via b.ending of(m

关键词： Additive manufacturing b.ending s.rface functionalization s.rface dens.ty Click chemis.ry Human

s.nthes.s.and Eros.on b.haviors.of Nanos.ale Coatings.Prepared b. Wire Arc s.raying

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稀有金属材料与工程 2012年第S1期41卷 144-147页

作者： Cheng, J. b. Xiang, X. b. Wang, Z. H. Xu, b. s. Hohai Univ Coll Mech & Mat Nanjing 210098 Jiangsu Peoples R China Natl Key Lab.Remfg Beijing 100072 Peoples R China

The effects.of eros.ve parameters.s.ch as.impact angles.and environment temperature,on eros.on properties.of Feb.iCrMnNb.nanos.ale coatings.were inves.igated.A s.ries.of coatings.were prepared b. wire arc s.raying *** micros.ructure of the coating cons.s.s.of amorphous.andα(Fe,Cr)nanocrys.alline *** nanocrys.als.with average s.ze of 39 nm are homogenous.y dis.ers.d in amorphous.*** eros.on res.lts.reveal that the coating exhib.ts.b.tter eros.on res.s.ance at lower impact *** eros.on rates.of the coating decreas. as.function of environment *** relatively eros.on res.s.ance of the nanos.ale coating is.3.7 times.higher than that of AIs.1045 s.eel s.b.trate at 650°*** main failure mechanis. of the coating is.b.ittle fracture.

关键词： coatings nano materials ab.as.ve

Exploring Variab.lity in s.a Level at a Tide Gauge s.ation through Control Charts

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Journal of Environmental & Earth s.iences 2024年第1期6卷 11-18页

作者： H.b.kiİz Independent s.holar Boca Raton Florida33496USA

Monitoring temporal changes.in s.a level is.important in as.es.ing coas.al *** level anomalies.at a tide gauge s.ation,if kinematically conceived,include s.s.ematic variations.s.ch as.trend,acceleration,periodic os.illations.and random *** them,the non-s.ationary nature of the random s.a level variations.of known or unknown origin at coas.al regions.has.b.en long recognized b. the s.a level *** s.udy propos.s.the analys.s.of s.b.roups.of random res.dual s.atis.ics.of a rigorous.y formulated kinematic model s.lution of tide gauge variations.us.ng X-b.r and s.control *** approach is.demons.rated us.ng Key Wes.,Florida tide gauge *** mean and s.andard errors.of 5-year-long s.b.roups.of the res.duals.revealed that s.a level changes.at this.location have b.en progres.ively intens.fying from 1913 to the *** os.illations.in s.a level at this.locality may b. attrib.ted partly to the thermal expans.on of s.awater with increas.ng temperatures.caus.ng larger b.oyancy-related s.a level fluctuations.as.well as.the intens.fication of atmos.heric events.including wind patterns.and the impact of changes.in inverted b.rometer effects.that will alter coas.al ris. as.es.ments.for the future.

关键词： Climate change s.a level variance X-b.r s.control charts

Molecular Integrators.of Neuropathy and Pain in Diab.tes.Mellitus

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生物化学与生物物理进展 2014年第9期41卷 851-859页

作者： s.OYANOV s.oyan b. LENTZ s.ren L. VALDEs.HERRERA Jos. P. KRAs.EV Nikolai s. KRAs.EV Dimo s. Pathophys.ology of Dementia German Centre for Neurodegenerative Diseases Magdeburg 39120 Germany Molecular Neuroplas.icity German Centre for Neurodegenerative Diseases Magdeburg 39120 Germany Department of Anatomy Medical Academy of Sofia Sofia 1000 Bulgaria

Glycation of nucleotides. proteins.and phos.holipids.contrib.tes.to the development of late diab.tic complications.including the mos. deb.litating one——diab.tic neuropathy. Reactive intermediates.of AGE formation s.ch as.glyoxal, methylglyoxal(MG) and other dicarb.nyls.are detoxified b. the glyoxalas.-s.s.em. However little is.known ab.ut the regulation and nature of the mechanis.s.underlying neuropathology. Therefore we decided to focus.on the role of MG-glyoxalas. 1(GLO-1) s.s.em in modulation of painful diab.tic neuropathy.

关键词：摘要编辑部编辑工作读者

Enhancing the clinical relevance of haemorrhage prediction models.in trauma

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Military Medical Res.arch 2024年第3期11卷 467-468页

作者： s.nkalp Tandle Jared M.Wohlgemut Max E.R.Mars.en Erhan Pis.rir Evangelia Kyrimi Reb.cca s.s.oner William Mars. Zane b.Perkins.Nigel R.M.Tai Centre for Trauma s.iences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hos.ital Barts Health NHS TrustLondon E11FRUK Academic Department of Military s.rgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer s.ience Queen Mary University of LondonLondon E14NSUK

We read with interes. the recent s.s.ematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careob. Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury b.ood trans.us.on Mas.ive trans.us.on Prediction Artificial intelligence Machine learning

Comb.ning ab.lity of Egyptian cotton(Gos.ypium b.rb.dens. L.)reveals.genetic potential for improved yield and fib.r quality

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Journal of Cotton Res.arch 2024年第2期7卷 109-122页

作者： Ab.elghany Ahmed M. El-b.nna Aly A.A. Lamlom s.b.i F El-s.rady Gawhara A. s.lama Ehab.A.A. Ren Honglei s.aib. Ab.ulwahab.s. Yehia Waleed M.b. Crop s.ience Department Faculty of AgricultureDamanhour UniversityDamanhour 22516Egypt Plant Production Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Agricultural b.tany Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Heilongjiang Academy of Agricultural s.iences Soybean Research InstituteHarbin 150086China Department of Agronomy Bayero University KanoKano 700001Nigeria Cotton b.eeding Department Cotton Research InstituteAgriculture Research CenterGizaEgypt

b.ckground As.the mos. widely cultivated fib.r crop,cotton production depends.on hyb.idization to unlock the yield potential of current varieties.A deep unders.anding of genetic dis.ection is.crucial for the cultivation of enhanced hyb.id plants.with des.red traits.s.ch as.high yield and fine fib.r *** this.s.udy,the general comb.ning ab.lity(GCA)and s.ecific comb.ning ab.lity(s.A)of yield and fib.r quality of nine cotton parents.s.x lines.and three tes.ers.and eighteen F1 cros.es.produced us.ng a line×tes.er mating des.gn were *** The res.lts.revealed s.gnificant effects.of genotypes.parents.cros.es.and interactions.b.tween parents.and cros.es.for mos. of the s.udied ***,the effects.of b.th additive and non-additive gene actions.played a notab.y s.gnificant role in the inheritance of mos. of the yield and fib.r quality *** F1 hyb.ids.of(Giza 90×Aus.)×Giza 86,Uzb.kis.an 1×Giza 97,and Giza 96×Giza 97 demons.rated s.perior performance due to their favorab.e integration of high yield attrib.tes.and premium fib.r quality *** analys.s.revealed that lint yield has.the highes. pos.tive direct effect on s.ed cotton yield,while lint percentage s.owed the highes. negative direct effect on s.ed cotton *** component analys.s.identified s.ecific parents.and hyb.ids.as.ociated with higher cotton yield,fib.r quality,and other agronomic *** This.s.udy provides.ins.ghts.into identifying potential s.ngle-and three-way cros. hyb.ids.with s.perior cotton yield and fib.r quality characteris.ics.laying a foundation for future res.arch on improving fib.r quality in cotton.

关键词： Gos.ypium b.rb.dens. L. Comb.ning ab.lity s.ed cotton yield Fib.r quality Clus.er analys.s Path analys.s

Gas.roes.phageal reflux following per-oral endos.opic myotomy:Can we improve outcomes.

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World Journal of Gas.roenterology 2024年第22期30卷 2834-2838页

作者： Inian s.maras.m Raj Kumar Joel Anna b.Pulimood Department of s.rgery Upper Gastrointestinal Surgery UnitChristian Medical College&HospitalVellore 632004TamilnaduIndia Department of Cardiothoracic s.rgery Christian Medical College&HospitalVellore 632004TamilnaduIndia Department of Gas.rointes.inal s.iences Christian Medical College and HospitalVellore 632004Tamil NaduIndia

This.editorial is.an analys.s.the review article b. Nab. et al recently pub.is.ed in this.*** Cardia is.a dis.as. whos. pathophys.ology is.s.ill *** is.known that there is.inflammation of unknown aetiology leading to los. of ganglion cells.in the mus.ularis.*** end res.lt is.lower oes.phageal s.hincter s.as.,los. of receptive relaxation,decreas.d oes.phageal peris.als.s.all leading on to varying degrees.of *** treatment of this.condition is.palliative in nature,performed b. myotomy of the lower oes.phagus.either s.rgically or *** reflux dis.as.(GERD)has.b.en as.ociated with the myotomy performed,particularly with the Peroral Endos.opic Myotomy(POEM)*** et al have provided an excellent overview of the lates. developments.in predicting,preventing,evaluating,and managing GERD s.b.equent to *** on this.theme,this.review article explores.the concept of us.ng his.ology of the oes.phageal mus.le layer,to grade the dis.as. and thereb. help tailoring the length/type of myotomy performed during the POEM *** the future,will a his.ology b.s.d algorithm availab.e preoperatively,help modify the POEM procedure,thereb. decreas.ng the incidence of GERD as.ociated with POEM?

关键词： Achalas.a cardia Peroral endos.opic myotomy Laparos.opic Heller’s.myotomy His.opathology His.ologic grading

The Making of a Health Profes.ion:How Chines. Medicine b.came a Nationally Regis.ered Allied Health Profes.ion in Aus.ralia

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Chines. Medicine and Culture 2024年第1期7卷 51-62页

作者： John L McDonald Judy b.James s.hool of Chines. Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Aus.ralia Brisbane 4120Australia

In 2012, traditional Chines. medicine(TCM) practitioners.in Aus.ralia b.came nationally-regis.ered allied health profes.ionals.in three categories. acupuncturis., Chines. herb.l medicine practitioner, and Chines. herb.l medicine dis.ens.r. Aus.ralia was.the firs. Wes.ern country to introduce national regis.ration for Chines. medicine, followed b. Portugal and, recently, New Zealand. The practice of TCM in Aus.ralia can b. traced b.ck to the b.ginning of Chines. immigration to Aus.ralia during the Victorian Gold Rus. which b.gan in the 1850s. The proces. which led to national regis.ration commenced in the early 1970s.with the es.ab.is.ment of the firs. acupuncture cours.s. Decades.of gradual development of cours.s.from unaccredited part-time diplomas.to accredited b.chelor degrees. and the development, b. the profes.ion, of national cons.ns.s.on educational s.andards.were es.ential elements.in the proces. which led to regis.ration. Profes.ional as.ociations. s.ch as.the Aus.ralian Acupuncture and Chines. Medicine As.ociation Ltd.(AACMA), als. developed a framework of profes.ional s.lfregulation, including Codes.of Ethics. Codes.of Conduct, ongoing profes.ional development requirements.and Infection Control Guidelines. and provided leaders.ip in the development of the profes.ion. After decades.of trib.lis. and divis.on within the TCM profes.ion, the National Academic s.andards.Committee b.ought almos. all s.akeholders.together to reach a cons.ns.s.on the Aus.ralian Guidelines.for Traditional Chines. Medicine Education which were pub.is.ed b. AACMA in 2001. Profes.ional as.ociations.als. collab.rated on joint s.b.is.ions.to the government in s.pport of regis.ration, which was.introduced firs. in the s.ate of Victoria in 2000, and s.b.equently b.came national in 2012. Des.ite national regis.ration, s.me b.rriers.s.ill remain, and profes.ional as.ociations.continue to lob.y the federal government for inclus.on in Medicare, chronic dis.as. management s.heme, and Veterans

关键词： Acupuncture Chines. medicine Regis.ration Regulation Education s.andards Aus.ralia TCM

TOEPLITZ DETERMINANTs.IN ONE AND HIGHER DIMENs.ONs

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Acta Mathematica s.ientia 2024年第5期44卷 1931-1944页

作者： s.rya GIRI s.s.vapras.d KUMAR Department of Applied Mathematics Delhi Technological UniversityNew Delhi110042India

In this.s.udy,we derive the s.arp b.unds.of certain Toeplitz determinants.whos. entries.are the coefficients.of holomorphic functions.b.longing to a clas. defined on the unit dis. ***,thes. res.lts.are extended to a clas. of holomorphic functions.on the unit b.ll in a complex b.nach s.ace and on the unit polydis. inℂ*** ob.ained res.lts.provide the b.unds.of Toeplitz determinants.in higher dimens.ons.for various.s.b.las.es.of normalized univalent functions.

关键词： holomorphic mappings s.arlike mappings Toeplitz determinants coefficient inequalities