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Recovery rates of p.rsistent p.st-COVID-19 olfactory dysfunction using p.ychop.ysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy p.Tervo p.tricia T.Jacob.on b.andon J.Vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Josep. b.Gary David A.Gudis p.ule V.Josep. D.p.Devanand Terry E.Goldb.rg Jonathan b.Overdevest Columb.a University Vagelos College of p.ysicians and Surgeons New YorkNew YorkUSA Dep.rtment of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Dep.rtment of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Dep.rtment of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA national Institute of Alcohol Ab.se and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-p.esb.terian/Columb.a University Irving Medical Center New YorkNew YorkUSA

Ob.ectives:p.rsistent olfactory dysfunction(OD)following loss of smell associated with SARS-CoV-2 infection is a major feature of long *** on the p.evalence of p.rsistent OD p.edominantly rely on self-rep.rted olfactory *** studies have tracked longitudinal rates of recovery using p.ychop.ysical assessment among p.tients p.esenting for evaluation of p.rsistent OD b.yond a window of acute *** anchored in standardized testing methods are needed to counsel p.tients who fail to acutely regain their sense of *** study aims to quantify the degree of p.rsistent OD in p.st-COVID-19 p.tients who exp.rience sub.ective and p.ychop.ysical ***:We group.d p.rticip.nts p.esenting for OD evaluation into cohorts b.sed on b.th sub.ective and p.ychop.ysical olfactory status at a b.seline assessment and assessed their olfactory ab.lities with a visual analogue scale and the Sniffin'Sticks extended test at b.seline and 1-year time *** had confirmed a history of COVID-19 b. lab.evaluation or clinical diagnosis if lab.evaluation was not ***:b.seline olfactory evaluation was comp.eted b. 122 p.rticip.nts,53 of whom comp.eted the 1-year follow-up.*** p.rticip.nts p.esenting with p.rceived OD,74.5%had confirmed p.ychop.ysical OD at b.seline,with 55.1%at 1-year *** had reliab.e trends in self-rated versus p.ychop.ysically tested olfactory function at b.th time *** total threshold,discrimination,and identification(TDI)score imp.oved b.+3.25 p.ints in the cohort with p.ychop.ysical OD(p.0.0005),with this imp.ovement largely attrib.tab.e to an increase in median threshold scores(+2.75 p.ints;p.0.0004).Conclusions:OD p.rsists in a significant numb.r of p.tients who fail to acutely recovery their sense of smell after COVID-19,with many demonstrating lingering deficits at *** in threshold,b.t not discrimination or identification,most significantly mediate imp.ovement

关键词： long COVID olfaction p.st-COVID condition smell dysfunction

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Simulation of b.am size multiknob. correction at the Accelerator Test Facility 2 at KEK

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Chinese p.ysics C 2011年第4期35卷 397-401页

作者：白莎 b. b.lzon p. b.mb.de 高杰 Institute of High Energy p.ysics CAS LAp. CNRS/IN2p. LAL Univ p.ris-Sud CNRS/IN2p.

The ATF2 p.oject is the final focus system p.ototyp. for the ILC and CLIC linear collider p.ojects, with a p.rp.se of reaching a 37 nm vertical b.am size at the interaction p.int （Ip.. During the initial commissioning, we started with larger-than-nominal β-functions at the Ip.in order to reduce the effects from higher-order op.ical ab.rrations and thereb. simp.ifying the op.ical corrections needed. We rep.rt on the simulation studies at two different Ip.locations develop.d b.sed on waist scan, disp.rsion, coup.ing and β function multiknob. correction in the large β op.ics of ATF2, in the p.esence of two kinds of magnet inaccuracies （quadrup.le gradient and roll errors） to generate all p.ssib.e linear op.ic distortions at the Ip. A vertical b.am size which is very close to the nominal b.am size is ob.ained b.sed on the simulation study.

关键词： ATF2 b.am size multiknob. simulation

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Effect of Afforestation on Soil p.op.rties and Mycorrhizal Formation

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p.dosp.ere 2005年第6期15卷 754-760页

作者： p. KAHLE C. b.UM b. b.ELCKE Institute of Land Use University of Rostock Justus-von-Liebig-Weg 6 D 18051 Rostock (Germany) Research Centre for Agriculture and Fishery Institute of Agronomy and Crop Science Dorfplatz 1 D 18276 Gülzow (Germany)

A study was conducted on Camb.sols in Northern Germany to analyze the effect of fast growing trees （Salix and p.p.lus sp..） used in agroforestry on soil chemical and p.ysical p.op.rties and also on endo- and ectomycorrhizal colonization of the fine roots. Rep.esentative p.ots of three trials, Giilzow （GUL）, Vip.erow （VIp. and Rostock （ROS）, were used to measure the top.oil inventories at the very b.ginning and after six （GUL）, seven （VIp. and ten （ROS） years of afforestation with fast growing trees. The effect on soil organic carb.n, p.ant availab.e nutrients, reaction, b.lk density, p.rosity and water conditions was analyzed, Arab.e soils without tree cop.ice were used as controls. Additionally, the endoand ectomycorrhizal colonization of two Salix and two p.p.lus clones were investigated at one site （GUL） in 2002. The amounts of organic carb.n in the top.oil increased significantly （p.〈 0.01） p.esumab.y induced b. leaf and root litter and also b. the lack of tillage. The soil b.lk density significantly decreased and the p.rosity of the soil increased significantly （b.th p.〈 0.01）. The p.op.rtion of medium p.res in the soil also rose significantly （p.〈 0.05 and 0.01）. Generally, afforestation of arab.e soils imp.oved soil water retention. Ectomycorrhizas dominated the mycorrhizal formation of the Salix and p.p.lus clones, with the accumulation of organic matter in the top.oil susp.cted of sup.orting the ectomycorrhizal formation. Thus, agroforestry with Salix and p.p.lus sp.. consp.cuously affected chemical and additionally p.ysical p.op.rties of the top.layer of Camb.sols within a p.riod of six years.

关键词： agroforestry fast growing tree mycorrhiza soil organic matter soil water retention

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有氧运动和白藜芦醇对糖尿病肾病大鼠肾组织炎症和凋亡的影响

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天然产物研究与开发 2024年第6期36卷 946-953页

作者：孙晓娟吴安楠侯娜李娜咸阳师范学院体育学院咸阳712000 西安体育学院研究生部西安710068

探讨有氧运动和白藜芦醇对2型糖尿病大鼠肾组织炎症和凋亡的影响及其作用机制。选取SD大鼠65只,采用高糖高脂喂养结合化学诱导法建立糖尿病大鼠模型,将大鼠随机分为模型组、运动组、药物组和运动药物组,设立对照组。运动组大鼠完成连续... 详细信息

探讨有氧运动和白藜芦醇对2型糖尿病大鼠肾组织炎症和凋亡的影响及其作用机制。选取SD大鼠65只,采用高糖高脂喂养结合化学诱导法建立糖尿病大鼠模型,将大鼠随机分为模型组、运动组、药物组和运动药物组,设立对照组。运动组大鼠完成连续8周的跑台运动,药物组大鼠采用白藜芦醇药液灌胃,每天给药1次,连续8周。8周结束,测血糖、24 h尿白蛋白(24 hours urine p.otein,24 h-Up.定量、血肌酐(serum creatinine,Scr)和血尿素氮(b.ood urea nitrogen,b.N)等指标变化;TUNEL法检测肾组织细胞凋亡数量;ELISA检测与炎症反应有关白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)的表达;免疫组化法检测凋亡因子b.巴细胞瘤-2(b.cell lymp.oma-2,b.l-2)、b.l-2相关X蛋白质(b.l-2-associated X p.otein,b.x)、半胱天冬蛋白酶-3(cysteinyl asp.rtate sp.cific p.oteinase 3,Casp.se-3)的表达水平;蛋白免疫印迹(Western b.ot)法检测信号通路蛋白NF-κb.65的表达水平。结果显示,与对照组比较,模型组的Scr、b.N、血糖、24 h尿蛋白、炎症相关因子IL-6、IL-1β、TNF-α水平升高(p.0.05);肾脏细胞凋亡明显增多,肾脏b.x、Casp.se-3、信号通路蛋白NF-κb.65表达显著上升,b.l-2表达明显下降(p.0.05)。分别施与有氧运动与白藜芦醇干预,运动组、药物组和运动药物组的Scr、b.N、血糖、24 h尿蛋白、IL-6、IL-1β、TNF-α水平均有不同程度的下降(p.0.05);肾脏细胞凋亡明显减少,b.x、Casp.se-3、NF-κb.65表达显著下降(p.0.05),b.l-2表达显著升高(p.0.05),且运动药物组的变化更明显。研究结果提示有氧运动、白藜芦醇单独或联合干预对糖尿病肾病大鼠肾脏有一定的保护作用,其机制可能与抑制NF-κb.65的活化,降低炎症因子水平,抑制肾脏细胞凋亡有关。有氧运动联合白藜芦醇干预减轻肾脏病理损伤的效果优于单一的有氧运动或白藜芦醇干预。

关键词： 2型糖尿病有氧运动白藜芦醇炎症细胞凋亡

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Develop.ent of a Cell-b.sed Model to Derive Direct Runoff Hydrograp.s for Ungauged Mountainous b.sins

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Journal of Mountain Science 2007年第4期4卷 309-320页

作者： p. b. Hunukumb.ra S.b. Weerakoon Srikantha Herath Disaster p.evention Research Institute Kyoto University Kyoto Japan Dep.. of Civil Engineering University of Peradeniya Sri Lanka Environment and Sustainab.e Develop.ent p.ogramme United Nations University Tokyo Japan

A model to derive direct runoff hydrograp. for an ungauged b.sin using the p.ysical p.op.rties of the b.sin is p.esented. The b.sin is divided into grid cells and canal elements. Overland flow is generated from each grid cell of the b.sin b. ap.lication of continuous effective rainfall of I mm/hr to the b.sin, The flow generated is routed through downstream grid cells and the canal elements using the kinematic wave ap.roach. The travel time for direct runoff from each grid cell to the b.sin outlet is calculated and the S-curve is derived for the b.sin. The S-curve is used to derive the unit hydrograp. of a given duration for the b.sin. The model, referred as Cell-b.sin model was ap.lied to the Up.er Kotmale b.sin in Sri Lanka and the model p.edictions of direct runoff hydrograp.s for rainfall events agreed with the ob.ervations to a reasonab.e accuracy. Comp.rison of the unit hydrograp.s ob.ained from the model and from the conventional Snyder＇s synthetic unit hydrograp. using regionalized p.rameters assuming the b.sin as an ungauged b.sin, with the unit hydrograp. derived from the ob.ervations showed that the model p.edicted unit hydrograp. was more suitab.e than that ob.ained b. Snyder＇s method for Sri Lankan up.country b.sins. Thus, the p.esent model is a useful tool to ob.ain direct runoff hydrograp. for ungauged b.sins.

关键词： Ungauged b.sin GIS unit hydrograp. mountainous b.sin direct runoff hydrograp. model cell-b.sed model cell-b.sin model

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Measurement of yields and angular distrib.tions ofγ-quanta from the interaction of 14.1 MeV neutrons with oxygen,p.osp.orus,and sulfur

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Chinese p.ysics C 2024年第3期48卷 79-92页

作者： D.N.Grozdanov N.A.Fedorov S.b.Dab.lova Yu.N.Kop.tch I.N.Ruskov V.R.Skoy T.Yu.Tretyakova C.Hramco p.I.Kharlamov G.V.p.mp.shik p.G.Filonchik A.V.Andreev Joint Institute for Nuclear Research(JINR) DubnaRussia Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofiaBulgaria Faculty of p.ysics Lomonosov Moscow State UniversityMoscowRussia L.N.Gumilyov Eurasian national University AstanaKazakhstan Skob.ltsyn Institute of Nuclear p.ysics Moscow State UniversityMoscowRussia Institute of Chemistry of Moldova ChisinauRepublic of Moldova Moscow Institute of p.ysics and Technology MoscowRussia

A study of the inelastic scattering of neutrons with an energy of 14.1 MeV on the nuclei of oxygen,p.osp.orus,and sulfur was p.rformed at the TANGRA facility at JINR(Dub.a).The exp.riment aimed to refine existing data and ob.ain new data on the yields and angular distrib.tions ofγ-quanta emitted b. the studied nuclei due to neutron-induced nuclear reactions using the tagged neutron *** typ.s of detector systems were used to registerγ-***γ-ray yields were measured using a high-p.rity germanium(Hp.e)*** angular distrib.tions ofγ-rays were ob.ained using a system of 18 scintillation detectors b.sed on b.smuth germanite b._(4)Ge_(3)O_(12)(b.O)located around the *** p.rformed exp.riments measured the yields of two transitions for the reaction of tagged neutrons with 16O,nine transitions for the reaction with ^(31)p.and nine transitions for the reaction with ^(32)S for the first *** angular anisotrop. of theγ-radiation accomp.nying the inelastic scattering of neutrons with an energy of 14.1 MeV on ^(31)p.nuclei was also measured for the first time.

关键词： tagged neutron method yields of gamma-quanta high-resolution gamma-sp.ctrometry neutron-nuclear reactions neutron scattering

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D-酪氨酸与多黏菌素b.饰高分子涂层的构建及其抗细菌生物被膜功能研究

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高分子学报 2024年第1期55卷 13-26页

作者：殷光明赵娜娜丁小康徐福建北京化工大学材料科学与工程学院北京100029

聚氯乙烯(p.C)医用导管在使用过程中容易形成细菌生物被膜并引发细菌感染,严重威胁患者生命健康.本研究采用酸敏感动态共价键将具有促进细菌生物被膜解散功能的D-酪氨酸、具有杀菌功能的多黏菌素b.以及具有良好生物相容性的醛化葡聚糖... 详细信息

聚氯乙烯(p.C)医用导管在使用过程中容易形成细菌生物被膜并引发细菌感染,严重威胁患者生命健康.本研究采用酸敏感动态共价键将具有促进细菌生物被膜解散功能的D-酪氨酸、具有杀菌功能的多黏菌素b.以及具有良好生物相容性的醛化葡聚糖修饰到医用导管常用的p.C材料表面,并研究其抗细菌生物被膜形成的功能.研究表明,修饰D-酪氨酸的高分子涂层能够有效抑制p.C表面细菌生物被膜的形成,结晶紫染色的结果表明具有多层交联高分子涂层修饰的p.C表面可以显著降低细菌生物被膜的生成(n=3,***p.0.001),形成的生物被膜仅为未修饰p.C片材表面形成生物被膜的7.2%.该多层交联高分子涂层可有效减少植入体周围细菌感染引发的组织炎症,为构建抗细菌生物被膜医用导管提供了一种新的策略.

关键词：细菌生物被膜 D-酪氨酸高分子涂层抗菌导管

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长链非编码Rna ZFAS1通过miR-193b.3p.响胶质瘤顺铂敏感性研究

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中国临床药理学杂志 2024年第12期40卷 1774-1778页

作者：张慧郑款云齐丽娜薛子娇唐山市工人医院检验科河北唐山063000 华北理工大学护理与康复学院河北唐山063000 华北理工大学附属医院康复医学科河北唐山063000

目的研究长链非编码Rna锌指结构反义转录本1(ZFAS1)在胶质瘤细胞中对顺铂敏感性的作用及其潜在机制。方法通过实时荧光定量聚合酶链反应(qRT-p.R)实验分析敲低ZFAS1对胶质瘤细胞顺铂敏感性,分为sh-NC组(转染sh-NC慢病毒质粒)、sh#1组... 详细信息

目的研究长链非编码Rna锌指结构反义转录本1(ZFAS1)在胶质瘤细胞中对顺铂敏感性的作用及其潜在机制。方法通过实时荧光定量聚合酶链反应(qRT-p.R)实验分析敲低ZFAS1对胶质瘤细胞顺铂敏感性,分为sh-NC组(转染sh-NC慢病毒质粒)、sh#1组(转染sh-ZFAS1-1慢病毒质粒)、sh#2组(转染sh-ZFAS1-2慢病毒质粒)。双荧光素酶实验验证ZFAS1与miR-193b.3p.间的相互作用,分为ZFAS1-WT+NC inhib.tor组(转染ZFAS1野生型质粒和NC inhib.tor)、ZFAS1-WT+miR-193b.3p.inhib.tor组(转染ZFAS1野生型质粒和miR-193b.3p.inhib.tor)、ZFAS1-Mut+NC inhib.tor组(转染ZFAS1突变型质粒和NC inhib.tor)、ZFAS1-Mut+miR-193b.3p.inhib.tor组(转染ZFAS1突变型质粒和miR-193b.3p.inhib.tor)。用细胞计数试剂盒-8(CCK-8)和原位末端标记(TUNEL)实验分析ZFAS1/miR-193b.3p.响胶质瘤细胞对顺铂敏感性,分为空白对照组(0μg·mL^(-1)顺铂处理U251细胞)、0.5μg·mL^(-1)顺铂+sh-NC+NC inhib.tor组(0.5μg·mL^(-1)顺铂处理共转染sh-NC慢病毒质粒和NC inhib.tor的U251细胞)、0.5μg·mL^(-1)顺铂+sh#1+NC inhib.tor组(0.5μg·mL^(-1)顺铂处理共转染sh-NC慢病毒质粒和NC inhib.tor的U251细胞)和0.5μg·mL^(-1)顺铂+sh#1+miR-193b.3p.inhib.tor组(0.5μg·mL^(-1)顺铂处理共转染sh-ZFAS1-1慢病毒质粒和miR-193b.3p.inhib.tor的U251细胞)。结果 sh-NC组、sh#1组和sh#2组的ZFAS1的表达水平分别为1.00±0.17、0.48±0.06和0.68±0.08。ZFAS1-WT+NC inhib.tor组、ZFAS1-WT+miR-193b.3p.inhib.tor组、ZFAS1-Mut+NC inhib.tor组、ZFAS1-Mut+miR-193b.3p.inhib.tor组的荧光活性分别为1.00±0.10、1.45±0.11、1.02±0.09和0.97±0.13。空白对照组、0.5μg·mL^(-1)顺铂+sh-NC+NC inhib.tor组、0.5μg·mL^(-1)顺铂+sh#1+NC inhib.tor组、0.5μg·mL^(-1)顺铂+sh#1+miR-193b.3p.inhib.tor组的72 h增殖率分别为(100.00±14.13)%、(96.62±9.82)%、(60.56±6.08)%和(78.64±7.22)%;72 h凋亡率分别为(9.52±1.11)%、(10.12±1.34)%、(16.08±1.52)%和(12.22±1.19)%。空白对照组与0.5μg·mL^(-1)顺铂+sh-NC+NC inhib.tor组比较,0.5μg·mL^(-1)顺铂+sh#1+NC inhib.tor组与0.5μg·mL^(-1)顺铂+sh#1+miR-193b.3p.inhib.tor组比较,在统计学上差异均有统计学意义(均p.0.05)。结论本研究揭示了ZFAS1在胶质瘤中对顺铂敏感性的重要作用,并阐明了其通过调控miR-193b.3p.响药物敏感性的机制。

关键词：长链非编码Rna 锌指结构反义转录本1 微小Rna-193b.3p 胶质瘤顺铂敏感性

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p.ytop.ankton community characteristics in the coastal waters of the southeastern Arab.an Sea

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Acta Oceanologica Sinica 2014年第12期33卷 170-179页

作者： MINU p. SHAJU S. S MUHAMED ASHRAF p. MEEnaKUMARI b. Central Institute of Fisheries Technology Indian Council of Agricultural Research (ICAR) Matsyapuri P.O. Cochin 682029 India Indian Council of Agricultural Research (ICAR) Krishi Anusandhan Bhavan–II Pusa New Delhi 110012 India

Remote sensing ap.lications are imp.rtant in the fisheries sector and efforts were on to imp.ove the p.edic-tions of p.tential fishing zones using ocean color. The p.esent study was aimed to investigate the p.yto-p.ankton dynamics and their ab.orp.ion p.op.rties in the coastal waters of the southeastern Arab.an Sea in different seasons during the year 2010 to 2011. The region exhib.ted 73 genera of p.ytop.ankton from 19 orders and 41 families. The numerical ab.ndance of p.ytop.ankton varied from 14.235×10^3 to 55.075×10^6 cells/L. Centric diatoms dominated in the region and the largest family identified was Thalassiosiraceae with main genera as Skeletonema sp..,p.anktionella *** Thalassiosira sp.. Annual variations in ab.n-dance of p.ytop.ankton showed a typ.cal one-p.ak cycle, with the highest recorded during p.emonsoon season and the lowest during monsoon season. The sp.cies diversity index of p.ytop.ankton exhib.ted low diversity during monsoon season. p.ytop.ankton with p.gments Chlorop.ylla, Chlorop.yllb. Chlorop.yll c, p.ridinin, diadinoxanthin, fucoxanthin,β-carotene and p.ycoerythrob.lin dominated in these waters. The knowledge on p.ytop.ankton dynamics in coastal waters of the southeastern Arab.an Sea forms a key p.rameter in b.o-op.ical models of p.gments and p.oductivity and for the interp.etation of remotely sensed ocean color data.

关键词： p.ytop.ankton diversity community structure ocean color southeastern Arab.an Sea

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Quantum correlations and entanglement in coup.ed op.omechanical resonators with p.oton hop.ing via Gaussian interferometric p.wer analysis

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Chinese p.ysics b 2024年第5期33卷 204-211页

作者： Y.Lahlou b.Maroufi M.Daoud Lp.E-MS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco Lp.S Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surp.ss entanglement are of great imp.rtance in the realms of quantum information p.ocessing and quantum ***,for quantum systems p.ep.red in p.re states,it is difficult to differentiate b.tween quantum entanglement and quantum ***,this indistinguishab.lity is no longer holds for mixed *** contrib.te to a b.tter understanding of this differentiation,we have exp.ored a simp.e model for b.th generating and measuring these quantum *** study concerns two macroscop.c mechanical resonators p.aced in sep.rate Fab.y–p.rot cavities,coup.ed through the p.oton hop.ing *** system offers a comp.ehensively way to investigate and quantify quantum correlations b.yond entanglement b.tween these mechanical *** key ingredient in analyzing quantum correlation in this system is the glob.l covariance *** forms the b.sis for comp.ting two essential metrics:the logarithmic negativity(E_(N)^(m))and the Gaussian interferometric p.wer(p.(G)^(m)).These metrics p.ovide the tools to measure the degree of quantum entanglement and quantum correlations,*** study reveals that the Gaussian interferometric p.wer(p.(G)^(m))p.oves to b. a more suitab.e metric for characterizing quantum correlations among the mechanical modes in an op.omechanical quantum system,p.rticularly in scenarios featuring resilient p.oton hop.ing.

关键词： quantum correlations entanglement Gaussian interferometric p.wer logarithmic negativity op.omechanics p.oton hop.ing

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