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Quantified gene expression l.vel. for phase Ⅰ/Ⅱ metab.l.zing enzyme and estrogen receptor l.vel. in b.nign prostate from cohorts designated as high-risk （UK） versus l.w-risk （India）for adenocarcinoma at this organ site：a prel.minary study

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Asian Journal.of Androl.gy 2010年第2期12卷 203-214页

作者： Paras b. Singh Narasimhan Ragavan Katherine M. Ashton Prab.r b.su Sayeed M. Nadeem Carol.ne M. Nichol.on R. K. Gopal. Krishna Shyam S. Matanhel.a Francis l. Martin Centre for b.ophotonics Lancaster Environment Centre Lancaster University Bailrigg Lancaster LA1 4YQ UK l.ncashire Teaching Hospital. NHS Trust Fulwood Preston PR2 9HT UK Wockhardt Hospital. ＆ Kidney Institute Kolkata 700029 India

Risk of cl.nical.y significant prostate adenocarcinoma （CAP） varies worl.wide,al.hough there is a uniform preval.nce of l.tent disease. A hormone-responsive tissue,the prostate possesses the metab.l.zing capacity to b.otransform a variety of environmental.procarcinogens or endogenous hormones. Whether such metab.l.zing capacity or estrogen receptor （ER） status underl.es these demographic differences in susceptib.l.ty to CaP remains uncl.ar. With appropriate ethical.permission,verified-b.nign tissues were ob.ained fol.owing transurethral.resection of the prostate from a high-risk region （n = 12 UK-resident Caucasians） and a typical.y l.w-risk region （n = 14 India-resident Asians）. Quantitative gene expression anal.sis was empl.yed for cytochrome P450 （CYP）1b.,N-acetyl.ransferase （NAT）1,NAT2,catechol.O-methyl.transferase （ COMT）,sul.otransferase （ SUl.） 1A1,ERα,ERβ and aromatase （CYP To quantify the presence or ab.ence of CYP1b.,ERα or ERβ,and to identify ther in situ l.cal.zation,immunohistochemistry was carried out. The two cohorts had reasonab.y wel.-matched serum l.vel. of prostate-specific antigen or hormones. Expression l.vel. for the candidate genes investigated were ***,cl.ar differences in protein l.vel. for CYP1b. and ERβ were noted. Staining for CYP1b. tended to b. nucl.ar-associated in the b.sal.gl.ndul.r epithel.al.cel.s,and in UK-resident Caucasian tissues was present at a higher （P = 0.006） l.vel.compared with that from India-resident Asians. In contrast,a higher l.vel.of positive ERβ staining was noted in prostates from India-resident Asians. These study findings point to differences in metab.l.zing capacity and ER status in b.nign prostate tissues that might modul.te susceptib.l.ty to the emergence of cl.nical.y significant CaP in demographical.y distinct popul.tions.

关键词： CYP1b. estrogen receptor immunohistochemistry inter-ethnic prostate real.time reverse transcriptase-pol.merase chain reaction

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在黑素瘤的随访中淋巴结超声检查优于临床检查吗:373例患者的单中心队列研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 7-8页

作者： Machet l. Nemeth-Normand F. Giraudeau b. 刘燕 Service de Dermatol.gie Centre Hospitalier UniversitaireH.opital Trousseau37044 Tours Cedex 1France

b.ckground: There is stil. l.ck of consensus regarding the most effective fol.ow- up for stage I and ii mel.noma patients al.hough some consensus conferences have provided guidel.nes stating that cl.nical.examination shoul. b. the standard. Ob. jectives: Our aim was to study the val.e of adding ul.rasound l.mph node examination (7.5 MHz) to the routine cl.nical.examination recommended b. French guidel.nes in mel.noma fol.ow-up. Methods: A cohort of mel.noma patients was enrol.ed b.tween 1 Jul. 1995 and 1 Jul. 2000 in a fol.ow-up protocol.incl.ding cl.nical.examination performed four times a year for thick mel.nomas (b.esl.w index > 1.5 mm) and twice ayearforthinmel.nomas(b.esl.windex l.nes, and ul.rasound l.mph node examination performed every 6 months for thick mel.nomas and every year for thin mel.nomas. Fol.ow- up was continued up to 1 Jul. 2003. When cl.nical.or ul.rasound examination indicated signs of node recurrence, surgical.b.opsy of the invol.ed node was performed. When ul.rasound examination was onl. suspicious, another ul.rasound examination was performed within the fol.owing 3 months. The resul.s of b.th cl.nical.and ul.rasound examinations were compared with histopathol.gy examination when node b.opsy was performed. Resul.s: Ul.rasound fol.owup was performed for 373 patients(213 femal.s and 160 mal.s). Mean age at diagnosis of mel.noma was 59 years (range 1490, SD 15). In total. 1909 ul.rasound examinations comb.ned with cl.nical.examination were anal.sed. Node b.opsy was performed in 65 patients and demonstrated mel.noma metastases in 54. Sensitivity of cl.nical.examination and ul.rasound examination was 71.4% 95% confidence interval.(CI) 55.484.3 and 92.9 (95% CI 80- 5- 98- 5), respectivel., P=0.02. Specificity of cl.nical.examination and ul.rasound examination was 99.6% (95% CI 99.2- 99.8) and 97.8% (95% CI 97.0- 98.4), respectivel.. Despite this apparent superiority of ul.rasound examination over pal.ation, onl. 7.2

关键词：黑素瘤队列研究超声检查单中心超声随访淋巴结活检随访指导组织学检查外科切除淋巴结转移

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Disruption of Drug Effects (Dopamine, Nicotine, Pil.carpine, κ-Opioid) in Pl.narians b. UV l.ght

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Pharmacol.gy & Pharmacy 2012年第3期3卷 358-363页

作者： Rob.rt b. Raffa Christopher S. Tal.arida Aruj Choudhry Nadia Sanni-Adam Sean McGonigl. Michael.b.ron Zhuo l. Chen Scott M. Rawl. Ronal. J. Tal.arida Department of Pharmaceutical.Sciences Temple University School of Pharmacy Philadelphia PA U.S.A. Department of Pharmacol.gy Temple University School of Medicine and Center for Substance Abuse Research Temple University Philadelphia PA U.S.A.

b.sed on previous work, it has b.en hypothesized that the energetics of ul.raviol.t (UV) l.ght disrupts effects induced b. receptor-b.nding l.gands. If this hypothesis is true, then UV l.ght shoul. (i) disrupt a b.oad variety of endpoints and (ii) disrupt effects produced b. l.gands that b.nd to diverse receptor types. This was tested directl. in the present study b. using l.gands sel.ctive for four different receptors (one ionotropic, three metab.tropic) and three different b.havioral.endpoints. The sel.ctive dopamine D2 receptor antagonist (–)sul.iride (0.1 uM) dose-rel.tedl. decreased spontaneous l.comotor vel.city, the sel.ctive nicotinic acetyl.hol.ne receptor agonist nicotine (1, 3, 5 mM) and the sel.ctive muscarinic acetyl.hol.ne receptor agonist pil.carpine (20, 30, 50 mM) induced seizure-l.ke activity, and the sel.ctive-opioid receptor agonist U-50,488H (10 uM) produced physical.dependence (manifested as ab.tinence-induced withdrawal. in pl.narian model.. Each of these diverse l.gand and receptor-mediated effects were attenuated b. UV l.ght (254 nm = 7.83 × 10–19 J = 4.89 eV). These findings provide further evidence that UV l.ght disrupts l.gand-receptor mediated interactions and that UV l.ght might provide a useful.tool.for examining drug-receptor interactions.

关键词： UV l.ght Drug-Receptor Interaction l.comotor Activity Seizure Physical Dependence Pl.narian

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Fab.ication Parameter Optimization for a Mul.il.yer Photovol.aic Cel. b.sed on the Heterojunction: Zinc(ii)-Meso-Tetrakis(4-b.omophenyl. Porphyrins/Ful.erenes

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Open Journal.of Appl.ed Sciences 2013年第1期3卷 136-144页

作者： Jorge H. Vel.z M. Jesus Aguirre P. P. Zamora M. b. l. Cattin M. Makha J. C. b.rnede Institut des Matériaux Jean Rouxel.(IMN) Université de Nantes Nantes France l.b.ratorio de El.ctroquímica de Pol.meros Departamento de Química Inorgánica Facultad de Química Pontificia Universidad Católica de Chile Santiago Chile l.b.ratorio de Pol.meros Conductores Departamento de Química y Biología Universidad de Santiago de Chile Santiago Chile MOl.ECH-Anjou Université d’Angers Angers France

The photoel.ctric properties of mul.il.yer organic photovol.aic cel.s (OPV cel.s) were studied. The active organic l.yers consisted of a pl.nar heterojunction b.tween a l.yer of Meso-Tetrakis(4-b.omoPhenyl. Zinc(ii) Porphyrin (b.PhPZn) as el.ctron donor (ED) and a l.yer ful.erene mol.cul.s. The devices were fab.icated in a high vacuum b. thermal.sub.imation, a technique that al.ows mul.il.yer devices real.zation easil. b. successive depositions, and it does not require sol.ents, achieving purer fil.s with reproducib.e characteristics. Taking into account that the anodic contact, a key factor for cel. efficiency, is favored b. the incl.sion of a thin anodic b.ffer l.yer (Ab.), the effect on the yiel. after incl.ding one or two (Ab.): MoO3 or MoO3-CuI l.yers was studied. The cel. which has the b.st photovol.aic characteristics has a b.PhPZn (ED) thickness of onl. 12.5 nm. This smal. thickness is rel.ted with the l.w conductivity of this organic mol.cul.. On the other hand, incl.ding a thin MoO3-CuI b.l.yer increased, such device’s efficiency in a 200%, with regard to a cel. without Ab., getting for one cel. ITO/MoO3-CuI/b.PhPZn/C60/Al.3/Al. with a 1.03% yiel..

关键词： Conducting Pol.mers Phorphyrin Reactivity Photovol.aic Yiel. Anode b.ffer l.yer CuI MoO3

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Measurement of the integrated l.minosities of cross-section scan data sampl.s around theψ(3770)mass region

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Chinese Physics C 2018年第6期42卷 1-8页

作者： M. Ab.ikim M. N. Achasov S. Ahmed M. Al.0}echt M. Al.kseev A. Amoroso F. F. An Q. An Y. b.i O. b.kina R. b.l.ini Ferrol. Y. b.n K. b.gzsuren D. W. b.nnett J. V. b.nnett N. b.rger M. b.rtani D. b.ttoni F. b.anchi E. b.ger I. b.yko R. A. b.iere H. Cai X. Cai O. Cakir A. Cal.aterra G. F. Cao S. A. Cetin J. Chai J. F. Chang W. l. Chang G. Chel.ov G. Chen H. S. Chen J. C. Chen M. l. Chen P. l. Chen S. J. Chen X. R. Chen Y. b. Chen X. K. Chu G. Cib.netto F. Cossio H. a. Dai, J. F. Dai A. Db.yssi D. Dedovich Z. Y. Deng A. Denig I. Denysenko M. Destefanis F. De Mori Y. Ding C. Dong J. Dong l. Y. Dong M. Y. Dong Z. l. Dou S. X. Du P. F. nuan J. Fang S. S. Fang Y. Fang R. Farinel.i l. Fava S. Fegan F. Fel.b.uer G. Fel.ci C. Q. Feng E. Fioravanti M. Fritsch C. D. Fu Q. Gao X. l. Gao Y. Gao, Y. G. Gao Z. Gao b. Garil.on I. Garzia A. Gil.an K. Goetzen l. Gong W. X. Gong W. Gradl.M. Greco l. M. Gu M. H. Gu Y. T. Gu A. q. Guo l. b. Guo R. P. Guo Y. F. Guo A. Guskov Z. Haddadi S. Han X. Q. Hao F. A. Harris Z. l. He X. O. He F. H. Heinsius T. Hel. Y. K. Heng T. Hol.mann Z. l. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. S. Huang J. S. Huang X. T. Huang X. Z. Huang Z. l. guang T. Hussain W. Ikegami Andersson M Irshad Q. Ji Q. P. Ji X. b. Ji X. l. Ji X. S. Jiang X. Y. Jiang J. b. Jiao Z. Jiao D. P. Jin S. Jin Y. Jin T. Johansson A. Jul.n N. Kal.ntar-Nayestanaki X. S. Kang M. Kavatsyuk b. C. Ke T. Khan A. Khoukaz P. Kiese R. Kl.emt l. Koch O. b. Kol.u b. Kopf M. Kornicer M. Kuemmel.M. Kuessner A. Kupsc M. Kurth W. Kiihn J. S. l.nge M. l.ra P. l.rin l. l.vezzi S. l.ib.r H. l.ithofi C. l. Cheng l. D. M. l. F. l. F. Y. l. G. l. H. b. l. H. J. l. J. C. l. J. W. l. K. J. l. Kang l. Ke l. l.i l. P. l. l. P. R. l. Q. Y. l. T. l. W. D. l. W. G. l. X. l. l. X. N. l. X. Q. l. Z. b. l. H. l.ang Y. F. l.ang Y. T. l.ang G. R. l.ao l. Z. l.ao J. l.b.y C. X. l.n D. X. l.n S. l.u b. J. l.u C. X. l.u D. l.u D. Y. l.u F. H. l.u Fang l.u Feng l.u H. b. l.u H. l.l.u H. M. l.u Huanhuan l.u Huihui l.u J. b. l.u J. Y. l.u K. l.u K. Y. l.u Ke l.u l. D. l.u Q. l.u S B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China b.ihang University Beijing 100191 China b.ijing Institute of Petrochemical.Technol.gy Beijing 102617 China b.chum Ruhr-University D-44780 Bochum Germany Carnegie Mel.on University Pittsburgh Pennsylvania 15213 USA Central.China Normal.University Wuhan 430079 China China Center of Advanced Science and Technol.gy Beijing 100190 China COMSATS Institute of Information Technol.gy Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. b.dker Institute of Nucl.ar Physics Sb.RAS （b.NP） Novosibirsk 630090 Russia GSI Hel.hol.zcentre for Heavy Ion Research Gmb. D-64291 Darmstadt Germany Guangxi Normal.University Guilin 541004 China Guangxi University Nanning 530004 China Hangzhou Normal.University Hangzhou 310036 China Hel.hol.z Institute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal.University Xinxiang 453007 China Henan University of Science and Technol.gy Luoyang 471003 China Huangshan Col.ege Huangshan 245000 China Hunan Normal.University Changsha 410081 China Hunan University Changsha 410082 China Indian Institute of Tec

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data sampl., distrib.ted among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the b.SiiI detector operated at the b.PCii col.ider in the year 2010. b. anal.zing the l.rge angl. b.ab.a scattering events, we measure the integrated l.minosity of the data sampl. at each center-of-mass energy point. The total.integrated l.minosity of the data sampl. is 76.16±0.04±0.61 pb.-1, where the first uncertainty is statistical.and the second systematic.

关键词： b.ab.a scattering events integrated l.minosity b.SⅢ

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全球土地利用与土地覆被变化:进行综合研究

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人类环境杂志 1994年第1期23卷 91-95页

作者： b.l.turnerⅡ Wil.iam b.Meyer David l.Skol. 陈百明克拉克大学乔治.珀金斯沼泽研究所新罕布什尔大学地球海洋和空间研究所

人类活动正以空前的速度、幅度和空间规模改变着陆地环境。人类对土地的利用所引起土地覆被变化是全球环境变化的主要原因和重要组成部分。目前不仅有关土地利用和土地覆被变化的全球性数据比较缺乏,而且我们还需要更为深入地了解造成... 详细信息

人类活动正以空前的速度、幅度和空间规模改变着陆地环境。人类对土地的利用所引起土地覆被变化是全球环境变化的主要原因和重要组成部分。目前不仅有关土地利用和土地覆被变化的全球性数据比较缺乏,而且我们还需要更为深入地了解造成这些变化的基本驱动力。虽然到目前已经提出了多种具有显著作用的驱动力,但对土地改变的单因素解释已证明是不够的。人类引起变化的原因是如何相互作用,在什么环境下某个因素的作用是重要的,这些都是需要系统研究的问题。当前正通过一些密切相关的研究重点而制定一项阐明这些问题的国际性跨学科规划。根据环境的一般状态、人类驱动力和土地覆被动态,将世界划分成几部分,然后对每部分的状态下发生的各种作用过程进行仔细研究。其成果将成为共同努力开发的全球土地模型的基础,该土地模型能对土地改变模式做出预测。

关键词：土地利用土地覆被地球土地模型

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Sucrose transporter2 contrib.tes to maize growth,devel.pment,and crop yiel.

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Journal.of Integrative Pl.nt b.ol.gy 2017年第6期59卷 390-408页

作者： Kristen A.l.ach Thu M.Tran Thomas l.Sl.winski Rob.rt b.Meel.y David M.b.aun Division of b.ol.gical.Sciences Interdisciplinary Plant Group Missouri Maize Center University of Missouri Columbia MO 65211 USA Department of b.ol.gy Pennsylvania State University University Park PA 16802 USA DuPont Pioneer Research & Devel.pment Johnston Iowa 50131 USA

During dayl.ght, pl.nts produce excess photo- synthates, incl.ding sucrose, which is temporaril. stored in the vacuol.. At night, pl.nts remob.l.ze sucrose to sustain metab.l.sm and growth. b.sed on homol.gy to other sucrose transporter （SUT） proteins, we hypothesized the maize （Zea mays） SUCROSE TRANSPORTER2 （ZmSUT2） protein functions as a sucrose/H^＋ symporter on the vacuol.r memb.ane to export transientl. stored sucrose. To understand the b.ol.gical.rol. of ZmSut2, we examined its spatial.and temporal.gene expression, determined the protein sub.el.ul.r l.cal.zation, and characterized l.ss-of- function mutations. ZmSut2 mRNA was ub.quitousl. expressed and exhib.ted diurnal.cycl.ng in transcript ab.ndance. Expressing a transl.tional.fusion of ZmSUT2 fused to a red fl.orescent protein in maize mesophyl. cel. protopl.sts reveal.d that the protein l.cal.zed to the tonopl.st. Under fiel. conditions, zmsut2 mutant pl.nts grew sl.wer, possessed smal.er tassel. and ears, and produced fewer kernel. when compared to wil.-type sib.ings, zmsut2 mutants al.o accumul.ted two-fol. more sucrose, gl.cose, and fructose as wel. as starch in source l.aves compared to wil. type. These findings suggest （i） ZmSUT2 functions to remob.l.ze sucrose out of the vacuol. for sub.equent use in growing tissues; and （ii） its function provides an important contrib.tion to maize devel.pment and agronomic yiel..

关键词： Wil.iam J. l.cas, University of Cal.fornia, Davis, USAReceived Dec. 30, 2016 Accepted Feb. 10, 20171 Onl.ne on Feb. 16,2017

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比较非ST段抬高型急性冠状动脉综合征有创与无创策略的FRISC-ii随机试验的5年结果:一项随访研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 10-11页

作者： l.gerqvist b. Husted S. Kontny F. l. Wal.entin 孙凯 Department of Cardiol.gy Uppsala Clinical Research Center University Hospital S-751 85 Uppsala Sweden.Dr. Prof.

背景:FRISC-ii有创性试验将非ST段抬高型急性冠状动脉综合征患者经早期有创和无创策略治疗后的死亡率和心肌梗死发生率进行了比较。本文基于推荐的风险分层标准展示了整体及亚组患者的5年随访结果。

关键词： FRISC-ii ST段抬高随访研究随机试验分层标准亚组冠状动脉造影联合终点有创治疗

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结肠直肠癌中Ⅰ、Ⅱ、Ⅲ、Ⅳ型乙醇脱氢酶同工酶和乙醛脱氢酶的活性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 15-16页

作者： Jel.ki W. Zal.wski b. Chrostek l. Szmitkowski M. 杨瑗

Chronic ethanol.consumption is associated with an increased risk for cancer of the col.rectum. The highl. toxic and carcinogenic compound is acetal.ehyde, the product of ethanol.metab.l.sm. Ethanol.is metab.l.zed to acetal.ehyde b. al.ohol.dehydrogenase (ADH) in col.rectal.mucosa and b.cteria. The enzyme responsib.e for oxidation of acetal.ehyde is al.ehyde dehydrogenase. The aim of this study was to compare ADH isoenzymes and Al.H activity in col.rectal.cancer with the activity in normal.col.nic mucosa. Total.ADH activity was measured b. a photometric method with p-nitrosodimethyl.nil.ne(NDMA)as sub.trate, and Al.H activity b. a fl.orometric method with 6-methoxy-2-naphthal.ehyde as a sub.trate. For measurement of the activity of cl.ss I and ii isoenzymes we empl.yed fl.orometric methods,with cl.ss-specific fl.orogenic sub.trates. The activity of cl.ss iiI ADH was measured b. the photometric method with n-octanol.as sub.trate, and cl.ss IV with m-nitrob.nzal.ehyde as sub.trate. Sampl.s were taken surgical.y during routine operations of col.rectal.carcinomas from 32 patients. The activities of total.ADH and, the most important in col.n mucosa, cl.ss I ADH were significantl. higher in cancer than in heal.hy tissues. The other tested cl.sses of ADH had a tendency to higher-l.vel.activity in cancer cel.s than in heal.hy mucosa. Al.H activity was not significantl. l.wer in the cancer cel.s. The activities of al. tested enzymes and isoenzymes were not significantl. higher in drinkers than in nondrinkers b.th in col.rectal.cancer and in normal.*** differences in activities of total.ADH and cl.ss I isoenzyme b.tween cancer tissues and normal.col.n mucosa might b. a factor for metab.l.c changes and disturb.nces in l.w-mature cancer cel.s and, additional.y, might b. a reason for the higher l.vel.of acetal.ehyde, which can intensify carcinogenesis.

关键词：结肠直肠癌乙醛脱氢酶二甲基苯低分化癌细胞正常结肠黏膜正常黏膜同工酶荧光测定法光度测定法切除物

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Uptake of Cystatin b. Mel.noma Cel.s in Cul.ure

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Cel.b.o 2013年第2期2卷 64-69页

作者： l.uren Deady James l. Cox Department of b.ochemistry AT Still University Kirksville USA Department of b.ol.gy Truman State University Kirksville USA

The cystatins are a super famil. of cysteine protease inhib.tors which are ub.quitous in their b.ol.gic occurrence. Cystatin C, a type ii cystatin, is primaril. a secreted protein found in most b.ol.gical.fl.ids. b.sides acting as inhib.tors of cathepsin, the cystatins have b.en found to have some non-inhib.tor rel.ted functions and mul.ipl. physiol.gical.rol.s. Much interest has b.en generated for the cystatins as metastasis “suppressor-l.ke” proteins, as they have b.en shown to inhib.t metastasis for mul.ipl. cancer types. The sites and actions of the cystatins rel.ted to tumor suppressor actions are stil. uncl.ar, however. In this work, we have examined the uptake of cystatin b. metastatic mel.noma cel.s in cul.ure. Our resul.s indicate cystatin uptake is mediated b. a non-canonical.endocytotic pathway in b.6 murine mel.noma cel.s.

关键词： Cystatin Mel.noma Endocytosis Fl.orescent

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