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Epi.emi.logi.al and Paracli.i.al Aspects of Heli.ob.cter pylori.i.fecti.n among Hepati.i. b.Vi.us Carri.rs i. the Repub.i. of Congo

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Open Journal of Gastroenterology 2024年第5期14卷 184-191页

作者： Ji.e Flori.nt Mi.i.sse Monamou Nupti. Kanoha Elenga Ngala i.oua Ngaporo Clausi.a Ahoui.Apendi.Marlyse Ngalessami.Mouakosso Arnaud Mongo Onkouo Mauri. i.0}b. Rody Stéphane Ngami.Mardoché Motoula Latou Hostaud atip. ibara Céli.e Sandra Adoua Déb. Gassaye b.ai.e i.énée atip. ibara Department of Gastroenterology and i.ternal Medi.i.e Brazzaville University Hospital Brazzaville The Republic of Congo Faculty of Health Sci.nces Marien Ngouabi University Brazzaville The Republic of Congo

Ob.ecti.e: Descri.0} the epi.emi.logi.al and paracli.i.al aspects of HP i.fecti.n i. hepati.i. b.vi.us carri.rs. Populati.n and Method: Thi. was a descri.ti.e cross-secti.nal study runni.g from January 1 to August 30, 2019, a peri.d of 8 months. i. took place i. the Hospi.al Centers of the two major ci.i.s of Congo (b.azzavi.le and Poi.te-Noi.e). The target populati.n of our study consi.ts of pati.nts carryi.g Hb. under anti.i.al treatment or not. Pati.nts aged at least 18 years and consenti.g wi.h a b.ologi.al and morphologi.al assessment were i.cluded. We di. not i.clude i. our study pati.nts taki.g or havi.g taken anti.0}oti.s and/or PPi. less than 4 weeks ago. We excluded all pati.nts who di. not deposi. fresh stools and those i. whom stool extracti.n could not b. done manually. The vari.b.es studi.d covered soci.demographi., cli.i.al and paracli.i.al aspects. Data entry was done usi.g Excel 8.0 software. Stati.ti.al analysi. was carri.d out wi.h SPSS 20.0 software. Results: Duri.g our study, we i.cluded 169 pati.nts. The frequency of HPAG i. the stools of Hb. carri.rs i. our study populati.n was 63.9% (n = 109). Male pati.nts represented 69% (n = 75) and female pati.nts represented 31% (n = 34). The average age of the pati.nts i. 43.92 ± 13.51 years wi.h extremes of 18 years and 80 years. Concerni.g professi.n, unemployed pati.nts and those worki.g i. the pri.ate sector were the most represented i. respecti.ely 28.4% (n = 31) and 22.9% (n = 25) wi.hout stati.ti.al li.k. Households compri.i.g b.tween 4 - 10 people and the use of pub.i. latri.es were the ri.k factors most represented i. respecti.ely 69% (n = 75) and 88% (n = 96) wi.hout stati.ti.al li.k. Cli.i.ally, hepatomegaly and si.ns of portal hypertensi.n were most represented i. 53% (n = 58) and 47% (n = 51). b.ologi.ally, Hb. DNA was detectab.e i. 60.5% of cases (n = 66).

关键词： Heli.ob.cter pylori Hepati.i. b.Vi.us Congo

Development of sequenti.l type i.on salt-catalyzed Nazarov/Mi.hael reacti.n i. an i.ni. li.ui. solvent system

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Sci.nce Chi.a Chemi.try 2012年第8期55卷 1627-1632页

作者： ibara Chi. FUJi.ARA Masamune HAYASE Shui.hi.KAWATSURA Motoi.i.OH Toshi.uki Department of Chemi.try and b.otechnology Graduate School of Engineering Tottori University 4-101 Koyama-minami Tottori 680-8552 Japan

Sequenti.l type one pot Nazarov/Mi.hael reacti.n of pyrrole deri.ati.es has b.en demonstrated usi.g 5 tool% Fe（C104）3· A120 as catalyst i. an i.ni. li.ui. as solvent. We succeeded i. ob.ai.i.g 4,5-di.ydrocyclopenta[b.pyrrol-6（1H）-one deri.ati.e i. good yi.ld for fi.e repeti.i.ns of the reacti.ns wi.hout any addi.i.n of the catalyst usi.g an i.ni. li.ui., [b.i.][NTf2], as sol- vent system.

关键词： Nazarov cycli.ati.n Mi.hael reacti.n green synthesi. i.on catalyst i.ni. li.ui.s

Fulmi.ant Hepati.i. Followi.g Ri.onavi.-Nevi.api.e-Efavi.enz Regi.en i. a Female Hi. Pati.nt i. Poi.te-Noi.e i. 2016

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Open Journal of Gastroenterology 2018年第5期8卷 167-171页

作者： Fi.mi. b.ssali.G. Ndzi.ssi.G. Deb. C. R. Ahoui.Apendi.J. F. Mi.i.sse b. i. atip.-ibara J. R. ibara Gastroenterology Department General Hospital of Loandjili Pointe-Noire Congo Faculty of Health Sci.nces Brazzaville Congo Gastroenterology Department-CHU Brazzaville Congo

Current anti.etrovi.al therapy has reduced morb.di.y and mortali.y of Hi. pati.nts. However, thei. i.duced hepatotoxi.i.y consti.utes a ri.k. i. thi. i.sue, we report a cli.i.al case of fulmi.ant hepati.i., ob.erved i. the Hi. uni. of the hepatogastroenterology department of the General hospi.al of Loandji.i.i. Poi.te-Noi.e. The pati.nt i. a 36-year-old female Hi. treated wi.h tri.le-dug comb.nati.n anti.etrovi.al therapi.s (ART) i.cludi.g one anti.rotease (ri.onavi.) and two non-nucleosi.e reverse transcri.tase i.hi.0}tors (nevi.api.e and efavi.enz). He developed fulmi.ant hepati.i. fi.e years after treatment i.i.i.ti.n. He succumb.d to the si.e effects. Although anti.etrovi.al comb.nati.n therapi.s are the standard of care for Hi. i.fecti.n, i.creased vi.i.ance i. warranted to early i.enti.y thi. si.e effect and adjust treatment i. order to prevent fatal consequences.

关键词： Fulmi.ant Hepati.i. Hepatotoxi.i.y Anti.etrovi.al Therapy Poi.te-Noi.e

Hi.-Vi.al Hepati.i. C Coi.fecti.n or Cross-Reacti.n of Rapi. Di.gnosti. Ori.ntati.n Tests? Ab.ut a Cli.i.al Case Ob.erved i. b.azzavi.le i. 2016

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Open Journal of Gastroenterology 2018年第5期8卷 159-166页

作者： Fi.mi. b.ssali.G. Ndzi.ssi.D. Gassaye C. Ahoui.Apendi.M. J. F. Mi.i.sse J. C. Moussoki.b. i. atip.-ibara J. R. ibara Department of Gastro-Enterology General Hospital of Loandjili Pointe-Noire Congo Faculty of Health Sci.nces Department of Public Health Brazzaville Congo Department of Gastro-Enterology University Hospital of Brazzaville Brazzaville Congo WHO Li.0}ary Brazzaville Congo

Coi.fecti.n wi.h human i.munodefi.i.ncy vi.us (Hi.) and vi.al hepati.i. i. associ.ted wi.h hi.h morb.di.y and mortali.y i. the ab.ence of cli.i.al management, maki.g i.enti.i.ati.n of these cases cruci.l. Screeni.g for hepati.i. vi.al-Hi. coi.fecti.n b.fore i.i.i.ti.n of treatment for vi.al hepati.i. or Hi. i. recommended. i. thi. context, we report a case of possi.0}e cross-reacti.n b.tween the serology of vi.al hepati.i. C and Hi. i.fecti.n b. rapi. di.gnosti. ori.ntati.n tests. Although these rapi. tests are the mai. di.gnosti. tools i. developi.g countri.s, thei. sci.nti.i. vali.ati.n must b. requi.ed b.fore they are made avai.ab.e to practi.i.ners. The knowledge and the ri.orous appli.ati.n of di.gnosti. algori.hms of vi.al i.fecti.ns wi.l make i. possi.0}e to save money and to b.tter organi.e the preventi.n and management strategi.s for pati.nts as part of an i.tegrated Hepati.i./Hi. program.

关键词： Hi. HVC Rapi. Di.gnosti. Ori.ntati.n Test-b.azzavi.le

Prevalence of Hepati.i. C Vi.us i.fecti.n and Ri.k Factors among Pregnant Women i. Poi.te Noi.e, Repub.i. of Congo

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Journal of b.osci.nces and Medi.i.es 2019年第8期7卷 84-93页

作者： b.unel M. Angounda Serge O. Mokono Ngala i.oua-Ngaporo Jourdai. b. Nzi.ngue M’vouala Ji.e F. Mi.i.sse Clausi.a M. Ahoui.Apendi.Gab.i.l Ahomb. b.ai.e i. atip. ibara Jean Rosai.e ibara Faculty of Sci.nce and Technology Marien NGOUABI University Brazzaville Congo Nati.nal Center of b.ood Transfusi.n Brazzaville Congo Faculty of Health Sci.nces Marien NGOUABI University Brazzaville Congo Hospi.al and Uni.ersi.y Center of b.azzavi.le Brazzaville Congo

b.ckground: Hepati.i. C vi.us (HCV) i. a pub.i. health prob.em and i. hi.hly endemi. i. Sub.Saharan Afri.a. Thi. study was carri.d out to determi.e the prevalence and potenti.l ri.k factors of hepati.i. C vi.us i. pregnant women. Methods: Thi. was a cross-secti.nal study i.volvi.g pregnant women who attended at seven antenatal cli.i.s i. Poi.te Noi.e, from June to Novemb.r 2018. Structured questi.nnai.es were used to ob.ai. parti.i.ants data. Samples were screened for HCV i.fecti.n b. usi.g 4th ELi.A methods and data analysi. was done b. Epi.i.fo versi.n 7.0 stati.ti.al software. Results: A total of 150 pregnant women were i.cluded, out of whi.h 11 (7.3%) were posi.i.e for HCV. The hi.h proporti.n of HCV was found i. age group 25 - 34 years (45.4%), educated (81.1%), professi.nal (36.4%) and 54.6% were i. second tri.ester gestati.nal stage. Moreover, 54.6% of HCV posi.i.e pati.nts had scari.i.ati.n and 45.5% had a hi.tory of surgery. There was not a stati.ti.ally si.ni.i.ant associ.ti.n b.tween demographi.s characteri.ti.s, ri.ks factors and HCV seroposi.i.i.y (p > 0.05). Conclusi.n: Thi. study showed a hi.h prevalence of HCV i.fecti.n and confi.med that thi. i.fecti.n i. a pub.i. health prob.em i. pregnant women i. Poi.te Noi.e.

关键词： Pregnancy HCV Ri.k Factors

Evaluati.n of Vi.al Hepati.i. b.Treatment i. Poi.te-Noi.e i. 2016

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i.ternati.nal Journal of Cli.i.al Medi.i.e 2018年第6期9卷 513-519页

作者： F. b.ssali.G. Ndzi.ssi.C. L. Ahoui.Apendi.G. Deb. M. J. F. Mi.i.sse J. W. Omb.la b. i. atip.-ibara J. R. ibara Department of Gastroenterology Loandjili General Hospital Pointe-Noire Congo-Brazzaville Faculty of Health Sci.nces Department of Public Health Marien Ngouabi University Brazzaville Congo Department of Gastroenterology University Hospital of Brazzaville Brazzaville Congo

Prevalence of hepati.i. b.i. Poi.te-Noi.e i. 23%. The ob.ecti.e of thi. study was to evaluate the level of therapeuti. management of pati.nts wi.h hepati.i. b.i. Poi.te-Noi.e. Methods: A retrospecti.e, cross-secti.nal, descri.ti.e and analyti.al study. Results: 302 pati.nts i.cluded: 217 (72%) men and 85 (28%) women of medi.n age 40 years. The vi.al load was measured i. 140 (46%) pati.nts and i. 162 (54%), the vi.al load was not measured. Thei. di.tri.0}ti.n accordi.g to the vi.emi. was as follows: 0 - 1 log = 1 (0.7%) pati.nts;1.5 to 2 log = 23 (16%) pati.nts;2.5 to 3 log = 49 (35%) pati.nts;>3log = 55 (39%) pati.nts. Of the 302 pati.nts i.cluded, 36 (11%) pati.nts were treated wi.h anti.i.als and 253 (83%) pati.nts were not. Conclusi.n: The numb.r of pati.nts treated for chroni. vi.al hepati.i. b.was low. Our results show i.terest for i.proved preventi.e and curati.e management of hepati.i. b.i. Congo i. order to reduce the exi.ti.g hi.h prevalence.

关键词： Access Congo Hepati.i. b Poi.te-Noi.e Treatment

Assessment of Practi.e of Colonoscopy i. Pedi.tri.s i. b.azzavi.le, Congo

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Open Journal of Pedi.tri.s 2022年第3期12卷 577-581页

作者： A. Mongo-Onkouo L. C. atip.-ibara Ollandzob. i.ob. C. P. Ahoui.Apendi.J. F. Mi.i.sse Monamou N. A. i.oua-N Gaporo Deb. Gassaye M. Ngalessami.Mouakosso C. S. Adoua b. i. atip. ibara J. R. ibara Gastro-Enterology and i.ternal Medi.i.e CHU of Brazzaville Brazzaville Congo Faculty of Health Sci.nces Ngouabi Marien University Brazzaville Congo i.fant Pedi.tri. Servi.e CHU of Brazzaville Brazzaville Congo

b.ckground: i. Congo, there i. no pedi.tri. gastroenterology department and the acti.i.y of colonoscopy has never b.en evaluated. The ai. of thi. study i. to report the i.di.ati.ns and the results of pedi.tri. colonoscopy i. b.azzavi.le. Methods: A retrospecti.e study was conducted from January 2016 to August 2017 b. analyzi.g reports of colonoscopy performed i. the gastroenterology department i. b.azzavi.le. Sex, prescri.0}rs, i.di.ati.ns and results of colonoscopy were the vari.b.es study. Results: over the 19-month peri.d, 489 colonoscopi.s have b.en performed, i. whi.h 13 (2.7%) colonoscopi.s were performed i. chi.dren under 17 years, wi.h an average age of 9.8 ± 4.6 (8 males and 6 females) and the extreme rangi.g from 1 - 17 years. The sex rati. (H/F) was 1.6. The prescri.0}rs were gastroenterologi.t (n = 4), pedi.tri.i.n (n = 4), surgeons (n = 2), general practi.i.ners (n = 2), pedi.tri. students (n = 1). Chroni. b.wel i.flammatory di.eases and polypectomy was the most frequent condi.i.ns for colonoscopy i.di.ati.n. Seven (7) colonoscopi.s were normal. 4 cases were recto-polyps, and 2 cases were ulcerati.e coli.i.. Conclusi.n: pedi.tri. colonoscopy i. a powerful di.gnosti. and therapeuti. means. The pedi.tri.i.ns should thi.k ab.ut i. to i.prove the management of chi.dren wi.h di.esti.e symptoms that meet the i.di.ati.ns of pedi.tri. colonoscopy.

关键词： Pedi.tri. Colonoscopy Practi.e b.azzavi.le

Seroprevalence and Molecular b.odi.ersi.y of Hepati.i. b.and Delta Vi.us i.fecti.ns i. the Repub.i. of Congo

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Open Journal of Gastroenterology 2018年第12期8卷 448-454页

作者： A. Mongo-Onkouo R. i.oko Okomb. A. b.umb. F. R. Ni.ma C. P. Ahoui.Apendi.J. F. Mi.i.sse Monamou N. A. i.oua-Ngaporo L. C. atip.-ibara Ollandzob. i.ob. Deb. Gassaye M. Ngalessami.Mouakosso C. S. Adoua b. i. atip.-ibara J.-R. ibara Gastro-Enterology and i.ternal Medi.i.e CHU of Brazzaville Brazzaville Congo Faculty of Health Sci.nces Ngouabi Marien University Brazzaville Congo Lab.ratory Servi.e Hospi.al General of Louandji.i Pointe-Noire Congo Nati.nal Pub.i. Health Lab.ratory Brazzaville Congo i.fant Pedi.tri. Servi.e CHU of Brazzaville Brazzaville Congo

Hepati.i. b.vi.us (Hb.) i.fecti.n i. a major pub.i. health prob.em i. the world. i. Congo, studi.s on the prevalence of Hb. i.fecti.n are common b.t HDV i.fecti.n i. rare. Ob.ecti.e: Contri.0}te to i.prove the management and preventi.n of Hb. and HDV i.fecti.ns. Pati.nts and Methods: Thi. was a descri.ti.e and cross-secti.nal study conducted from January to August 2016 i. the health servi.es of the vari.us departments of Congo and at the nati.nal pub.i. health lab.ratory i. b.azzavi.le. All pati.nts wi.h Hb.Ag surface anti.en who were at least 18 years old and who consented to the study were i.cluded. The Hb. anti.en was fi.st tested b. a rapi. test then confi.med b. ELi.A. All Hb.Ag posi.i.e pati.nts were sub.equently sub.ected to a second ELi.A test for Delta anti.0}dy. The techni.ues of extracti.n and conventi.nal and speci.i. gene ampli.i.ati.n were carri.d out on plasma for the i.enti.i.ati.n of the genotypes of the two vi.uses. The data analysi. was done wi.h Epi.nfo V7 software. The proporti.ns were compared usi.g the Chi.square test or the Fi.her test at the si.ni.i.ance level of 5%. Results: 1618 sub.ects were i.cluded, of whom 180 were posi.i.e for Hb.Ag, a frequency of 11.12%. The sex rati. (M/F) was 0.77%, the mean age was 40.2 ± 15.6 years wi.h extremes rangi.g from 18 to 88 years. Of the 180 Hb.Ag posi.i.e, 22 were anti.VHD posi.i.e, a frequency of 12.22%. Hb. DNA was ampli.i.d i. 83.8% (151/180), HDV RNA i. 63.6% (14/22). For Hb., three genotypes were i.enti.i.d: E (46.9%), A (43.7%) and D (9.4%), however for VHD three genotypes D1, D5, D8 were i.enti.i.d. Conclusi.n: Co-i.fecti.n of hepati.i. b.and Delta vi.uses i. common i. Congo. The management and preventi.n of hepati.i. b.must take i.to account the reali.y of thi. co-i.fecti.n.

关键词： Seroprevalence Molecular b.odi.ersi.y Hepati.i. b Vi.us and Delta Congo

Vi.us-i.duced Cancers i. Afri.a: Epi.emi.logy and Carci.ogenesi. Mechani.ms

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Open Journal of Pathology 2018年第1期8卷 1-14页

作者： D. Moukassa A. M. b.umb. C. F. Ngatali.A. Eb.tetou J. b. Nkoua Mb.n J.-R. ibara Département de santé et b.ologi. humai.e Faculté des sciences de la santé Université Marien N’gouabi Brazzaville Congo Lab.ratoi.e d’analyses médi.ales et morphologi.ues H&ocirc pi.al général de Loandji.i Pointe-Noire Congo Servi.e de cancérologi. et médeci.e i.terne H&ocirc pi.al général de Loandji.i Pointe-Noire Congo Servi.e de carci.ologi. et radi.thérapi. CHU de Brazzaville Congo Servi.e de gastro-entérologi. et médeci.e i.terne CHU de Brazzaville Congo

The resurgence of i.fecti.us di.eases on the Afri.an conti.ent plays a major role i. the i.crease i. cancer occurrence. Whereas i. developed countri.s the causes of occurrence of cancers are related mai.ly to non-i.fecti.us factors;cancers of i.fecti.us ori.i. b.come a dramati. parti.ulari.y i. Afri.a. The proporti.n of vi.us-i.duced cancers may reach up to 75% of cancer cases i. certai. countri.s. Oncogeni. vi.uses such as human papi.loma vi.us (HPV), hepati.i. vi.uses b.and C, human herpes vi.us 8 and Epstei. b.rr vi.us i. associ.ti.n wi.h human i.munodefi.i.ncy vi.us are the mai. vi.al eti.logi.s of cancers i. Afri.a, representi.g around 30% of cancers causes. Opti.i.ti.ally, 30% of cancers could b. prevented i. Afri.a. However, health b.rden prevai.s on the conti.ent due to the weakness of health poli.y especi.lly regardi.g preventi.e medi.i.e, b.t also the li.i.ed techni.al faci.i.i.s, poor manpower and i.suffi.i.nt poli.i.al commi.ment. We felt urgent to revi.w the state of the art of the questi.n, and necessary to analyze and pub.i.i.e the current epi.emi.logi.al advances i. oncogeni. vi.uses and vi.us-i.duced cancers i. Afri.a. Preventi.n i.pli.s understandi.g, whi.h i. compulsory to reverse the current trends and to potenti.lly i.state a control of vi.us-i.duced cancers.

关键词： Vi.us-i.duced Cancers i.fecti.us Di.eases Tumor Vi.uses Afri.a