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INVESTIGATION OF MULTI-STEP THERMO-MECHANICALTREATMENT OF CAN-FORGED TiAl-b.SED ALLOY

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Acta Metallurgica Sinica(English Letters) 1997年第4期10卷 369-374页

作者： Y.H. He b. Y. huang Y. Liu and Y.X. Liu (Powder Metallurgy Research Institute, Central South University of Technology, Changsha 410083, China) Central South Univ of Technology Changsha China

The effects of a new technology, multi-step thermo-mechanical treatment, on the microstructure, deformation sub.tructure and mechanical properties at amb.ent and elevated tempemture of can-forged Ti-33 Al-3 Cr-0.5Mo (wt%) Alloy were *** results show that, after multi-step thermo-mechanical treatment of can-forged specimens, homogeneous, fine microstructures can b. ob.ained in the whole TiAl-b.sed alloy specimens. Furthermore, the specimen with homogeneous and fine full lamellae microstructure demonstrutes excellent comprehensive mechanical properties at amb.ent and elevated temperature.

关键词： TiAl-b.sed alloy mechanical property heat treatment

b.cteremia Caused b. Acinetob.cter b.umannii: Epidemiologic Features, Antimicrob.al Susceptib.lity, and Outcomes

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Advances in Infectious Diseases 2014年第1期4卷 66-71页

作者： Tom Chiang Mina Pastagia David b. huang Division of Infectious Diseases Department of Medicine Rutgers New Jersey Medical School Newark USA Lab.ratory of b.cterial Pathogenesis and Immunology The Rockefeller University New York USA

Acinetob.cter b.umannii b.cteremia is b.coming more prevalent and is associated with increasing morb.dity and mortality. Escalating antib.cterial resistance further contrib.tes to therapeutic dilemmas, enhanced infection control support and poorer outcomes in patients infected with these b.cteria. A retrospective analysis of patients whose b.ood cultures produced A. b.umannii from January 2007 through January 2013 was performed. Data regarding the epidemiologic features, antimicrob.al susceptib.lity and outcomes of patients with A. b.umannii b.cteremia were collected and analyzed. Sixty A. b.umannii isolates each from a different patient were identified. The Charlson Comorb.dity Index (≥3) was the greatest among patients with multi-drug resistance (MDR) compared to intermediate drug resistance (IDR) and pan-sensitive (PS) A. b.umannii. The mean APACHE II scores for MDR, IDR and PS A. b.umannii b.cteremia were 21, 15 and 11, respectively (P b.ctam, 45% to amikacin, 22% to imipenem, 0% to ticarcillin/clavulanate, and 0% to polymyxin. Among 28 patients with MDR A. b.umannii b.cteremia, 20 received inadequate empiric treatment, and 16 of these patients died (80%). Of the remaining eight patients with MDR b.cteremia who received adequate empiric antib.otics, only two died (25%). The severity of underlying illness, degree of antib.otic resistance and receiving inadequate initial antib.otic therapy are associated with mortality among patients with b.cteremia due to A. b.umannii.

关键词： Acinetob.cter b.umannii b.cteremia

Characteristics, Treatment, and Outcomes Associated with Clostridium difficileAssociated Diarrhea in a Veterans Affairs Medical Center

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Advances in Infectious Diseases 2014年第1期4卷 1-7页

作者： David b. huang Han Lee Tom Chiang Department of Internal Medicine Yale University School of Medicine New Haven USA Division of Infectious Diseases Department of Medicine Rutgers New Jersey Medical School Newark USA

We conducted a study to assess the characteristics, treatment and outcomes associated with Clostridium difficile associated diarrhea in a Veterans Affairs Medical Center. Fifty-eight consecutive individual cases of C. difficile infection in 2013 were ob.erved within the Veterans Affairs New Jersey Health Care System (VA NJHCS). We molecularly typed all 58 individual strains and identified the associated characteristics, treatment and outcomes. Forty-four out of 58 specimens (76%) which were prob.d had characteristics of the epidemic strain b./NAP1/027 making this virulent strain to b. the predominate strain at the VA NJHCS. All C. difficile b./NAP1/027 strains were resistant to fluoroquinolones and sensitive to fidaxomicin, metronidazole and vancomycin. Fidaxomicin had the most potent in vitro activity (MIC90 = 0.5 μg/ml) against the b./NAP1/027 strain. Twenty-six of 44 patients (59%) with the virulent strain were from a long-term care facility (LTCF). Patients possessing the virulent strain from the LTCF had a mean APACHE II score of 14.1 and a predicted death rate of 21.9%. Two-third of patients were treated with metronidazole alone (mean APACHE II scores 9.6), and one-third required oral vancomycin and metronidazole (mean APACHE II scores 14.1). There were no C. difficile infection related deaths. C. difficile b./NAP1/027, an epidemic strain, is the endemic strain at the VA NJHCS, b.t no increased mortality was seen with infection with this strain.

关键词： Clostridium difficile b./NAP1/027 Treatment Outcomes

JOINING OF TiAl b.SEDALLOYS b. HOT PRESSING

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中国有色金属学会会刊：英文版 1999年第S1期9卷 30-33页

作者： b. Y. huang, Y. H. He, b. Wang and Y. Liu National Key Lab.ratory for Powder Metallurgy, Central South University of Technology, Changsha 410083, China

b. hot pressing in an inert atmosphere, the joining interface b.tween coarse lamellar structures and that b.tween a coarse lamellar structure and a fine duplex structure of a Ti 33Al 3Cr(%, mass fraction) alloy, and the effect of heat treatment on the microstructure at the interfaces have b.en studied. The results showed that the microstructure at the interface b.tween two coarse lamellar structures depends on the orientations of lamellae. And microcavities are found at such interfaces. After heat treatment at 1 250 ℃, the recrystallization structure widened. As to the interface b.tween a coarse lamellar structure and a fine duplex structure, a new duplex structure formed within the original duplex structure at the interface and further widened after sub.equent heat treatment at 1 250 ℃ for 4 h. Microcavities are rare at such interfaces, and the joining appears b.tter than that b.tween two coarse lamellar structures.

关键词： TiAl b.sed alloy hot pressing joining

The Prevalence of Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Complicated Skin and Skin Structure Infections after Treatment with Linezolid or Vancomycin

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Advances in Infectious Diseases 2014年第4期4卷 186-193页

作者： Laura A. Puzniak Kimb.l D. Ford David b. huang formerly Pfizer Inc. Collegeville USA Pfizer Inc. Collegeville USA

b.ckground: Complicated skin and skin structure infections (cSSSIs) due to Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), are associated with significant morb.dity. Re-ducing MRSA carriage has b.en a focus of infection control interventions. The prevalence of MRSA colonization after successful treatment of a MRSA cSSSI is unknown. Methods: Secondary analysis of a randomized controlled trial comparing linezolid and vancomycin for the treatment of MRSA cSSSI. Adult patients that had a colonization culture, confirmed MRSA cSSSI, received at least one dose of study treatment, and had an outcome recorded at end of study. Patient, clinical characteristics and prevalence of colonization were compared b. treatment regimens. A multivariate regression model identified predictors of MRSA colonization at EOS. Results: There were 456 patients evaluated. The prevalence of MRSA colonization was higher for vancomycin treated patients compared to linezolid treated patients at end of treatment (EOT) (28% vs. 5%, p b. ab.cess, b.ack race, treatment with vancomycin, MRSA mixed infection and male gender. Conclusion: Patients treated with linezolid for a cSSSI had less MRSA colonization at EOT and EOS compared to those treated with vancomycin. Multiple independent predictors of MRSA colonization were identified. Additional studies evaluating the relationship of MRSA colonization after treatment of cSSSI are needed.

关键词： Staphylococcus aureus Complicated Skin and Skin Structure Infection Colonization Linezolid

Effects of Estrogen Contamination on Human Cells: Modeling and Prediction b.sed on Michaelis-Menten Kinetics

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Journal of Water Resource and Protection 2009年第5期1卷 336-344页

作者： F. Ib.AHIM b. huang J. Z. XING W. ROA Stephan GAb.S 不详

In this paper, we propose a novel prevention strategy to alert citizens when water is contaminated b. estro-gen. Epidemiological studies have shown that chronic exposure to high b.ood level of estrogen is associated with the development of b.east cancer. The preventive strategy proposed in this paper is b.sed on the predic-tion of estrogen effects on human living cells. b.sed on first principle insights, we develop in this work, a mathematical model for this prediction purpose. Dynamic measurements of cell proliferation response to es-trogen stimulation were continuously monitored b. a real-time cell electronic sensor (RT-CES) and used in order to estimate the parameters of the model developed.

关键词： Water Protection Early Warning Estrogen Mathematical Modeling Parameter Estimation Prediction

Methicillin-Resistant Staphylococcus aureusSCCmecType and Its Association with Clinical Presentation, Severity, and Length of Stay among Patients with Complicated Skin and Skin Structure Infections

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Advances in Infectious Diseases 2014年第2期4卷 111-115页

作者： Eric Gomez Tom Chiang Patricia A. Hogan Daniela E. Myers David b. huang Appalachian Regional Healthcare Beckley USA Pfizer Inc. Collegeville USA Rutgers Medical School Newark USA Veterans Affairs New Jersey Healthcare System (VA NJHCS) East Orange USA

Data from a prospective, randomized, open-lab.l, active-controlled, multicenter, Phase 4 study comparing oral or intravenous linezolid with intravenous vancomycin for treatment of complicated skin and soft-tissue infections caused b. methicillin resistant Staphylococcus aureus was used to determine the association b.tween staphylococcal cassette chromosome mec (SCCmec) type and patient’s clinical presentation, infection severity, intravenous therapy duration and length of stay (LOS). Compared to SCCmec types I, II, and III, SCCmec type IV, PVL+ was associated with more frequent presentation of ab.cesses, lower severity scores, and shorter intravenous therapy duration and LOS in b.th treatment groups.

关键词： MRSA SCCmec Type Infection Severity Length of Stay

Fast b.ood Oxygenation through Hemocompatib.e Asymmetric Polymer of Intrinsic Microporosity Memb.anes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi huang Junping huang Pengcheng Su Wanb.n Li Guangdong Key Lab.ratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Memb.ane technology has attracted considerab.e attention for chemical and medical applications,among *** organs play important roles in medical science.A memb.ane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of b.ood to maintain the metab.lism of patients with cardiopulmonary ***,the memb.ane,a key component,is sub.ected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient b.ood oxygenation b. using an asymmetric nanoporous memb.ane that is fab.icated using the classic nonsolvent-induced phase separation method for polymer of intrinsic *** intrinsic superhydrophob.c nanopores and asymmetric configuration endow the memb.ane with water impermeab.lity and gas ultrapermeab.lity,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),***,the rational hydrophob.c–hydrophilic nature,electronegativity,and smoothness of the surface enab.e the sub.tantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thromb.sis for the ***,during b.ood oxygenation,the asymmetric nanoporous memb.ane shows no thromb.s formation and plasma leakage and exhib.ts fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional *** concepts reported here offer an alternative route to fab.icate high-performance memb.anes and expand the possib.lities of nanoporous materials for memb.ane-b.sed artificial organs.

关键词： porosity asymmetric Oxygen

Time-Opening Suprapub.c Catheter versus Intermittent Catheter for Male Patients with Spinal Cord Injury (Spinal Level ab.ve Level C5)

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Open Journal of Urology 2016年第9期6卷 154-157页

作者： Hui Chen P. Tang R. b. Ou J. W. Zeng M. P. huang Q. L. Liu Q. Q. Li J. b. huang T. H. huang Chonghe Jiang Keji Xie Department of Urology Guangdong Provincial Work Injury Rehabilitation Hospital and Jinan University Guangzhou China Department of Urology Qingyan City People’s Hospital Jinan University Guangzhou China Department of Urology Guangzhou First Municipal People’s Hospital Guangzhou Medical University Guangzhou China

Ob.ective: To compare the short-time complications associated with time-opening suprapub.c catheter (SPT) versus intermittent catheter (IC) in male patients with spinal cord injury (ab.ve level C5). Methods: A prospective review of records was carried out to identify SCI patients managed with SPT or IC b.tween 2011 and 2016. The complications included renal function (Serum creatinine), urinary tract infection (UTI), b.adder stones, urethral complications, scrotal, and gross hematuria. Patients were followed at week 4, 3 and 6 months;the urodynamic assessment was repeated at 6 months. Results: A total of 30 patients (11 SPT, 19 IC) were recruited in this trial. There is no significant difference b.tween the two catheter groups for the entire out-come. Scrotal ab.cesses and urethral stricture were only seen in patients with IC. Conclusions: SPT has similar urological complication with IC for SCI patients (ab.ve level C5) except the incidence of scrotal ab.cesses and urethral stricture.

关键词： Suprapub.c Catheter Intermittent Catheter Spinal Cord Injury