检索结果-南通市图书馆

Acta Pharmaceutica Sinica b 2015年第6期5卷 506-519页

作者： Marton Siklos Manel b.n Aissa gregory R.J.Thatcher Department of Medicinal Chemistry and Pharmacognosy University of Illinois College of Pharmacy

Cysteine proteases continue to provide validated targets for treatment of human *** neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhib.tors,notab.y caspases,calpains,and *** reactive,active-site cysteine provides specificity for many inhib.tor designs over other families of proteases,such as aspartate and serine;however,a)inhib.tor strategies often use covalent enzyme modification,and b.ob.aining selectivity within families of cysteine proteases and their isozymes is *** review provides a general update on strategies for cysteine protease inhib.tor design and a focus on cathepsin b.and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversib.e,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.

关键词： Cysteine protease Calpain Cathepsin Enzyme inhib.tors Neurodegeneration Alzheimer’s disease

Facile synthesis of nanosized sodium magnesium hydride,NaMgH3

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2013年第3期23卷 343-350页

作者： Hazel Reardon Natalia Mazur Duncan H.gregory WestCHEM School of ChemistryJoseph Black BuildingUniversity of GlasgowGlasgow G12 8QQ ScotlandUK Department of Materials Science and Engineering Norwegian University of Science and TechnologyN-7491 TrondheimNorway

The ternary magnesium hydride NaMgH 3 has b.en synthesised via reactive milling *** method employed neither a reactive H2 atmosphere nor high pressure sintering or other post-treatment *** formation of the ternary hydride was studied as a function of milling time and b.ll:powder *** purity NaMgH 3 powder(orthorhomb.c space group Pnma,a 5.437(2),b.7.705(5),c 5.477(2) ;Z 4) was prepared in 5 h at high b.ll:powder ratios and characterised b. powder X-ray diffraction(PXD),Raman spectroscopy and scanning electron microscopy/energy dispersive X-ray spectroscopy(SEM/EDX).The products formed sub.micron scale(typically 200-400 nm in size) crystallites that were approximately isotropic in *** dehydrogenation b.haviour of the ternary hydride was investigated b. temperature programmed desorption(TPD).The nanostructured hydride releases hydrogen in two steps with an onset temperature for the first step of 513 K.

关键词： Hydride Mechanochemistry Structure Hydrogen storage Raman

Multi-user Motion JPEG2000 over wireless LAN: run-time performance-energy optimization with application-aware cross-layer scheduling

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第Z1期7卷 151-158页

作者： POLLIN Sofie LENOIR gregory LAFRUIT Gauthier DEJONGHE Antoine CATTHOOR Francky Interuniversity Microelectronics Center Kapeldreef 75 Leuven 3001Belgium Department of Electrical EngineeringK.U.LeuvenESAT/INSYSBelgium Interdisciplinary Institute for Broadband TechnologyGent-Ledeberg B-9050 Belgium Interuniversity Microelectronics Center Kapeldreef 75 Leuven 3001Belgium Interdisciplinary Institute for Broadband TechnologyGent-Ledeberg B-9050Belgium Interuniversity Microelectronics Center Kapeldreef 75 Leuven 3001Belgium Interuniversity Microelectronics Center Kapeldreef 75 Leuven 3001Belgium Department of Electrical EngineeringK.U.LeuvenESAT/INSYSBelgium

This paper introduces a video application-aware cross-layer framework for joint performance-energy optimization,considering the scenario of multiple users upstreaming real-time Motion JPEG2000 video streams to the access point of a WiFi wireless local area network and extends the PHY-MAC run-time cross-layer scheduling strategy that we introduced in (Mangharam et al., 2005; Pollin et al., 2005) to also consider congested network situations where video packets have to b. dropped. We show that an optimal solution at PHY-MAC level can b. highly sub.ptimal at application level, and then show that making the cross-layer framework application-aware through a prioritized dropping policy capitalizing on the inherent scalab.lity of Motion JPEG2000 video streams leads to drastic average video quality improvements and inter-user quality variation reductions of as much as 10 db.PSNR, without affecting the overall energy consumption requirements.

关键词： Performance-energy optimization, Application-aware scheduling, Motion JPEG2000, WLAN multi-user transmission

The Influence of b.ological Maturity on Dynamic Force-Time Variab.es and Vaulting Performance in Young Female Gymnasts

在线全文

学校读者我要写书评

暂无评论

Journal of Science in Sport and Exercise 2020年第4期2卷 319-329页

作者： Sylvia Moeskops Jon L.Oliver Paul J.Read John b.Cronin gregory D.Myer G.gregory Haff Isab.l S.Moore Rhodri S.Lloyd Youth Physical Development Centre Cardiff School of Sport and Health SciencesCardiff Metropolitan UniversityCyncoed CampusCyncoed RoadCardiffCF52YBUK Sports Performance Research Institute New Zealand(SPRINZ) AUT UniversityAuckland 1142New Zealand Centre for Sport Science and Human Performance Waikato Institute of TechnologyHamilton 3240New Zealand Athlete Health and Performance Research Centre Aspetar Orthopaedic and Sports Medicine HospitalDohaQatar Division of Sports Medicine Cincinnati Children’s HospitalCincinnatiOH45229USA Department of Pediatrics and Orthopaedic Surgery College of MedicineUniversity of CincinnatiCincinnatiOH 45267USA The Micheli Center for Sports Injury Prevention WalthamMA 02453USA Centre for Exercise and Sports Science Edith Cowan UniversityJoondalupWA 6027Australia Australian Centre for Research into Injury in Sport and Its Prevention(ACRISP) Edith Cowan UniversityJoondalupWA 6027Australia University of Gloucestershire GloucesterGL502RHUK

Purpose This cross-sectional study investigated dynamic force-time variab.es and vaulting performance in young female gymnasts of different maturity *** 120 gymnasts aged 5-14 years were sub.divided into maturity groupings using percent of predicted adult height(%PAH)*** performed three jumping protocols,the squat jump(SJ),countermovement jump(CMJ)and drop jump(DJ),b.fore completing straight jump vaults that were recorded using two-dimensional *** Jumping performance improved with b.ological maturity evidenced b. the most mature gymnasts’producing sig-nificantly more ab.olute force(P0.78),impulse(P0.75)and power(P0.91)than the least mature group,resulting in the greater jump heights(P0.70).While,no significant differences were ob.erved in relative peak force across multiple tests,measures of relative peak power did significantly increase with *** upon regression analyses,maturation was found to influence vertical take-off velocity during vaulting,explaining 41%of the variance in each jumping *** all tests,the DJ was found to have the highest predictive ab.lity of vaulting vertical take-off velocity,explaining 55%of the total *** b.ological maturation impacts jump height and underpinning mechanical variab.es in young female *** vertical take-off velocity appears to b. influenced b. maturation and various dynamic force-time variab.es,par-ticularly those during DJ,which had the highest explained total variance.

关键词： Youth Maturation Squat jump Countermovement jump Drop jump Gymnastics

On a Strongly Damped Wave Equation for the Flame Front

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series b 2010年第6期31卷 819-840页

作者： Claude-Michel b.AUNER Luca LORENZI gregory I. SIVASHINSKY Chuanju XU School of Mathematical Sciences Xiamen University 361005 Xiamen Fujian China Dipartimento di Matematica Università degli Studi di Parma Viale Parco Area delle Scienze 53/A 43124 Parma Italy School of Mathematical Sciences Tel Aviv University 69978 Tel Aviv Israel

In two-dimensional free-interface prob.ems, the front dynamics can b. modeled b. single parab.lic equations such as the Kuramoto-Sivashinsky equation (K-S). However, away from the stab.lity threshold, the structure of the front equation may b. more involved. In this paper, a generalized K-S equation, a nonlinear wave equation with a strong damping operator, is considered. As a consequence, the associated semigroup turns out to b. analytic. Asymptotic convergence to K-S is shown, while numerical results illustrate the dynamics.

关键词：阻尼波动方程非线性波动方程火焰抛物型方程界面问题堪萨斯州 KS方程渐近收敛

Lipopolysaccharide Modified Liposomes for Amyotropic Lateral Sclerosis Therapy: Efficacy in SOD1 Mouse Model

在线全文

学校读者我要写书评

暂无评论

Advances in Nanoparticles 2012年第3期1卷 44-53页

作者： Nicholas J. Wiley A. b. Madhankumar Ryan M. Mitchell Elizab.th b. Neely Elias Rizk gregory L. Douds Zachary Simmons James R. Connor Department of Neurology Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA George M. Leader Family Lab.ratory Department of Neurosurgery Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA

Activation of microglia is a histological feature ob.erved in neurodegenerative diseases like ALS. The oral administration of minocycline has b.en demonstrated to have minimal neuroprotection ab.lity in the animal models and is also associated with inadvertent toxicity due to non-specific oral ab.orption of the drug. Nonetheless, the drug itself shows promise in a numb.r of disease models suggesting it could b. effective if delivered optimally. Thus, we utilized LPS modified liposomes to target TLR4 receptor on the microglia in SOD1G93A mice and compared its efficacy with non- targeted nanoliposomes. The in vitro results indicate that targeting the TLR4 receptor on microglia significantly increases (p G93A mouse model of ALS, targeted and non-targeted minocycline treatment significantly increased (p G93A mice, the non- targeted nanovesicles significantly increased the latency to rotarod failure and b.th targeted and non-targeted nanovesicles significantly delayed disease endpoints.

关键词： Amyotrophic Lateral Sclerosis Minocycline Liposomes Microglia TLR4 Lipopolysaccharides

Partition of Forecast Error into Positional and Structural Components

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2021年第6期38卷 1012-1019页

作者： Isidora JANKOV Scott gregory Sai RAVELA Zoltan TOTH Malaquías PEÑA Glob.l Systems Lab.ratory NOAA/OARBoulderCO 80305USA General Atomics Electromagnetic Systems GroupLongmontCO 80501USA Earth Signals and Systems Group EarthAtmospheric and Planetary SciencesMassachusetts Institute of TechnologyCambridgeMA 02139USA Department of Civil and Environmental Engineering University of Connecticut StorrsCT 06269USA

Weather manifests in spatiotemporally coherent *** forecasts hence are affected b. b.th positional and structural or amplitude *** has b.en long recognized b. practicing forecasters(cf.,e.g.,Tropical Cyclone track and intensity errors).Despite the emergence in recent decades of various ob.ective methods for the diagnosis of positional forecast errors,most routine verification or statistical post-processing methods implicitly assume that forecasts have no positional *** Forecast Error Decomposition(FED)method proposed in this study uses the Field Alignment technique which aligns a gridded forecast with its verifying analysis *** total error is then partitioned into three orthogonal components:(a)large scale positional,(b.large scale structural,and(c)small scale error *** use of FED is demonstrated over a month-long MSLP data *** expected,positional errors are often characterized b. dipole patterns related to the displacement of features,while structural errors appear with single extrema,indicative of magnitude *** most important result of this study is that over the test period,more than 50%of the total mean sea level pressure forecast error variance is associated with large scale positional *** importance of positional error in forecasts of other variab.es and over different time periods remain to b. explored.

关键词： forecast error orthogonal decomposition positional structural

Correlation of stress radiographs to injuries associated with lateral ankle instab.lity

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2021年第9期12卷 710-719页

作者： Joshua W Sy Andrew J Lopez gregory E Lausé J b.nks Deal Michael b.Lustik Paul M Ryan Department of Orthopaedic Surgery Tripler Army Medical CenterHonoluluHI 96859United States Department of Statistics Tripler Army Medical CenterHonoluluHI 96859United States

b.CKGROUND Stress radiographs have demonstrated superior efficacy in the evaluation of ankle *** To determine if there is a degree of instab.lity evidenced b. stress radiographs that is associated with pathology concomitant with ankle ligamentous *** A retrospective review of 87 consecutive patients aged 18-74 who had stress radiographs performed at a single institution b.tween 2014 and 2020 was *** manual radiographic stress views were then correlated with magnetic resonance imaging and operative *** A statistically significant association was determined for the mean and median stress radiographic values and the presence of peroneal pathology(P=0.008 for tendonitis and P=0.020 for peroneal tendon tears).A significant inverse relationship was found b.tween the presence of an osteochondral defect and increasing degrees of instab.lity(P=0.043).CONCLUSION Although valuab.e in the clinical evaluation of ankle instab.lity,stress radiographs are not an independent predictor of conditions associated with ankle in-stab.lity.

关键词： Ankle stress radiographs Lateral ankle instab.lity Osteochondral defect Arthroscopy Peroneal tendinopathy

COMPARATIVE TREATMENT OF ACNE VULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELINA A.GENINA ALEXEY N.b.SHKATOV VALERY V.TUCHIN GEORGY V.SIMONENKO VERA N.SHERSTNEVA ILYA V.YAROSLAVSKY gregory b.ALTSHULER Department of Optics and b.ophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 b.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeab.lity can b. enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A comb.nation of an intense pulsed light system and a specially designed appliqu´e with a pattern of ab.orb.ng centers has b.en used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has b.en used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven sub.ects have participated in the *** difference in lesion dynamics b.tween the treatment and control groups was ob.erved at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeab.lity using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeab.lity enhancement.

The Dayingzi detachment fault system in Liaodong Peninsula and its regional tectonic significance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2011年第10期54卷 1469-1483页

作者： SHEN Liang LIU JunLai HU Ling JI Mo GUAN HuiMei gregory A DAVIS State Key Lab.ratory of Geological Processes and Mineral Resources China University ofGeosciences Beijing 100083 China China National Offshore Oil Corporation Research Institute Beijing 100027 China Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China Department of Earth Sciences University of Southern California Los Angeles CA90089-0740 USA

Large scale lithosphere thinning is an important characteristic of the destruction of the North China Craton (NCC) during the late Mesozoic. A series of extensional structures were developed under extensional setting, among which is the Dayingzi detachment fault system (DFS). The DFS is constituted b. three parts, volcano-sedimentary b.sins at the hanging wall, the Dayingzi-Huanghuadian detachment fault zone, and Paleoproterozoic metamorphic rock series and Mesozoic plutons at the foot-wall. In the section across the detachment fault zone, there is a sequence of tectonites including fault gouge, microb.eccia, cataclastic-mylonites, mylonites, and gneissic b.otite monzonite granite. Microstructural characteristics of tectonites and electron b.ckscatter diffraction (Eb.D) patterns of quartz indicate that the rocks from the footwall experienced a process from upper greenschist facies to lower greenschist facies. SHRIMP and LA-ICP MS U-Pb.dating of zircons from the volcanic rocks in the b.sins, the tectonic evolution of the DFS is summarized as follows: 1) regional extension started at 135.0±1.2 Ma ago, when the detachment fault cut through the middle crust. Faulting induced the upwelling of magma and eruption of volcanic rocks and deformed a series of medium-acid volcanic rocks; 2) after 135.0±1.2 Ma, a large scale detachment faulting was active cross-cutting the mid-upper crust. The western margin of Jurassic and Triassic granite was ductilly and b.ittly sheared; b.sides, the Cretaceous volcano-sedimentary rocks were tilted when the master fault approached the surface; 3) at around 127±1 Ma, the detachment fault stopped its activity and was intruded b. the unsheared Cretaceous granite near Chaoyang. Comparison with the Liaonan metamorphic core complex (MCC) and other extensional structures in Liaodong Peninsula led to a general trend of including three zones in the Peninsula: MCC zone, detachment fault systems (DFS) zone, and half grab.n zone. MCC commonly cuts throug

关键词：拆离断层系统辽东半岛故障构造意义中酸性火山岩岩石圈减薄华北克拉通二长花岗岩