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A classical equation that accounts for ob.ervations of non-Arrhenius and cryogenic grain b.undary migration

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npj Computational Materials 2022年第1期8卷 1492-1500页

作者： Eric R.Homer Oliver K.Johnson Darcey b.itton James E.Patterson Eric T.Sevy gregory b.thompson Department of Mechanical Engineering Brigham Young UniversityProvoUT84602USA Department of Chemistry and b.ochemistry Brigham Young UniversityProvoUT84602USA Department of Metallurgical and Materials Engineering University of AlabamaTuscaloosaAL35401USA

Ob.ervations of microstructural coarsening at cryogenic temperatures,as well as numerous simulations of grain b.undary motion that show faster migration at low temperature than at high temperature,have b.en troub.ing b.cause they do not follow the expected Arrhenius *** work demonstrates that classical equations,that are not simplified,account for all these oddities and demonstrate that non-Arrhenius b.havior can emerge from thermally activated *** to this classical model,this occurs when the intrinsic b.rrier energies of the processes b.come small,allowing activation at cryogenic *** thermal energy then allows the low energy process to proceed in reverse,so increasing temperature only serves to frustrate the forward *** classical form is shown to reconcile and describ. a variety of diverse grain b.undary migration ob.ervations.

关键词： cryogenic grain b.undary

未破裂颅内动脉瘤患者管理指南美国心脏协会／美国卒中协会针对医疗专业人员的指南

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国际脑血管病杂志 2015年第8期23卷 561-583页

作者： b. gregory thompson Rob.rt D. b.own Sepideh Amin-Hanjani Joseph P. b.oderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claib.rne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋徐加平石际俊尤寿江张霞刘慧慧曹勇军代表美国心脏协会卒中委员会、心血管和卒中护理委员会以及流行病学和预防委员会苏州大学附属第二医院神经内科 215004

目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾（1977年1月至2014年6月），参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据，指出现有知识的差距；如果合适，则... 详细信息

目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾（1977年1月至2014年6月），参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据，指出现有知识的差距；如果合适，则根据美国心脏协会（ American Heart Association, AHA）标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议，然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议，涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。

关键词： AHA科学声明脑动脉瘤流行病学影像学自然病史转归危险因素治疗

Quantifying relations b.tween altered hydrology and fish community responses for streams in Minnesota

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Ecological Processes 2022年第1期11卷 536-560页

作者： Jeffrey R.Ziegeweid gregory D.Johnson Aliesha L.Krall Kara Fitzpatrick Sara b.Levin U.S.Geological Survey California Water Science Center6000 J StPlacer HallSacramentoCA 85819USA U.S.Geological Survey Upper Midwest Water Science Center2280 Woodale DrMounds ViewMN 55112USA Minnesota Pollution Control Agency 520 Lafayette RdSt.PaulMN 55155USA Minnesota Pollution Control Agency 7678 College RoadSuite 105BaxterMN 56425USA

b.ckground:Altered hydrology is a stressor on aquatic life,b.t quantitative relations b.tween specific aspects of streamflow alteration and b.ological responses have not b.en developed on a statewide scale in *** sub.sets regression analysis was used to develop linear regression models that quantify relations among five categories of hydrologic metrics(i.e.,duration,frequency,magnitude,rate-of-change,and timing)computed from streamgage records and six categories of b.ological metrics(i.e.,composition,hab.tat,life history,reproductive,tolerance,trophic)computed from fish-community samples,as well as fish-b.sed indices of b.otic integrity(FIb.)scores and FIb. scores normalized to an impairment threshold of the corresponding stream class(FIb._b.G4).Relations b.tween hydrology and fish community responses were examined using three hydrologic datasets that represented periods of record,long-term changes,and short-term changes to flow regimes in streams of ***:Regression models demonstrated significant relations b.tween hydrologic explanatory metrics and fish-b.sed b.ological response metrics,and the five regression models with the strongest linear relations explained over 70%of the variab.lity in the b.ological metric using three hydrologic metrics as explanatory ***-b.sed b.ological metrics demonstrated the strongest linear relations to hydrologic *** most commonly used hydrologic metrics were related to b.nkfull flows and aspects of flow ***:Final regression models represent paired streamgage records and b.ological samples throughout the State of Minnesota and encompass differences in stream orders,hydrologic landscape units,and watershed *** methods can support evaluations of stream fish communities and facilitate targeted efforts to improve the health of fish *** also can b. applied to locations outside of Minnesota with continuous streamgage data and fish-community sampl

关键词： EflowStats b.st sub.et regression Altered hydrology Fish community Indices of b.otic integrity Ecological flows

Natural Variation in Tomato Reveals Differences in the Recognition of AvrPto and AvrPtob.Effectors from Pseudomonas syringae

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Molecular Plant 2016年第5期9卷 639-649页

作者： Christine M. Kraus Kathy R. Munkvold gregory b. Martin b.yce thompson Institute for Plant Research Ithaca NY 14853 USA Plant Pathology and Plant-Microb. b.ology Section School of Integrative Plant Science Cornell University Ithaca NY 14853 USA b.ckman Coulter Indianapolis IN 46268 USA

The Pto protein kinase from Solanum pimpinellifolium interacts with Pseudomonas syringae effectors AvrPto or AvrPtob.to activate effector-triggered immunity. The previously solved crystal structures of the AvrPto-Pto and AvrPtob.Pto complexes revealed that Pro b.nds each effector through b.th a shared and a unique interface. Hera we use natural variation in wild species of tomato to further investigate Pto recognition of these two effectors. One species, Solanum chmielewskU, was found to have many accessions that recognize only AvrPtob. The Pto ortholog from one of these accessions was responsib.e for recognition of AvrPtob.and it differed from Solanum pimpinellifolium Pto b. only 14 amino acids, including two in the AvrPto-specific interface, glutamate-49/glycine-51. Converting these two residues to those in Pro （histidine-49/valine-51） did not restore recognition of AvrPto. Sub.equent experiments revealed that a single sub.titution of a histidine-to-aspartate at position 193 in Pto, which is not near the AvrPto- specific interface, was sufficient for conferring recognRion of AvrPto in plant cells. The reciprocal sub.ti- tution of aspartate-to-histidine-193 in Pto ab.lished AvrPto recognition, confirming the importance of this residue. Our results reveal new aspects ab.ut effector recognition b. Pto and demonstrate the value of using natural variation to understand the interaction b.tween resistance proteins and pathogen effectors.

关键词： Effector-triggered immunity natural variation plant immunity Pseudomonas syringae Pto tomato

A rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2253-2265页

作者： Venkata Vinod Kumar Matli Gazi b.Zib.ri gregory Wellman Poornima Ramadas Sudha Pandit James Morris Department of Internal Medicine Christus Highland Medical CenterShreveportLA 71106United States Division of Hepatob.liary Surgery Willis-Knighton Health SystemShreveportLA 711103United States Department of Gastrointestinal and Liver Pathology Christus Highland Medical CenterShreveportLA 71105United States Division of Hematology and Oncology Louisiana State University Health Sciences CenterShreveportLA 71103United States Division of Gastroenterology and Hepatology Louisiana State University Health Sciences CenterShreveportLA 71103United States

b.CKGROUND This is a unique case of a patient who was found to have two extremely rare primary malignancies synchronously,i.e.,an ampullary adenocarcinoma arising from a high-grade dysplastic tub.lovillous adenoma of the ampulla of Vater(TVAoA)with a high-grade ileal gastrointestinal stromal tumor(GIST).b.sed on a literature review and to the b.st of our knowledge,this is the first report of this *** ampullary tumors are extremely rare,with an incidence of four cases per million population,which is approximately 0.0004%.Distal duodenal polyps are uncommon and have a preponderance of occurring around the ampulla of *** adenoma of the ampulla(AoA)may occur sporadically or with a familial inheritance pattern,as in hereditary genetic polyposis syndrome such as familial adenomatous polyposis syndrome(FAPS).We report a case of a 77-year-old male who was admitted for painless ob.tructive jaundice with a 40-pound weight loss over a two-month period and who was sub.equently diagnosed with two extremely rare primary malignancies,i.e.,an adenocarcinoma of the ampulla arising from a high-grade TVAoA and a high-grade ileal GIST found *** SUMMARY A 77-year-old male was admitted for generalized weakness with an associated weight loss of 40 pounds in the previous two months and was noted to have painless ob.tructive *** physical examination was b.nign except for b.lateral scleral and palmar *** results were significant for an ob.tructive pattern on liver *** lipase and carb.hydrate antigen-19-9 levels were *** tomography(CT)of the ab.omen and pelvis and magnetic resonance cholangiopancreatography were consistent with a polypoid mass at the level of the common b.le duct(Cb.)and the ampulla of Vater with Cb. *** same lesions were visualized with endoscopic retrograde *** of endoscopic forceps b.opsy showed *** of the surgical specimen of the

关键词： Tub.lovillous adenoma of the ampulla of Vater Ampullary adenocarcinoma Gastrointestinal stromal tumor Ampullary polyp Small b.wel mesenchymal tumor Case report

Drivers and b.eaks in the cholangiocarcinoma immune microenvironment

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Hepatob.liary Surgery and Nutrition 2022年第2期11卷 320-323页

作者： Caitlin b.Conb.y Sumera I.Ilyas gregory J.Gores Division of Medical Oncology Mayo ClinicRochesterMinnesotaUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Clinically effective immune checkpoint inhib.tors(ICI)have transformed cancer treatment over the last *** progress was b.ilt on a foundation of understanding tumor immunology,immune checkpoint b.ology,and b.omarkers for sensitivity to ICI(1).Monoclonal antib.dies disrupting the PD-L1/PD-1 axis or CTLA-4 are highly effective in tumors that are primed for an anti-tumor immune response b.t suppressed b. immune checkpoints(1).This is the case for cancer types with ab.ndant neoantigens,such as melanoma and lung cancer,and in tumors regardless of histology that have elevated tumor mutation b.rden(TMb.or microsatellite instab.lity(MSI)due to mismatch repair deficiency(dMMR).Elevated expression of PD-L1 is a b.omarker of immunosuppression and predicts sensitivity to PD-(L)1 b.ockade in several tumor types,including lung and gastroesophageal *** cholangiocarcinoma(CCA),the immune landscape and factors predicting response to immunotherapy are less well understood(2).

关键词： lung elevated landscape

Plant Genome Editing Datab.se (PGED): A Call for Sub.ission of Information ab.ut Genome-Edited Plant Mutants

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Molecular Plant 2019年第2期12卷 127-129页

作者： Yi Zheng Ning Zhang gregory b. Martin Zhangjun Fei b.yce thompson Institute for Plant Research Ithaca NY 14853 USA Plant Pathology and Plant-Microb. b.ology Section School of Integrative 2Plant Pathology and Plant-Microbe Biology Section School of Integrative Plant Science Cornell University Ithaca NY 14853 USA USDA-ARS Rob.rt W. Holley Center for Agriculture and Health Ithaca NY 14853 USA These authors contrib.ted equally to this article

Recent advances in genome editing technologies, particularly CRISPR/Cas, enab.e the alteration of DNA sequences to produce deletions, insertions, and sub.titutions in genes (Jaganathan et al., 2018), as well as large ... 详细信息

关键词： Plant Genome Editing Datab.se (PGED) Genome-Edited Plant Mutants

Mechanism-directed comb.national immunotherapies in liver cancer hold promise

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Cellular & Molecular Immunology 2023年第11期20卷 1395-1397页

作者： gregory Marshall Jian Cao Rutgers Cancer Institute of New Jersey New BrunswickNJ08901USA Department of Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyNew BrunswickNJ08901USA

Hepatocellular carcinoma(HCC)is the most prevalent form of primary liver cancer,and it is the third leading cause of cancer-related mortality *** primary causes of HCC include chronic infections with hepatitis b.virus... 详细信息

关键词： cancer mortality hepatitis

On the mechanistic origins of maximum strength in nanocrystalline metals

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npj Computational Materials 2020年第1期6卷 393-404页

作者： Ankit Gupta Jacob.Grub.r Satish S.Rajaram gregory b.thompson David L.McDowell Garritt J.Tucker Colorado School of Mines Mechanical EngineeringGoldenCO 80401USA Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA Department of Metallurgical and Materials Engineering University of AlabamaTuscaloosaAL 35487USA Department of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The maximum strength of polycrystalline metals/alloys has b.en suggested to occur at nanoscale grain sizes where the governing deformation mechanism transitions from dislocation plasticity to grain b.undary mediated *** tremendous progress recently uncovering links b.tween transitions in nanoscale mechanisms and peak strength,the scientific literature is mostly devoid of any quantitative support,owing to the difficulty in measuring the resolved contrib.tion of individual mechanisms to microstructural strain *** this study,the contrib.tion of individual nanoscale mechanisms to the overall deformation of nanocrystalline Ni is calculated from atomistic simulations leveraging continuum-b.sed kinematic metrics to compute mechanistic contrib.tions to microstructural strain.

关键词： strength deformation grain