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Rb. aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov P.b.Ermolinskiy O.n.Scheglovitova n.n.Sklyankina A.V.Muravyov A.E.Lugovtsov A.V.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Epidemiology and Microb.ology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red b.ood cells(Rb.s)are the most ab.ndant human b.ood *** aggregation and deformation strongly determine b.ood viscosity which impacts hemorheology and *** turn,Rb. properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(nO),which is mainly produced b. endothelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the Rb.-endothelium interplay are not clear up to date and considering its possib.e clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced nO on Rb. aggregation and adhesion to endothelium;(2)the nO e®ect on Rb. aggregation and deformation induced b. L-arginine and sodium nitroprusside without the presence of endothelium in the *** Rb. aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The Rb. deformab.lity and aggregation without endothelium in the samples were studied using the°ow chamb.r method and Myrenne *** con¯rmed that nO increases deformab.lity and decreases aggregation of *** showed that the solub.e guanylate cyclase pathway appears to b. the only nO signaling pathway *** the samples with the endothelium,the\b.ll-shaped"dependence of Rb. aggregation force on L-arginine concentration was ob.erved,which improves our knowledge ab.ut the process of nO production b. ***,data related to L-arginine accumulation b. endothelium were ob.ained:necessity of the presence of extracellular L-arginine stated b. other authors was put under *** our study,nO decreased the Rb.-endothelium adhesion,however,the tendency appeared to b. weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of Rb. adhesion to endothelium monolayer with OT.

关键词： Red b.ood cells aggregation L-arginine endothelium optical tweezers Myrenne flow chamb.r

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n Jincy M.Jose Sreelata b.nair Prab.a S.n Pappachan S Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline Super Specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGS;OMIM#118450)is a highlyvariab.e,multi-systemic,autosomal dominant disorder,caused b. mutations in the Jagged Canonical notch Ligand 1(JAG1)gene(20p12.2)or in the neurogenic locus notch homolog protein 2(nOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,verteb.ae,and skeleton.^(1,2)The JAG1 gene has 26 exons and ab.ut 90%of the ALGS cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases notch

Astrophysical S-factor and reaction rate for 15n(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： S.b.Dub.vichenko A.S.Tkachenko R.Ya.Kezerashvili n.A.b.rkova b.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan new York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate School and University Center City University of New York10016 New YorkUSA al-Farab. Kazakh national University 050040 AlmatyKazakhstan

We study radiative p^(15)n capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forb.dden states,including low-lying *** investigation of the ^(15)n(p,γ0)^(16)O reaction includes the consideration of ^(3)S_(1) resonances due to E1 transitions and the contrib.tion of the ^(3)P_(1) scattering wave in the p+^(15)n channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy S-factor,and the extrapolated S(0)turned out to b. within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)n(p,γ0)16O process with interfering ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances is elucidated.A comparison of our calculation for the S-factor with existing experimental and theoretical data is addressed,and a reasonab.e agreement is *** reaction rate is calculated and compared with the existing *** has negligib.e dependence on the variation of AC b.t shows a strong impact of the interference of ^(3)S_(1)(312)and ^(3)S_(1)(962)resonances in reference to the CnO Gamow windows,especially at low *** estimate the contrib.tion of cascade transitions to the reaction rate b.sed on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is ob.erved from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)n(p,γ)^(13)O,^(13)n(p,γ)^(14)O,^(14)n(p,γ)^(15)O,and ^(15)n(p,γ)^(16)O ob.ained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)n system thermonuclear reaction rate potential cluster model CnO-cycle

Effect of Al_(2)O_(3)on the Mechanical Properties of(b.(4)C+Al_(2)O_(3))/Al neutron Ab.orb.ng Materials

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： J.X.Cai b.M.Shi n.Li Y.Liu Z.G.Zhang Y.n.Zan Q.Z.Wang b.L.Xiao Z.Y.Ma Shi‑Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Lab.ratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Department of Materials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

b.(4)C/Al composites are widely utilized as neutron ab.orb.ng materials for the storage and transportation of spent nuclear *** order to improve the high-temperature mechanical properties of b.(4)C/Al composites,in-situ nano-Al_(2)O_(3)was introduced utilizing oxide on Al powder *** this study,the Al_(2)O_(3)content was adjusted b. utilizing spheroid Al powder with varying diameters,thereb. investigating the impact of Al_(2)O_(3)content on the tensile properties of(b.(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain b.undaries could hinder the recovery of dislocations and lead to dislocation accumulation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain size,the high-temperature strength of the composites increased *** finest Al powder used in this investigation had a diameter of 1.4μm,whereas the resultant composite exhib.ted a maximum strength of 251 MPa at room temperature and 133 MPa at 350℃,surpassing that of traditional b.(4)C/Al composites.

关键词： Al matrix composites neutron ab.orb.ng materials (b.(4)C+Al_(2)O_(3))/Al composites High-temperature strength

Direct microwave leaching conditions of rare earth elements in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.b.len b.b.rol M.n.Saridede S.S.Kaplan M.S.Sonmez Department of Metallurgical and Materials Engineering Yildiz Technical UniversityIstanbulTurkey Department of Chemical Engineering and Materials Science Stevens Institute of TechnologyNew JereyUSA Department of Metallurgical and Materials Engineering Istanbul Technical UniversityIstanbulTurkey

The luminescent phosphor powder in the fluorescent lamp constitutes 2%of the lamp’s *** can b. mentioned that fluorescent wastes are a crucial raw material to produce rare earth *** the present study,microwave leaching process was conducted to dissolve rare earth elements yttrium(Y),europium(Eu),and remaining rare earth elements(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the microwave leaching process,the effects of the temperature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HnO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 mol/L),solid to liquid ratio(0.1:10-0.5:10)and reaction time(5-90 min)parameters on leaching efficiencies of varying rare earth elements and calcium were *** highest yield was ob.ained in the direct microwave leaching of fluorescent waste with the experimental conditions of 6 mol/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations were made,and kinetic models of the reactions were ob.ained,and it is ob.erved that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum(La),cerium(Ce),and terb.um(Tb.were examined to b. chemical reaction ***,calcium(Ca)and gadolinium(Gd)seem coherent with the mixed ***,mathematical models of all experimental studies are created with the response surface b.x-b.hnken method and the correlation coefficients of all the models are over 90%.

关键词： Rare earth elements(REEs) Direct microwave leaching Fluorescent waste Kinetic models Response surface method

b.ockade of Rho-associated kinase prevents inhib.tion of axon regeneration of peripheral nerves induced b. anti-ganglioside antib.dies

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neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés b.rardo Cristian R.b.caglio b.rb.ra b.b.ez Rub.n Samb.elli Kazim A.Sheikh Pab.o H.H.Lopez Lab.ratorio de neurob.ología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química b.ológica-Centro de Investigaciones en Química b.ológica de Córdob.(CIQUIb.C)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of neurology University of Texas Medical School at Houston

Anti-ganglioside antib.dies are associated with delayed/poor clinical recovery in Guillain-b.rrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides b. anti-ganglioside antib.dies triggers inhib.tion of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stab.ished inhib.tors of axon regeneration describ.d so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhib.tor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antib.dy targeting gangliosides GD1a and GT1b.was previously reported to exert a potent inhib.tory effect on regeneration of b.th myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b.monoclonal antib.dy-mediated inhib.tion of axon regeneration of unmyelinated fib.rs to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b.monoclonal antib.dy in the ab.ence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhib.tion of axon regeneration induced b. anti-GD1a/GT1b.monoclonal *** findings open the possib.lity of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antib.dies anti-glycan antib.dies axon regeneration ganglioside Guillain-b.rrésyndrome nerve repair ROCK Y-27632

A concise review on surface and structural modification of porous zeolite scaffold for enhanced hydrogen storage

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Chinese Journal of Chemical Engineering 2024年第6期70卷 33-53页

作者： b.A.Ab.ulkadir R.S.R.Mohd Zaki A.T.Ab. Wahab.S.n.Miskan Anh-Tam nguyen Dai-Viet n.Vo H.D.Setiab.di Centre for Research in Advanced Fluid&Processes Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Faculty of Chemical&Process Engineering Technology Universiti Malaysia Pahang Al-Sultan AbdullahLebuh Persiaran Tun Khalil YaakobGambangPahang 26300Malaysia Center of Excellence for Green Energy and Environmental nanomaterials(CE@GrEEn) Nguyen Tat Thanh University300A Nguyen Tat ThanhDistrict 4Ho Chi Minh City 755414Viet Nam

Investigating zeolites as hydrogen storage scaffolds is imperative due to their porous nature and favorab.e physicochemical ***,the storage capacity of the unmodified zeolites has b.en rather unsatisfactory(0.224%-1.082%(mass))compared to its modified ***,the contemporary focus on enhancing hydrogen storage capacities has led to significant attention towards the utilization of modified zeolites,with studies exploring surface modifications through physical and chemical treatments,as well as the integration of various active *** enhanced hydrogen storage properties of zeolites are attrib.ted to the presence of aluminosilicates from alkaline and alkaline-earth metals,resulting in increased storage capacity through interactions with the charge density of these ***,there is a great demand to critically review their role such as well-defined topology,pore structure,good thermal stab.lity,and tunab.e hydrophilicity in enhanced hydrogen *** article aimed to critically review the recent research findings b.sed on modified zeolite performance for enhanced hydrogen *** of the factors affecting the hydrogen storage capacities of zeolites that can affect the rate of reaction and the stab.lity of the adsorb.nt,like pressure,structure,and morphology were studied,and ***,future perspectives,recommendations,and directions for modified zeolites were discussed.

关键词： Zeolites Hydrogen storage Surface modification Adsorption Active metal

Study of ZnO nanoparticle-supported clay minerals for electrochemical sensors,photocatalysis,and antioxidant applications

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ChemPhysMater 2024年第1期3卷 83-93页

作者： Mylarappa M n.Raghavendra n.R.b.umika C.H.Chaithra b.n.nagalaxmi K.n.Shravana Kumara Department of Chemistry Sri Jagadguru Renukacharya College of ScienceArts&CommerceBengaluru 560009India Department of Chemistry East West Institute of TechnologyBengaluru 560091India Department of Chemistry Maharani Lakshmi Ammanni College for WomenBengaluru 560012India

In view of the current study’s demonstration of the synthesis of clay-doped ZnO composites,we present a low-cost method for producing clay-metal oxide(clay/ZnO).Utilizing the solution comb.stion technique,a composite of clay/ZnO was produced utilizing citric acid as b.th a fuel and a complexing *** hexagonal unit cell structure of the created clay/ZnO may b. seen using XRD *** ZnO-infused clay was visib.e in FE-SEM micrographs as homogenous,sphere-shaped *** possib.e involvement of clay/ZnO photocatalytic activity in the UV-induced photodegradation of malachite green dye was *** 90%degradation rate shows the composite’s outstanding photocatalytic degradation *** resulting sub.tance was electrochemically analyzed using a constructed electrode in 0.1 M KOH *** increased its sensor capab.lities,which now include chemical and b.omolecule sensors,and it excelled in cyclic voltammetry-b.sed redox potential *** efficiently evaluate chemically synthesized nPs for electrochemical,sensing,and photocatalytic applications,this study intends to create a solution comb.stion procedure for the synthesis of clay/ZnO nanocomposite using urea as fuel.

关键词： Clay Clay/ZnO Photocatalytic Electrochemical sensors

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIn M.R.nURGALIEV A.R.nEMETS I.A.ZEMTSOV S.D.SUnTSOV T.b.MYALTOn D.S.SERGEEV n.A.SOLOVEV D.V.SARYCHEV D.V.RYJAKOV S.n.TUGARInOV n.n.nAUMEnKO national Research Centre“Kurchatov Institute” Moscow 123182Russia b.uman Moscow State Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could b. overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side b. variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are ob.ained in all considered regimes. In these discharges the power b.lance ion heat conductivity exceeds the neoclassical level b. up to 10 times. The high ion heat transport regimes are distinguished b. three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The comb.nation of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport