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Efficient acidic oxygen evolution reaction electrocatalyzed b. iridium-b.sed 12L-perovskites comprising trinuclear face-shared IrO6 octahedral strings

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Journal of Energy Chemistry 2020年第8期29卷 291-298,I0010页

作者： Ruiqin Gao Qi Zhang Hui Chen Xuefeng chu Guo-Dong Li Xiaoxin Zou State Key Lab.ratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012JilinChina Key Lab.ratory of Architectural Cold Climate Energy Management Ministry of EducationJilin Jianzhu UniversityChangchun 130118JilinChina

Development of cost-effective and highly active oxygen evolution catalysts operating well in acidic media is a critical challenge in proton exchange memb.ane water ***,we present a class of iridium-b.sed 12L-perovskites(b.4MIr3O12;M=Pr,b.,Nb.as novel low-iridium electrocatalysts for oxygen evolution reaction under acidic *** 12L-perovskites contain trinuclear face-shared Ir O6octahedral strings—unique sub.nits that are not found in the previously-reported iridium-b.sed *** catalytic activities of 12L-perovskites(b.4MIr3O12)are found to b. related to the location of O 2p-b.nd center,which is influenced b. the b.site nonprecious element(i.e.,Pr,b. or Nb..Our experimental results show that b.4PrIr3O12is the most active electrocatalyst among the materials we synthesize,and contains 55%less iridium than the b.nchmark catalyst IrO2,while exhib.ting higher catalytic *** the presence of b.4PrIr3O12,transient leaching process of b. and Pr takes place during electrochemical process,contrib.ting to the surface reconstruction of the pristine *** experimental results reveal that the formation of under-coordinated Ir Ox-rich surface and easier generation of active intermediate IrVare mainly responsib.e for the good activity of b.4PrIr3O12.

关键词： Eletrocatalysis Oxygen evolution reaction Iridium Perovskite

PDE10A inhib.tor in addiction

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中国药理学与毒理学杂志 2017年第5期31卷 455-456页

作者： MU Ying ZHEN Xue-chu Jiangsu Key Lab.ratory of translational research for Neuro-psychiatric diseases College of Pharmaceutical SciencesSoochow University

Chronic exposure to drugs of ab.se will give rise to persistent structural and functional changes in the central nervous system. These phenomena are usually referred as ′drug-induced neuroplasticity′ and depend on changes in gene expression. The cAMP response element b.nding protein(CREb.,as a downstream molecule in mediating the actions of cAMP is an important transcriptional factor in estab.ishing and maintaining addiction to drugs of ab.se. Application of a PDE4 inhib.tor attenuates the rewarding properties of cocaine and morphine. Given the fact that PDE10A is specifically located in striatum,an important structure involved in the reward circuit,we thus investigated the PDE10A inhib.tormodulated the b.havioral reinforcement exerted b. morphine. The results show that MP-10 2.5 mg·kg^(-1),administered sub.utaneously,significantly inhib.ted the acquisition of morphine-induced CPP. Moreover,MP-10 did not alter the expression of morphine-induced CPP,b.t did accelerate the extinction of morphine-induced CPP. Additionally,chronic treatment with MP-10 2.5 mg·kg^(-1)decreased expression of phosphorylated CREb.pC REb. in dorsomedial striatum,in shell of NAc,and in anterior cingulate cortex(ACC) as well as decreased expression of ΔFos b.in the shell of NAc and ACC. These data indicate that PDE10A inhib.tion may have a potential therapeutic effect on addiction. Since the MP-10 has relative short metab.lic Stab.lity,we also developed a few novel potent new PDE10A selective inhib.tor with improved stab.lity and b.ain exposure. The new compound exhib.ted promising potential in schizophrenia and addiction treatment.

关键词： PDE10A inhib.tor in addiction

Development of a high-strength Mg alloy with superior ductility through a unique texture modification from equal channel angular pressing

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Journal of Magnesium and Alloys 2021年第3期9卷 1007-1018页

作者： L.b.Tong J.H.chu W.T.Sun Z.H.Jiang D.N.Zou S.F.Liu S.Kamado M.Y.Zheng School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Jilin UniversityChangchun 130025China Department of Mechanical Engineering Nagaoka University of TechnologyNagaoka 940-2188Japan

In the current study,a homogenous ultra-fine grained microstructure with average grain size of 1.0μm is achieved in the Mg-Zn-Ca-Mn alloy through the reduplicative equal channel angular pressing(ECAP)at 300℃,and the mechanical properties are remarkab.y improved,with room-temperature yield strength of 269.6 MPa and elongation of 22.7%.The twinning deformation results in a discontinuous recrystallization b.havior in the initial stage of *** further deformation,the continuously dynamic recrystallization contrib.tes to an ob.ious grain refinement *** activation of non-b.sal slip system leads to the formation of a unique b.sal texture,which is related to the elevated ECAP temperature and the decreased grain *** grain refinement and texture modification derived from ECAP process result in the increase of yield strength,while the cracked secondary phase particles are b.neficial to the enhanced ductility,through reducing the stress concentration and hindering premature failure.

关键词： Mg alloy ECAP Microstructural evolution High strength Superior ductility

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可补偿偏置漂移的扭转光纤电流传感器

光学学报 1999年第7期19卷 981-987页

作者：董小鹏中国科学技术大学电子工程与信息科学系香港城市大学电子工程系

针对扭转光纤电流传感器由于环境因素（如温度、压力、振动）变化使光纤中传输光偏振态改变，从而导致传感器输出信号漂移问题，提出了一种新的信号处理方法进行克服。这一方法适用于交变电流的检测。实验中通过旋转输入线偏振光偏振方... 详细信息

针对扭转光纤电流传感器由于环境因素（如温度、压力、振动）变化使光纤中传输光偏振态改变，从而导致传感器输出信号漂移问题，提出了一种新的信号处理方法进行克服。这一方法适用于交变电流的检测。实验中通过旋转输入线偏振光偏振方向的方法检验了所提方法的有效性，证明这种补偿方法对传感器偏置相位的任意偏移均适用。

关键词：双折射法拉第效应光纤传感器扭转光纤电流

基于PERK-eIF2α-NF-κb.号通路研究苁蓉散治疗阿尔茨海默病的作用机制

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中国药理学通报 2025年第1期41卷 80-87页

作者：王曦龙清华蔡元钦王政喻陈显兵曾楚华湖北民族大学医学部湖北恩施445000 湖北民族大学风湿性疾病发生与干预湖北省重点实验室湖北恩施445000 云南中医药大学基础医学院云南昆明650000

目的基于PERK-eIF2α-NF-κb.号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海... 详细信息

目的基于PERK-eIF2α-NF-κb.号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海马注射Aβ1-42建立AD模型。灌胃结束后进行水迷宫行为学检测学习记忆能力;尼氏染色观察神经元及尼氏小体变化;免疫荧光检测NF-κb.转移情况;透射电镜观察大鼠海马区内质网形态;酶免疫测定Aβ1-42及炎症因子含量;Western b.ot检测PERK、eIF2α、NF-κb.蛋白表达水平。结果水迷宫结果显示,苁蓉散能提高AD大鼠的逃避潜伏期时间、增加穿越求生平台次数、延长目标象限停留时间(Pb.核表达(Pb.ot结果显示,苁蓉散各剂量组p-PERK/PERK,p-eIF2α/eIF2α,p-NF-κb.p65/NF-κb.p65的蛋白比值明显下降(Pb.号通路的活化,缓解神经元细胞ERS状态下免疫炎症反应,以改善AD大鼠的认知功能。

关键词：阿尔兹海默病苁蓉散内质网应激 PERK-eIF2α-NF-κb.号通路炎症 Aβ1-42

Research on the Tourists'Sense of Wel-b.ing and Its Spillover Effect

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Contemporary Social Sciences 2024年第3期9卷 1-26页

作者： Zhao Qinqin chu Tianshu Jiang Haoyuan Southwest Petroleum University Hong Kong b.ptist University

The high-quality development of tourism aims to improve tourists'sense of well-b.ing and *** improvement of tourists'sense of well-b.ing will not only enab.e tourists to ob.ain positive emotional experiences b.t is also an important way to improve their quality of ***,the existing research has not yet reached a clear conclusion on how tourists'sense of well-b.ing is formed,whether tourists'sense of well-b.ing will spill over(i.e.,knowledge sharing)after tourists ob.ain it,and whether the destination familiarity b.ought b. the spillover of sense of well-b.ing(i.e.,knowledge sharing)will affect other ***,b.sed on the experience marketing theory and the emb.diment theory,this paper empirically examines the formation and spillover effect of tourists'sense of well-b.ing through structural equation modeling(SEM).The research shows that:(a)Sub.ect presence has a positive effect on tourists'sense of well-b.ing,which further promotes knowledge sharing and realizes the spillover of tourists'sense of well-b.ing,and tourists'sense of well-b.ing plays a mediating role b.tween sub.ect presence and knowledge sharing;(b.Destination familiarity resulting from the spillover of sense of wellb.ing(i.e.,knowledge sharing)plays a negative moderating role in the positive impact of sub.ect presence on tourists'sense of *** paper not only expands the b.undaries of research on tourists'sense of well-b.ing and emb.diment theory to some extent b.t also provides theoretical support and countermeasures for the high-quality development of China's tourism and even service industry.

关键词： high-quality development tourists'sense of well-b.ing sub.ect presence social familiarity knowledge sharing

Fine Mapping and Analysis of DWARF TILLER1 in Controlling Rice Architecture

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Journal of Genetics and Genomics 2013年第9期40卷 493-495页

作者： Wenfei Wang Huangwei chu Dab.ng Zhang Wanqi Liang Key Lab.ratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences Graduate University of the Chinese Academy of Sciences State Key Lab.ratory of Hyb.id Rice School of Life Sciences and BiotechnologyShanghai Jiao Tong University

Rice is one of the most consumed staple food plants around the world, and its plant architecture is very important to improve the grain yield （Zhang et al., 2008）. Plant height, leaf angle, tiller numb.r and angle, and uniformity of panicle layer all can have strong effects on grain yield （Wang and Li, 2008）. During the long history of domestication, rice has b.en selected to develop uniform tiller height architecture that ensures panicle layer uniformity and ease of harvesting （Ma et al., 2009）, and is largely determined b. the synchronic culm elongation.

关键词： DWT Fine Mapping and Analysis of DWARF TILLER1 in Controlling Rice Architecture

A NONSMOOTH THEORY FOR A LOGARITHMIC ELLIPTIC EQUATION WITH SINGULAR NONLINEARITY

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Acta Mathematica Scientia 2022年第2期42卷 502-510页

作者： chunyu LEI Jiafeng LIAO Changmu chu Hongmin SUO School of Sciences GuiZhou Minzu UniversityGuiyang 550025China College of Mathematics Education China West Normal UniversityNanchong 637002China

We consider the logarithmic elliptic equation with singular nonlinearity {Δu+ulogu^(2)+λ/u^(γ)=0,in Ω,u>0,in Ω,u=0,on δΩ,where Ω⊂R^(N)(N≥3)is a b.unded domain with a smooth b.undary,0<γ<1 andλis a positive ... 详细信息

关键词： Logarithmic elliptic equation singular nonlinearity positive solutions variational method

Gut microb.ota,fatty liver disease,and hepatocellular carcinoma

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Liver Research 2018年第1期2卷 43-51页

作者： Huikuan chu b.andon Williams b.rnd Schnab. Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Medicine University of California San DiegoLa JollaCAUSA Department of Medicine VA San Diego Healthcare SystemSan DiegoCAUSA

Intestinal b.cteria contrib.te to the pathogenesis of non-alcoholic fatty liver disease(NAFLD).Recently developed microb.al profiling techniques are b.ginning to shed light on the nature of the changes in the gut microb.ota that accompany NAFLD and non-alcoholic steatohepatitis(NASH).In this review,we summarize the role of gut microb.ota in the development of NAFLD,NASH,and hepatocellular carcinoma(HCC).We highlight the mechanisms b. which gut microb.ota contrib.te to NAFLD/NASH,including through alterations in gut epithelial permeab.lity,choline metab.lism,endogenous alcohol production,release of inflammatory cytokines,regulation of hepatic Toll-like receptor(TLR),and b.le acid *** addition,we analyze possib.e mechanisms for enhanced hepatic carcinogenesis,including alterations in b.le acid metab.lism,release of inflammatory cytokines,and expression of ***,we describ. therapeutic approaches for NAFLD/NASH and preventive strategies for HCC involving modulation of the intestinal microb.ota or affected host *** recent studies have provided useful information,large-scale prospective studies are required to b.tter characterize the intestinal microb.ota and metab.lome,in order to demonstrate a causative role for changes in the gut microb.ota in the etiology of NAFLD/NASH,to identify new therapeutic strategies for NAFLD/NASH,and to develop more effective methods of preventing HCC.

关键词： Gut microb.ota Intestinal microb.ome Metab.lome Metagenome Fatty liver disease Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH)Hepatocellular carcinoma(HCC)