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Nanostructural origins of irreversib.e deformation in b.ne revealed b. an in situ atomic force microscopy study

Nano Research 2022年第8期15卷 7329-7341页

作者： Tianb.o Qian Lijing Teng Yongji Zhou Minghao Zhang Zuquan Hu Xiaofeng chen Fei Hang School of b.ology&Engineering Guizhou Medical UniversityGuiyang 550025China School of Medicine South China University of TechnologyGuangzhou 510006China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Key Lab.ratory of b.omedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China Key Lab.ratory of b.omedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China

The structural origins of b.ne toughness at the nanoscale are not completely ***,we performed in situ scanning using atomic force microscopy during macroscopic mechanical testing of antler and b.vine b.ne,to reveal the origins of the irreversib.e plastic deformation at the mineralized collagen fib.il(MCF)array and MCF *** found that the plastic deformation b.havior at the nanoscale level could b. divided into two *** first stage of plastic deformation at the nanoscale level was characterized b. slippage b.tween the MCF arrays,which contained mineral aggregate grains with regular shapes under *** the second stage of nanoscale plastic deformation,the MCFs b.oke through the b.nds of the extrafib.illar mineral aggregate grains and exhib.ted interfib.illar *** nanoscale plastic deformation b.haviors may thus b. the origins of stress whitening and irreversib.e plastic ***,the findings in this study not only shed light on the plastic deformation mechanisms of MCF arrays and MCFs,b.t also provide structural and mechanistic insights into b.oinspired materials design and mechanisms of relevant b.ne diseases.

关键词： cortical b.ne atomic force microscopy plastic deformation mineralized collagen fib.il interfib.illar slipping

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Engineering crystal phase of polytypic CuInS2 nanosheets for enhanced photocatalytic and photoelectrochemical performance

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Nano Research 2020年第2期13卷 583-590页

作者： He Li Wenjiang Li Wei Li Minfang chen Rony Snyders Carla b.ttencourt Zhihao Yuan Key Iab.ratory of Display Materials C Photoelectric Devices School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Chimie des Interactions Plasma-Surface University of Mons(UMONS)20 Place du Parc7000 MonsBelgium Materia Nova Research Centre 1 Avenue Nicolas CopernicB 7000 MonsBelgium

Crystal phase engineering on CulnS2(CIS)nanocrystals,especially polytypic structure,has b.come one of the research hotspots to design the advanced materials and devices for energy conversion and environment ***,the polytypic CIS nanosheets(NSs)including zincb.ende/wutzite and chalcopyrite/wurtzite types were first time achieved in a hot-injection system using oleic acid and liquid paraffin as the reaction ***-ob.ained polytypic CIS NSs exhib.t significantly enhanced light-ab.orption ab.llty and visib.e-light-driven photocatalytic performance originating from the rational hetero-crystalline interfaces and surface defect states,which efficiently inhib.t the recomb.nation of photo-generated ***,the polytypic CIS NSs were spin-coated onto the surface of fluorinated-tin oxide glass sub.trate and used as the photoelectrode,which shows an excellent photoelectrochemical(PEC)activity in aqueous *** present work not only provides a facile,rapid,low-cost,and environmental-friendly synthesis strategy to design the crystal phase and defect structure of ternary chalcogenides,b.t also demonstrates the relationships b.tween the polytypic structure and photocatalytic/photoelectrochemical properties.

关键词： CuInS2 polytypic defect hot injection photocatalytic photoelectrochemical activity

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Recent progress in aptamer-b.sed microfluidics for the detection of circulating tumor cells and extracellular vesicles

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Journal of Pharmaceutical Analysis 2023年第4期13卷 340-354页

作者： Duanping Sun Ying Ma Maoqiang Wu Zuanguang chen Luyong Zhang Jing Lu Guangdong Provincial Key Lab.ratory of Pharmaceutical b.oactive Sub.tances Center for Drug Research and DevelopmentGuangdong Pharmaceutical UniversityGuangzhou510006China Key Specialty of Clinical Pharmacy The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou510699China National and Local United Engineering Lab.of Druggab.lity and New Drugs Evaluation School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

Liquid b.opsy is a technology that exhib.ts potential to detect cancer early,monitor therapies,and predict cancer prognosis due to its unique characteristics,including noninvasive sampling and real-time *** tumor cells(CTCs)and extracellular vesicles(EVs)are two important components of circulating targets,carrying sub.tantial disease-related molecular information and playing a key role in liquid *** are single-stranded oligonucleotides with superior affinity and specificity,and they can b.nd to targets b. folding into unique tertiary ***-b.sed microfluidic platforms offer new ways to enhance the purity and capture efficiency of CTCs and EVs b. comb.ning the advantages of microfluidic chips as isolation platforms and aptamers as recognition *** this review,we first b.iefly introduce some new strategies for aptamer discovery b.sed on traditional and aptamer-b.sed microfluidic ***,we sub.equently summarize the progress of aptamer-b.sed microfluidics for CTC and EV ***,we offer an outlook on the future directional challenges of aptamer-b.sed microfluidics for circulating targets in clinical applications.

关键词： Aptamer Microfluidic Circulating tumor cells Extracellular vesicles b.oanalysis

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Spectrum Prediction b.sed on GAN and Deep Transfer Learning:A Cross-b.nd Data Augmentation Framework

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China Communications 2021年第1期18卷 18-32页

作者： Fandi Lin Jin chen Guoru Ding Yutao Jiao Jiachen Sun Haichao Wang College of Communications Engineering Army Engineering UniversityNanjing 210007China

This paper investigates the prob.em of data scarcity in spectrum prediction.A cognitive radio equipment may frequently switch the target frequency as the electromagnetic environment *** previously trained model for prediction often cannot maintain a good performance when facing small amount of historical data of the new target ***,the cognitive radio equipment usually implements the dynamic spectrum access in real time which means the time to recollect the data of the new task frequency b.nd and retrain the model is very *** address the ab.ve issues,we develop a crossb.nd data augmentation framework for spectrum prediction b. leveraging the recent advances of generative adversarial network(GAN)and deep transfer ***,through the similarity measurement,we pre-train a GAN model using the historical data of the frequency b.nd that is the most similar to the target frequency ***,through the data augmentation b. feeding the small amount of the target data into the pre-trained GAN,temporal-spectral residual network is further trained using deep transfer learning and the generated data with high similarity from ***,experiment results demonstrate the effectiveness of the proposed framework.

关键词： cognitive radio cross-b.nd spectrum prediction deep transfer learning generative adversarial network cross-b.nd data augmentation framework

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Pyroptosis: mechanisms and diseases

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1233-1253页

作者： Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang chen The Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunanChina Hunan Key Lab.ratory of Skin Cancer and Psoriasis Xiangya HospitalChangshaHunanChina Hunan Engineering Research Center of Skin Health and Disease Xiangya HospitalChangshaHunanChina Xiangya Clinical Research Center for Cancer Immunotherapy Central South UniversityChangshaHunanChina

Currently,pyroptosis has received more and more attention b.cause of its association with innate immunity and *** research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of *** relationship b.tween pyroptosis and tumors is diverse in different tissues and genetic *** this review,we provide b.sic knowledge of pyroptosis,explain the relationship b.tween pyroptosis and tumors,and focus on the significance of pyroptosis in tumor *** addition,we further summarize the possib.lity of pyroptosis as a potential tumor treatment strategy and describ. the side effects of radiotherapy and chemotherapy caused b. *** b.ief,pyroptosis is a doub.e-edged sword for *** rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs b.sed on pyroptosis.

关键词： immunity drugs chemotherapy

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Thermal field in water pipe cooling concrete hydrostructures simulated with singular b.undary method

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Water Science and Engineering 2017年第2期10卷 107-114页

作者： Yong-xing Hong Wen chen Ji Lin Jian Gong Hong-da cheng State Key Lab.ratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China College of Mechanics and Materials Hohai University Nanjing 211100 China School of Engineering University of Mississippi Mississippi 38677 USA

The emb.dded water pipe system is often used as a standard cooling technique during the construction of large-scale mass concrete hydrostructures. The prediction of the temperature distrib.tion considering the cooling effects of emb.dded pipes plays an essential role in the design of the structure and its cooling system. In this study, the singular b.undary method, a semi-analytical meshless technique, was employed to analyze the temperature distrib.tion. A numerical algorithm solved the transient temperature field with consideration of the effects of cooling pipe specification, isolation of heat of hydration, and amb.ent temperature. Numerical results are verified through comparison with those of the finite element method, demonstrating that the proposed approach is accurate in the simulation of the thermal field in concrete structures with a water cooling pipe.

关键词： Thermal field Singular b.undary method Semi-analytical method Water cooling pipe Concrete hydrostructure

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An acid-triggered porphyrin-b.sed b.ock copolymer for enhanced photodynamic antib.cterial efficacy

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Science China Chemistry 2021年第3期64卷 459-466页

作者： Fan Yu Chao chen Guoliang Yang Zhengtong Ren Hongliang Cao Liangshun Zhang Weian Zhang Shanghai Key Lab.ratory of Functional Materials Chemistry East China University of Science and TechnologyShanghai 200237China

b.cterial infection, especially multidrug-resistant(MDR) b.cterial infection has threatened pub.ic health drastically. Here, we fab.icate an "acid-triggered" nanoplatform for enhanced photodynamic antib.cterial activity b. reducing the aggregation of photosensitizers(PSs) in b.cterial acidic microenvironment. Specifically, a functional amphiphilic b.ock copolymer was first synthesized b. using a pH-sensitive monomer, 2-(diisopropylamino) ethyl methacrylate(DPA) and porphyrin-b.sed methacrylate(TPPC6MA) with poly(oligo(ethylene glycol) methyl ether methacrylate)(POEGMA) as the macromolecular chain transfer agent, and POEGMA-b.[PDPA-co-PTPPC6MA] b.ock copolymer was further self-assemb.ed into spherical nanoparticles(PDPA-TPP). PDPA-TPP nanoparticles possess an effective electrostatic adherence to negatively charged b.cterial cell memb.ane, since they could rapidly achieve positive charge in acidic b.cterial media. Meanwhile, the acid-triggered dissociation of PDPA-TPP nanoparticles could reduce the aggregation caused quenching(ACQ) of the photosensitizers, leading to around 5 folds increase of the singlet oxygen(1O2) quantum yield. In vitro results demonstrated that the "acid-triggered" PDPA-TPP nanoparticles could kill most of MDR S. aureus(Gram-positive) and MDR E. coli(Gram-negative) b. enhanced photodynamic therapy, and they could resist wound infection and accelerate wound healing effectively in vivo. Furthermore, PDPA-TPP nanoparticles could well disperse the b.ofilm and almost kill all the b.ofilm-containing b.cteria. Thus, b. making use of the b.cterial acidic microenvironment, this "acid-triggered" nanoplatform in situ will open a new path to solve the aggregation of photosensitizers for comb.ting b.oad-spectrum drug-resistant b.cterial infection.

关键词： photodynamic therapy antib.cterial porphyrin aggregation caused quenching(ACQ)

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Microstructural evolution of hyb.id aluminum matrix composites reinforced with SiC nanoparticles and graphene/graphite prepared b. powder metallurgy

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Progress in Natural Science:Materials International 2020年第2期30卷 192-199页

作者： Jiangshan Zhang Qing Liu Shufeng Yang Zhixin chen Qiang Liu Zhengyi Jiang State Key Lab.ratory of Advanced Metallurgy University of Science and Technology Beijing School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of Wollongong

The dispersion of ceramic nanoparticles is of significance to the microstructure and properties of particulate reinforced metal matrix *** this study,two hyb.id enhancers,SiC-graphite and SiC-graphene nanosheets（GNSs）,were incorporated into aluminum matrix composites using powder *** dispersion of the reinforcements and microstructural evolution of the composites were characterized b. using Scanning Electron Microscopy,X-Ray Diffraction,Transmission Electron Microscopy,and Raman *** results show that thin GNSs accelerated the deformation of the aluminum particles,and defects were introduced into the carb.naceous phases during the b.ll milling ***;C;needles generated during hot pressing,and were ob.erved to b.idge the aluminum *** with graphite,GNSs were more uniformly dispersed throughout the composite,which in turn restrained grain *** a result,a nanostructured composite（57.7 nm） was successfully produced upon the addition of SiC-GNSs.

关键词： Microstructure Aluminum matrix composite SiC nanoparticle SiC-Graphene nanosheets Powder metallurgy

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Molecular dynamics simulation on DNA translocating through MoS_(2) nanopores with various structures

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 922-934页

作者： Daohui Zhao Huang chen Yuqing Wang b.i Li Chongxiong Duan Zhixian Li Lib. Li School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528231China

The emergence of MoS_(2) nanopores has provided a new avenue for high performance DNA sequencing,which is critical for modem chemical/b.ological research and ***,molecular dynamics simulations were performed to design a conceptual device to sequence DNA with MoS_(2) nanopores of different structures(e.g.,pore rim contained Mo atoms only,S atoms only,or b.th Mo and S atoms),where various unfolded single-stranded DNAs(ssDNAs)translocated through the nanopores driven b. transmemb.ane b.as;the sequence content was identified b. the associating ionic *** ssDNAs adsorb.d onto the MoS_(2) surface and translocated through the nanopores b. transmemb.ane electric field in a stepwise manner,where the pause b.tween two permeation events was long enough for the DNA fragments in the nanopore to produce well-defined ionic b.ockage current to deduce the DNA’s b.se *** transmemb.ane b.as and DNA-MoS_(2) interaction could regulate the speed of the translocation ***,the structure(atom constitution of the nanopore rim)of the nanopore considerab.y regulated b.th the translocate process and the ionic ***,MoS_(2) nanopores could b. employed to sequence DNA with the flexib.lity to regulate the translocation process and ionic current to yield the optimal sequencing performance.

关键词： DNA sequencing MoS_(2) molecular dynamics simulation nanopore ionic current

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Study on the interannual variab.lity of the Kerama Gap transport and its relation to the Kuroshio/Ryukyu Current system

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Acta Oceanologica Sinica 2024年第3期43卷 1-14页

作者： Han Zhou Kai Yu Jianhuang Qin Xuhua cheng Meixiang chen Changming Dong Key Lab.ratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210003China College of Oceanography Hohai UniversityNanjing 210003China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 211800China

An analysis of a 68-year monthly hindcast output from an eddy-resolving ocean general circulation model reveals the relationship b.tween the interannual variab.lity of the Kerama Gap transport(KGT)and the Kuroshio/Ryukyu Current *** study found a significant difference in the interannual variab.lity of the upstream and downstream transports of the East China Sea-(ECS-)Kuroshio and the Ryukyu *** interannual variab.lity of the KGT was found to b. of paramount importance in causing the differences b.tween the upstream and downstream ***,it contrib.ted approximately 37%to the variab.lity of the Ryukyu *** interannual variab.lity of the KGT was well describ.d b. a two-layer rotating hydraulic *** was dominated b. its sub.urface-intensified flow core,and the upper layer transport made a weaker negative contrib.tion to the total *** sub.urface flow core was found to b. mainly driven b. the sub.urface pressure head across the Kerama Gap,and the pressure head was further dominated b. the sub.urface density anomalies on the Pacific *** density anomalies could b. traced b.ck to the eastern open ocean,and their propagation speed was estimated to b. ab.ut 7.4 km/d,which is consistent with the speed of the local first-order b.roclinic Rossb. *** the negative(positive)density anomaly signal reached the southern region of the Kerama Gap,it triggered the increase(decrease)of the KGT towards the Pacific side and the formation of an anticyclonic(cyclonic)vortex b. b.roclinic ***,there is an increase(decrease)in the upstream transport of the entire Kuroshio/Ryukyu Current system and an offshore flow that decreases(increases)the downstream Ryukyu Current.

关键词： Kerama Gap Kuroshio Ryukyu Current OGCM for the Earth Simulator(OFES) hydraulic theory

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