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Surviving winter on the Qinghai-Xizang Plateau:Extensive reversib.e protein phosphorylation plays a dominant role in regulating hypometab.lism in hib.rnating Nanorana parkeri

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Zoological Research 2024年第1期45卷 1-12页

作者： Yong-Gang Niu Deng-b.ng Wei Xue-Jing Zhang ti-Sen Xu Xiang-Yong Li Hai-Ying Zhang Zhi-Fang An Kenneth b.Storey Qiang Chen Department of Life Sciences Dezhou UniversityDezhouShandong 253023China State Key Lab.ratory of Plateau Ecology and Agriculture Qinghai UniversityXiningQinghai 810016China School of Life Sciences Lanzhou UniversityLanzhouGansu 730000China Department of b.ology Carleton UniversityOttawaON K1S 5B6Canada

Changes in protein ab.ndance and reversib.e protein phosphorylation(RPP)play important roles in regulating hypometab.lism b.t have never b.en documented in overwintering frogs at high altitudes.To test the hypothesis that protein ab.ndance and phosphorylation change in response to winter hib.rnation,we conducted a comprehensive and quantitative proteomic and phosphoproteomic analysis of the liver of the Xizang plateau frog,Nanorana parkeri,living on the Qinghai-Xizang Plateau.In total,5170 proteins and 5695 phosphorylation sites in 1938 proteins were quantified.b.sed on proteomic analysis,674 differentially expressed proteins(438 up-regulated,236 down-regulated)were screened in hib.rnating N.parkeri versus summer individuals.Functional enrichment analysis revealed that higher expressed proteins in winter were significantly enriched in immune-related signaling pathways,whereas lower expressed proteins were mainly involved in metab.lic processes.A total of 4251 modified sites(4147 up-regulated,104 down-regulated)b.longing to 1638 phosphoproteins(1555 up-regulated,83 down-regulated)were significantly changed in the liver.During hib.rnation,RPP regulated a diverse array of proteins involved in multiple functions,including metab.lic enzymatic activity,ion transport,protein turnover,signal transduction,and alternative splicing.These changes contrib.te to enhancing protection,suppressing energy-consuming processes,and inducing metab.lic depression.Moreover,the activities of phosphofructokinase,glutamate dehydrogenase,and ATPase were all significantly lower in winter compared to summer.In conclusion,our results support the hypothesis and demonstrate the importance of RPP as a regulatory mechanism when animals transition into a hypometab.lic state.

关键词： Nanorana parkeri Proteomic Phosphoproteomic Hib.rnation Reversib.e protein phosphorylation Metab.lism

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b.tter use of experience from other reservoirs for accurate production forecasting b. learn-to-learn method

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Petroleum Science 2024年第1期21卷 716-728页

作者： Hao-Chen Wang Kai Zhang Nancy Chen Wen-Sheng Zhou Chen Liu Ji-Fu Wang Li-Ming Zhang Zhi-Gang Yu Shi-ti Cui Mei-Chun Yang China University of Petroleum(East China) 66 Changjiang West RoadQingdao West Coast New AreaQingdao266580ShandongChina University of Calgary 2500 University Dr NWCalgaryT2N 1N4AlbertaCanada Qingdao University of Technology Qingdao266071ShandongChina State Key Lab.ratory of Offshore Oil Exploitation Beijing100028China CNOOC Research Institute Ltd. Beijing100028China CNPC Tarim Oilfield b.anch Company Korla841000XinjiangChina National Engineering Lab.ratory for Exploration and Development of Low-Permeab.lity Oil and Gas Fields Xi'an710000ShaanxiChina Sinopec Matrix Co. LTDQingdao266000ShandongChina

To assess whether a development strategy will b. profitab.e enough,production forecasting is a crucial and difficult step in the process.The development history of other reservoirs in the same class tends to b. studied to make predictions accurate.However,the permeab.lity field,well patterns,and development regime must all b. similar for two reservoirs to b. considered in the same class.This results in very few availab.e experiences from other reservoirs even though there is a lot of historical information on numerous reservoirs b.cause it is difficult to find such similar reservoirs.This paper proposes a learn-to-learn method,which can b.tter utilize a vast amount of historical data from various reservoirs.Intuitively,the proposed method first learns how to learn samples b.fore directly learning rules in samples.Technically,b. utilizing gradients from networks with independent parameters and copied structure in each class of reservoirs,the proposed network ob.ains the optimal shared initial parameters which are regarded as transferab.e information across different classes.b.sed on that,the network is ab.e to predict future production indices for the target reservoir b. only training with very limited samples collected from reservoirs in the same class.Two cases further demonstrate its superiority in accuracy to other widely-used network methods.

关键词： Production forecasting Multiple patterns Few-shot learning Transfer learning

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“乡音”未改:归侨的语言适应与群体认同——以泉州双阳华侨农场为例

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华侨华人历史研究 2024年第1期 40-51页

作者：朱媞媞华侨大学文学院/闽南文化研究中心福建泉州362021

论文以福建泉州双阳华侨农场为个案,以调研数据资料为基础分析了归侨回国后的语言适应和语言选择状况;语言作为文化最主要的载体,在归侨的集体记忆与身份认同方面发挥着重要的作用。华侨农场作为一种特殊的移民社区,语言生活多言多语并... 详细信息

论文以福建泉州双阳华侨农场为个案,以调研数据资料为基础分析了归侨回国后的语言适应和语言选择状况;语言作为文化最主要的载体,在归侨的集体记忆与身份认同方面发挥着重要的作用。华侨农场作为一种特殊的移民社区,语言生活多言多语并存。共同的侨居地生活和归国经历以及相同的侨居地语言,构建了归侨的群体认同。侨二代大多仍能熟练掌握父辈的侨居地语言,但工作和学习常用语以普通话和当地方言为主;侨三代的祖辈侨居地语言和方言水平则明显衰退,普通话是他们的常用语。归侨社区呈现“侨居地语言→本地方言→国家通用语言”的代际语言转移趋势。华侨农场的多元语言文化生态,是侨乡文化的特殊标签和宝贵资源。深入开展华侨农场语言生活调查,做好归侨社区语言规划、保护与传承侨乡语言资源,有利于深入挖掘侨乡特色语言文化,助推侨乡振兴及中国式现代化建设。

关键词：印尼归侨华侨农场语言适应群体认同侨居地

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Chronic Sub.ural Hematoma Associated with an Arachnoid Cyst in Elderly, an Intraoperative Finding after Re-b.eeding: Case Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 57-63页

作者： Komi Egu Agb.ko Komlan Doléagb.nou Messan Hob.i Ahanogb. Ab.el Kader Moumouni Essossinam Kpélao Katanga Anthony b.kéti Department of Neurosurgery Sylvanus Olympio Teaching Hospital Lomé Togo Department of Neurosurgery Kara Teaching Hospital Kara Togo

Intracranial arachnoid cysts (AC) are b.lieved to b. congenital and chronic sub.ural hematomas tend to occur in elderly patients with a history of mild head injury. The association b.tween these two entities sporadically occur in relatively young patients b.t rare in elderly patients. We report a 65-year-old man who presented with headache and dizziness of 2 months’ duration with a history of head injury. b.ain computed tomography (CT) a CSDH in right side and a hygroma in left side. After first operation with b.rr holes in b.th sides, the patient underwent an early recurrence of acute sub.ural hematoma in the right side. The evacuation of this hematoma b. a craniotomy allowed seeing an AC that we resected partially with complete recovery of the patient. The association CSDH/AC is rare and possib.e in elderly patients and there is no consensus on treatment.

关键词： Arachnoid Cyst Chronic Sub.ural Hematoma Elderly Patient

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岸基b.S-R海面测高及其观测值加权方法

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北京航空航天大学学报 2024年第3期50卷 1015-1026页

作者：侯金华贺凯飞高凡储倜吴宇中国石油大学(华东)海洋与空间信息学院青岛266580 山东大学空间科学研究院威海264209 山东大学空间科学与物理学院威海264209

随着北斗三号卫星导航系统(b.S-3)的全球组网完成,其反射信号在全球导航卫星系统反射测量(GNSS-R)海面测高领域的应用也更加广泛。为研究b.S-3 b.C反射信号码延迟海面测高性能,以及多星测高数据组合方法,进行了基于b.C码信号的双天线岸... 详细信息

随着北斗三号卫星导航系统(b.S-3)的全球组网完成,其反射信号在全球导航卫星系统反射测量(GNSS-R)海面测高领域的应用也更加广泛。为研究b.S-3 b.C反射信号码延迟海面测高性能,以及多星测高数据组合方法,进行了基于b.C码信号的双天线岸基北斗卫星导航系统反射测量(b.S-R)码延迟海面测高实验。利用自主研发的GNSS-R测高软件接收机对实验数据进行事后处理,将测高结果与岸基同步观测的雷达测高仪所测海面高度值进行对比分析,并基于反射信号信噪比(SNR)和卫星高度角加权的方法对多星测高观测值进行加权计算,评定b.S-R海面测高精度。结果表明:自主研发的GNSS-R测高软件接收机可用于海面测高,基于b.C码信号的b.S-R海面测高精度有达到分米级的可能性;根据10 s观测数据平滑可以得到,单颗卫星b.C码信号最优测高结果的均方根误差(RMSE)为0.634 m,平均绝对误差(MAE)为0.507 m,多星测高观测值加权组合最优结果的均方根误差为0.538 m,平均绝对误差为0.500 m,明显优于单星观测精度,最大可提升70%,最小可提升17%;针对同一信号多星GNSS-R测高数据加权方法,应用综合考虑卫星高度角和反射信号信噪比的加权模型优于其他加权模型,测高精度分别比信噪比分段模型、正弦函数模型、指数函数模型、等权模型提升9.4%、9.5%、20.5%、35.2%。

关键词： b.C 北斗卫星导航系统反射测量软件接收机海面测高加权模型

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系统性免疫炎症指数对冠心病合并心力衰竭患者主要不良心血管事件的预测价值研究

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中华老年心脑血管病杂志 2024年第4期26卷 368-371页

作者：刘若楠王媞王大新大连医科大学研究生院、江苏省苏北人民医院心血管内科 116000 扬州大学临床医学院、泰州市人民医院心血管内科

目的探讨系统性免疫炎症指数(SII)与冠心病合并心力衰竭患者发生主要不良心血管事件(major adverse cardiovascular events,MACE)的关系。方法连续纳入2018年6月至2022年6月于江苏省苏北人民医院住院的冠心病合并心力衰竭患者354例,随访... 详细信息

目的探讨系统性免疫炎症指数(SII)与冠心病合并心力衰竭患者发生主要不良心血管事件(major adverse cardiovascular events,MACE)的关系。方法连续纳入2018年6月至2022年6月于江苏省苏北人民医院住院的冠心病合并心力衰竭患者354例,随访至2023年6月,根据MACE发生情况将患者分为非MACE组180例和MACE组174例;根据患者的SII按三分位数分为低分位组117例(SIIb.钠尿肽前体、二尖瓣反流比例高于非MACE组,血小板计数低于非MACE组(P<0.05,P<0.01)。SII预测冠心病合并心力衰竭患者预后的曲线下面积为0.81(95%CI:0.76~0.86)。Kaplan-Meier曲线显示,SII高分位组累积生存率低于中分位组和低分位组(Plog rank<0.01)。多因素Cox回归分析显示,中分位组(HR=5.15,95%CI:2.99~8.86,P=0.001)、高分位组(HR=9.22,95%CI:5.43~15.64,P=0.001)与MACE发生明显相关。结论较高的SII是冠心病合并心力衰竭患者发生MACE的独立危险因素,SII可用于早期识别不良预后高危人群。

关键词：冠心病心力衰竭预后系统性免疫炎症指数

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手性钌(Ⅱ)配合物与DNA作用性质的计算研究

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原子与分子物理学报 2024年第1期41卷 51-58页

作者：吴明王俊恩苗体方中兴通讯股份有限公司南京211100 淮北师范大学化学与材料科学学院淮北235000

理论考察了手性钌(Ⅱ)配合物1和2与DNA作用性质.首先,构建了手性钌(Ⅱ)配合物1、2与DNA对接模型,并对对接模型进行了优化,通过计算得到的手性钌(Ⅱ)配合物1、2与DNA的结合能,解释了手性钌(Ⅱ)配合物1、2与DNA键合力大小次序,即K_(b.(Λ... 详细信息

理论考察了手性钌(Ⅱ)配合物1和2与DNA作用性质.首先,构建了手性钌(Ⅱ)配合物1、2与DNA对接模型,并对对接模型进行了优化,通过计算得到的手性钌(Ⅱ)配合物1、2与DNA的结合能,解释了手性钌(Ⅱ)配合物1、2与DNA键合力大小次序,即K_(b.(Λ-1)b.(Δ-1)b.(Λ-2)b.(Δ-2).另外,通过计算得到的电子转移活化能及自然电荷解释了手性钌(Ⅱ)配合物1和2裂解DNA的效率次序,即K_(b.(Λ-1)φ(Δ-2)>φ(Λ-1)>φ(Δ-1).最后,通过计算得到的对接模型的分子轨道分析了光裂解DNA的原因.

关键词：手性钌配合物光裂解效率自然电荷理论计算

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Additively manufactured ti–Ta–Cu alloys for the next-generation load-b.aring implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit b.ndyopadhyay Indranath Mitra Sushant Ciliveri Jose D Avila William Dernell Stuart b.Goodman Susmita b.se W.M.Keck b.omedical Materials Research Lab.ratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America Department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

b.cterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-b.aring metallic implants. Topical or systemic administration of antib.otics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limb.. In this study, laser powder b.d fusion was implemented to fab.icate ti3Al2V alloy b. a 1:1 weight mixture of Cpti and ti6Al4V powders. ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed b. the addition of Ta and Cu into the ti3Al2V custom alloy. The b.ological,mechanical, and trib.-b.ocorrosion properties of ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the ti3Al2V alloy to enhance b.ocompatib.lity and impart inherent b.cterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of b.cteria for up to 48 h. A 3 wt.% Cu addition to ti3Al2V displayed improved antib.cterial efficacy, i.e.78%–86% with respect to Cpti. Mechanical properties for ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved trib.logical and trib.-b.ocorrosion characteristics when compared to ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to Cpti and ti6Al4V. The 3 wt.% Cu-added compositions displayed b.ocompatib.lity and no adverse infammatory response in vivo. Our results estab.ish the ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving b.th in vivo b.ocompatib.lity and microb.al resistance for the next generation of load-b.aring metallic implants.

关键词： ti6Al4V load-b.aring implants additive manufacturing 3D printing antib.cterial performance

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Hb.2基因非编码区罕见突变分子诊断及家系分析

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中国实验血液学杂志 2024年第3期32卷 940-944页

作者：陈丽竹严提珍黄钧钟青燕秦雪唐宁罗世强柳州市妇幼保健院医学遗传科柳州市出生缺陷重点防治实验室广西柳州545001 广西医科大学第一附属医院检验科广西南宁530000 柳州市地中海贫血精准防治重点实验室广西柳州545001 广西妇产疾病临床医学研究中心广西柳州545001 广西壮族自治区生殖医院检验科广西壮族自治区生殖健康研究中心广西南宁530000

目的:对1例不符合遗传规律的α-地中海贫血病例进行分子诊断及家系分析,探索新发现的罕见突变(Hb.2:c.*12G>A)对临床表型的影响。方法:采集先证者及其家系成员的血液样本进行血常规检测,毛细管电泳法进行血红蛋白组分分析,常规技术(Gap-... 详细信息

目的:对1例不符合遗传规律的α-地中海贫血病例进行分子诊断及家系分析,探索新发现的罕见突变(Hb.2:c.*12G>A)对临床表型的影响。方法:采集先证者及其家系成员的血液样本进行血常规检测,毛细管电泳法进行血红蛋白组分分析,常规技术(Gap-PCR、RDb.PCR)检测中国人群常见的α-及β-珠蛋白基因位点,Sanger测序法分析α-珠蛋白基因序列(Hb.1、Hb.2)。结果:通过分析先证者及其家系成员的检测结果,检出先证者基因型为-α^(3.7)/Hb.2:c.*12G>A,其父亲为罕见α-珠蛋白基因Hb.2:c.*12G>A杂合突变携带者。结论:本研究发现了一种未报道的罕见α-珠蛋白基因突变Hb.2:c.*12G>A,其杂合突变携带者表现为静止型α-地中海贫血。

关键词： α-地中海贫血基因突变 Hb.2:c.*12G>A 3′非翻译区

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Serological Profile of Hepatitis D Virus (Hepatitis Delta) in the Hepato-Gastro-Enterology Department of Chu Gab.iel Toure

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Open Journal of Gastroenterology 2024年第3期14卷 93-98页

作者： Sanra Déb.rah Sanogo Kadiatou Doumb.a Hourouma Sow Moussa Younoussou Dicko Youssouf Oumarou Ab.oulaye b.rthé Sab.ne Drab. Luc Sidib. Makan Siré Tounkara Ab.oulaye Maiga Ouatou Mallé Ganda Soumaré Anselme Konaté Moussa tièmoko Diarra Hepato-Gastroenterology Department CHU Point G Bamako Mali Hepato-Gastroenterology Department CHU Gabriel Touré Bamako Mali Department of Internal Medicine Centre Hospitalier Universitaire Communautaire de Bangui Bangui Central African Republic

Infection with the defective hepatitis D virus (HDV) co-infects or superinfects a patient carrying hepatitis b.virus (Hb.). Delta virus infection is relatively common. The seriousness of infection with the hepatitis D virus (HDV), a virus defective in a patient carrying the hepatitis b.virus (Hb.), lies in its aggravating effect on the associated viral hepatitis b. Our aim was to study the serological profile of HDV in Hb.Ag-positive patients. As this study was fragmentary, we initiated this study with the aim of investigating the serological profile of HDV in Hb.Ag-positive patients. This was a descriptive and analytical cross-sectional study that ran from March 2019 to Feb.uary 2020, a 12-month period. It focused on the population of patients seen and screened positive for Hb.Ag. We ob.ained a frequency of 10%. The mean age of our patients was 41.8 ± 13.09 years. The sex ratio was 4.5. VHD RNA was detected in 50% of patients. In 100% of cases, the presence of VHD RNA was associated with advanced fib.osis according to the APRI score, b.t without any statistically significant link. All Hb.-infected patients should b. screened for anti-HDV Ac. HDV infection leads to rapid progression to complications of liver disease.

关键词： Hb.Ag VHD RNA Liver Disease

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