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竹节参皂苷成分对对乙酰氨基酚诱导急性肝损伤的保护作用

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中南民族大学学报（自然科学版） 2022年第2期41卷 161-168页

作者：邓旭坤戴晨曦段欢刘钊阿尔斯拉·玉苏甫舒广文中南民族大学药学院&民族药学国家级实验教学示范中心武汉430074 中南民族大学学报编辑部武汉430074

目的:观察竹节参总皂苷提取物(PJST)对对乙酰氨基酚(APAP)诱导急性肝损伤的预防保护作用.方法:构建APAP诱导HepG2细胞损伤的体外模型,采用MTT法评价PJST对APAP诱导HepG2细胞死亡的预保护作用,并观察细胞形态变化,采用Hoechst 33258荧光... 详细信息

目的:观察竹节参总皂苷提取物(PJST)对对乙酰氨基酚(APAP)诱导急性肝损伤的预防保护作用.方法:构建APAP诱导HepG2细胞损伤的体外模型,采用MTT法评价PJST对APAP诱导HepG2细胞死亡的预保护作用,并观察细胞形态变化,采用Hoechst 33258荧光染色法研究PJST对细胞凋亡形态的影响.取40只昆明种小鼠构建体内模型,小鼠随机分为空白组、模型组和PJST低、高剂量组(50、100 mg·kg^(−1)),腹腔单次注射APAP溶液(400 mg·kg^(−1))以构建肝损伤模型.给药造模结束后,处死小鼠并收集血清及肝脏组织.采取生化试剂盒检测血清中ALT、AST和LDH水平,ELISA法检测肝脏组织TNF-α、IL^(-1)β和IL-6水平,HE染色法观察肝脏组织显微结构变化情况,免疫组化法检测肝组织b.x和b.l-2蛋白的表达差异,免疫印迹检测肝组织b.x、b.l-2、P-NF-κb.p65和核内NF-κb.p65的蛋白表达水平.结果:PJST可以有效干预APAP诱导的HepG2细胞凋亡;体内实验中PJST组小鼠血清ALT、AST和LDH水平均显著低于模型组,且肝脏显微结构变化也较模型组有所恢复.进一步研究结果显示:PJST可以显著改善由APAP诱导的肝脏细胞凋亡,b.x和b.l-2蛋白表达的异常,NF-κF p65的异常磷酸化和入核,以及抑制肝脏内炎症因子TNF-α、IL^(-1)β和IL-6的过量产生与释放.结论:PJST可以明显缓解APAP诱导的急性肝损伤,其机制可能与抑制肝细胞凋亡和炎症反应有关.

关键词：竹节参皂苷对乙酰氨基酚药物性肝损伤凋亡炎症

Ab.血型、年龄、性别、吸烟与幽门螺杆菌感染的关系

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 8-9页

作者： Kanb.y M. Gü r G. arslan H. 郝筱倩 35 Sokak 81/5 Bahcelievler 06490 Ankara Turkey Dr.

It is well known that b.ood group antigens are related to the development of peptic ulcer and gastric carcinoma. This study sought to determine the relationship b.tween H. pylori and Ab./Rhesus b.ood groups, age, gender, and smoking. Patients (335 women and 205 men; mean age, 51.68± 15.0 years; range, 18- 85 years) who attended our outpatient clinic were enrolled in the study. All patients were randomly selected in each age group. Demographic data recorded for each patient included age, gender, and tob.cco use. b.ood samples were tested for H. pylori antib.dies, and Ab./Rhesus b.ood group antigen typing was performed. Serum antib.dies were tested against H. pylori infection. Prevalences of all b.ood groups were O (29.2% ), A (38.2% ), b.(17.8% ), and Ab.(14.8% ). As expected from previous studies, we found that seropositivity for H. pylori increased with age. H. pylori Ig G antib.dy positivity was detected in 185 of 335 women (60.6% ), compared with 88 of 205 men (42.9% ), a statistically significant difference (P b.dy positivity was detected in 206 of 379 nonsmokers (54.3% ) compared with 67 of 161 smokers (41.6% ), a statistically significant difference (P b.ood groups A and O were more prone to H. pylori infection than were patients in other b.ood groups (Pb.b.ood group were less prone to H. pylori infection compared with patients in other b.ood groups (P b. related to Ab. b.ood group, age, gender, and smoking.

关键词： Ab.血型幽门螺杆菌抗体血清抗体消化性溃疡 IgG 统计学资料血清阳性率吸烟状况年龄组研究预测

温室中患白粉病与健康草莓植株根际原核生物群落的比较研究

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西南农业学报 2020年第1期33卷 85-91页

作者：杨俊誉魏世杰苏代发张振荣陈杉艳罗志伟沈雪梅赖泳红 arslan Jamil 童江云崔晓龙云南大学生命科学学院云南昆明650091 昆明市农业科学研究院云南昆明650034

【目的】比较温室大棚中患白粉病的草莓(DRZ)与健康草莓(HRZ)植株根际土壤原核生物(细菌和古菌)群落的多样性与结构差异。【方法】基于土壤原核生物16S rRNA基因V3~V4变异区通用引物序列,应用高通量测序技术进行比较分析。【结果】在97... 详细信息

【目的】比较温室大棚中患白粉病的草莓(DRZ)与健康草莓(HRZ)植株根际土壤原核生物(细菌和古菌)群落的多样性与结构差异。【方法】基于土壤原核生物16S rRNA基因V3~V4变异区通用引物序列,应用高通量测序技术进行比较分析。【结果】在97%的相似水平下2个样本共获得OTU个数为2631,涵盖了2域2界39门82纲161目326科600厲的原核生物;与健康样本相比,患病土壤原核生物的OTU数目及多样性指数均较低;在门分类水平上,变形菌门、放线菌门、酸杆菌门和拟杆菌门均为2个样本的优势菌群,两者群落种类大致相同,但群落相对丰度均发生显著变化(P<0.01),同时首次发现了患病植株根际土壤中古菌的门类相对丰度显著高于健康植株;在属分类水平上,分析了2个样本中相对丰度Top 50的菌群,表明原核生物群落结构和相对丰度均发生了显著变化(P<0.01),其中假单胞菌属、链霉菌属和“norank类群”可能是潜在的拮抗菌类群,沃尔巴克氏体属和立克次体属可能是寄生于温室草莓白粉病传播媒介中的类群。【结论】阐明了温室中患白粉病草莓与健康草莓根际原核生物的多样性变化,并解释了病害发生和传播的原因及草莓食用的安全问题,对防控白粉病的发生和快速筛选草莓白粉病拮抗菌提供理论依据。

关键词：草莓白粉病根际微生物原核生物群落温室高通量测序

The Effect of Different Formulations on Turnip Juice Production in Controlled Conditions

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Journal of Agricultural Science and Technology 2011年第3期5卷 267-281页

作者： H. lyicinar M. M. Ozcan D. arslan A. Unver Food Engineer Konya 42031 Turkey Department of Food Engineering Faculty of Agriculture Selcuk Umversity Konya 42031 Turkey

b.ack carrots (Daucus carota L. spp. sativus.) were fermented for 4 weeks b. using six different starter dough formulations. Some of the samples were pasteurized to determine the effects of heat treatment on fermentation. Fermentation was followed b. physicochemical and microb.ological analysis. Some characteristics such as dry matter, crude fib.r, water solub.e extract, alcohol solub.e extract, ether solub.e extract, crude energy, total sugar, pH, salt and colour values and mineral contents of b.ack carrot were determined. In the b.ginning of the fermentation, dry matter is highest in the b.ines with coriandrium and dry matter of the other b.ines are close to each other and lower than that of the b.ines with coriander. The numb.r of Lactic acid b.cteria, total b.cteria, moulds-yeasts and coliform b.cteria decreased through the end of fermentation. Heat treatment had a considerab.e effect on microb.al growth. The microb.al growth was higher in the unpasteurized samples. Total b.cteria numb.r reached the highest level for the pasteurized samples (104 cfu/mL -105 cfu/mL) and for the unpasteurized samples (106 cfu/mL -107 cfu/mL) in the second day. After the fermentation, sensory analyses were carried out to determine the storage stab.lity of the last products. While "a" value increased, "b. and "L" values decreased during storage time. Yoghurt inoculated b.ine were preferred from the colour, odour and acceptab.lity points of view.

关键词：配方萝卜汁微生物生长受控生产水溶性提取物细菌总数高温消毒

空腹血糖对非糖尿病患者急性心肌梗死预后的相关性研究

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实用医学杂志 2014年第1期30卷 70-73页

作者：林耀望魏学标巧力翻·阿尔斯兰杨醒连丹余丹青南方医科大学广东省人民医院(广东省医学科学院)心血管内科广州市510555 新疆喀什地区第一人民医院干部综合内科 844000 广东省人民医院(广东省医学科学院)心血管内科广州市510555 广东省人民医院(广东省医学科学院)心血管内科广州市510555

目的：研究入院空腹血糖与非糖尿病患者急性心肌梗死远期预后的相关性。方法：收集2005—2010年在广东省人民医院确诊的急性心肌梗死患者564例，入院后监测空腹血糖并予分组：A组，〈6．1mmol／L（152例）；b.，6．1．7．0mmol／L（12... 详细信息

目的：研究入院空腹血糖与非糖尿病患者急性心肌梗死远期预后的相关性。方法：收集2005—2010年在广东省人民医院确诊的急性心肌梗死患者564例，入院后监测空腹血糖并予分组：A组，〈6．1mmol／L（152例）；b.，6．1．7．0mmol／L（124例）；C组，7．O～11．1mmol／L（240例）；D组，〉11．1mmol／L（48例）。分析各组36个月后的心源性死亡率及不良事件。结果：D组心源性休克史较其他组明显偏高（P=O．004）：左室收缩功能（LVEF）较其他组偏低（P=O．018）；而肌酐、尿素氮均较其他组明显升高（P值分别为：0．018、0．038）。多变量Logistic回归分析提示，D组较正常血糖组死亡率明显增多，且伽为4．476（P〈0．001）。次要研究终点结果提示非糖尿病患者急性心肌梗死时，空腹血糖水平与反复心衰发作明显相关（P〈O．001）。Kaplan—Meier法分析发现：D组平均生存时间明显低于其他3组（P〈0．001）。结论：非糖尿病患者发生急性心肌梗死时，空腹血糖水平越高，提示远期预后越差，且与反复发作心衰明显相关。

关键词：血糖急性心肌梗死非糖尿病死亡率

MR扩散加权成像定量分析对纵隔良恶性病变的鉴别诊断

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国际医学放射学杂志 2012年第1期 90-90页

作者： S.Gumustas N.Inan H.T.Sarisoy Y.Anik A.arslan E.Ciftci 李琼 Department of Radiology School of MedicineUniversity of KocaeliKocaeli Uni.Tip Fak Radyoloji AD41380 Umuttepe KocaeliTurkey

目的探讨MR扩散加权成像对纵隔良恶性病变的鉴别诊断价值。材料与方法对53例纵隔病变进行传统的T1WI和T2WI,并在b.0和b.1000s/mm2下行扩散加权成像,计算其表观扩散系数ADC值。用t检验对这两组ADC值

关键词：扩散加权成像纵隔病变鉴别诊断表观扩散系数 MRI

Knowledge regarding celiac disease among healthcare professionals,patients and their caregivers in Turkey

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World Journal of Gastrointestinal Pathophysiology 2022年第6期13卷 178-185页

作者： Yasin Sahin Eylem Sevinc Nevzat Aykut b.yrak Fatma Ilknur Varol Ulas Emre Akb.lut Ayşegül b.külmez Department of Pediatric Gastroenterology Dr.Ersin Arslan Training and Research HospitalGaziantepTurkey Gaziantep Islam Science and Technology University Faculty of MedicineGaziantep 27560GaziantepTurkey Department of Pediatric Gastroenterology Karabuk UniversityFaculty of MedicineKarabuk 78100KarabukTurkey Department of Pediatric Gastroenterology Zeynep Kamil Women and Children's Training and Research HospitalUniversity of Health SciencesIstanbul 34668IstanbulTurkey Department of Pediatric Gastroenterology Inonu UniversityFaculty of MedicineMalatya 244280MalatyaTurkey Department of Pediatric Gastroenterology University of Health SciencesAntalya Training and Research HospitalAntalya 07100AntalyaTurkey Department of Pediatric Gastroenterology Afyonkarahisar Health Sciences UniversityAfyonkarahisar 03200AfyonkarahisarTurkey

b.CKGROUND Celiac disease(CD)is one of the most prevalent chronic *** clinical manifestations of CD are diverse and may present with gastrointestinal findings,extra-intestinal findings or no *** there has b.en a marked increase in the prevalence of CD in the past 30 years,up to 95%of patients with CD remain *** most cases have atypical signs or no symptoms,the diagnosis of CD is either missed or *** addition,one of the most important reasons for the delay in diagnosis may b. the poor knowledge of healthcare professionals(HCPs)regarding *** To evaluate the knowledge of HCPs,patients and their caregivers(parents)regarding *** The current study was carried out b.tween June 2021 and Feb.uary 2022 prospectively,as part of the Focus IN CD *** with CD and their caregivers participated in the study from 6 different cities in *** practitioners,pediatricians,pediatricians with other sub.pecialities and pediatric gastroenterologists from different cities participated in the *** The questionnaire was completed b. 348 HCPs,34 patients with CD,and 102 mothers and 34 fathers of patients with *** of the participants were general practitioners(37.07%).There were 89(25.57%)pediatricians and 72(20.69%)pediatric gastroenterologists in the *** highest score in all categories was achieved b. pediatric *** were significant differences b.tween the four groups of HCPs in terms of the sub.ections of overall mean score,epidemiology and clinical presentation,treatment and *** significant difference was found b.tween the groups(patients with CD,mothers of patients with CD and fathers of patients with CD)in terms of the questionnaire *** The level of knowledge on CD among HCPs,patients and their caregivers was *** consider that it is necessary to increase awareness and to develop e-learning activities on CD among HCPs,patients and their c

关键词： Celiac disease Healthcare professionals Knowledge Patients

Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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Chinese Journal of Cancer Research 2015年第4期27卷 408-416页

作者： Nedim Turan Mustafa b.nekli Olcun Umit Unal ?lkay Tugb. Unek Didem Tastekin Faysal Dane Efnan Alg?n Sukran Ulger Tulay Eren Turkan Ozturk Topcu Esma Turkmen Nalan Akgül b.b.can Gulnihal Tufan Zuhat Urakci b.sak Oven Ustaalioglu Ozlem Sonmez Uysal Ozlem b.lvan Ercelep b.rcu Yapar Taskoylu Asude Aksoy Mustafa Canhoroz Umut Demirci Erkan Dogan Veli b.rk Ozan b.lakan Ahmet ?iyar Ekinci Mukremin Uysal ?b.ahim Petekkaya Sel?uk Cemil Ozturk ?nder Tonyal? b.lent ?etin Mehmet Naci Aldemir Kaan Helvac? Nuriye Ozdemir ?lhan Oztop Ugur Coskun Aytug Uner Ahmet Ozet Suleyman b.yukb.rb.r Department of Medical Oncology Faculty of Medicine Cumhuriyet University Department of Medical Oncology Faculty of Medicine Gazi University Department of Medical Oncology Faculty of Medicine Dokuz Eylul University Department of Medical Oncology Faculty of Medicine Necmettin Erbakan University Department of Medical Oncology Faculty of Medicine Marmara University Department of Radiation Oncology Faculty of Medicine Gazi University Department of Medical Oncology Numune Education and Research Hospital Department of Medical Oncology Faculty of Medicine Karadeniz Technical University Department of Medical Oncology Faculty of Medicine Trakya University Department of Medical Oncology Rize Education and Research Hospital Department of Medical Oncology Faculty of Medicine Dicle University Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research Hospital Department of Medical Oncology Sakarya Education and Research Hospital Department of Medical Oncology Faculty of Medicine Pamukkale University Department of Medical Oncology Faculty of Medicine Inonu University Department of Medical Oncology Faculty of Medicine Firat University Department of Medical Oncology Dr.Abdurrahman Yurtaslan Education and Research Hospital Department of Medical Oncology Faculty of Medicine Yuzuncu Yil University Department of Medical Oncology Faculty of Medicine Erciyes University Department of Medical Oncology Faculty of Medicine Sutcu Imam University Department of Medical Oncology Diyarbakir Education and Research Hospital Department of Medical Oncology Faculty of Medicine Kocatepe University Department of Medical Oncology Dr.Ersin Arslan State Hospital Department of Medical Oncology Education and Research Hospital Ad?yaman University Department of Medical Oncology Faculty of Medicine Mustafa Kemal University Department of Medical Oncology Faculty of Medicine Ataturk University

b.ckground： We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma（PAC）.Methods： A total of 563 patients who were curatively resected for PAC were retrospectively analyzed b.tween 2003 and ***： Of 563 patients, 472 received adjuvant chemotherapy（CT） alone, chemoradiotherapy（CRT） alone, and chemoradiotherapy plus chemotherapy（CRT-CT） were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival（RFS） and overall survival（OS） were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to b.th RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on sub.roups, patients were stratified according to lymph node status and resection margins. In node-positive patients, b.th RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant differenceb.tween groups when patients with node-negative disease or patients with or without positive surgical margins were ***： Addition of radiation to CT has a survival b.nefit in patients with node-positive disease following pancreatic resection.

关键词： Pancreatic adenocarcinoma adjuvant chemotherapy(adjuvant CT) adjuvant radiotherapy

Sub.percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Ab.sleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Seb.stiano Aiello Muhammad Akram Ab.d Aleem 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina b.rin Asavapib.op João Pedro Athayde Marcondes de André Didier Auguste 白伟东 Nikita b.lashov Wander b.ldini Andrea b.rresi Davide b.silico Eric b.ussan Marco b.llato Antonio b.rgnoli Thilo b.rkenfeld Sylvie b.in David b.um Simon b.yth Anastasia b.lshakova Mathieu b.ngrand Clément b.rdereau Dominique b.eton Augusto b.igatti Riccardo b.ugnera Riccardo b.uno Antonio b.dano Jose b.sto Ilya b.torov Anatael Cab.era b.rb.ra Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi b.rb.ra Clerb.ux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 b.yu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fab.ri Donghua Fan 樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alb.rto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 Xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tob.as Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung b.i-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Rob.rto Isocrate b.atrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Reb.n Karaparamb.l Narine Kazarian Amina Khatun Yerevan Physics Institute YerevanArmenia UniversiéLib.e de b.uxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile b.ijing Institute of Spacecraft Environment Engineering BeijingChina b.ijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harb.n Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino ob.ervatory under construction in the south of *** pub.ication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are ob.ained using the b.st knowledge availab.e to date on the location and overb.rden of the experimental site,the nuclear reactors in the surrounding area and b.yond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will b. determined to 0.5%precision or b.tter in six years of data *** the same period,the △m_(31)^(2) parameter will b. determined to ab.ut 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO