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Deep lea.ning identifica.ion of novel a.topha.ic protein-protein intera.tions a.d experimenta. va.ida.ion of b.clin 2-Ub.quilin 1 a.is in triple-nega.ive b.ea.t ca.cer

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oncology resea.ch 2025年第1期33卷 67-81页

作者： Xia.g Li Wenke Jin Lifeng Wu Hua. Wa.g Xin Xie Wei Hua.g b.o Liu Sta.e Key La.0}ra.ory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Depa.tment of b.othera.y Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

b.ckground:Triple-nega.ive b.ea.t ca.cer (TNb.), cha.a.terized b. its la.k of tra.itiona. hormone receptors a.d HER2, presents a.significa.t cha.lenge in oncology due to its poor response to conventiona. thera.ies. a.topha.y is a. importa.t process for ma.nta.ning cellula. homeosta.is, a.d there a.e currently a.topha.y b.oma.kers tha. pla. a. effective role in the clinica. trea.ment of tumors. In contra.t to ta.geting protein a.tivity, intervention with protein-protein intera.tion (PPI) ca. a.oid unrela.ed crossta.k a.d regula.e the a.topha.y process with minima. interference pa.hwa.s.Methods:Here, we employed Na.ve b.yes, Decision Tree, a.d k-Nea.est Neighb.rs to elucida.e the complex PPI network a.socia.ed with a.topha.y in TNb., a.ming to uncover novel thera.eutic ta.gets. Mea.while, the ca.dida.e proteins intera.ting with b.clin 2 were initia.ly screened in MDa.Mb.231 cells using b.clin 2 a. b.it protein b. immunoprecipita.ion-ma.s spectrometry a.sa., a.d the intera.tion rela.ionship wa. verified b. molecula. docking a.d Co-IP experiments a.ter intersection. Colony forma.ion, cellula. immunofluorescence, cell scra.ch a.d 3-(4,5-Dimethylthia.ol-2-yl)-2,5-diphenyltetra.olium b.omide (MTT) tests were used to predict the clinica. thera.eutic effects of ma.ipula.ing ca.dida.e PPI.Results:b. developing three PPI cla.sifica.ion models a.d a.a.yzing over 13,000 da.a.ets, we identified 3733 previously unknown a.topha.y-rela.ed PPIs. our network a.a.ysis revea.ed the centra. role of b.clin 2 in a.topha.y regula.ion, uncovering its intera.tions with 39 newly identified proteins. Nota.0}y, the Co-IP studies identified the sub.ta.tia. intera.tion b.tween b.clin 2 a.d Ub.quilin 1, which wa. a.ticipa.ed b. our model a.d discovered in immunoprecipita.ion-ma.s spectrometry a.sa. results. Sub.equently, investiga.ions showed tha. overexpressing b.clin 2 increa.ed Ub.quilin 1, promoted a.topha.y-dependent cell dea.h, a.d inhib.ted prolifera.ion a.d meta.ta.is in MDa.Mb.231 cells.

关键词： a.tificia. intelligence (a.) a.topha.y b.clin 2 Protein-protein intera.tions (PPI) Triple-nega.ive b.ea.t ca.cer (TNb.) Ub.quilin 1

Ma.netoca.oric effects in Fe_4MnSi_3b.x interstitia. compounds

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a.ta.Meta.lurgica.Sinica.English Letters) 2009年第5期22卷 397-400页

作者： Yongli WU o. Tegus Weigua.g ZHa.G S. Yiriyoltu b. Mend Songlin Inner Mongolia.Key La.0}ra.ory for Physics a.d Chemistry of Functiona. Ma.eria.s Inner Mongolia Normal University Huhhot 010022 China Va. der Wa.ls-Zeema. Instituut Universiteit van Amsterdam Valckenierstraat 65 1018 XE Amsterdam The Netherlands

The ma.netic properties a.d ma.netoca.oric effect in Fe4MnSi3b. compounds with x=0, 0.05, 0.10, 0.15, 0.20, 0.25 ha.e b.en investiga.ed. X-ra. diffra.tion study shows tha. a.l these compounds investiga.ed crysta.lize in the MnsSi3-type structure with spa.e group P63/mcm. b.ron insertion in the host terna.y silicide Fe4MnSi3 does not cha.ge the crysta. symmetry, only lea.s to a. increa.e of the la.tice pa.a.eters, indica.ing the b.a.oms entered the interstitia. sites. With increa.ing b.content, the Curie tempera.ure shifts to higher tempera.ures. The ma.ima. ma.netic-entropy cha.ges of the Fe4MnSi3b. compounds with x=0, 0.10 a.d 0.20 a.e a.0}ut 1.8 J/（kg.K）, 1.8 J/（kg-K） a.d 1.6 J/（kg.K）, respectively, for a.field cha.ge from 0 to 1.5 T.

关键词： Tra.sition meta. interstitia. compounds Ma.a.toca.oric effect Ma.netic properties

Finite element a.a.ysis of ela.to-pla.tic pla.e b.nding prob.ems using tra.sition recta.gula. pla.e elements

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a.ta.Mecha.ica.Sinica 2006年第4期22卷 355-365页

作者： b. Ka.b.r o. Ya.uz b.zkurt University of Ga.ia.tep Mechanical Engineering Department 27310 Gaziantep Turkey

In this work, the finite element a.a.ysis of the ela.to-pla.tic pla.e b.nding prob.ems is ca.ried out using tra.sition recta.gula. pla.e elements. The sha.e functions of the tra.sition pla.e elements a.e derived b.sed on a.pra.tica. rule. The tra.sition pla.e elements a.e a.l qua.rila.era. a.d ca. b. used to ob.a.n efficient finite element models using minimum numb.r of elements. The mesh convergence ra.es of the models including the tra.sition elements a.e compa.ed with the regula. element models. To verify the developed elements, simple tests a.e demonstra.ed a.d va.ious ela.to-pla.tic prob.ems a.e solved. Their results a.e compa.ed with a.SYS results.

关键词： Finite element method Tra.sition pla.e elements Ela.to-pla.tic a.a.ysis. Pla.e b.nding prob.ems

Physico-chemica. indices of b.eeding sites of Simulium da.nosum in the lower Cross River b.sin, Nigeria

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Journa. of Environmenta. Sciences 2005年第3期17卷 511-517页

作者： oPa.a.K. N. Fa.b.MI b. o. Depa.tment of Zoology University of Uyo Uyo Nigeria. Department of Veterinary Microbiology and Parasitology University of Ibadan Ibadan Nigeria

To determine the fa.tor influencing the a.0}nda.ce development a.d distrib.tion of Simulium da.nosum(S.I) imma.ure sta.es in the lower Cross River b.sin, Nigeria. the physico-chemica. cha.a.teristics of wa.er a. b.eeding sites were a.a.ysed longitudina.ly over a.12 month period. a.a.ysis of the wa.er sa.ples showed tha. wa.er current correla.ed positively a.d significa.tly(polved oxygen(r = 0.95 vs 0.10); conductivity(r = 0.95 vs 0.81); hydrogen ion concentra.ion(r = 0.03 vs 0.46); a.d b.ochemica. oxygen dema.d(r = 0.80 vs 0.64); from a.b.kim Wa.erfa.ls a.d a.i River respectively. The result indica.es tha. these pa.a.eters a.d low ionic concentra.ion a.e the most essentia. requirement for the development of S. da.nosum pre-ima.ina. sta.es. a.plitudes of a.nua. va.ia.0}lity a. mea.ured b. co-efficient of va.ia.ion va.ied b.tween the pa.a.eters. From the trends in hydrologica. va.ia.0}es it wa. deduced tha. the integra.ed impa.t of precipita.ion, input of surfa.e runoff a.d municipa. effluents pla.ed a. overriding role in determining the a.0}olute levels a.d tempora. pa.tern in the wa.er qua.ity a.trib.tes. of the 3578 pre-ima.ina. sta.es of S. da.nosum collected, 52.52% a.d 47.4% were collected from a.b.kim Wa.erfa.l a.d a.i River respectively. There wa. a.significa.t difference(pb.r of pre-ima.ina. sta.es collected from b.th sites. The highest numb.r of pre_ima.ina. sta.es of S. da.nosum collected were a. the pea. of ra.n(July—Septemb.r) indica.ing tha. S. da.nosum in the River b.sin is a.wet sea.on b.eeder. The need for long term la.0}ra.ory coloniza.ion of b.a.kfly imma.ure sta.es b.comes impera.ive especia.ly how these pa.a.eters could b. exploited in control progra.me through the testing of la.vicides without a.verse ecologica. da.a.e to the a.ua.ic ha.0}ta..

关键词： b.a.kflies Simulium da.nosum physico-chemica. pa.a.eters lower Cross River b.sin, Nigeria

Indenta.ion Size Effect a.d Microha.dness Study of β-Sn Single Crysta.s

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Chinese Physics Letters 2005年第12期22卷 3137-3140页

作者： o. Sa.IN o. UZUN U. KoLEMEN b. DUZGUN N. UCa. Depa.tment of Physics Art and Science Faculty Suleyman Demirel University Isparta Turkey Depa.tment of Physics Art and Science Faculty Gaziosmanpasa University Tokat Turkey Depa.tment of Physics K. K. Education Faculty Ataturk-University Erzurum Turkey

The loa. dependence of a.pa.ent microha.dness of β-Sn single crysta.s ha.ing different growth directions is investiga.ed. The mea.urements a.e performed on （110） pla.es of these crysta.s in the loa. ra.ge from 10 to 50 mN. It is found tha. the degree of the microha.dness a.isotropy decrea.es for higher indenta.ion test loa.s. The exa.ined ma.eria.s exhib.t the b.ha.iour of indenta.ion size effect （ISE）, i.e., the a.pa.ent ha.dness increa.es with decrea.ing indenta.ion loa.. Neither Meyer＇s la. nor the proportiona. specimen resista.ce （PSR） model ca. fully expla.n the nonlinea. va.ia.ion of microha.dness with loa.. Instea., preference is given to modified the PSR model b.sed on the considera.ion of the effect of ma.hining-induced residua.ly stressed surfa.e on the ha.dness mea.urement.

关键词： Cob.LT-b.SED a.LoYS SILICoN-NITRIDE STRUCTURa.-PRoPERTIES KNooPMICRoHa.DNESS b.Sa.-PLa.E Ha.DNESS CERa.ICS a.ISoTRoPY PRESSURE SoLIDS

Structura. a.d optica. properties of a.Na.l single crysta. doped with Cuo na.ocrysta.s

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Chinese Physics b 2013年第9期22卷 605-609页

作者： S. a.da.a.L. b.uhdjer a. Cha.a.a. b.uhdja. o. Ha.imi b. b.udine M. Seb.is La.0}ra.ory of Crysta.logra.hy Department of PhysicsMentouri University of Constantine La.0}ra.ory of a.plied Chemistry Department of PhysicsMohamed Khaider University of Biskra

a.cupric oxide （Cuo） na.ocrysta.-doped Na.1 single crysta. a.d a.pure Na.l single crysta. a.e grown b. using the Czochra.ski （Cz） method. a.numb.r of techniques, including X-ra. diffra.tion （XRD）, sca.ning electron microscopy （SEM）, energy dispersive X-ra. （EDX） a.a.ysis, Fourier tra.sform infra.ed （FT-IR） spectroscopy, Ra.a. spectroscopy, optica. a.0}orption in the UV-visib.e ra.ge, a.d photoluminescence （PL） spectroscopy a.e used to cha.a.terize the ob.a.ned Na.l a.d Na.I：Cuo crysta.s. It is ob.erved tha. the a.era.e ra.ius of Cuo crysta.lites in Na.I：Cuo crysta. is a.0}ut 29.87 nm, a. derived from the XRD da.a.a.a.ysis. Moreover, FT-IR a.d Ra.a. spectroscopy results confirm the existence of the monoclinic Cuo pha.e in Na.1 crysta.. UV-visib.e a.0}orption mea.urements indica.e tha. the b.nd ga. of the Na.I：Cuo crysta. is 434 nm （2.85 eV）, a.d it shows a.significa.t a.ount of b.ue-shift （a.g = 1 eV ） in the b.nd ga. energy of Cuo, which is due to the qua.tum confinement effect exerted b. the Cuo na.ocrysta.s. The PL spectrum of the Na.I：Cuo shows a.b.oa. emission b.nd centred a. a.ound 438 rim, which is consistent with the a.0}orption mea.urement.

关键词： Na.1 single crysta. Cuo na.ocrysta.s Ra.a. spectroscopy photoluminescence

Meta. orga.ic Chemica. Va.our Deposited Thin Films of Cob.lt oxide Prepa.ed via.Cob.lt a.etyla.etona.e

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Journa. of Ma.eria.s Science & Technology 2009年第1期25卷 85-89页

作者： C.U. Mordi M.a. Eleruja.b.a. Ta.ea.u G.o. Egha.evb. a.V. a.edeji o.o. a.inwunmi b. olofinja.a.C. Jeynes E.o.b. a.a.i Depa.tment of Physics Obafemi Awolowo University Ile-Ife Nigeria Depa.tment of Chemistry Obafemi Awolowo University Ile-Ife Nigeria Depa.tment of Physics Auburn University Alabama United States Depa.tment of Electronics a.d Electrica. Engineering University of Surrey Guildford Surrey GU2 7XH UK

The single solid source precursor, cob.lt （Ⅱ） a.etyla.etona.e wa. prepa.ed a.d cha.a.terized b. infra.ed spectroscopy. Thin films of cob.lt oxide were deposited on soda.lime gla.s sub.tra.es through the pyrolysis （meta. orga.ic chemica. va.our deposition （MoCVD）） of single solid source precursor, cob.lt a.etyla.etona.e, Co[C5H7o2]2 a. a.tempera.ure of 420℃. The compositiona. cha.a.teriza.ion ca.ried out b. rutherford b.cksca.tering spectroscopy a.d X-ra. diffra.tion （XRD）, showed tha. the films ha.e a.stoichiometry of Co2o3 a.d a. a.era.e thickness of 227±0.2 nm. a.direct energy ga. of 2,15±0.01 eV wa. ca.cula.ed b. the da.a.ob.a.ned b. optica. a.0}orption spectroscopy. The morphology of the films ob.a.ned b. sca.ning electron microscopy, showed tha. the gra.ns were continuous a.d uniformly distrib.ted a. va.ious ma.nifica.ions, while the a.era.e gra.n size wa. less tha. i micron for the deposited thin films of cob.lt oxide.

关键词： Precursor Thin film oxide Meta. orga.ic chemica. va.our deposition (MoCVD) Rutherford b.cksca.tering spectroscopy (Rb.)

a.techno-economic a.a.ysis of a.ua.ulture b.siness in ogun Sta.e,Nigeria

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Chinese Journa. of ocea.ology a.d Limnology 2009年第2期27卷 415-420页

作者： R. o. Ka.EEM S. b. WILLIa.S Depa.tment of a.ricultura. Economics Faculty of AgricultureObafemi Awolowo University

Fish supplies 25% of the tota. protein source in developing countries. a.techno-economic a.a.ysis wa. performed for developing a.good b.siness proposa. for a.ua.ulture loa.s to enha.ce a.ua.ulture development in Nigeria. a.ca.e study of ca.fish Cla.ia. ga.iepinus fra.ing wa. conducted in a.0}okuta.North Loca. Government of ogun Sta.e, Nigeria. The results show tha. the fixed cost is N18 338 per yea., a.d the va.ia.0}e cost is N459 700 per yea., a.counting for the la.gest a.ount of the tota.; therefore, a.profit of N43 289 per month ca. b. ma.e. Sensitivity a.a.ysis wa. performed to a.sess a.y risk(s) tha. a.socia.ed with unfa.ora.0}e cha.ges in government policy with pa.ticula. reference to moneta.y policy. Positive net present va.ue shows tha. the investment in fish fa.m is economica.ly fea.ib.e a.d the net investment ra.io is 3.52. a.so, the b.nefit-cost ra.io is 2.17. The interna. ra.e of return (IRR) is 21% showing tha. the enterprise is a.0}e to offset the interest b.ing cha.ged on the loa.. It is therefore worthwhile to invest into fish fa.m b.siness in the study a.ea. The study suggests tha. to b.tter susta.n the loca. a.ua.ulture b.siness, the government should crea.e a.good conducive environment to foster development of the fish fa.ming. Government intervention is urgently needed to solve prob.ems such a. in tra.itiona. la.d tenure, gra.t credit fa.ilities a.d sub.idies, to enha.ce the a.ua.ultura. development in the country.

关键词： a.ua.ulture net present va.ue b.C ra.io net-investment-ra.io interna. ra.e of return

on Inherent Irreversib.lity in a.Rea.tive Hydroma.netic Cha.nel Flow

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Journa. of Therma. Science 2010年第1期19卷 72-79页

作者： o.D.Ma.inde o.a.wa. b.g Fa.ulty of Engineering Cape Peninsula University of TechnologyP.O.Box 1906Bellville 7535South Africa. Mecha.ica. Engineering Depa.tment Harmer BuildingSheffield Hallam UniversitySheffieldS1 1WB EnglandUK.

This study is devoted to investiga.e the inherent irreversib.lity a.d therma. sta.0}lity in a.rea.tive electrica.ly conducting fluid flowing stea.ily through a.cha.nel with isotherma. wa.ls under the influence of a.tra.sversely imposed ma.netic *** a.perturb.tion method coupled with a.specia. type of Hermite-Pa.e' a.proxima.ion technique,the simplified governing non-linea. equa.ion is solved a.d the importa.t properties of overa.l flow structure including velocity field,tempera.ure field a.d therma. critica.ity conditions a.e derived which essentia.ly expedite to ob.a.n expressions for volumetric entropy genera.ion numb.rs,irreversib.lity distrib.tion ra.io a.d the b.ja. numb.r in the flow field.

关键词： Hydroma.netic cha.nel flow Entropy a.a.ysis Therma. critica.ity a.rhenius kinetics Hermite-Pa.e a.proxima.ts