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a.timicrob.a. Resista.ce a.d Pla.mid Profiles of <i>Sa.monella.enterica.lt;/i>Serova.s from Different Sources in La.os, Nigeria

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Hea.th 2018年第6期10卷 758-772页

作者： K. O. a.inyemi S. O. a.oseh b. a. iwalokun a. O. b. Oyefolu C. O. Fa.orede R. O. a.1}gunrin O. a.unmo Depa.tment of Microb.ology Lagos State University Ojo Lagos Nigeria b.ochemistry Unit a.d Ma.a.ia.Resea.ch La.0}ra.ory Nigerian Institute of Medical Research Yaba Lagos Nigeria

Introduction: Sa.monella.enterica.Serova.s rema.ns one of the lea.ing pa.hogens tha. ca.se dia.rhoea.a.d b.oodstrea. infections in developing countries. The emergence of multidrug resista.t (MDR) Sa.monella.ha. b.come a.serious prob.em glob.lly. This study investiga.ed the a.tib.otic resista.ce a.d pla.mid profiles of Sa.monella.isola.es from different sources. Methods: Seventy-three sa.ples comprised of clinica. (30), ha.d swa.0}(15), food (10) a.d wa.er (18) were a.a.yzed b.cteriologica.ly. Sa.monella.isola.es were identified a.d cha.a.terized b. sta.da.d procedures. Isola.es were sub.ected to a.timicrob.a. susceptib.lity testing a.d were further screened for pla.mid DNa.b. sta.da.d methods. Results: a.tota. of 27 Sa.monella.isola.es ma.e up of 5 (18.5%) S. typhi, 6 (22.2%) S. enteritidis, 9 (33.3) S. typhimurium, 5 (18.5%) S. cholera.uis, a.d 1 (3.7%) ea.h of *** a.d S. vichow were ob.a.ned in this study. a.l the isola.es developed resista.ce to three or more a.tib.otics eva.ua.ed. Four distinct resista.ce profiles: Teta.pCol, Teta.pColCot, Teta.pColCip a.d Teta.pColCotCip were recorded with 63% of the isola.es exhib.ting resista.ce profile Teta.pColCot. Specifica.ly 23 of 27 (85.2%) of the isola.es ha.b.ured pla.mid DNa.comprised of 12 distinct pla.mid profiles of different sizes ra.ging from 3.2 kb.to 30.2kb. Sa.monella.isola.es of the sa.e species from different sources differed in pla.mid profile. Pla.mid profile wa. found to show good discrimina.ory ca.a.0}lity compa.ed to a.tib.otics resista.ce profile. Conclusion: This study revea.ed tha. b.th resista.ce a.tib.ogra. a.d pla.mid profile a.e still via.0}e epidemiologica. tools for tra.ing the source of Sa.monella.isola.es. a.need for prudent use of a.tib.otics is suggested.

关键词： Sa.monella Resista.t a.tib.ogra. Pla.mid Epidemiology Disea.e

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Seropreva.ence of pa.vovirus b.9 a.tib.dies a.d evidence of viremia.a.ong Nigeria. pa.ients with sickle cell a.emia

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The Journa. of b.omedica. Resea.ch 2013年第4期27卷 272-282页

作者： b.midele a.0}odun iwalokun Sena.on Olusola.iwalokun Sema.de Olufunmila.o Hodonu b.ochemistry a.d Nutrition Nigerian Institute of Medical Research Ma.erna. a.d Child Hea.th Unit Iru/VI Primary Health Centre (PHC) Depa.tment ofb.ochemistry Lagos State University

Clinica., b.ochemica. a.d molecula. evidence for the sickle cell a.emia.（SCa. crisis in Nigeria. pa.ients a.ising from pa.vovirus b.9 infection rema.ns ina.equa.e. This study determined the preva.ence a.d correla.es of a.tipa.vovirus b.9 a.tib.dies in a.popula.ion of SCa.pa.ients a.d non-SCa.hea.thy controls in La.os, Nigeria. In this prospective cross-sectiona. study, we enrolled 73 confirmed SCa.pa.ients from 5 district hospita.s in La.os a.d 81 sex a.d a.e-ma.ched non-SCa.hea.thy controls. Serum sa.ple from ea.h study pa.ticipa.t wa. screened for a.ti-pa.vovirus b.9 b. ELISa.a.d PCR techniques. Sta.da.d b.omedica. a.sa.s were a.so done. a.ti-pa.vovirus b.9 IgM a.d IgG a.tib.dies were detected in 22 （14.3%） a.d 97 （62.9%） of the 154 sera.screened, 13 （17.8%） a.d 45 （61.6%） in SCa.pa.ients; 9 （11.1%） a.d 52 （64.2%） in non-SCa.controls. The overa.l seronega.ivity ra.e wa. 19.5%. Pa.vovirus b.9 DNa.wa. found in 2 （11.1%） of the 18 IgM seropositive SCa.serum sa.ples screened. On the whole, pa.vovirus b.9 infection wa. more commonly a.ymptoma.ic in non-SCa.controls b.t ca.sed significa.t eleva.ion in liver enzymes in infected SCa.pa.ients （P 〈 0.05）. The risk of a.ute pa.vovirus b.9 infection increa.ed 65 times during unstea.y sta.e a.ong the SCa.pa.ients. a.though no dea.hs of infected pa.ients were recorded during the study, a.e b.low 12 yea.s, hospita.iza.ion a.d overcrowded environment were risk fa.tors for infection. We conclude tha. pa.vovirus b.9 is common in SCa.pa.ients, incurring grea.er susceptib.lity to infections.

关键词： pa.vovirus b.9 infection seropreva.ence sickle cell a.emia

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