检索结果-南通市图书馆

Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides Vb4

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical biomedicine 2011年第3期1卷 223-226页

作者： b valentin bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel Department of biotechnology Sathyabama University

Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove ***:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated *** search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora *** the seven isolates, one fungi Irpex hydnoides was selected for further *** fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)be Tetradecane(6.26%) with the RT ***:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening *** results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off.

关键词： Mangrove fungi Cytotoxic activity ITS sequencing GC MS Irpex hynoides Characterization Cytotoxic compound Endophytic fungi Mangrove bioactive metabolite

Isolation and characterization of secondary metabolites from the mangrove plant Rhizophora mucronata

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 602-604页

作者： Elsa Lycias Joel valentin bhimba Institute for Environmental Research and Social Education(IERSE) NagercoilKanyakumari District Research Scholar Department of BiotechnologySathyabama UniversityRajiv Gandhi SalaiChennai-119 Department of biotechnology Sathyabama UniversityRajiv Gandhi SalaiChennai-119

Objective:To evaluate the antibacterial activity of foliar extracts of Rhizophora mucronnata(R. mucronata) against pathogens belonging to human origin and to identify the compound hitherto unprecedented in nature by GC-MS ***:Soxhlet extraction method was used to get the corresponding extracts of ethanol,petroleum ether,acetone,methanol and ethyl *** antimicrobial activities of the organic solvent extracts on the various test organisms using agar well diffusion technique were carried *** acetate extract exhibited promising antimicrobial activity and hence minimum inhibitory concentration(MIC) was performed for the *** chromatography was done for partial purification of crude extract and fractions were analyzed by ***:A column chromatographic fractionation of the extracts and further UV visible and GS-MS analysis suggested the active principle compound were a mixture of squalene(19.19%),n-Hexadecanoic acid(6.59%),phytol(4.74%).2-cyclohexane-l- one, 4-hydroxy-3,5,(4.20%) and oleic acid(2.88%).Conclusions:The results are good enough to serve to transform the practice of research in this sub field across a range of different benefit streams that include drug *** and large this type of structure analyses are most important as aids to more rational decision taking in safety models versus *** general,structural data provide prima facie support for drug hypothesis.

关键词： Antibacterial activity Secondary metabolite Rhizophora mucronata GC-MS

Green synthesis of luminescent La-MOF nanoparticle from waste poly(ethylene terephthalate) for high-performance in Fe(Ⅲ) detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第8期43卷 3833-3843页

作者： Zhi Gong Zhi-Kui Dai Zhi-Yue Dong Qiu-Xuan Liu valentin A.Milichko Hua-Jian Liu Jie Liu Ran Niu Jiang Gong Key Laboratory of Material Chemistry for Energy Conversion and Storage Hubei Key Laboratory of Material Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSemiconductor Chemistry CenterSchool of Chemistry and Chemical EngineeringMinistry of EducationHuazhong University of Science and TechnologyWuhan 430074China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430073China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China School of Physics and Engineering ITMO UniversitySt.Petersburg197101Russia School of Materials Science and Engineering Hubei UniversityWuhan430062China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing School of Mechanical and Automotive EngineeringKey Laboratory of Polymer Processing EngineeringMinistry of EducationSouth China University of TechnologyGuangzhou 510641China

Developing luminescent metal-organic frameworks(MOFs) capable of high-efficiency Fe^(3+)sensing has aroused great attraction in the fields of biology,chemistry,***,previous solvothermal methods are limited by organic solvent usage,time consuming,high pressure,and high-energy ***,we propose the waste-toMOF strategy towards the scale-up production of La-MOF nanoparticles through the ball milling of recycled poly(-ethylene terephthalate)(PET) bottles and La(NO_(3))_(3)·_(6)H_(2)*** goes on alkaline hydrolysis to form 1,4-benzenedicarboxylic acid sodium salt(Na_(2)bDC) and ethylene glycol by ball ***,bDC reacts with La^(3+)to form *** as-prepared La-MOF crystal nanoparticles possess a rod-like morphology with the size of few hundred ***,La-MOF nanoparticles display high selectivity and sensitivity for Fe^(3+)*** quenching constant and limit of detection are 5.29×10^(3)(mol·L^(-1))^(-1) and 0.147 μmol·L^(-1),respectively,thus surpassing many advanced Fe^(3+) *** to the result of density functional theory,the high Fe^(3+) detection performance of La-MOF is related to the complexing of Fe^(3+)with La-MOF,which leads to the gradual dissociation of the coordination bond between terephthalic acid and La^(3+).It is anticipated that the mechanochemistry milling-based wasteto-MOF strategy provides a new platform for the massive production of functional MOFs in a green manner.

关键词： Metal-organic framework Waste polyester Mechanochemistry milling Fluorescence sensor

Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 544-546页

作者： valentin bhimba b J Meenupriya Elsa Lycias Joel D Edaya Naveena Suman kumar M Thangaraj Department of biotechnology Sathyabama University Rajiv Gandhi SalaiChennai-119Tamil naduIndia Institute for Environmental Research and Social Education Nagercoil Kanyakumari DistrictIndia Research Scholar Department of BiotechnologySathyabama UniversityRajiv Gandhi Salai.Chennai-119Tamil naduIndia CAS in Marine biology Annamalai UniversityParangipettai-608 502Cuddalore DistrictIndia

Objective:To explore antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis(***).Methods:In the present study the leaf extracts of *** were examined for its antibacterial potential using five different solvents against some reference strains of human pathogenic bacteria for the crude *** activity was observed for ethyl acetate and hence different concentrations like 15μL,25μL,and 50μL of ethyl extracts was checked for its antibacterial *** purification of crude extract was carried by column chromatography and fractions were analyzed using gas chromatography-mass spectrometry(GC-MS) to identify ***:The crude ethyl acetate extracts of *** showed remarkable antibacterial activity with zones of inhibition of 13 mm against Eschericia coli(***) and 11 mm against Staphylococcus aureus (***).Fraction 13(ethyl acetate:methanol= 8:2) as the most potent one against with the minimal inhibitory concentration of 30 mm against *** and 25 mm against *** GCMS resultsof active column fraction(F13) revealed that the active principals were a mixture of hydroxy- 4 methoxybenzoic acid,diethyl phthalate,oleic ***:The leaf extracts with proven antibacterial effects can clearly be directed towards cancer treatment as to inhibiting cancer cell *** limited number of test organisms owes to a constraint of ***,the effect of strong bursts of leaf extracts on human pathogenic bacteria should further be tested on a wide range of test organisms.

关键词： Mangrove Avicennia officinalis Antibacterial GC-MS

Cholera Recurrence within benin Littoral County: Analysis of Epidemics from 2008, 2016 to 2023

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Epidemiology 2024年第2期14卷 353-365页

作者： Mongbo Virginie Avahoun valentin Agbomakouzo Evariste Sopoh Ghislain Aguemon badirou Ouendo Edgard-Marius Regional Institute of Public Health Ministry of Public health of benin Cotonou B&#233ninBenin Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Cholera is an acute diarrheal infection caused by the bacillus Vibrio cholerae, which can be fatal in a few hours if left untreated. It rages in endemic-epidemic mode in several countries, including benin. Despite being the economic capital, the largest city in benin and the most urbanized municipality in the country, the Littoral County, confounded with the city of Cotonou, is subject to recurrent epidemics. This paper aims to analyze successive cholera epidemics with a view of highlighting the factors contributing to this recurrence. Methods: A secondary analysis was done of the cholera-related databases of the County health office from 2016 to 2023, and its Situation Report No. 79 of December 7th, 2016, to describe the 2016 epidemic. Database data were analyzed in Excel. Results: Similarly to 2008, the 2016 cholera epidemic in Cotonou, which recorded 519 cases and 07 deaths, i.e. a case-fatality rate of 1.35%, spread to the town and six neighboring municipalities. The municipality of So-Ava, home to the index case, had the highest overall attack rate. The two epidemics share the same period of severity. both epidemic and endemic cases are concentrated in the first seven boroughs of Cotonou, located on the lagoon shore, with low levels of hygiene and sanitation and a poor supply of drinking water. Conclusion: Low levels of hygiene, sanitation and drinking water supply all play a part in the recurrence of cholera epidemics. Sanitation work. Undertaken by the beninese government is a ray of hope for improving this situation. Meanwhile, public awareness of hygiene measures must continue.

关键词： Recurrence Cholera Cotonou

Antibacterial screening of silver nanoparticles synthesized by marine micro algae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 797-799页

作者： D Devina Merin S Prakash b valentine bhimba Department of biotechnology Udaya School of EngineeringUdaya NagarVellamodiAmmandivillai post-629204Kanyakumari DistrictTamil NaduIndia Department of biotechnology Sathyabama UniversityChennai-600 119TamilnaduIndia

Objective:To explore the biosynthesis of silver nanoparticles synthesized by marine microalgae. Methods:Marine microalgae was collected from Central Marine Fisheries Research Institute (CMFRI,tuticorin) and cultured in the *** nanoparticles synthesis were observed in normal and microwave irradiated microalgae and screened against human pathogens for the presence of ***:The presence of silver nanoparticle was confirmed by UV-Visible spectroscopy at 420 nm by the presence of plasmon *** confirmation was done by scanning electron microscope(SEM).Conclusions:These results not only provide a base for further research but are useful for drug development in the present and future.

关键词： Silver nanoparticle Marine microalgae Screening antimicrobials Synthesize

Quantitative interactomic of CD40 in primary b cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

hLife 2024年第2期2卷 88-93页

作者： Jeremy Argenty Emilie Maturin Mylene Camus valentin Mellado Jeanne Perroteau benoit Pasquier Guillaume Voisinne Odile burlet-Schiltz Lih-Ling Lin Anne Gonzalez de Peredo Romain Roncagalli bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut de Pharmacologie et de biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTRODUCTION Over the past few decades,antibody-based therapies have emerged as an additional tool to treat patients developing cancer and auto-immune *** natural properties of the developed antibodies may lead to agonist or blocking functions for the targeted ***,antibodies developed for clinical trials are extensively analyzed in vitro and in vivo for safety and efficacy,yet they are not routinely evaluated for their potential signaling effectiveness.

关键词： routine antibodies clinical

The role of tangential velocity in explosive initiation by fragment impact

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2022年第12期18卷 2190-2197页

作者： Vitaly Leus Roy Ceder valentin Ognev Meir Mayseless RAFAEL ballistic Center P.O.Box 2250HaifaIsrael Faculty of Engineering Sciences Ben-Gurion University of the NegevBeer-Sheva84105Israel

An initiation study is presented in which we examine the effect of the normal and the tangential velocity components of a fragment that impacts a covered and a bare Comp-b explosive. The study is based on calibrated numerical Lagrangian simulations using the LS-Dyna hydrocode. A special procedure was developed to present the estimated initiation point and the shock wave transition into detonation for various impact angles. The influence of the fragment strength and the steel cover thickness on the detonation threshold were also examined. The velocity threshold results are presented and used to modify the Jacobs-Roslund initiation model.

关键词： High explosive initiation Lee-tarver Jacobs-roslund Fragment

Non-Adiabatic Phonon Dispersion of Metallic Single-Walled Carbon Nanotubes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2010年第11期3卷 822-829页

作者： valentin N.Popov Philippe Lambin Faculty of Physics University of SofiaBG-1164 SofiaBulgaria Research Center in Physics of Matter and Radiation Facultés Universitaires Notre Dame de la PaixB-5000 NamurBelgium

Non-adiabatic effects can considerably modify the phonon dispersion of low-dimensional metallic ***,these effects are studied for the case of metallic single-walled carbon nanotubes using a perturbative approach within a density-functional-based non-orthogonal tight-binding *** adiabatic phonon dispersion was found to have logarithmic Kohn anomalies at the brillouin zone center and at two mirror points inside the *** obtained dynamic corrections to the adiabatic phonon dispersion essentially modify and shift the Kohn anomalies as exemplified in the case of nanotube(8,5).Large corrections have the longitudinal optical phonon,which gives rise to the so-called G-band in the Raman spectra,and the carbon hexagon breathing *** results obtained for the G-band for all nanotubes in the diameter range from 0.8 to 3.0 nm can be used for assignment of the high-frequency features in the Raman spectra of nanotube samples.

关键词： Nanotube phonons G band tight-binding model