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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational biology and Systems biomedicine Biodonostia Health Research InstituteSan SebastianSpain basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GbD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Performance effects of feed-borne Fusarium mycotoxins on broiler chickens: Influences of timing and duration of exposure

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Animal Nutrition 2019年第1期5卷 32-40页

作者： Anhao Wang Natacha S.hogan Department of Animal and Poultry Science College of Agriculture and Bioresources University of Saskatchewan Toxicology Centre University of Saskatchewan

In commercial practice, broiler chickens may be exposed to Fusarium mycotoxins either during specific growth stages or throughout the entire production cycle. A 34-day feeding trial was conducted to identify sensitive periods for mycotoxin effects during the growth cycle of broiler chickens. A total of 420 newly-hatched Ross 308 male broilers were randomly assigned to 60 cages with 7 birds/cage. Sources of clean wheat(broilers according to treatments(control, DON 1 to 14 d, DON 15 to 21 d, DON 22 to 34 d and DON 1 to 34 d). birds were monitored daily for morbidity or mortality. broiler growth performance(body weight, average daily gain, average daily feed intake and feed to gain ratio) was measured *** of duodenum, jejunum and ileum were collected at 21 and 34 d and morphometric parameters(villus height, crypt depth, villus width, muscularis thickness and villi:crypt ratio) were measured. birds fed the DON starter diet during the first 14 d did not exhibit any changes in growth performance;however, growth performance was suppressed in birds fed DON-contaminated diets during the grower period(22 to 34 d). At 34 d, birds that received the DON grower diet(DON 22 to 34 d and DON 1 to 34 d)were lighter(1,433 vs. 1,695 g) than birds fed the control diet. Feed to gain ratio was higher in birds fed the DON grower diet from 22 to 28 d(1.77 vs. 1.56) and 28 to 34 d(2.24 vs. 1.85) compared with corresponding controls. These results suggest that providing older broiler chicks(22 to 34 d) feed contaminated with Fusarium mycotoxins(specifically DON) may result in production losses. Histopathological analysis of the ileum region revealed that birds provided the DON diets throughout the

关键词： Deoxynivalenol Chicken Sensitive period Feed contamination Intestine

Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography

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Chinese Optics Letters 2017年第9期15卷 25-30页

作者： Roshan Dsouza Hrebesh Subhash Kai Neuhaus Paul M.McNamara josh hogan Carol Wilson Martin j.Leahy Tissue Optics and Microcirculation Imaging Group School of PhysicsNational University of IrelandGalway H91 CF50Ireland Compact Imaging Ireland Ltd. Galway H91 CF50Ireland Colgate-Palmolive Global Technology Centre Piscataway NJ 08855USA Compact Imaging Inc.Mountain View 94043USA Royal College of Surgeons(RCSI) DublinIreland

Multiple reference optical coherence tomography（MR-OCT） is a recently developed, low-cost and compact time-domain OCT solution for primary care and consumer level applications. A combination of a voice coil actuator and a partial mirror（PM） extends the scan range for imaging depths of approximately 1 mm in biological samples. Our previous research on MR-OCT is based only on intensity information obtained from the depth-resolved interference signal. In this Letter, we extract the phase information from the MR-OCT signal and, hence, provide an additional contrast modality. The phase sensitivity of the system is measured to be approximately 0.2 and 1.5 rad for the first and twelfth orders of reflection when using a mirror as the *** Letter describes first results of phase-sensitive data measured on a phantom obtained with MR-OCT. Data from a chick embryo chorioallantoic membrane（CAM） is used to demonstrate the feasibility of MR-OCT for in vivo phase-sensitive imaging.

关键词： Feasibility study of phase-sensitive imaging based on multiple reference optical coherence tomography VCM Figure CAM

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy b, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3b’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

NONLINEAR FREE SURFACE ACTION WITH AN ARRAY OF VERTICAL CYLINDERS

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Acta Mechanica Sinica 2004年第3期20卷 247-262页

作者： HUANG j.b. Department of Engineering Science University of OxfordUK

Nonlinear diffraction of regular waves by an array of bottom-seated circular cylindersis investigated in frequency domain,based on a Stokes expansion approach.A complete semi-analyticalsolution is developed which allows an efficient evaluation of the second-order potentials in the entirefluid domain,and the wave forces on the *** are derived for the second-orderpotential in the vicinity of individual *** expressions have a simple form,thus providingan effective means for investigating the wave enhancement due to nonlinear interactions with *** on the present method,the wave run-up and free-surface elevations around an arrayof two,three and four cylinders are investigated numerically.

关键词： nonlinear wave diffraction water waves frequency analysis semi-analytical method

Irreversibility investigation of Casson fluid flow in an inclined channel subject to a Darcy-Forchheimer porous medium:a numerical study

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Applied Mathematics and Mechanics(English Edition) 2021年第1期42卷 95-108页

作者： A.ROjA b.j.GIREESHA b.NAGARAjA Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShimoga 577451KarnatakaIndia

The heat transfer and entropy generation characteristics of the magnetohydrodynamic Casson fluid flow through an inclined microchannel with convective boundary conditions are ***,the effects of the viscous forces,joule heating,heat source/sink,and radiation on the flow are taken into *** non-dimensional transformations are used to solve the governing ***,the reduced system is resolved by the fourth-fifth order Runge-Kutta-Fehlberg method along with the shooting *** effects of different physical parameters on the heat transfer and entropy generation are discussed in detail through *** the perspective of numerical results,it is recognized that the production of entropy can be improved with the joule heating,viscous dissipation,and convective heating *** is concluded that the production of entropy is the maximum with increases in the Casson parameter,the angle of inclination,and the Hartmann *** the Reynolds number and the radiation parameter cause the dual impact on entropy generation.

关键词： inclined channel Casson fluid magnetism radiation entropy generation bejan number

Optimization of heat transfer in the thermal Marangoni convective flow of a hybrid nanomaterial with sensitivity analysis

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Applied Mathematics and Mechanics(English Edition) 2021年第11期42卷 1663-1674页

作者： j.MACKOLIL b.MAHANTHESH Centre for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Bengaluru 560029KarnatakaIndia

The heat transfer rate of the thermal Marangoni convective flow of a hybrid nanomaterial is optimized by using the response surface methodology(RSM).The thermal phenomenon is modeled in the presence of a variable inclined magnetic field,thermal radiation,and an exponential heat *** estimated values of the thermal conductivity and viscosity of the hybrid nanomaterial are utilized in the *** governing intricate nonlinear problem is treated numerically,and a parametric analysis is carried out by using graphical visualizations.A finite difference-based numerical scheme is utilized in conjunction with the 4-stage Lobatto IIIa formula to solve the nonlinear governing *** interactive effects of the pertinent parameters on the heat transfer rate are presented by plotting the response surfaces and the contours obtained from the *** mono and hybrid nanomaterial flow fields are *** hybrid nanomaterial possesses enhanced thermal fields for nanoparticle volume fractions less than 2%.The irregular heat source and the thermal radiation enhance the temperature *** high level of the thermal radiation and the low levels of the exponential heat source and the angle of inclination(of the magnetic field)lead to the optimized heat transfer rate(Nux=7.46275).

关键词： inclined magnetic field Marangoni boundary layer flow sensitivity analysis hybrid nanofluid exponential heat source response surface methodology(RSM)

Water Vapor Information from Satellite and Its Applications

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Advances in Atmospheric Sciences 2024年第1期41卷 188-189页

作者： b.j.SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea

Water vapor is a critical component of the hydrological cycle because it plays a vital role in transporting water from one part of the cycle to *** vapor evaporated from surfaces such as oceans,lakes,and rivers conden... 详细信息

关键词： motion oceans lakes