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Plasma Science and Technology 2020年第8期22卷 63-70页

作者： J COSFELD P DREWS b blackwell M JAKUbOWSKI H NIEMANN D ZHANG Y FENG the Wendelstein-X Team Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC)52425 JülichGermany JARA-HPC Jülich Supercomputing CentreForschungszentrum Jülich GmbH52425 JülichGermany Australian National University Acton ACT2601 CanberraAustralia Max-Plank-Insitut für Plasmaphysik 17491 Greifswald/85748 GarchingGermany

The recently modified EMC3-EIRENE code package has been widely applied as an edge-plasma analysis tool and resulted in successful validation against various measured trends seen in stellarator and tokamak plasma *** has been shown that the code package applied for Wendelstein 7-X(W7-X)discharges in the interpretive mode can assess the impact of impurity effects on the electron density,measured by a set of Langmuir *** particular the spatial quantification of impurities and effects from the effective charge state Zeff and effective mass meff,which are non-trivial to record by diagnostics,were *** results showed that earlier assumptions of the effective charge-state distribution and effective mass for reported Langmuir probe measurements must be ***,reprocessing these measurements with code-interpreted spatial profiles of the effective charge state and effective mass led to an overall improved physical consistency.

关键词： Wendelstein 7-X plasma-wall interaction numerical-diagnostics EMC3-EIRENE

EGR1 is essential for transcriptional regulation of bMPR2

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American Journal of Molecular biology 2011年第3期1卷 131-139页

作者： Radhika Gaddipati James D. West James E. Loyd Thomas blackwell Kirsten A. Lane Nicole M. Lane Kirk b. Lane 不详

In this study, RLM-RACE was used to identify the transcriptional start site 387 bp upstream of the translational start. Evolutionarily conserved transcription factor binding sites were identified, and a series of luciferase reporter constructs driven by bMPR2 promoter elements used to determine their functional relevance. We found the promoter area from 983 bp to 90 bp upstream of the transcriptional start gave maximal activity, greater than longer constructs, with an area between 570 bp and 290 bp upstream of the transcriptional start containing an important repressor element. To characterize this repressor, we used a combination of EMSA, mutation of the EGR1 binding site, transfection with EGR1 and NAb1 constructs, and mutation of the NAb1 binding site within the EGR1 protein. From this we conclude that EGR1 is essential to bMPR2 transcription, but that NAb1 binding to EGR1 causes it to act as a repressor.

关键词： Transcription bMPR2 Regulation EGR1 NAb1 Pulmonary Hypertension

Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman bret H.Goodpaster Stephen b.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne b.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(Sb)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(pbehavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

Spectroscopic studies of fuel recycling and impurity behaviors in the divertor region of Wendelstein 7-X

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Plasma Science and Technology 2019年第10期21卷 17-27页

作者： Yanling WEI Erhui WANG Yunfeng LIANG Southwestern Institute of Physics Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung—PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC) Max Planck Institute for Plasma Physics Australian National University

The first divertor operation phase (OP1.2a) was carried out on Wendelstein 7-X in the second half of 2017. Fuel recycling and impurity behaviors in the divertor region were investigated by employing a newly built ultraviolet–visible–near infrared overview spectroscopy system. The characteristic spectral lines of the working gases (hydrogen and helium), intrinsic impurities (carbon, oxygen and iron), and seeded impurities (neon and nitrogen) were identified and analyzed. The divertor electron temperature and density were measured using He I (667.8, 706.5, and 728.1 nm) line intensity ratios. The Hα(656.3 nm), He I (587.6 nm), C II (514.5 nm), and O I (777.2 nm) emissions were investigated over a wide range of operating conditions. The results showed that fuel and impurity emissions in the divertor region exhibit a strong dependence on magnetic topology and plasma conditions. The levels of Hα, He I, C II, and O I emissions are all reduced moving from the standard configuration to the high mirror configuration, and even further reduced for the high iota configuration, which is associated with decreasing connection length in these island divertor configurations. The H/He influx ratio shows that the plasma is a mixture of helium and hydrogen. The neutral and impurity influxes from the divertor target tend to increase with increasing divertor electron temperature.

关键词： spectroscopy diagnostic fuel recycling impurity

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西方字体设计一百年 1版

用于精确打击的一种DoD优化的全球DGPS

2005年

作者：（英）路易斯·布莱克威尔（Lewis blackwell）许捷译

本书对20世纪字体设计历史以及平面设计中的种种问题进行了分析。包括：大规模生产的形成、艺术指导的诞生、线格的出现、非印刷媒介的发明与Macintosh系统的采用，以及该系统如何带领那些由数字技术催生的新一代设计师向前发展等内容。

ISBN: (纸本)753224248X

关键词：美术字字体设计美术史西方国家

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战术导弹控制技术 2005年第1期13卷 91-99页

作者：马宝国陈友清 Earl blackwell Mark Moeglein David Nakayama SRI International

低成本、全天候、且不需要昂贵的基于导引头制导的精确打击武器投放,对美国国防部(DoD)来说是感兴趣的.本文给出了基于军用型差分全球定位系统(DGPS)的概念,它提供潜在的亚米级、基于GPS的导航精度.这种DGPS概念的主要特征能使基准接收... 详细信息

低成本、全天候、且不需要昂贵的基于导引头制导的精确打击武器投放,对美国国防部(DoD)来说是感兴趣的.本文给出了基于军用型差分全球定位系统(DGPS)的概念,它提供潜在的亚米级、基于GPS的导航精度.这种DGPS概念的主要特征能使基准接收机/用户的间隔超过1000nmi(海里),且修正延迟为30min或更多.这项技术能使GPS系统实现亚米级的精密定位服务(PPS)精度.本文给出了一种长基线(2000nmi)DGPS实验的概念及可行性演示结果.同时,也给出了用于广域美国大陆DGPS网络的应用情况,包括四个授权的GPS基准接收机地点以及网络修正精度测量.联合直接攻击弹药(JDAM)项目对这种概念的研发和演示提供了机会。实际上，这项技术能用于任何一种授权的GPS接收机.

关键词：精确打击导引头制导差分全球定位系统导航精度

数据驱动方法评价帕金森病临床早期阶段的异质性

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 19-20页

作者： Lewis S.J.G. Foltynie T. blackwell A.D. 袁海峰 Cambridge Centre for brain Repair Forvie Site Addenbrooke's Hospital Cambridge CB2 2PY United Kingdom

Objective: To investigate the heterogeneity of idiopathic Parkinson’s disease (PD) in a data driven manner among a cohort of patients in the early clinical s tages of the disease meeting established diagnostic criteria. Methods: Data on d emographic,motor, mood, and cognitive measures were collected from 120 consecuti ve patients in the early stages of PD (Hoehn and YahrI-III) attending a special ist PD research clinic. Statistical cluster analysis of the data allowed the exi stence of the patient subgroups generated to be explored. Results: The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a t remor dominant subgroup of patients; (c) a nontremor dominant subgroup with sign ificant levels of cognitive impairment and mild depression; and (d) a subgroup w ith rapid disease progression but no cognitive impairment. Conclusions:This stud y complements and extends previous research by using a data driven approach to d efine the clinical heterogeneity of early PD. The approach adopted in this study for the identifi cation of subgroups of patients within Parkinson’s disease ha s important implications for generating testable hypotheses on defining the heterogeneity of this common co ndition and its aetiopathological basis and thus its treatment.

关键词：帕金森病数据驱动异质性 impairment 聚类分析轻度抑郁 subgroups 亚组 heterogeneity 发病学

抗生素、细菌和抗生素耐药基因:从牲畜饲养场通过颗粒物的空气传播

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环境与职业医学 2015年第9期32卷 855-855页

作者： Andrew D.McEachran brett R.blackwell J.Delton Hanson Kimberly J.Wooten Gregory D.Mayer Stephen b.Cox Philip N.Smith

[背景]抗生素耐药性的出现与蔓延已成为全球性的人类健康威胁，它常常与滥用和误用临床和兽医的化学药物联系在一起。现代工业规模的动物饲养操作很大程度上依赖于兽医药物，包括抗生素，以促进动物的生长。由此产生的排泄物中的抗生素... 详细信息

[背景]抗生素耐药性的出现与蔓延已成为全球性的人类健康威胁，它常常与滥用和误用临床和兽医的化学药物联系在一起。现代工业规模的动物饲养操作很大程度上依赖于兽医药物，包括抗生素，以促进动物的生长。由此产生的排泄物中的抗生素通过径流、淋溶和土地中使用的粪肥而传递到环境中。然而，牲畜饲养场空气传播的特征目前尚未经研究。[目的]确定在何种程度上，抗生素、抗生素耐药基因（ARG）和反刍动物相关的微生物是通过大型肉牛饲养场的颗粒物（PM）在空气中扩散的。[方法]收集10个肉牛饲养场顺风和逆风向的PM。提取PM后，使用高效液相色谱一串联质谱法量化5种兽用抗生素，用靶向定量聚合酶链式反应量化ARG，并用16SrRNA基因扩增和测序分析微生物群落多样性。[结果]来源于牲畜饲养场的气载PM促进了几种兽用抗生素以及包含ARG的微生物群落的扩散。下风向紧邻饲养场的气载PM中几种抗生素的浓度范围在0．5～4．6mg／gPM。饲养场下风向收集的PM微生物群落中，与反刍动物相关的类群变得丰富，并且与上风向PM中的类别组合明显不同。此外，与上风向收集的PM相比，下风向收集的PM中的抗四环素类抗生素基因编码显着更为丰富。[结论]来自牲畜饲养场的经风扩散的PM包含了抗生素、细菌和ARGs。

关键词：抗生素耐药性动物饲养空气传播耐药基因颗粒物牲畜细菌定量聚合酶链式反应

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《食品安全——鲜活农产品的微生物学》出版

标准生活 2009年第11期 86-87页

作者：钟华（译） Xuetong Fan brendan A. Niemira Christopher J. Doona Florence E. Feeherry Rohert b．Gravani 不详美国农业部（USDA）农业研究署的食品技术 USDA农业研究署美国陆军Natick军人研究、发展和工程中心康奈尔大学

著名的Wiley—blackwell出版社出版了一部有关食品安全的新书《食品安全——鲜活农产晶的微生物学（MICRObIAL SAFETY OF FRESH PRODUCE）》。该书的作者都是美国食品安全领域的知名专家。

关键词：食品安全微生物学鲜活农产品出版社网上书店 IEC SAFETY