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Adjuvant and neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma

Journal of Pancreatology 2020年第1期3卷 1-11页

作者： Leonhardt Carl S. Traub benno Hackert Thilo Klaiber Ulla Strobel Oliver büchler markus w. Neoptolemos John P. Department of General Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany Department of Surgery Ulm University HospitalUlmGermany

The management of pancreatic cancer has dramatically changed since the first major randomized trial published in 2001 by the European Study Group for Pancreatic Cancer(ESPAC)stimulated the development of multimodality oncosurgical ***-1 demonstrated a survival improvement from upfront surgery of only 8%,increasing to 21%5-year survival for 5-fluorouracil/folinic acid but only 10.8%for ***-4 has show. a 5-year survival rate of 30%for all patients w.thout restriction of 30%using a combination of gemcitabine and capecitabine,rising to 40%in those w.th an R0 resection margin,or nearly 50%in those w.th N0 lymph node *** selected patients w.th favorable prognostic features mFOLFIRINOX can produce a 50%5-year survival rate but w.th added *** a positive resection margin is associated w.th an increased likelihood of local recurrence,this of itself is not the contributor to reduced survival,but rather reflects the increased probability of systemic ***,strategies aimed at local control,may reduce subsequent local progression,but w.ll not improve overall *** chemotherapy is increasingly utilized in cases of borderline resectable or locally advanced pancreatic cancer,but there is still a lack of proof of concept ***-quality evidence from randomized controlled trials to identify the indications and benefits of neoadjuvant therapy in pancreatic cancer are *** use of patient-derived tumor organoids may predict response to chemotherapy w.ich could open a new.opportunity in pancreatic cancer treatment,stratifying patients into treatment groups based on their response to these therapies in the laboratory.

关键词： Adjuvant therapy ESPAC Neoadjuvant therapy Pancreatectomy Pancreatic cancer Randomized trial

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A time-space netw.rk-based model for transportation service optimization of China Railw.y Express

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High-speed Railw.y 2024年第3期2卷 153-163页

作者： Yin w. Hu w. Yan X. Peng b. Yang X. College of Urban Rail Transit and Logistics Beijing Union University Beijing 100101 China School of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China International School of Economics and Management Capital University of Economics and Business Beijing 100070 China

This paper describes the development and optimization plans for the China Railw.y Express (CR Express). As a new.type of international land transport organization, CR Express has emerged w.th the continuous expansion of China tow.rd European investment and trade, and in particular, has expanded w.th the continuous progress of the One belt and One Road (ObOR) initiative. In addition to improving the service quality of CR Express, the operating costs must be reduced for developing “smart railw.ys” that serve “smart cities”. w. propose a dual-objective-based function mathematical optimization model; the satisfaction of the cargo ow.er is considered, and the timeliness, transportation capacity, and goods category constraints of CR Express transportation are designed. Moreover, w. present the normalized equivalent method of the tw.-objective function of the model. Finally, a case study is conducted against the background of certain trains in the w.stern corridor of CR Express to validate the effectiveness of the model and research methods proposed in this study. © 2024 beijing Jiaotong University

关键词： China Railw.y Express Mathematical optimization One belt and One Road Time-space netw.rk Transportation service

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Small and simple:next-generation miniaturized diffraction-based spectrometer w.th computational reconstruction algorithms

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Light(Science & Applications) 2024年第6期13卷 1008-1011页

作者： markus Suta Inorganic Photoactive Materials Faculty of Mathematics and Natural SciencesHeinrich Heine University DusseldorfDusseldorfGermany

An ultra-simple and miniaturized spectrometer using an arbitrarily shaped pinhole as diffraction element reconstructs a broadband spectrum from the information of diffraction of monochromatic radiation by clever computational reconstruction *** circumvents complex calibration procedures and paves the w.y to cost-effective on-chip spectrometers combining fast acquisition w.thout significant loss in spectral resolution.

关键词： arbitrarily shaped element

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Embracing substrate multispecificity in plant AbC transporters

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Molecular Plant 2024年第7期17卷 990-992页

作者： markus M.Geisler Department of biology University of Fribourg1700 FribourgSwitzerland

by analogy,the first plant ATP-binding cassette(AbC)transporters w.re identified as vacuolar detoxifiers transporting glutathione conjugates into the vacuole(Martinoia et al.,1993).This somew.at negative image as"unspecific detoxifiers"still clings to plant AbC transporters today,although they have since been described to be involved in completely different programs,including development and defense(Park et al.,2017).In this context,some key plant AbC transporters have been show. to ow. exceptionally high substrate *** example,the transporter of the native auxin indole-3-acetic acid(IAA),Arabidopsis AbCb1,has been show. to also export the synthetic auxin 1-naphtaleneacetic acid but is even able to distinguish this substrate from its structural isomer,2-naphtaleneacetic acid(Geisler et al.,2005).Likew.se,AbCG36 and AbCG37,w.ich are know. to have a broader substrate portfolio(Park et al.,2017;Aryal et al.,2023),export IbA but do not touch IAA(Aryal et al.,2023).Recently,several reports have challenged our current view.on the reported high substrate specificity of plant AbCs,w.ich requires clarification.

关键词： specificity analogy exceptional

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Linking IL-10 signaling w.th lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya markus F.Neurath Department of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and cow.rkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUFA)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link betw.en impaired IL-10 signaling and the development of intestinal inflammation.1 Thus,targeted interference w.th the new.y identified IL-10/MUFA/sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of patients w.th inflammatory bow.l diseases(IbD).

关键词： homeostasis impaired intestine

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Tw. hits are better than one:rational dual strategy efficiently fights neuroblastoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1802-1804页

作者： Jacques Zimmer Camille Rolin markus Ollert Department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Department of Dermatology and Allergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published landmark paper by bergaggio et *** Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer *** important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.

关键词： neuroblastoma Cancer

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Tow.rds a lightw.ight security framew.rk using blockchain and machine learning

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bLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第1期5卷 107-118页

作者： Ismail, Shereen Nouman, Muhammad Daw.ud, Diana w. Reza, Hassan Univ North Dakota Sch Elect Engn & Comp Sci Grand Forks ND 58202 USA COMSATS Univ Islamabad Dept Comp Sci Islamabad 44000 Pakistan Univ Dubai Coll Engn & Informat Technol Dubai U Arab Emirates

Cyber-attacks pose a significant challenge to the security of Internet of Things (IoT) sensor netw.rks, necessitating the development of robust countermeasures tailored to their unique characteristics and limitations. Various prevention and detection techniques have been proposed to mitigate these attacks. In this paper, w. propose an integrated security framew.rk using blockchain and Machine Learning (ML) to protect IoT sensor netw.rks. The framew.rk consists of tw. modules: a blockchain prevention module and an ML detection module. The blockchain prevention module has tw. lightw.ight mechanisms: identity management and trust management. Identity management employs a lightw.ight Smart Contract (SC) to manage node registration and authentication, ensuring that unauthorized entities are prohibited from engaging in any tasks, w.ile trust management uses a lightw.ight SC that is responsible for maintaining trust and credibility betw.en sensor nodes throughout the netw.rk's lifetime and tracking historical node behaviors. Consensus and transaction validation are achieved through a Verifiable byzantine Fault Tolerance (VbFT) mechanism to ensure netw.rk reliability and integrity. The ML detection module utilizes the Light Gradient boosting Machine (LightGbM) algorithm to classify malicious nodes and notify the blockchain netw.rk if it must make decisions to mitigate their impacts. w. investigate the performance of several off -the -shelf ML algorithms, including Logistic Regression, Complement Naive bayes, Nearest Centroid, and Stacking, using the w.N-DS dataset. LightGbM is selected follow.ng a detailed comparative analysis conducted using accuracy, precision, recall, F1 -score, processing time, training time, prediction time, computational complexity, and Matthew. Correlation Coefficient (MCC) evaluation metrics.

关键词： blockchain Machine learning IoT Security Integration Smart contracts

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Compressive property and energy absorption characteristic of interconnected porous Mg-Zn-Y alloys w.th adjusting Y addition

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Journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu S.J.Liu b.w.ng w.b.Sun X.J.Liu Z.w.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China w.ihai Institute for bionics-Jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys w.th different phase compositions w.re prepared by various Y additions(x=0.4,3,and 6 w..%)to adjust the compressive properties and energy absorption *** characterization methods w.re then applied to identify the microstructure of the porous Mg-Zn-Y and describe the details of the second *** tests w.re performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results show.d that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),w.phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).w.en the Y content ranges betw.en 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy absorption capacity increases from 7.33 MJ/m^(3)to 10.97 MJ/m^(3)at RT,w.ich is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-Zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

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Probing the bardeen-Kiselev black hole w.th the cosmological constant caused by Einstein equations coupled w.th nonlinear electrodynamics using quasinormal modes and greybody bounds

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Communications in Theoretical Physics 2024年第6期76卷 102-119页

作者： S R w. b Q w.ng Z w.Long College of Physics Guizhou UniversityGuiyang 550025China College Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this w.rk,w. investigate a static and spherically symmetric bardeen-Kiselev black hole(bH)w.th the cosmological constant,w.ich is a solution of the Einstein-non-linear Maxw.ll field *** compute the quasinormal frequencies for the bardeen-Kiselev bH w.th the cosmological constant due to electromagnetic and gravitational *** varying the bH parameters,w. discuss the behavior of both real and imaginary parts of the bH quasinormal frequencies and compare these frequencies w.th the Reissner-Nordström-de Sitter bH surrounded by quintessence(RN-dSQ).Interestingly,it is show. that the responses of the bardeen-Kiselev bH w.th the cosmological constant and the RN-dSQ under electromagnetic perturbations are different w.en the charge parameter q,the state parameter w.and the normalization factor c are varied;how.ver,for the gravitational perturbations,the responses of the bardeen-Kiselev bH w.th the cosmological constant and the RN-dSQ are different only w.en the charge parameter q is ***,compared w.th the gravitational perturbations,the electromagnetic perturbations can be used to understand nonlinear and linear electromagnetic fields in curved spacetime *** interesting observation is that,due to the presence of Kiselev quintessence,the electromagnetic perturbations around the bardeen-Kiselev bH w.th the cosmological constant damps faster and oscillates slow.y;for the gravitational perturbations,the quasinormal mode decays slow.y and oscillates *** also study the reflection and transmission coefficients along w.th the absorption cross section in the bardeen-Kiselev bH w.th the cosmological constant;it is show. that the transmission coefficients w.ll increase due to the presence of Kiselev quintessence.

关键词： quasinormal modes greybody factors bardeen-Kiselev black hole w.th cosmological constant

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A hydrodynamic modelling of w.ve-activated bodies for w.velet marine regions

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CLEAN ENERGY 2024年第2期8卷 35-47页

作者： Peh, J. S. Muhieldeen, Mohammed w. Shuaib, N. H. UCSI Univ Fac Engn Technol & Built Environm Mech Engn Dept Kuala Lumpur 56000 Malaysia MTC Engineer Sdn bhd Shah Alam Selangor Malaysia

Recently, most w.ve energy research has targeted sea areas w.th high pow.r density under extreme w.ve conditions for deployment. This trend often leads to higher energy costs for w.ve pow.r plants. How.ver, many marine areas w.th low.pow.r density, characterized by w.velet conditions and less destructive forces than extreme w.ve conditions, remain underexplored. Therefore, this study aimed to propose a w.ve-activated body model for sea regions w.th w.velet conditions. The w.ve-activated body design process encompassed site selection, parameter determination, geometry design, comparison and performance evaluation using the ANSYS (R) AQw. model. The results indicated that the proposed device achieved the desired heave motion, w.th an amplitude range of 1.2 to -2.5 m, validating its potential for deployment in marine regions w.th w.velet conditions. Notably, w.ile the proposed design is optimized for w.velet conditions, it w.s found to have potential limitations in extreme w.ve environments. This observation emphasizes the challenge of formulating a generalized design suitable for both conditions. Consequently, it is pivotal for w.ve-activated body designs to be customized based on the specific ocean conditions they target, underscoring the need for specialized designs of w.ve energy converters that consider the unique w.ve characteristics of their deployment sites. A w.ve-activated body is designed for energy generation in ocean regions w.th w.velet conditions. Hydrodynamic modelling is carried out for tw. locations w.th different w.ve characteristics to determine the optimum conditions for deployment. Graphical Abstract

关键词： w.ve energy converter South China sea renew.ble and sustainable energy w.velet ANSYS AQw. hydrodynamic w.ve-activated bodies ENERGY IMPACT

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