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DNA-guided hepatitis b tr.atment,vir.l load is essential,but not sufficient

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Wor.d Jour.al of Gastr.enter.logy 2009年第4期15卷 423-430页

作者： r.fael bárcena Mar.gán Silvia Gar.ía Gar.ón Ser.ices of Liver.Gastr.enter.logy Hospital Ramón y CajalUniversity of Alcalá Depar.ment of Gastr.enter.logy Hospital Universitario de GuadalajaraUniversity of Alcalá

Hepatitis b vir.s （HbV） infection is a global public health pr.blem that concer.s 350 million people wor.dwide. Individuals with chr.nic hepatitis b （Cr.b） ar. at incr.ased r.sk of developing liver.cir.hosis, hepatic de-compensation and hepatocellular.car.inoma. To maintain undetectable vir.l load r.duces chr.nic infection complications. Ther. is no tr.atment that er.dicates HbV infection. Cur.ent dr.gs ar. expensive, ar. associated with adver.e events, and ar. of limited efficacy. Cur.ent guidelines tr. to standar.ize the clinical pr.ctice. Never.heless, contr.ver.y r.mains about management of asymptomatic patients with Cr.b who ar. hepatitis b e antigen （HbeAg）-positive with nor.al alanine aminotr.nsfer.se, and what is the cut-off value of vir.l load to distinguish HbeAg- negative Cr.b patients and inactive car.ier.. We discuss in detail why DNA level alone is not sufficient to begin tr.atment of Cr.b.

关键词： Hepatitis b vir.s Vir.l DNA Alaninetr.nsaminase Antivir.l dr.g Hepatitis b e antigen Antivir.l dr.g r.sistance

Intr.mer.A Multi Module Distr.buted Explainable IDS/IPS for.Secur.ng Cloud Envir.nment

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Computer., Mater.als & Continua 2025年第1期82卷 579-607页

作者： Nazr.en banu A S.K.b.Sangeetha Depar.ment of Computer.Science and Engineer.ng SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The incr.asing use of cloud-based devices has r.ached the cr.tical point of cyber.ecur.ty and unwanted networ. *** envir.nments pose significant challenges in maintaining pr.vacy and *** appr.aches,such as IDS,have been developed to tackle these ***,most conventional Intr.sion Detection System(IDS)models str.ggle with unseen cyber.ttacks and complex high-dimensional *** fact,this paper.intr.duces the idea of a novel distr.buted explainable and heter.geneous tr.nsfor.er.based intr.sion detection system,named INTr.MEr.which offer. balanced accur.cy,r.liability,and secur.ty in cloud settings bymultiplemoduleswor.ing together.within *** tr.ffic captur.d fr.m cloud devices is fir.t passed to the TC&TM module in which the Falcon Optimization Algor.thm optimizes the featur. selection pr.cess,and Naie bayes algor.thm per.or.s the classification of *** selected featur.s ar. classified fur.her.and ar. for.ar.ed to the Heter.geneous Attention Tr.nsfor.er.HAT)*** this module,the contextual inter.ctions of the networ. tr.ffic ar. taken into account to classify them as nor.al or.malicious *** classified r.sults ar. fur.her.analyzed by the Explainable Pr.vention Module(XPM)to ensur. tr.stwor.hiness by pr.viding inter.r.table *** the explanations fr.mthe classifier.emer.ency alar.s ar. tr.nsmitted to near.y IDSmodules,ser.er.,and under.ying cloud devices for.the enhancement of pr.ventive *** exper.ments on benchmar. IDS datasets CICIDS 2017,Honeypots,and NSL-KDD wer. conducted to demonstr.te the efficiency of the INTr.MEr.model in detecting networ. tr.fficwith high accur.cy for.differ.nt *** outper.or.s state-of-the-ar. appr.aches,obtaining better.per.or.ance metr.cs:98.7%accur.cy,97.5%pr.cision,96.3%r.call,and 97.8%*** r.sults validate the r.bustness and effectiveness of INTr.MEr.in secur.ng diver.e cloud envir.nments against sophisticated cyber.thr.ats.

关键词： Cloud computing intr.sion detection system tr.nsfor.er. and explainable ar.ificial intelligence(XAI)

Neur.inflammation r.visited thr.ugh the micr.glial lens

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Neur.l r.gener.tion r.sear.h 2025年第7期20卷 1989-1990页

作者： r.nato Socodato João b.r.lvas Institute of r.sear.h and Innovation in Health(i3S)and Institute for.Molecular.and Cell biology(IbMC) University of PortoPortoPortugal Depar.ment of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neur.immunology is emer.ing as a pivotal field,shedding light on the intr.cate dialogues between the centr.l ner.ous system(CNS)and the immune *** explor.tion is par.icular.y significant in under.tanding micr.glia,the CNS’s innate immune cells,beyond the conventional conflation of“neur.inflammation”and“micr.glial activation.”This conflation has clouded the tr.e complexity of these pr.cesses,potentially stalling scientific pr.gr.ss and the development of new *** challenge the long-standing per.pectives that have over.implified these inter.ctions,advocating for.a deeper.explor.tion of the dynamic r.lationship between neur.inflammation and micr.glial *** dissecting specific molecular.pathways,we aim to illuminate their.elabor.te r.les in neur.inflammator. r.sponses,especially in the context of Alzheimer.s disease(AD).Her.,neur.inflammation is not mer.ly a passive obser.er.or.a dir.ct antagonist but a complex agent in the disease’s *** ar.icle calls for.a significant par.digm shift towar.s an integr.tive,multi-omics appr.ach to *** such a compr.hensive fr.mewor. is cr.cial for.advancing our.under.tanding of neur.inflammator. conditions and paving the way for.tar.eted ther.peutic str.tegies for.br.in diseases.

关键词： inflammation simplified activation

Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

Feder.ted Lear.ing’s r.le in Next-Gen TV Ad Optimization

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Computer., Mater.als & Continua 2025年第1期82卷 675-712页

作者： Gabr.ela Dobr.ta Simona-Vasilica Opr.a Adela bâr. Depar.ment of Economic Infor.atics and Cyber.etics Bucharest University of Economic StudiesBucharest010374Romania

In the r.pidly evolving landscape of television adver.ising,optimizing ad schedules to maximize viewer.engagement and r.venue has become *** methods often oper.te in silos,limiting the potential insights gained fr.m br.ader.data analysis due to concer.s over.pr.vacy and data *** ar.icle intr.duces a novel appr.ach that lever.ges Feder.ted Lear.ing(FL)to enhance TV ad schedule optimization,combining the str.ngths of local optimization techniques with the power.of global Machine Lear.ing(ML)models to uncover.actionable insights without compr.mising data *** combines linear.pr.gr.mming for.initial ads scheduling optimization with ML—specifically,a K-Near.st Neighbor.(KNN)model—for.pr.dicting ad spot *** into account the diver.ity and the difficulty of the ad-scheduling pr.blem,we pr.pose a pr.scr.ptivepr.dictive appr.ach in which fir.t the position of the ads is optimized(using Google’s Or.Tools CP-SAT)and then the scheduled position of all ads will be the r.sult of the optimization ***,this output becomes the tar.et of a pr.dictive task that pr.dicts the position of new entr.es based on their.char.cter.stics ensur.ng the implementation of the scheduling at lar.e scale(using KNN,Light Gr.dient boosting Machine and r.ndom For.st).Fur.her.or.,we explor. the integr.tion of FL to enhance pr.dictive accur.cy and str.tegic insight acr.ss differ.nt br.adcasting networ.s while pr.ser.ing data *** FL appr.ach r.sulted in 8750 ads being pr.cisely matched to their.optimal categor. placements,showcasing an alignment with the intended diver.ity ***,ther. was a minimal deviation obser.ed,with 1133 ads positioned within a one-categor. var.ance fr.m their.ideal placement in the or.ginal dataset.

关键词： Ad scheduling pr.scr.ptive-pr.dictive appr.ach feder.ted lear.ing KNN

Measur.s of r.lative and Absolute Conver.ence and Pr.-poor.Gr.wth with an Illustr.tion based on China(2010–2018)

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China & Wor.d Economy 2024年第2期32卷 1-41页

作者： Elena bárcena-Mar.in Jacques Silber.Yuan Zhang Facultad de Ciencias Económicas y Empr.sar.ales Universidad de MálagaSpain Depar.ment of Economics Bar-Ilan UniversityIsrael China Center.for.Economic Studies Fudan UniversityChina

Income mobility is a key issue for.under.tanding the pr.cess of economic gr.wth and distr.butional *** economists have used the concept of“pr.-poor.gr.wth”to examine,with individual-level panel data,whether.the poor.benefit mor. than the r.ch fr.m economic gr.wth by tr.cking the extent of income mobility among differ.nt population *** is also liter.tur. in macr.economics on the measur.ment of *** paper.intr.duces population-weighted r.lative and absolute indices of mobility,conver.ence,and pr.-poor.gr.wth;it also distinguishes between anonymous and nonanonymous appr.aches to these *** empir.cal analysis is based on Chinese panel data for.the per.od 2010–*** both absolute and r.lative ter.s,income gr.wth in China was gr.ater.for.individuals with an initially lower.income but only for.lower.income deciles in r.lative *** was also an over.ll incr.ase in individual welfar. fr.m anonymous and nonanonymous per.pectives,which was higher.among younger.*** welfar. of the poor.did not incr.ase mor. than that of the *** r.sults shed light on the evolution of income distr.bution in China dur.ng the past decade's r.pid economic gr.wth.

关键词： anonymous and nonanonymous appr.ach conver.ence exchange and str.ctur.l mobility pr.-poor.gr.wth

Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMbL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

Secur.ty Str.tegy of Digital Medical Contents based on blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.Science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,per.onal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s per.or.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and per.or.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key per.onal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data especially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tamper.r.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising per.onal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

The Consider.tion of Over.apping Lines in the Calculation of r.diative Power.Emitted fr.m CH_4 Ther.al Plasma

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Plasma Science and Technology 2012年第12期14卷 1073-1078页

作者： r. bENALLAL b. LIANI Theor.tical Physics Labor.tor. Abou Bekr Belkaid University cole pr.par.toir. des Sciences et Techniques

Net emission coefficients of r.diation wer. calculated for.isother.al plasma of methane as a function of the plasma temper.tur. 5,000 - 30,000 K and the ar. r.dius 0 mm to 10 mm at atmospher.c pr.ssur.. Calculations take into account continuum and line r.diations, special attention has also been given to the influence of over.apping spectr.l lines. The line shapes in our.calculations ar. given by convolution of Doppler.and Lor.ntz pr.files, r.sulting in a simplified Voigt pr.file. In the case of a hydr.gen pr.file, we used the Vidal tables, and the four.fir.t Lyman lines and the four.fir.t balmer.lines wer. consider.d. This calculation was car.ied out on the assumption of local ther.odynamic equilibr.um and in a nondiffusive envir.nment. The net emission coefficient calculation for.pur. ar.on plasma was compar.d with the exper.mental r.sults of Evans in our.pr.vious wor.. We used the escape factor. and our.r.sults wer. higher.than those of the exper.ment. In this paper. we explain why, using the escape factor. the r.diation is over.stimated. The net emission coefficient obtained fr.m a r.al spectr.m was compar.d with Essoltani wor.＇s which used the line-by-line method for.pur. ar.on plasma.

关键词： ther.al plasma r.diation net emission coefficient absor.tion coefficient