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Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata

Asian Pacific Journal of Tropical biomedicine 2016年第8期6卷 671-676页

作者： Rizwan Ahmad Niyaz Ahmad Atta Abbas Naqvi Paul cos Louis Maes Sandra Apers Nina Hermans Luc Pieters Natural Products and Alternative Medicine College of Clinical Pharmacy University of Dammam Department of Pharmaceutics College of Clinical Pharmacy University of Dammam Department of Pharmacy Practice College of Clinical Pharmacy University of Dammam Faculty of Pharmaceutical Biomedical and Veterinary Sciences Laboratory of Microbiology Parasitology and Hygiene (LMPH) University of Antwerp Faculty of Pharmaceutical Biomedical and Veterinary Sciences Natural Products & Food–Research and Analysis (NatuRA)University of Antwerp

Objective: To search for the most active antimicrobial and antioxidant sub-fractions related to traditional use of Ziziphus oxyphylla(Z. oxyphylla) and Cedrela serrata(C. serrata) in Pakistan against infectious and liver ***: Factions of different polarity were tested in vitro for their antiprotozoal,antimalarial, antibacterial and antifungal activity against different pathogens. Cytotoxicity on MRC-5 cell lines(human lung fibroblasts) as well as, in vitro radical scavenging activity was evaluated using the 1, 1-diphenyl-2-picrylhydrazyl radical ***: The highest antiprotozoal activity was observed for the CHCl3 fractions of Z. oxyphylla roots and leaves, and C. serrata bark. The CHCl3 and Et OAc fractions of Z. oxyphylla roots, the CHCl3 fraction of Z. oxyphylla leaves, the Et OAc and the residual Me OH: H2 O fraction of C. serrata bark showed antibacterial activity against Staphylococcus aureus. The same residual Me OH: H2 O fraction of C. serrata bark was active against Candida albicans. The highest antioxidant activity was observed for the more hydrophilic Et OAc fractions of Z. oxyphylla leaves, C. serrata bark and leaves, and the residual Me OH: H2 O fraction of C. serrata ***: This study supports at least in part the traditional uses of these plants for antimicrobial purposes and against liver diseases.

关键词： Antifungal Antibacterial Antiprotozoal Cytotoxicity Antioxidant Ziziphus oxyphylla Cedrela serrata Rhamnaceae Meliaceae Pakistan

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Software Project Visualization Using Task Oriented Metaphors

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Journal of Software Engineering and Applications 2010年第11期3卷 1015-1026页

作者： Amaia Aguirregoitia José Javier Dolado cosín Concepción Presedo 不详

This paper presents T-Cube and MetroMap, two new graphical representation models for controlling and managing the processes of software project development. They both use metaphors and visual representation techniques to address typical project management tasks. T-Cube uses a metaphor with the Rubik-Cube whereas MetroMap uses a metaphor with a metro map. The tools have been tested on real project data and a qualitative assessment shows the results of testing the visualizations with users attempting several information retrieval tasks. The utility of the tools has been positively evaluated and the article demonstrates the possibilities of visual approaches in project management.

关键词： Project Management Information Systems Managing Information Systems Managing Integration

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Chromium OS使用体验

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微型计算机 2010年第3期30卷 133-136页

作者： cos

操作系统（OS）已经成为我们生活中必不可少的一部分。相比windows、Mac OS等传统的本地操作系统来说，一种新的、应用“云计算”来实现大部分功能、本地计算机只存储少量信息的新操作系统模式渐渐崭露头角。ChromiumOS就是这样的一款... 详细信息

操作系统（OS）已经成为我们生活中必不可少的一部分。相比windows、Mac OS等传统的本地操作系统来说，一种新的、应用“云计算”来实现大部分功能、本地计算机只存储少量信息的新操作系统模式渐渐崭露头角。ChromiumOS就是这样的一款轻量型、云计算为主的操作系统。

关键词： OS windows 操作系统计算机 Mac 信息

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预防肉鸡坏死性肠炎的实用营养措施

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中国家禽 2010年第19期32卷 58-59页

作者： José Ignacio barragan cos 李燕曲立新西班牙卡德纳尔.埃雷拉大学

近年来肉鸡营养学取得了重大进展。抗生素生长促进剂和肉骨粉的禁用迫使我们提出改进措施来保持家禽肠道健康和提高饲料营养利用率。

关键词：鸡坏死性肠炎营养学肉鸡抗生素生长促进剂预防营养利用率肠道健康肉骨粉

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Efficacy of different doses of sugammadex after continuous infusion of rocuronium

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World Journal of Clinical Cases 2015年第4期3卷 360-367页

作者： Diego Soto Mesa Mounir Fayad Fayad Laura Pérez Arviza Verónica Del Valle Ruiz Fernando cosío Carreño Luis Arguelles Tamargo Manuel Amorín Díaz Sergio Fernández-Pello Montes Department of Anaesthesiology Hospital of Cabueñes33394 GijónSpain Department of Neurology Hospital of JoveEduardo Castro s/n33290 GijónSpain Department of Urology Hospital of Cabueñes33394 GijónSpain

AIM: To evaluate the effects of two different doses of sugammadex after maintenance anesthesia with sevofluorane and remifentanil and deep rocuroniuminduced neuromuscular blockade(NMb).METHODS: Patients between 20 and 65 years of age, with American Society of Anesthesiologists physical status classification Ⅰ-Ⅱ, undergoing gynecological surgery were included in a prospective, comparative and randomized study. NMb was induced with an injection of 0.6 mg/kg of rocuronium followed by continuous infusion of 0.3-0.6 mg/kg per hour to maintain a deep block. Anesthesia was maintained with sevofluorane and remifentanil. Finally, when surgery was finished, a bolus of 2 mg/kg(group A) or 4 mg/kg(group b) of sugammadex was applied when the NMb first response in the train-of-four was reached. The primary clinical endpoint was time to recovery to a train-of-four ratio of 0.9. Other variables recorded were the time until recovery of train-of-four ratio of 0.7, 0.8, hemodynamic variables(arterial blood pressure and heart rate at baseline, starting sugammadex, and minutes 2, 5 and 10) and adverse events were presented after one hour in the post-anesthesia care ***: Thirty-two patients were included in the study: 16 patients in group A and 16 patients in group b. Only 14 patients each group were recorded because arterial pressure values were lost in two patients from each group in minute 10. The two groups were comparable. Median recovery time from starting of sugammadex administration to a train-of-four ratio of 0.9 in group A and b was 129 and 110 s, *** estimated difference in recovery time between groups was 24 s(95%CI: 0 to 45 s, Hodges-Lehmann estimator), entirely within the predefined equivalence interval. Times to recovery to train-of-four ratios of 0.8(group A: 101 s; group b: 82.5 s) and 0.7(group A: 90 s; group b: 65 s) from start of sugammadex administration were not equivalent between groups. There was not a significant variation in the arterial pr

关键词： Rocuronium Sugammadex Neuromuscular block antagonism Monitoring neuromuscular function Neuromuscular block rocuronium

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bioassay-guided in vitro study of the antileishmanial and cytotoxic properties of bixa orellana seed extract

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Journal of Coastal Life Medicine 2014年第6期 484-489页

作者： Marley García Ramón Scull Osmany Cuesta Gaëlle boulet Louis Maes Paul cos Lianet Monzote Department of Parasitology Institute of Tropical Medicine“Pedro Kourí”HavanaCuba Department of Chemistry Institute of Pharmacy and FoodHavana UniversityHavanaCuba Laboratory of Microbiology Parasitology and Hygiene(LMPH)Faculty of PharmaceuticalBiomedical and Veterinary SciencesAntwerp UniversityAntwerpBelgium

Objective:To investigate the leishmanicidal effect of the bixa orellana crude seed extract and its fractions against Leishmania ***:Four main fractions(bO-A,bO-b,bO-C and bO-D)were obtained by exhaustion with solvent with increased polarity from the bixa orellana crude seed extract and 28 *** antileishmanial activity was evaluated in intracellular amastigotes and the cytotoxicity was assessed in murine intraperitoneal ***:The bO-A and bO-b fractions showed a good antileishmanial activity with IC50 values of(12.9±4.1)and(12.4±0.3)μg/mL,*** sub-fractions bO-b1(IC_(50)=(11.8±3.8)μg/mL)and bO-b3[IC_(50)=(13.6±4.7)μg/mL]also proved to have a good leishmanicidal *** general,the sub-fractions showed a lower toxicity than the crude extract.A selectivity index of 9 indicated a moderate selectivity of the bO-A,bO-b and bO-C fractions and bO-b1 ***:Potential of this plant against cutaneous leishmaniasis should be further investigated.

关键词： bixa orellana Traditional medicine bioassay-guided fractionation Leishmania amazonensis

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Primary testicular lymphoma:Clinical characteristics and oncological outcomes

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Current Urology 2023年第2期17卷 130-134页

作者： Alberto Artiles Medina Javier Lorca Álvaro Irene Carretero del barrio Inés Laso García Mónica García cosío Marina Mata Alcaraz Manuel Hevia Palacios Victoria Gómez Dos Santos Francisco Javier burgos Revilla Department of Urology Hospital Universitario Ramón y CajalInstituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid28034Spain Department of Pathology Hospital Universitario Ramón y CajalMadridSpain

background:Primary testicular lymphoma(PTL)is a rare testicular malignancy,despite being considered the most common testicular tumorin patients olderthan 60 *** testicularlymphoma represents only 1%-9%oftesticular *** studies have been published regarding its clinical features and *** study aimed to analyze the clinical characteristics and outcomes of *** and methods:Orchiectomy specimens of 15 patients with PTL diagnosed during 2000-2020 at our institution were retrospectively *** collected information on demographic data,clinical features,management aspects,and outcomes of PTL ***-Meier survival curves and Cox regression analyses were used to study ***:The median patient age was 69 years(interquartile range,61-72 years).The most prevalent clinical presentation was testicular swelling(80%),and only 13.33%of the patients presented with systemic *** system involvement was detected in 6 patients(40%).Of the 15 patients,5(33.33%)had stage IE and 10(66.67%)had stage IVE *** large b-cell lymphoma was the most common histological *** patients(80%)received *** follow-up,4 patients(26.67%)*** recurrence ratein the contralateraltesticle was 13.33%.The median cancer-specific survivalwas 21.58 months(95%confidence interval,0-43.95 months).Univariate Cox regression analysis showed that central nervous system involvement and International Prognostic Index score were significantly associated with shorter cancer-specific ***:Primary testicularlymphoma has a high relapse rate and poor *** strategies typicallyinclude radical orchiectomy and systemic *** nervous system involvement and International Prognostic Index scores were associated with lymphoma-specific survival.

关键词： Testicular neoplasms Testis Primary testicular lymphoma Non-Hodgkin lymphoma Prognosis

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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio barrios Carlos Perez Muñoz Juan cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling Carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of biochemistry and Molecular biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.bidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P bLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P ban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-bLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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用现代UOP技术提高bTX生产的灵活性

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石油炼制译丛 1992年第8期 13-16,32页

作者： cos.,TLL 王安川

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Contribution of Different Agronomic Practices and the Fungus beauveria bassiana on the Coffee berry borer

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Journal of Life Sciences 2013年第9期7卷 980-992页

作者： Alberto Fernandez Turro Ernesto Castafieda Hidalgo Francisco Simon Ricardo Everton Kort Kamp Fernandes Juana Iris Duran cos Odisa baque Fuentes Universidad de Guantanamo UG Km 212 Carretera a Santiago de Cuba Guantanamo 95100 Cuba Instituto Tecnologico del Valle de Oaxaca. Ex Hacienda de Nazareno Xoxocotlan Oaxaca 71230 Mexico Ministerio de la Agricultura. Laboratorio Provincial de Sanidad Vegetal de Santiago de Cuba Carretera a Siboney Santiago de Cuba Cuba Federal University of Goias UFG Carretera 235 Sector Universitario Goiania 74605-050 Brasil

The research was carried out to study the effect of varying certain ecological conditions in the coffee through the implementation of different agronomic practices such as regulation of the shade, ground cover and rehabilitation of plantations on the populations of the coffee berry borer Hypothenemus hampei Ferrari （Coleoptera： Curculionidae）, it was also evaluated the influence of these conditions in the introduction and transfer of new variants of application of the fungus beauveria bassiana （balsamo） Vuillemin. The results showed that the pest damage was lower under a system of sustainable coffee, designed after the restoration of the population density of coffee, conducting systematic pruning and plant health, sanitation of the forest, shade management to double stratum with scattered light intensity of 60-70% and a combination of systems of denominated handling of weeds （Strip weeding - Ring weeding）, it was found that under these conditions the technical effectiveness of the fungus b. bassiana was higher compared with applications made in the trees less enlightened, being more advantageous to spray the foliage four times with a frequency of 40 days from 60 days to peak flowering with positive economic indicators even when used as single biological control strategy against the coffee berry borer.

关键词： Coffee berry borer coffee plantation management beauveria bassiana

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