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Short mucin 1 alleles are associated with low virulent H pylori strains infection

World Journal of Gastroenterology 2007年第12期13卷 1885-1886页

作者： bárbara peleteiro Nuno Lunet Filipe Santos-Silva Leonor David Céu Figueiredo Henrique barros Department of Hygiene and Epidemiology Medical Faculty University of Porto Portugal Institute of Molecular Pathology and Immunology of the University of Porto Portugal

TO THE EDITORWe read with interest the article published by Nguyen et al in the World Journal of Gastroenterology, showing an association between short MUC6 alleles and H pjloff infection. These results, together with previous observations by Vinall et al, reinforce the role of mucin genes （MUC6 and MUC1） VNTR polymorphisms for the variability in individual susceptibility to H pylori infection that cannot be explained by differences in environmental factors.

关键词： H pylori MUC1 Polymorphism cagA vacA

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Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage

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Neural Regeneration Research 2017年第4期12卷 558-561页

作者： Juan Pías-peleteiro Francisco Campos José Castillo Tomás Sobrino Clinical Neurosciences Research Laboratory Department of NeurologyStroke UnitUniversity Clinical HospitalUniversidade de Santiago de CompostelaHealth Research Institute of Santiago de Compostela (IDIS)

Intracerebral hemorrhage （ICH） is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells （EPCs） have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.

关键词： cellular therapy endothelial progenitor cells growth factors intracerebral hemorrhage neurorepair outcome

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Extramedullary Hematopoiesis Mimicking a Neoplasm in a Goeldi＇s Monkey （Callimico goeldii）

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Journal of Life Sciences 2013年第12期7卷 1228-1235页

作者： Rute Marina Noiva Hugo Pissarra Teresa Fernandes Rui bernardino Luis Madeira de Carvalh~ Femando Alves Afonso Maria Conceicao peleteiro Interdisciplinary Research Centre on Animal Health Faculty of Veterinary Medicine Technical University of Lisbon(CI1SA/FMV/UTL) Avenida da Universidade Tecnica Lisbon 1300-477 Portugal Jardim Zoologico de Lisboa Estrada de Benfica 158-160 Lisbon 1549-004 Portugal

Extramedullary hematopoiesis consists in the appearance and proliferation of hematopoietic cells outside the bone marrow. In this article, the authors describe a case of hepatosplenic hematopoiesis in a 9-year-old, male Goeldi＇s monkey concurrent with a Calodium hepaticum infestation, belonging to the Lisbon＇s Zoo primate collection （Portugal）. Lesions were identified upon necropsy after euthanasia due to the presence of an apparently non-excisable, metastatic aortic mass. Histopathological analysis of samples taken was carried out and immunohistochemical staining was used to characterize the cellular population involved, confirming the diagnosis of extramedullary hematopoiesis. To the best of the authors＇ knowledge, this is the first report of hepatosplenic extramedullary hematopoiesis in a Goeldi＇s monkey.

关键词： Extramedullary hematopoiesis Goeldi's monkey Callimico goeldii Calodium hepaticum liver spleen.

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