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Biomedical and Environmental Sciences 2015年第9期28卷 660-665页

作者： Faridah Yusof Atheer Awad Mehde Wesen Adel Mehdi Raha Ahmed Raus Hamid Ghazali azlina abd rahman Department of Biotechnology Engineering College of EngineeringInternational Islamic University Malaysia Department of Medical Analysis Health and Medical Technical College Department of Chemistry College of Sciences for WomenUniversity of Baghdad Department of Urology Hospital Tengku Ampuan Afzan Department of Pathology Hospital Tengku Ampuan Afzan

Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase Ⅰ/Ⅱ activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase Ⅰ/Ⅱ activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase（P〈0.01） in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase Ⅰ and Ⅱ were significantly elevated in nephrolithiasis patients（P〈0.01）. Conclusion This study suggests that an increase in serum concentrations of DNase Ⅰ/Ⅱ and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.

关键词： Nephrolithiasis DNase Ⅰ DNase Ⅱ E3 SUMO-protein ligase NSE2 NSMCE2

The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 476-482页

作者： Faridah Yusof Atheer Awad Mehde Wesen Adel Mehdi Hamid Ghazali azlina abd rahman Department of Biotechnology Engineering College of Engineering International Islamic University Malaysia Department of Medical analysis Health and Medical Technical College Department of Chemistry College of Sciences for Women University of Baghdad Department of Urology Hospital Tengku Ampuan Afzan Department of Pathology Hospital Tengku Ampuan Afzan

Objective: To verify possible associations between adenosine aminohydrolase(ADA) and AMP-aminohydrolase(AMPDA) to E3 SUMO-protein ligase NSE2(NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy ***: A total of 60 renal stones patients and 50 control were enrolled in a case-control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ***: Serum ADA, AMPDA and specii c activity of enzymes showed signii cant decrease(P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a signii cant increase(P < 0.01 and P < 0.05, respectively) in patients compared to control ***: The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inl ammation disorders in the patients with kidney stones.

关键词： Renal stone Adenosine aminohydrolase AMP-aminohydrolase Uric acid

Study the effect of kidney stones on serum xanthine oxidase, ecto-5'-nucleotidase activity and E3 SUMO-protein ligase NSE2(NSMCE2) in Malaysian individuals

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 665-668页

Objective: To verify possible relations between 5'-nucleotidase, xanthine oxidase to E3 small ubiquitin-like modifier-protein ligase non structural maintenance of chromosomes elements 2 in sera patients with kidney stones and to evaluate the possibility of a new biomarker for the evaluation of kidney damage. Methods: A sixty patients with known kidney stones who appeared the government health clinics in Kuantan–Pahang and fifty apparently healthy were taken as control group. The 5'-nucleotidase,xanthine oxidase and other biochemical parameters were measured by colorimetric tests. The serum NSMCE2 were measured by enzyme linked immunosorbent ***: The mean serum xanthine oxidase [(39.98±19.70) IU/L] and ecto-5'-nucleotidase activity(40.03±9.53 IU/L) were significantly higher than the controls' levels of(18.04 ±6.26) and(16.06 ±4.61) IU/L respectively. There were 85.00% and 83.33%, of patients with kidney stones who had abnormal ecto-5'-nucleotidase activity and uric acid respectively while xanthine oxidase activity was less sensitive 58.33%.Conclusions: The present study suggests that the increase in serum of xanthine oxidase,ecto-5'-nucleotidase activities E3 small ubiquitin-like modifier-protein ligase NSE2 concentration can be used as biomarkers for diagnosis of kidney damage in patients with kidney stone,also in developments of change DNA damage and inflammation disorders in these patients.

关键词： Kidney stones Xanthine oxidase Ecto-5’-nucleotidase E3 SUMO-protein ligase NSE2

Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 249-252页

作者： Atheer Awad Mehde Faridah Yusof Wesen Adel Mehdi Raha Ahmed Raus Layla Othman Farhan Jwan abdulmohsin Zainulabdeen Zaima Azira Zainal Abidin Hamid Ghazali azlina abd rahman Department of Biotechnology Engineering College of EngineeringInternational Islamic University MalaysiaKuala Lumpur50728Malaysia Department of Technical Medical Analysis College of Health and Medical TechnologyMiddle Technical UniversityBaghdad10047Iraq Department of Chemistry College of Sciences for WomenUniversity of BaghdadBaghdad10071Iraq Department of Chemistry College of SciencesUniversity of BaghdadBaghdad10071Iraq College of Science International Islamic University MalaysiaKuantan25200Malaysia Department of Urology Hospital Tengku Ampuan AfzanKuantan25200Malaysia Department of Pathology Hospital Tengku Ampuan AfzanKuantan25200Malaysia

Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2(NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis ***: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ***: A significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly ***: The study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis.

关键词： Nephrolithiasis Peroxynitrite Nitric oxide E3 SUMO-protein ligase NSE2 Total oxidant status

An Improved Hybrid Indoor Positioning Algorithm via QPSO and MLP Signal Weighting

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Computers, Materials & Continua 2023年第1期74卷 379-397页

作者： Edgar Scavino Mohd Amiruddin abd rahman Zahid Farid Department of Physics Faculty of ScienceUniversiti Putra MalaysiaUPM Serdang43400Malaysia Department of Electrical Engineering Abasyn UniversityKhyber-PakhtunkhwaPakistan

Accurate location or positioning of people and self-driven devices in large indoor environments has become an important necessity The application of increasingly automated self-operating moving transportation units,in large indoor spaces demands a precise knowledge of their *** like WiFi and Bluetooth,despite their low-cost and availability,are sensitive to signal noise and fading *** these reasons,a hybrid approach,which uses two different signal sources,has proven to be more resilient and accurate for the positioning determination in indoor ***,this paper proposes an improved hybrid technique to implement a fingerprinting based indoor positioning,using Received Signal Strength information from available Wireless Local Area Network access points,together with the Wireless Sensor Networks *** signals were recorded on a regular grid of anchor points,covering the research *** optimization was performed by relative signal weighting,to minimize the average positioning error over the research *** optimization process was conducted using a standard Quantum Particle Swarm Optimization,while the position error estimate for all given sets of weighted signals was performed using aMultilayer Perceptron(MLP)neural *** to our previous research works,the MLP architecture was improved to three hidden layers and its learning parameters were finely *** experimental results led to the 20%reduction of the positioning error when a suitable set of signal weights was calculated in the optimization *** final achieved value of 0.725 m of the location incertitude shows a sensible improvement compared to our previous results.

关键词： QPSO indoor localization fingerprinting neural networks WiFi WSN

Multi-Scale Network with Integrated Attention Unit for Crowd Counting

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Computers, Materials & Continua 2022年第11期73卷 3879-3903页

作者： Adel Hafeezallah Ahlam Al-Dhamari Syed abd rahman Abu-Bakar Department of Electrical Engineering Taibah UniversityMadinahSaudi Arabia Department of Electronics and Computer Engineering School of Electrical EngineeringFaculty of EngineeringUniversiti Teknologi Malaysia81310JohorMalaysia Department of Computer Engineering Hodeidah UniversityHodeidahYemen

Estimating the crowd count and density of highly dense scenes witnessed in Muslim gatherings at religious sites in Makkah and Madinah is critical for developing control strategies and organizing such a large ***,since the crowd images in this case can range from low density to high density,detection-based approaches are hard to apply for crowd ***,deep learning-based regression has become the prominent approach for crowd counting problems,where a density-map is estimated,and its integral is further computed to acquire the final count *** this paper,we put forward a novel multi-scale network(named 2U-Net)for crowd counting in sparse and dense *** proposed framework,which employs the U-Net architecture,is straightforward to implement,computationally efficient,and has single-step *** layers are used to retrieve the pooling layers’erased information and learn hierarchically pixelwise spatial *** helps in obtaining feature values,retaining spatial locations,and maximizing data integrity to avoid data *** addition,a modified attention unit is introduced and integrated into the proposed 2UNet model to focus on specific crowd *** proposed model concentrates on balancing the number of model parameters,model size,computational cost,and counting accuracy compared with other works,which may involve acquiring one criterion at the expense of other *** on five challenging datasets for density estimation and crowd counting have shown that the proposed model is very effective and outperforms comparable mainstream ***,it counts very well in both sparse and congested crowd *** 2U-Net model has the lowest MAE in both parts(Part A and Part B)of the ShanghaiTech,UCSD,and Mall benchmarks,with 63.3,7.4,1.5,and 1.6,***,it obtains the lowest MSE in the ShanghaiTech-Part B,UCSD,and Mall benchmarks with 12.0,1.9,and 2.1,respectively.

关键词： Computer vision crowd analysis crowd counting U-Net max-pooling index unpooling attention units

Deep-piRNA:Bi-Layered Prediction Model for PIWI-Interacting RNA Using Discriminative Features

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Computers, Materials & Continua 2022年第8期72卷 2243-2258页

作者： Salman Khan Mukhtaj Khan Nadeem Iqbal Mohd Amiruddin abd rahman Muhammad Khalis abdul Karim Department of Computer Science Abdul Wali Khan University MardanKhyber Pakhtunkhwa23200Pakistan Department of Information Technology University of HaripurKhyber Pakhtunkhwa22620Pakistan Faculty of Science Universiti Putra MalaysiaUPM Serdang43400Malaysia

Piwi-interacting Ribonucleic acids(piRNAs)molecule is a wellknown subclass of small non-codingRNAmolecules that are mainly responsible for maintaining genome integrity,regulating gene expression,and germline stem cell maintenance by suppressing transposon *** piRNAs molecule can be used for the diagnosis of multiple tumor types and drug *** to the vital roles of the piRNA in computational biology,the identification of piRNAs has become an important area of research in computational *** paper proposes a two-layer predictor to improve the prediction of piRNAs and their function using deep learning *** proposed model applies various feature extraction methods to consider both structure information and physicochemical properties of the biological sequences during the feature extraction *** outcome of the proposed model is extensively evaluated using the k-fold cross-validation *** evaluation result shows that the proposed predictor performed better than the existing models with accuracy improvement of 7.59%and 2.81%at layer I and layer II *** is anticipated that the proposed model could be a beneficial tool for cancer diagnosis and precision medicine.

关键词： Deep neural network DNC TNC CKSNAP PseDPC cancer discovery Piwi-interacting RNAs Deep-piRNA

Framework for a Computer-Aided Treatment Prediction (CATP) System for Breast Cancer

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Intelligent Automation & Soft Computing 2023年第6期36卷 3007-3028页

作者： Emad abd Al rahman Nur Intan Raihana Ruhaiyem Majed Bouchahma Kamarul Imran Musa School of Computer Sciences Universiti Sains MalaysiaPenang11800Malaysia School of Computer Science Higher Colleges of TechnologyRAKUAE Department of Community Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang KerianKelantan16150Malaysia

This study offers a framework for a breast cancer computer-aided treat-ment prediction(CATP)*** rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagno-sis and frequent *** has been the most utilized breast ima-ging technique to *** have begun to use computer-aided detection and diagnosis(CAD)systems to improve the accuracy of breast cancer diagnosis by minimizing human *** the progress of artificial intelligence(AI)in the medical field,this study indicates that systems that can anticipate a treatment plan once a patient has been diagnosed with cancer are few and not widely *** such a system will assist clinicians in determining the optimal treatment plan and avoid exposing a patient to unnecessary hazardous treatment that wastes a significant amount of *** develop the prediction model,data from 336,525 patients from the SEER dataset were split into training(80%),and testing(20%)*** Trees,Random Forest,XGBoost,and CatBoost are utilized with feature importance to build the treatment prediction *** best overall Area Under the Curve(AUC)achieved was 0.91 using Random Forest on the SEER dataset.

关键词： Breastcancer machinelearning featureimportance featureselection treatment prediction SEER dataset computer-aided treatment prediction(CATP) clinical decision support system

Association between vision and cognitive function among community-dwelling older adults in Selangor,Malaysia

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 115-120页

作者： Zainora Mohammed Qiu-Ting Kee Norliza Mohamad Fadzil Mohd Harimi abd rahman Normah Che Din Vanitha Mariappan Suzana Shahar Programme of Optometry and Vision Science Faculty of Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz 50300Kuala LumpurMalaysia Centre for Rehabilitation and Special Needs Study Faculty of Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz 50300Kuala LumpurMalaysia Center of Toxicology and Risk Health Faculty of Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz 50300Kuala LumpurMalaysia Programme of Dietetic Faculty of Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz 50300Kuala LumpurMalaysia.

AIM:To determine the association between distance and near visual acuity(VA)and cognitive function among older adults in Selangor,***:A total of 230 older adults(age≥60y)participated in this *** distance and near VA were measured using the Early Treatment Diabetic Retinopathy Study Chart and Lighthouse Near Visual Acuity Chart,*** cognitive function was assessed using the Mini-Mental State Examination(M-MSE)and the Malay language version of the Montreal Cognitive Assessment(M-MoCA).Digit Symbol(DS)subtest was used to measure information ***:No significant association was observed between vision and M-MSE and M-MoCA ***,poor distance and near VA were found to be significantly associated with low DS scores[distance VA:β=-0.01,R2=0.1,P=0.02;odds ratio(OR)=2.84,95%confidence interval(CI),1.10-7.33,P=0.03;near VA:β=-0.05,R2=0.08,P=0.00;OR=3.32,95%CI,1.28-8.59,P=0.01].CONCLUSION:Poor vision is associated with a decline in information processing in older adults and substantiates the importance of preserving good vision in maintaining cognitive function.

关键词： ageing cognition global cognitive function information processing vision

Development of Knowledge,Attitude and Practice Questionnaire for age-related macular degeneration patients

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 589-600页

作者： Mohd Harimi abd rahman Prashanti Amirtharatnam Sharanjeet Sharanjeet-Kaur Sumithira Narayanasamy Hanif Farhan Mohd Rasdi Mae-Lynn Catherine Bastion Optometry and Vision Science Programme Center for Rehabilitation and Special Needs Studies(iCaRehab)Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 53000Malaysia Optometry and Vision Science Programme Center for Community Health Studies(Reach)Faculty of Health SciencesUniversity Kebangsaan MalaysiaKuala Lumpur 53000Malaysia Occupational Therapy Programme Center for Rehabilitation and Special Needs Studies(iCaRehab)Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 53000Malaysia Ophthalmology Department Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia

AIM:To develop and validate a questionnaire to evaluate knowledge,attitude and practice of patients diagnosed with age-related macular degeneration(AMD)who have undergone intravitreal injection ***:This study was conducted among patients diagnosed with AMD in Kuala *** generation of the instrument included four phases which included item and domains development,content,face validity and exploratory factor *** validity and modified Kappa was used for validation of knowledge *** factor analysis was used for validation of both attitude and practice *** validity was conducted in 12 patients,content validity was ascertained in 120 patients and test-retest reliability was determined in 39 patients with ***:Content validity index(CVI)and modified kappa showed excellent values for most items in the knowledge domain with CVI for item(I-CVI)values between 0.78-1.0 and Kappa values of>*** Kaiser-MeyerOlkin(KMO)sampling adequacy showed acceptable scores of 0.70 and 0.75 for both attitude and practice domains respectively and Bartlett’s Test of sphericity were significant(χ^(2)=0.00,P0.70 and good test-retest *** final version of the questionnaire consisted of 93 items from four sections consisting of demographic details,knowledge,attitude and ***:The findings of this validation and reliability study show that the developed questionnaire has a satisfactory psychometric property for measuring KAP of patients diagnosed with AMD undergoing intravitreal injection treatment.

关键词： knowledge attitudes practice age-related macular degeneration instrument development