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Salt Tectonics in the Southern Iran

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International Journal of Geosciences 2016年第3期7卷 367-377页

作者： azar Khodabakhshnezhad Mehran Arian Department of Education One Territory of Baharestan Education Office Ministry of Education Tehran Iran Department of Geology Science and Research Branch Islamic Azad University Tehran Iran

Based on geographic distribution and geological setting of salt plugs in southern Iran, three salt diapiric provinces have been distinguished. These provinces include the Hormuz, Shiraz-Kazerun and Nyriz-Jahrum sub-basins. There are more than hundred salt plugs which they have been formed and developed in the southern margin of Iran. The salt structures that originated from Hormuz formation in these areas have been restricted and separated from each other for the first time in this paper. Salt diapirism of these provinces has been triggered earlier by Halokinesis in the Zagros and Persian Gulf basins, but it has affected later by tectonic forces, because orientation, shape and position of salt plugs have been followed from convergence regime (especially in the Zagros hinterland). In the other hand, based on our results from salt plugs in Persian Gulf foreland basin and the Zagros hinterland, Halokinesis triggers has been affected more than Halotectonic forces.

关键词： Salt Tectonics Zagros Persian Gulf Iran

Cattle toxoplasmosis in Iran:a systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2015年第2期8卷 120-126页

作者： Shahabeddin Sarvi Ahmad Daryani Mohammad Taghi Rahimi Mohsen Aarabi azar Shokri Ehsan Ahmadpour Azadeh Mizani Mahdi Sharif Toxoplasmosis Research Center Mazandaran University of Medical SciencesSariIranPostal Code:48168-95475 Department of Parasitology and Mycology Sari Medical SchoolMazandaran University of Medical SciencesSariIranPostal Code:48168-95475 Sari Medical School Mazandaran University of Medical SciencesSariIranPostal Code:48168-95475

Objective:To analyze and review the overall seroprevalence rate of Toxoplasma gondii(***) infection in cattle from ***:In the current study,data collection(published and unpublished papers,abstracts of national scientific congresses and dissertations) using particular terms was carried out systematically on the following electronic databases like PubMed,Google Scholar,Ebsco,Science Direct,Scopus,Magiran,Irandoc,IranMedex and SID(Scientific Information Database).Results:A total of 22 studies since 1983 to 2012 reporting the seroprevalence of toxoplasmosis in cattle from different regions of Iran met our eligibility *** pooled proportion of toxoplasmosis,using random effect model,among cattle in Iran from over the 30-year period was estimated 18.1%(95%CI:9.9%to 28.2%).Conclusions:This study firstly establishes a crude seroprevalence rate of Toxoplasma infection in cattle which can lead us to understand the condition of eattle toxoplasmosis,which have to take into accounted fur an appropriate and effective prevention and ***,it compares and discusses elaborately the role of risk factors including sex,age and breed in the epidemiology of the ***,it determines gaps and drawbacks in the prior studies which are greatly useful to design more accurate investigations in the future.

关键词： Toxoplasma gondii Prevalence Systematic review Meta-analysis Iran

Vanishing cerebral vasculitis in a patient with Lewy pathology

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The Journal of Biomedical Research 2017年第6期31卷 559-562页

作者： Natalia Liapounova Kamran H.azar J.Max Findlay Jian-Qiang Lu Division of Pediatric Neurology University of AlbertaEdmontonAlbertaCanada Department of Pathology The North East Health Services Delivery AreaFort St.JohnBritish ColumbiaCanada Division of Neurosurgery University of AlbertaEdmontonAlbertaCanada Neuropathology Section Department of Laboratory Medicine and PathologyUniversity of AlbertaUniversity of AlbertaEdmontonAlbertaCanada

Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson’s disease（PD, brainstem-predominant Lewy pathology）, but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically confirmed vasculitis in a 73-year-old male patient whose postmortem examination revealed Lewy pathology diagnostic of PD. This case study suggests a comorbidity of cerebral vasculitis and Lewy pathology, as well as potential pathogenic interactions between these two disorders with immune-mediated mechanisms.

关键词： vasculitis cerebrovascular disease Parkinson’s disease Lewy pathology synucleinopathy immune pathogenesis

Anti-proliferative effects of a small molecule inhibitor of CDKAT7519 on chronic myeloid leukemia (CML) cells through haltingthe transition of cells from G2/M phase of the cell cycle

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BIOCELL 2020年第2期44卷 183-192页

作者： MASOUMEH OGHABI AVA SAFAROGHLI-azar ATIEH POURBAGHERI-SIGAROODI MOHAMMAD SAYYADI MOHSEN HAMIDPOUR MOHAMMAD HOSSEIN MOHAMMADI DAVOOD BASHASH Department of Hematology and Blood Banking School of Allied Medical SciencesShahid Beheshti University of Medical SciencesTehranIran Student Research Committee Department of Hematology and Blood BankingSchool of Allied Medical SciencesShahid Beheshti University of Medical SciencesTehranIran School of Allied Medical Sciences Arak University of Medical SciencesArakIran

Pathogenesis of chronic myeloid leukemia(CML)has mostly been studied with regard to the oncogenic role of BCR/ABL fusion,however,recent disclosures have declared that the challenges with the treatment of CML patients would not be resolved until the role of other aberrancies is *** the involvement of cyclin-dependent kinases(CDKs)in the pathogenesis of CML,the present study aimed to investigate the effects of a multi-CDK inhibitor AT7519 on BCR/ABL-harboring CML-derived K562 *** results showed that AT7519 effectively reduced the survival of K562 and induced its anti-proliferative effect through the induction of G2/M arrest due to elevated p21 and *** resulting data also revealed that either direct or indirect suppression of c-Myc using specific c-Myc inhibitor 10058-F4 and selective PI3K inhibitor CAL-101 resulted in a superior cytotoxicity,suggesting that the activation of PI3K pathway could attenuate antileukemic effects of the inhibitor,at least partly,through a c-Mycdependent *** the best of our knowledge,to date,no study has addressed the effect of autophagy on CML cell response to AT7519,and,herein,we proposed for the first time that the suppression of autophagy boosted AT7519 cytotoxicity against ***,we suggested that selective CDK inhibitor AT7519 exerted antileukemic effect against CML cells and propose a novel therapeutic application for the inhibitor either as a single agent or in combination with c-Myc and/or PI3K inhibitors.

关键词： Chronic myeloid leukemia (CML) Cyclin-dependent kinase (CDK) AT7519 Autophagy PI3K c-Myc

A randomized controlled trial of imipramine in patients with irritable bowel syndrome

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World Journal of Gastroenterology 2009年第29期15卷 3636-3642页

作者： Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara Department of Internal Medicine Division of Gastroenterology American University of Beirut Medical Center Riad El Solh 110 72020 Beirut Lebanon

AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response.

关键词：对照试验综合征患者随机肠

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培生高级英语语法

培生高级英语语法

Evaluation of site response characteristic using nonlinear method （Case study： Babol, Iran）

作者： (美)Betty S. azar，(美)Stacy A. Hagen

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Frontiers of Structural and Civil Engineering 2014年第1期8卷 69-82页

作者： Asskar Janalizadeh CHOOBBASTI Sadegh REZAEI Farzad FARROKHZAD Pedram Haidarzaeh azar Department of Civil Engineering Babol University of Technology Babol Mazandaran 484 Iran

In this the present study, an attempt has been made to evaluate the seismic hazard considering local site effects by carrying out detailed geotechnical site characterization in Babol, Iran. Use of geotechnical data and synthesis of drilling data extracted from the Babol＇s subsurface database have enabled authors to determine the geotechnical properties of each site. These data are consisted of twenty five boreholes up to depth of 40 m. Based on the obtained data from geotechnical investigation the study area is divided to five zones. Dynamic analysis was performed in time domain, using fully nonlinear model by PLAXIS. A series of analysis in the study area showed the site period, ranging from 0.4 to 0.8 s. Finally the obtained response spectra from fully nonlinear method were compared with site response spectra of Iran＇s 2800 （earthquake） code.

关键词： fully nonlinear method site effect dynamic analysis response spectra

Sedimentary Environments Can Be Changed by Geotechnology (Case Study: A Morphotectonic Idea for Design of Extensive Artificial Bay on the Iranian Plateau)

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International Journal of Geosciences 2015年第5期6卷 487-496页

作者： Mehran Arian azar Khodabakhshnezhad Department of Geology Science and Research Branch Islamic Azad University Tehran Iran Department of Education One Territory of Baharestan Education Office Ministry of Education Tehran Iran Department of Geology North Tehran Branch Islamic Azad University Tehran Iran

Iranian Plateau between the Lesser Caucasus-Alborz Mountains on the north and Zagros-Makran Ranges on the south has several inter-mountainous depressions which were filled by Quaternary deposits. Geologic evidence implied that, the last marine conditions in some depressions such as the Dasht-e Kavir, Dasht-e Lut and Jazmourian basins, had been changed to land conditions in middle Miocene. Based on shape and elevation of the Dasht-e Kavir, Dasht-e Lut and Jazmourian plains related to sea level and geomorphology of Iranian plateau, three semi-connective artificial lakes can be constructed upon the mentioned plains by consideration of many geologic and geotechnical parameters. These artificial lakes can feed by pumping of water from Oman Sea and form a triple artificial bay which they must be connected together by two gated straits. Therefore, a possible morphotectonic idea with many advantages has suggested that it can be present as an international geotechnologic design. This design has the important environmental impacts which can be changed desert to lake sedimentary basins.

关键词： Environments Geotechnology Artificial Bay Sedimentary Basin Quaternary Deposits Central Iran

Effectiveness of a Single High Dose of Platelet-Rich Plasma (PRP) Injection Over Corticosteroid and Hyaluronic Acid Injections on Osteoarthritis, Chronic Tendinitis and Tennis Elbow Treatment

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Open Journal of Regenerative Medicine 2022年第2期11卷 41-53页

作者： Charbel Khalil Diana Chaker Albert azar Elie El Kayem Rawad Salameh Mohamad Dar-Yahya Fadi Nader Alain Chebly Kamil Samaha Ahmad Ibrahim Reviva Stem Cell Platform for Research and Applications Center Bsalim Lebanon Middle East Institute of Health University Hospital Bsalim Lebanon Bone Marrow Transplant Unit Burjeel Medical City Abu Dhabi UAE Stem Cell Institute Faculty of Medical Sciences Lebanese University Beirut Lebanon NSERM National Institute of Health and Medical Research Paris XI Paris France Faculty of Medicine Lebanese American University Beirut Lebanon Lebanese University Faculty of Medicine Beirut Lebanon Medical Genetics Unit (UGM) Faculty of Medicine Saint Joseph University Beirut Lebanon Higher Institute of Public Health Saint Joseph University Beirut Lebanon

Background: Corticosteroid, hyaluronic acid (HA) injections and Anti-inflammatory agents are considered as non-invasive treatments for knee osteoarthritis (OA), Chronic Tendinitis (CT) and Tennis elbow (TE) that are supposed to provide symptomatic relief and to help surgical delay intervention. Platelet rich plasma (PRP) is a biological component shown to be beneficial for different orthopedic dysfunctionalities treatment. The presence of GFs in PRPs such as transforming growth factor-β, insulin-like growth factor 1co-stimulate the mesenchymal stem cells and fibroblasts secretions and promotes the fibrin matrix formation which effectively drive the healing process, induces regenerative response and lead to the damage structure repair in orthopedics trauma. Methods: Three groups of a total of 30 patients presenting OA, CT and TE diagnosis, non-responding to corticosteroid, HA and non-steroid anti-inflammatory treatments were randomized to undergo one intra-articular injections of single high dose of PRP. The efficacy of Intra-articular PRP Injections was evaluated before the injection and one month after. The efficiency assessment score was based on [1] Knee injury and Osteoarthritis Outcome Score, [2] Physical Function Short Form (KOOS-PS) Arabic (KSA) version LK 1.0, [3] HOOS-Physical Function Short form (HOOS-PS), and [4] Macdermid patient-rated Tennis Elbow. Results: A significant reduction of pain and a marked improvement in movements was observed in the 3 patient’s groups, PRP-injected patients showed significantly higher values compared with baseline: (p < 0.005 vs baseline), improve functional status and reduce clearly the articular dysfunctions over the time. In our study, single High dose injection of PRP provided an overall superior clinical improvement compared with HA and corticosteroid treatments over the time and the different follow-up checkpoints of the study.

关键词： Platelet Rich Plasma (PRP) Osteoarthritis Chronic Tendinitis Tennis Elbow Corticosteroid Hyaluronic Acid Non-Steroid Anti-Inflammatory