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Comparison of Ultrasound Blood Flow Characteristics of the Lower Limb in Diabetics with Early-Stage Peripheral Artery Disease and Non-Diabetic Controls

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Journal of Diabetes Mellitus 2023年第2期13卷 178-195页

作者： Josephine Sekai Tityiwe Newton-Hughes Anne azangwe godfrey Comfort Paul Radiography Department National University of Science and Technology Bulawayo Zimbabwe School of Health and Society University of Salford Greater Manchester UK

The aim of this study was to compare lower limb blood flow in asymptomatic diabetic patients with early-stage peripheral artery disease (PAD) and non-diabetic controls using duplex ultrasound parameters. This was a comparative cohort study of lower limb blood flow in 35 Black-African diabetic patients (25 females and 10 males with early-stage PAD median age 54 [IQR, 47 - 61] years;median HbA1c 6.3 [IQR, 5.7 - 8.0]%;BMI 29.2 ± 6.7;ABI 1.1 ± 0.1) and 36 non-diabetic controls (28 females and 8 males;median age 54 [IQR, 47 - 61] years;median HbA1c 6.3 [IQR, 5.7 - 8.0] %, BMI 29.2 ± 6.7;ABI 1.1 ± 0.1). Peak systolic velocity (PSV), pulsatility index (PI) and resistive index (RI), were utilised to compare blood flow in the popliteal arteries (PA), anterior tibial arteries (ATA) and posterior tibial arteries (PTA) in addition to ankle brachial index. All the ultrasound parameters showed good (ICC ≥ 0.7;0.50 - 0.85, 95% CI) to excellent (ICC = 1.0;1.0 - 1.0, 95% CI) reliability within groups as well as acceptable variability () other than pulsatility index of the anterior tibial artery within diabetic patients (11.1% CV). PSV, RI and PI were significantly and meaningfully higher (P;d ≥ 0.33), in diabetic patients compared to non-diabetic controls except for PI - PTA (P = 0.72;d = 0.11). Differences in PSV and RI highlighted the effects of early-stage PAD on lower limb blood flow of diabetic patients. In contrast, the effects of early-stage PAD on blood flow were not demonstrated in the PTA and ATA of diabetic patients by PI.

关键词： Atherosclerosis Peak Systolic Velocity Pulsatility Index Resistive Index

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Gut microbiome regulates inflammation and insulin resistance:a novel therapeutic target to improve insulin sensitivity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 825-827页

作者： Dilvin Semo Holger Reinecke Rinesh godfrey Vascular Signalling Molecular CardiologyDepartment of Cardiology I-Coronary and Peripheral Vascular DiseaseHeart FailureUniversity Hospital Münster48149 MünsterGermany

In a recent study published in Nature,Takeuchi et *** a multiomics strategy in humans to provide compelling evidence that increased carbohydrate metabolism by the gut microbiota contributes to insulin resistance(IR).The authors uncovered a previously unknown link between elevated gut monosaccharides and host inflammatory cytokines and suggest potential intervention opportunities to combat IR by targeting specific gut microbial species.

关键词： metabolism inflammation al.

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Comparison of Ultrasound Blood Flow Characteristics of the Lower Limb in Diabetics with Early-Stage Peripheral Artery Disease and Non-Diabetic Controls

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Journal of Diabetes Mellitus（糖尿病） 2023年第2期

作者： Josephine Sekai Tityiwe Newton-Hughes Anne azangwe godfrey Comfort Paul

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On the Road To Development

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ChinAfrica 2024年第6期16卷 42-43页

作者： godfrey OLUKYA 不详

Uganda’s President Yoweri Museveni has lamented that his country’s bad roads get easily damaged by heavy rains,while also expressing his confidence in the new roads recently built by Chinese construction companies.

关键词： companies expressing Road

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Convenience on Three Wheels China-made motor tricycles are transforming the way goods and people are transported in Uganda

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ChinAfrica 2024年第8期16卷 44-45页

作者： godfrey OLUKYA 不详

In most cities,towns and villages in Uganda,Chinamade motor tricycles have become a game-changer for commuters and entrepreneurs alike.

关键词： goods cycles motor

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Seeking More Influence In Global Affairs

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ChinAfrica 2024年第3期16卷 40-41页

作者： godfrey OLUKYA 不详

Uganda hosts NAM and G77+China summits with calls to push back against *** played host to two important summits in *** 19th Summit of Heads of State and Government of the Non-Aligned Movement(NAM)on 19 January,and the Third South Summit of the G77+China on 21 January,both took place in the nation’s capital of ***,it was the first time for the South Summit to be held in *** was well represented at both summits,which attracted over 2,000 leaders and delegates,including over 20 heads of states.

关键词： push Africa G77

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Powering Up

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ChinAfrica 2024年第7期16卷 38-39页

作者： godfrey OLUKYA 不详

Uganda launches giant China-constructed hydropower plant to bolster its electricity supply,and also assist South Sudan with theirs Ugandans and South Sudanese have had their lives lit up by the steady flow of electric... 详细信息

关键词： massive electricity Power

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Sur la voie du développement

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中国与非洲（法文版） 2024年第6期16卷 42-43页

作者： godfrey OLUKYA 不详

Le Président ougandais Yowerl Musevenl a exprimésa préoccupation concernant les routes endommagées par de fortes pluies dans son pays,tout en témoignant sa confiance envers les nouvelles routes récemment constru... 详细信息

关键词： les des occupation

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Defis mondiaux,sol lutions unies L'Ouganda,terre d'accueil pour le MNA et le G77+Chine

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中国与非洲（法文版） 2024年第3期16卷 40-41页

作者： godfrey OLUKYA 不详

En janvier,I'Ouganda aéte le theatre de deuxévenements majeurs sur la scene *** pays a accueilli,a Kampala,sa capitale,le 19e Sommet du Mouvement des non alignés(MNA)le 19 janvier,suivi de pres par le troisieme Sommet du Sud du G77+Chine le 2l *** rencontres ont marquéun moment historique car c'était la premiere fois que le Sommet du Sud se deroulait sur le continent africain.

关键词： des pour ill

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Spatio-Temporal Agricultural Drought Quantification in a Rainfed Agriculture, Athi-Galana-Sabaki River Basin

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Journal of Geographic Information System 2024年第4期16卷 201-226页

作者： Joe Ndundi Tete godfrey Ouma Makokha Oscar Owino Ngesa John Ngugi Muthami Bonface Wabwire Odhiambo Department of Informatics and Computing Taita Taveta University Voi Kenya Department of Finance and Economic Planning County Government of Kilifi Kilifi Kenya

This study employs a quantitative approach to comprehensively investigate the full propagation process of agricultural drought, focusing on pigeon peas (the most grown crop in the AGS Basin) planting seasonal variations. The study modelled seasonal variabilities in the seasonal Standardized Precipitation Index (SPI) and Standardized Agricultural Drought Index (SADI). To necessitate comparison, SADI and SPI were Normalized (from −1 to 1) as they had different ranges and hence could not be compared. From the seasonal indices, the pigeon peas planting season (July to September) was singled out as the most important season to study agricultural droughts. The planting season analysis selected all years with severe conditions (2008, 2009, 2010, 2011, 2017 and 2022) for spatial analysis. Spatial analysis revealed that most areas in the upstream part of the Basin and Coastal region in the lowlands experienced severe to extreme agricultural droughts in highlighted drought years. The modelled agricultural drought results were validated using yield data from two stations in the Basin. The results show that the model performed well with a Pearson Coefficient of 0.87 and a Root Mean Square Error of 0.29. This proactive approach aims to ensure food security, especially in scenarios where the Basin anticipates significantly reduced precipitation affecting water available for agriculture, enabling policymakers, water resource managers and agricultural sector stakeholders to equitably allocate resources and mitigate the effects of droughts in the most affected areas to significantly reduce the socioeconomic drought that is amplified by agricultural drought in rainfed agriculture river basins.

关键词： Agricultural Drought Food Security Standardized Precipitation Index Standardized Agricultural

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