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Unlocking the potential-vitamin D in prostate cancer prevention

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World Journal of Clinical Oncology 2024年第2期15卷 169-174页

作者： ayun cassell Solomane konneh Division of Urology Department of SurgeryJohn F Kennedy Medical CenterMonrovia 100010Liberia

Prostate cancer poses a significant health challenge globally,demanding proactive prevention *** editorial explores the emerging role of vitamin D in prostate cancer *** traditionally associated with bone health,vitamin D is increasingly recognized for its broader impact on immune function,cellular signaling,and cancer *** studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk,particularly in regions with limited sunlight ***,vitamin D regulates cellular processes,inhibiting unchecked cancer cell growth and bols-tering immune *** prevention strategies,considering individual factors,are deemed essential for harnessing the full potential of vitamin *** unlock this potential,the future calls for robust research,public awareness campaigns,dietary improvements,and vigilant medical *** efforts are poised to pave the way toward a future where vitamin D stands as a sentinel in prostate cancer prevention,ushering in hope and improved health for men worldwide.

关键词： Cell Cholecalciferol Prevention Prostate cancer Vitamin D

Current trend in the diagnosis and management of malignant pheochromocytoma:Clinical and prognostic factors

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World Journal of Meta-Analysis 2020年第5期8卷 375-382页

作者： ayun k cassell iii Abdoul Halim Bague Department of Urology and Andrology Hopital General de Grand YoffDakar 3270Senegal Unit of Surgical Oncology Department of General SurgeryYalgado Ouedraogo Teaching HospitalOuagadougou 160Burkina Faso

Pheochromocytomas are tumors arising from the chromaffin cell of the adrenal gland and paragangliomas as tumors from extra-adrenal sympathetic chromaffin *** combined yearly incidence of pheochromocytoma and paraganglioma(PPGL)is approximately 0.8 per 100000 person/*** pheochromocytoma is defined only by the presence of metastasis,as there is no confirmatory histology or *** most common metastatic sites of these chromaffin tumors are the lymph node,bone,lungs,and *** review focuses on relevant clinical and immunohistological factors that are predictive of malignant PPGL or metastasis and determinants of *** showed that the risk of malignant PPGL,along with disease survival,is closely associated with age,primary tumor size,gender,synchronous metastasis,and absence of surgical *** essential biomarkers or immunohistology investigated were galectin-3,COX-2,nm-23,microRNA-210,ERBB-2 overexpression and succinate dehydrogenase subunit mutation,which were predictive of malignancy as well as disease *** resection is possible but most metastatic diseases are amenable to radiopharmaceuticals and chemotherapy due to late *** therapeutic options,like molecular-targeted therapy,are still undergoing clinical trials.

关键词： Chromaffin Malignancy Metastatic Paraganglioma Pheochromocytoma Prognosis

Management of cancer patients during the COVID-19 pandemic:A comprehensive review

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Artificial Intelligence in Cancer 2020年第1期1卷 8-18页

作者： ayun k cassell iii Lydia T cassell Abdoul Halim Bague Department of Urology and Andrology Hopital General de Grand YoffDakar 3270Senegal Department of Public Health Cuttington UniversityGraduate School and Professional StudiesMonrovia 10010Liberia Unit of Surgical Oncology Department of General SurgeryYalgado Ouedraogo Teaching HospitalOuagadougou 160Burkina Faso

The novel 2019 corona virus disease also called severe acute respiratory syndrome coronavirus 2 has caused a global pandemic and more than 2.5 million people have been affected globally with over 100000 *** disease has caused an escalation in hospitalization with growing need for hospital beds and intensive care unit for severe *** evidence has shown that a significant proportion of cancer patients affected by the corona virus present with severe respiratory pneumonia-like illness with need for subsequent intensive care unit ventilation and higher mortality *** susceptibility may be due to the immunosuppressive state of patients with malignancy confounded by chemotherapy,immunotherapy and targeted *** solid tumors(lung cancer,pancreatic cancer)as well as hematological malignancies(leukemias)may require prompt diagnosis and treatment based on the disease aggression and *** centers lack clear guideline on the management of cancer during the *** objective of this review is to synthesize the available literature and provide recommendations on the management of various soft tissue and hematological *** review will also assess the management guidelines for hospitalized cancer patients;cancer patients in the outpatient setting as well as available modalities for follow-up.

关键词： Cancer Chemotherapy COVID-19 Coronavirus Pandemic Transmission Radiotherapy

The Outcome of Transvesical Prostatectomy—A Multicenter Retrospective Study

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Open Journal of Urology 2019年第5期9卷 85-92页

作者： Bashir Yunusa ayun cassell Solomane konneh Swaliho Sheriff Edet Ikpi Department of Surgery Liberia College of Physicians and Surgeons Monrovia Liberia Département d’Urologie et d’Andrologie H&ocirc pital Général de Grand Yoff Dakar Sénégal

Background: Benign Prostatic Hyperplasia (BPH) is one of the commonest causes of lower obstructive uropathy and usually presents with lower urinary tract symptoms. However, in developing nations, the presentation is late often large prostate and associated complications of bladder outlet obstruction (diverticulae, stones, impaired renal function etc.) warranting open prostatectomy. Objective: The objective of this study is to share our experience of perioperative outcomes of open transvesical prostatectomy over a year involving two referral centers in Monrovia Liberia. Methodology: This was a retrospective study performed at The John F. kennedy Medical Center and the Saint Joseph Catholic Hospital involving a total of 31 patients. Results: The mean age was 64.6 years (SD = 9.03) with a range 52 - 85 years. The study showed that 54.8% (17/31) of patients had preoperative catheter. The maximum duration of Catheter was greater than 4 weeks with a mean duration of 3.17 weeks. The mean hemoglobin was 11.30 g/dl. The commonest presenting complication was urinary retention at 25.8% (8/31) followed by hematuria 16.1% (5/31). Hypertension 41.9% (13/31) and diabetes 6.5% (/31) were the commonest comorbidity. The rate of postoperative complication was 38.7% with the commonest being surgical site infection 16.1% (5/31) and clot retentions 9.7% (3/31). There was a high rate of transfusion was 77.4% (24/31) patients. Up to about 13% (4/32) patients had coexisting stricture with 6.5% (2/31) patients treated with urethroplasty and 6.5% (2/31) patients treated by dilatation. The mortality rate was 6.5% (2/31) from renal impairment and severe sepsis. Conclusion: BPH is a common cause of lower obstructive uropathy. Most patients present with complications of the disease such as refractory symptoms, bladder stones or diverticulae necessitating surgery. However, due to the absence of endourological equipments in most parts of Africa and the large prostate at presentation, most settings

关键词： Benign Prostatic Hyperpalsia (BPH) Perioperative Complication Lower Obstructive Uropathy Open Transvesical Prostatectomy