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中华骨科杂志 2022年第12期42卷 800-806页

作者：陈明亮 kaneuji ayumi Takahashi Eiji Kawahara Norio 柳金浪周游三峡大学附属仁和医院骨科宜昌443001 金泽医科大学骨科石川(日本)9200293 三峡大学运动医学研究所宜昌443001 宜昌市运动损伤与修复临床医学研究中心宜昌443001

全髋关节置换术(total hip arthroplasty,THA)是近50年来最成功的骨科手术之一,具有20年以上的良好生存率。但是THA术后髋关节不稳、撞击、脱位和衬垫磨损仍然是导致THA失败和翻修的常见原因。为了降低术后各类并发症发生的风险,脊柱-... 详细信息

全髋关节置换术(total hip arthroplasty,THA)是近50年来最成功的骨科手术之一,具有20年以上的良好生存率。但是THA术后髋关节不稳、撞击、脱位和衬垫磨损仍然是导致THA失败和翻修的常见原因。为了降低术后各类并发症发生的风险,脊柱-髋关节-骨盆活动度异常及其对THA生存率的影响引起了越来越多的关注。基于这一理念,在制定THA术前计划时应充分考虑患者自身骨盆活动度的特点,根据患者矢状面平衡和骨盆活动度设置个性化的前倾角和外展角,以减少术后不良事件的发生,延长假体的寿命。新近的研究表明患者年龄老化,日常生活中姿势的转换,高体质指数,以及不同的手术入路及体位都会对脊柱-骨盆活动度产生影响,由于骨盆活动度的改变会转化成髋臼方位改变,患者在术中或术后骨盆活动度变化过大,都有可能造成术中假体方位设置不良,术后发生假体撞击,脱位,加速衬垫磨损,最终缩短假体的使用寿命。所以在术前对脊柱-骨盆活动度进行测量和评估,通过研究术中骨盆活动度变化的影响因素及使用辅助定位装置以精确地放置臼杯,在术后观察患者骨盆活动度变化及因此产生的不良后果是一项十分有意义的工作。以近年来国外文献所报道的脊柱-骨盆-髋关节之间的相互关系为切入点,介绍脊柱-骨盆活动度的影响因素及由此来指导THA围手术期诊疗策略的新进展。

关键词：全髋关节置换术年龄老化手术入路诊疗策略术后观察术前计划外展角体质指数

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The initial phase of oxidative stress in a steroid-induced osteonecrosis rabbit model

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Advances in Bioscience and Biotechnology 2012年第7期3卷 978-982页

作者： Toru Ichiseki ayumi kaneuji Yoshimichi Ueda Seiji Kaneko Syusuke Ueda Tadami Matsumoto Department of Orthopaedic Surgery Kanazawa Medical University Ishikawa Japan Department of Pathophysiological and Experimental Pathology Kanazawa Medical University Ishikawa Japan

Using a rabbit model, we examined N epsilon-(hexanoyl) lysine (HEL) levels in bone and urine to detect when peroxidative reaction first occurs after steroid administration. Japanese white rabbits weighing about 3.5 kg each were injected with a single intramuscular dose of methylprednisolone 40 mg/kg and divided into groups consisting of 10 rabbits each, which were killed after 1, 3, 5 and 14 days (groups A, B, C and D respectively). As a control, 10 untreated rabbits (group N) were also studied. The proximal femurs were examined histopathologically and immunohistochemically using monoclonal antibody HEL, which is a highly specific antibody against N epsilon-(hexanoyl) lysine, an early peroxidation marker. In addition, urinary levels of HEL were measured by enzyme-linked immunosorbent assay in group N, A, B and C. Osteonecrosis was detected only in group D (90%). Increase of positive reaction of HEL in the bone was observed in group A and D. HEL expression in group D was judged to be a secondary reaction resulting from the development of osteonecrosis. Urinary level of HEL showed a significant increase in only group A (P < 0.001). The present findings suggest that peroxidation in bone occurred within 24 hours after steroid administration in a rabbit model and that it is possible to noninvasively grasp the timing of this peroxidative reaction by measuring the urinary level of HEL.

关键词： Steroid Osteonecrosis Oxidative Stress Hexanoyl Lysine

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The timing and extent of intraosseous hypoxia in the oxidative stress-induced rat osteonecrosis model

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Advances in Bioscience and Biotechnology 2013年第8期4卷 814-817页

作者： Toru Ichiseki ayumi kaneuji Seiji Kaneko Syusuke Ueda Yoshimichi Ueda Hideto Yonekura Kiyokazu Fukui Tadami Matsumoto Department of Biochemistry Kanazawa Medical University Uchinada Ishikawa Japan Department of Orthopaedic Surgery Kanazawa Medical University Uchinada Ishikawa Japan Department of Pathophysiological and Experimental Pathology Kanazawa Medical University Uchinada Ishikawa Japan

Using a rat oxidative stress-induced femoral head osteonecrosis model, we determined the presence/ absence and timing of the generation of hypoxia in the femoral head. DL-Buthionine-(S,R)-sulfoximine (BSO) 500 mg/kg was administered intraperitoneally to male Wistar rats. The rats were killed at 1, 3, 6, 12 hours, and 1, 3, 5 days after BSO administration, and the bilateral femora were removed. A group not administered BSO (control group) was also studied (each group n = 5). In the femoral heads of each group, the expression of hypoxia-inducible factor-1 alpha (HIF-1α) as an index of hypoxia was confirmed by the Western blot method, and quantified using analytical software. In the femoral head increased HIF-1α expression was found in all groups from 1 hour after BSO administration (p < 0.05). In particular, in all specimens of the group 3 hours after BSO administration the most intense expression of HIF-1α amounting to about 13-fold of that of control group was noted (p < 0.001). The present results suggested that in the extremely short period of 3 hours after BSO administration hypoxia severe enough to cause osteonecrosis was induced by oxidative stress in the rat femoral head.

关键词： Osteonecrosis Oxidative Stress Buthionine Sulfoximine Hypoxia-Inducible Factor-1α

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A Sectioning Technique for Extraction of Impacted Third Molar by Using a Straight Handpiece and Carbide Bur: Case Report

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Open Journal of Stomatology 2015年第12期5卷 287-292页

作者： Ikuya Miyamoto Takeshi kaneuji Kokuryo Shinya Hiroki Tsurushima Izumi Yoshioka Division of Oral Medicine Department of Physical Functions Kyushu Dental University Kitakyushu City Japan

Extraction of the lower third molar is one of the most common procedures performed in oral surgery. In general, impacted tooth extraction involves sectioning the tooth’s crown and roots. In order to divide the impacted tooth so that it can be extracted, high-speed air turbine drills are frequently used. However, complications related to air turbine drills may occur. In this report, we propose an alternative tooth sectioning method that obviates the need for air turbine drill use by using a low-speed straight handpiece and carbide bur. A 21-year-old female patient presented to the institute’s dental hospital complaining of symptoms localized to the left lower third molar tooth that were suggestive of impaction. After physical examination, tooth extraction of the impacted left lower third molar was proposed and the patient consented to the procedure. The crown was divided using a conventional straight low-speed handpiece and carbide bur. This carbide bur can easily cut through the enamel of crown. On post-operative day number five, suture was removed and the wound was extremely clear. This technique could minimise intra-operative time and reduce the morbidity associated with air turbine drill assisted lower third molar extraction.

关键词： Carbide Bur Low-Speed Straight Handpiece Impacted Third Molar Extraction

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