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Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

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Open Journal of Gastroenterology 2014年第2期4卷 73-80页

作者： Engin Altintas Zuhal Mert Altintas Orhan Sezgin Enver Ucbilek Erdinc Nayir Mehmet Emin Erdal ayse polat Gulhan Orekeci Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey Department of Medical Biology and Genetic Faculty of Medicine University of Mersin Mersin Turkey Department of Pathology Faculty of Medicine University of Mersin Mersin Turkey Gastroenterology Department Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: The mechanism of steatosis in Hepatitis C virus infection is multifactorial;therefore, it is complex and unclear. The aim of this study was to investigate the effects of methylentetrahydrofolate reductase (MTHFR) gene polymorphisms on the course of chronic hepatitis C virus infection and the development of steatosis due to hepatitis C virus. Methods: This study included 109 patients with chronic hepatitis C virus infection. Necroinflammatory activity, degrees of fibrosis and steatosis and MTHFR gene polymorphisms were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to determine MTHFR C677T and A1298C polymorphisms. Results: Fibrosis was correlated with age (r = 0.336, p = 0.002), platelet (r = ?0.448, p < 0.0001), ALT (r = 0.241, p = 0.026), AST (r = 0.361) and GGT (r = 0.224, p = 0.039). Steatosis was only correlated with fibrosis. MTHFR C677T and A1298C polymorphisms did not have a significant effect on the degree of steatosis (p = 0.857, p = 0.202 respectively). There was a relation between MTHFR C677T and the degree of fibrosis but not A1298C (p = 0.014, p = 0.187 respectively). Conclusion: We found that MTHFR C677T polymorphism contributed to the development of fibrosis in patients with chronic hepatitis C virus infection.

关键词： Fibrosis Hepatitis C Gene Polymorphism Methylenetetrahydrofolate Reductase Steatosis

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Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats

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World Journal of Gastroenterology 2005年第13期11卷 1951-1956页

作者： Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin polat Mukadder ayse Selimoglu Department of Histology and Embryology Department of Physiology Department of Pediatric Gastroenterology

AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second, to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury. METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin, and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg·d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA), and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system. RESULTS: The histopathological changes including portal inflammation, necrosis,apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-inflammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8,0.74±0.02 μmol/g, and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels. CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to o

关键词： Cholestasis Melatonin Oxidative stress Free radicals Hepatic injury

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Effects of chronic smoking on color vision in young subjects

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 77-80页

作者： Hatice Arda G Ertugrul Mirza Osman A polat Sarper Karakucuk ayse Oner Koray Gumus Department of Ophthalmology Faculty of MedicalErciyes University

AIM: To evaluate the effects of chronic smoking on color vision in young ***: This study included 91 smokers and 88non-smokers(a total of 179 volunteers) without any ophthalmologic and systemical disorders. The subjects were between 18-40 years of age with a best corrected visual acuity(BCVA) of 20/20, normal anterior and posterior segment examinations and normal intraocular pressure. The color vision of the subjects were evaluated with Farnsworth-Munsell 100 Hue test(FMHT). The total error scores and axis calculation were performed for each subject and the results ***: Mean age and the standard deviation was28±5y in the smokers group, and 26.7±5.5y in the control group(P =0.101). Sex distribution was similar in the two groups(P =0.365). There was no significant correlation between age and FMHT total error scores(P =0.069).Median of FMHT total error scores of smokers and non-smokers were 65 and 50.50, respectively. FMHT total error scores was found significantly higher in smokers than non-smokers(P =0.004). There was no statisticaly significant difference between smoker and non-smoker groups with respect to axis ratio calculation(P =0.611).There was no significant correlation with FMHT total error scores with neither smoking duration nor number of cigarettes smoked per day(P =0.405, P =0.454,respectively).· CONCLUSION: This study suggested that chronic smoking affects the color vision of young smokers but this may not be sector selective.

关键词： cigarette smoking color vision defect vision test

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基于气候变化与人类活动双重作用的南疆水资源供需关系分析

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应用基础与工程科学学报 2024年第2期32卷 331-348页

作者：倪明霞普拉提·莫合塔尔孙婷宇夏建新中央民族大学生命与环境科学学院北京100081 新疆大学旅游管理学院新疆乌鲁木齐830046

全球变暖致使南疆周边冰川大幅退缩,冰川融水增加,南疆水资源因此增加.人类社会的发展带动生产和生活用水大幅增加.这打破了区域水资源供需平衡,水资源风险愈加突出.根据干旱地区水资源利用特点,考虑气候变化导致的降水、冰川融水和径... 详细信息

全球变暖致使南疆周边冰川大幅退缩,冰川融水增加,南疆水资源因此增加.人类社会的发展带动生产和生活用水大幅增加.这打破了区域水资源供需平衡,水资源风险愈加突出.根据干旱地区水资源利用特点,考虑气候变化导致的降水、冰川融水和径流的变化趋势,以及南疆人口和经济的发展,结合度日模型、定额需水法、彭曼公式、潜水蒸发法和水压力指数法对南疆三地区水资源压力现状及未来潜在变化进行了评估.研究结果表明:2000~2020年,南疆三地区的可利用水量呈增加趋势;总需水量变化存在地区差异,阿克苏地区和喀什地区显著增加,和田地区则有所减少;南疆三地区水压力均处于较高水平状态,水压力变化趋势与总需水量的变化趋势一致.21世纪30年代和70年代南疆三地区的可利用水量将持续增加;需水量和水压力的变化趋势与历史时期一致.人类取水活动在未来水压力的变化中起主导作用.该研究揭示了区域内水资源失衡的时空分异性,以期为南疆地区的水资源管理和合理利用提供科学参考.

关键词：南疆气候变化冰川融水人类活动绿洲扩张耕地增加水资源供需水资源压力水压力指数未来预估

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Ocular alignment and results of strabismus surgery in neurologically impaired children

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 113-115页

作者： igdem lk Can Sibel polat Meryem Yasar Bayazit ilhan ayse Gl Koak Altintas Ministry of Health Ulucanlar Eye Education and Research Hospital 3rd Clinic AnkaraTurkey

AIM:To evaluate ocular alignment and surgical results of strabismus surgery in neurologically impaired children.· METHODS:Files of 33 neurologically impaired squint children were *** patients had cerebral palsy(CP),4 had CP with mental retardation,therest had mental-motor retardation of unknown *** refractions,type and angle of strabismus,surgeries performed were recorded.· RESULTS:Mean follow-up was 34.0±16.5 ***-three patients had esodeviation,the remaining had *** 19 patients,angle of deviations measured at different visits were highly *** patients with stable angle of deviations or with unstable but high angle deviations had horizontal muscle *** horizontal deviation decreased from 43.75±10,69 D to 12.83±8.38D with surgery.· CONCLUSION:In neurologically impaired strabismic children,surgery is effective in patients with stable deviations or unstable but high angle *** for surgery should be made after a long follow up period.

关键词： cerebral palsy mental-motor retardation strabismus

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Evaluation of solvent-mediated phase transformation of glycine using oleic acid: Morphology and characterization study

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Chinese Journal of Chemical Engineering 2018年第9期26卷 1829-1836页

作者： Sevgi polat Perviz Sayan Department of Chemical Engineering Faculty of Engineering Marmara University

The polymorphic phase transformation of β-glycine to α-glycine was carried out both in the absence and presence of various concentrations of oleic acid used as additive at 25 ℃ in a water/ethanol medium. The effects of oleic acid and its concentration on phase transformation time were determined by continuously measuring the ultrasonic velocity. The crystals obtained by the completion of the phase transformation were characterized by XRD, SEM, and TG/DTG. The XRD and SEM results indicated that oleic acid significantly impacted phase transformation time and the morphological characteristics of the crystals. In addition to SEM analysis, detailed crystal shape analysis was performed and the circularity, elongation, and convexity parameters were determined quantitatively. TG/DTG analyses were performed to investigate thermal decomposition behavior and to calculate the activation energies based on different kinetic models such as FWO, KAS, Starink, and Tang kinetic models. With the addition of oleic acid to the medium, the calculated activation energy values increased from 89.63–90.63 to153.8–155.4 kJ·mol^（-1）. The activation energy values showed that oleic acid was adsorbed on the crystal surface;this result was supported by FTIR, elemental, and Kjeldahl analyses.

关键词： Glycine Oleic acid Crystallization Isoconversional methods Phase transformation

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SOME EULER SPACES OF DIFFERENCE SEQUENCES OF ORDER m

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Acta Mathematica Scientia 2007年第2期27卷 254-266页

作者： Harun polat Feyzi Basar Innü niversitesi Adiyaman Fen-Edebiyat Fakültesi 02040-Adiyaman Turkey Innü niversitesi E■itim Fakültesi 44280-Malatya Turkey

Kizmaz [13] studied the difference sequence spaces ∞（A）, c（A）, and co（A）. Several article dealt with the sets of sequences of m-th order difference of which are bounded, convergent, or convergent to zero. Altay and Basar [5] and Altay, Basar, and Mursaleen [7] introduced the Euler sequence spaces e0^r, ec^r, and e∞^r, respectively. The main purpose of this article is to introduce the spaces e0^r△^（m））, ec^r△^（m））, and e∞^r△^（m））consisting of all sequences whose mth order differences are in the Euler spaces e0^r, ec^r, and e∞^r, respectively. Moreover, the authors give some topological properties and inclusion relations, and determine the α-, β-, and γ-duals of the spaces e0^r△^（m））, ec^r△^（m））, and e∞^r△^（m））, and the Schauder basis of the spaces e0^r△^（m））, ec^r△^（m））. The last section of the article is devoted to the characterization of some matrix mappings on the sequence space ec^r△^（m））.

关键词： Difference sequence spaces of order m Schauder basis the α- β- and γ-duals matrix mappings

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Phase diagrams in mixed spin-3/2 and spin-2 Ising system with two alternative layers within the effective-field theory

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Chinese Physics B 2011年第6期20卷 112-124页

作者： Bayram Deviren Yasin polat Mustafa Keskin Department of Physics Nevsehir University Institute of Science Erciyes University Department of Physics Erciyes University

The phase diagrams in the mixed spin-3/2 and spin-2 Ising system with two alternative layers on a honeycomb lattice are investigated and discussed by the use of the effective-field theory with correlations. The interaction of the nearest-neighbour spins of each layer is taken to be positive （ferromagnetic interaction） and the interaction of the adjacent spins of the nearest-neighbour layers is considered to be either positive or negative （ferromagnetic or antiferromagnetic interaction）. The temperature dependence of the layer magnetizations of the system is examined to characterize the nature （continuous or discontinuous） of the phase transitions and obtain the phase transition temperatures. The system exhibits both second- and first-order phase transitions besides triple point （TP）, critical end point （E）, multicritical point （A）, isolated critical point （C） and reentrant behaviour depending on the interaction parameters. We have also studied the temperature dependence of the total magnetization to find the compensation points, as well as to determine the type of behaviour, and N-type behaviour in Neel classification nomenclature existing in the system. The phase diagrams are constructed in eight different planes and it is found that the system also presents the compensation phenomena depending on the sign of the bilinear exchange interactions.

关键词： mixed spin-3/2 and spin-2 Ising system effective-field theory compensation phenomena phase diagrams

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Performance evaluation of waste electrical and electronic equipment disassembly layout configurations using simulation

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Frontiers of Environmental Science & Engineering 2017年第5期11卷 65-75页

作者： Ozan Capraz Olcay polat Askiner Gungor Department of Industrial Engineering Naxmk Kemal University Corlu/Tekirdag 59860 Turkey Department of Industrial Engineering Pamukkale University Pamukkale/Denizli 20160 Turkey

Recycling of waste electrical and electronic equipment （WEEE） is crucially important since it handles hazardous waste according to ever tightening laws and regulations and it adds benefits to economy and sustainable environment. Disassembly is one of the most important processes performed during the recovery of WEEE. The overall goal of disassembly is to maximize the retrieval of various metals and plastics contained in WEEE in order to reduce their negative effects on human health and environmental sustainability and to increase economic gains. This study aims to evaluate alternative layout configurations for WEEE disassembly systems （WDS）. In this context, various configurations were compared in terms of pre-defined performance criteria, such as the total number of disassembled WEEE and the total revenue from sales, using simulation models. The results of this study show that the perfomaance of a WDS was significantly affected by output transfer systems along with the specialization of operators on certain types of WEEE.

关键词： WEEE Recovery Disassembly Layout planning Simulation

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Debris flow susceptibility and propagation assessment in West Koyulhisar, Turkey

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Journal of Mountain Science 2020年第11期17卷 2611-2623页

作者： Ali polat Dursun ERİK Provincial Directorate of Disaster and Emergency Sivas 58050Turkey Republic of Turkey General Directorate of Highway 16.DistrictSivas 58049Turkey

Turkey is highly prone to landslides because of the geological and geographic *** study area,which is located in a tectonically active region,has been significantly affected by mass *** type landslides are frequently observed due to this *** study aims at determining the source area and propagation of debris flows in the study *** used the heuristic method to extract source areas of debris flow,and then used receiver operating characteristic(ROC)curve analysis to assess the performance of the method,and finally calculated the Area under curve(AUC)values being 83.64%and 80.39%for the success rate and prediction rate,*** calculated potential propagation area and runout distance with Flow-R *** conclusion,the obtained results(susceptibility map,propagation and runout distance)are very important for decisionmakers at the region located on an active fault zone,which is highly prone to natural *** outputs of this study could be used in site selection studies,designing erosion prevention systems and protecting existing human-made structures.

关键词： Koyulhisar Debris flow Flow path assessment Heuristic method Landslide susceptibility mapping Geographical Information System(GIS)

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