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Supramolecular hybrid hydrogels as rapidly on-demand dissoluble,self-healing,and biocompatible burn dressings

Bioactive Materials 2023年第7期25卷 415-429页

作者： A.Aslihan Gokaltun Letao Fan Luca Mazzaferro Delaney Byrne Martin L.Yarmush Tianhong Dai ayse asatekin O.Berk Usta Center for Engineering in Medicine and Surgery Massachusetts General HospitalHarvard Medical School55 Fruit St.BostonMA02114USA Shriners Hospitals for Children 51 Blossom St.BostonMA02114USA Department of Chemical and Biological Engineering Tufts University4 Colby St.MedfordMA02474USA Department of Chemical Engineering Hacettepe University06532BeytepeAnkaraTurkey Department of Biomedical Engineering Rutgers University599 Taylor Rd.PiscatawayNJ08854USA Wellman Center for Photomedicine Massachusetts General HospitalDepartment of DermatologyHarvard Medical School50 Blossom StreetBostonMA02114USA

Despite decades of efforts,state-of-the-art synthetic burn dressings to treat partial-thickness burns are still far from *** dressings adhere to the wound and necessitate *** work describes the first“supramolecular hybrid hydrogel(SHH)”burn dressing that is biocompatible,self-healable,and on-demand dissoluble for easy and trauma-free removal,prepared by a simple,fast,and scalable *** SHHs leverage the interactions of a custom-designed cationic copolymer via host-guest chemistry with cucurbit[7]uril and electrostatic interactions with clay nanosheets coated with an anionic polymer to achieve enhanced mechanical properties and fast on-demand *** SHHs show high mechanical strength(>50 kPa),self-heal rapidly in~1 min,and dissolve quickly(4-6 min)using an amantadine hydrochloride(AH)solution that breaks the supramolecular interactions in the *** the SHHs nor the AH solution has any adverse effects on human dermal fibroblasts or epidermal keratinocytes in *** SHHs also do not elicit any significant cytokine response in ***,in vivo murine experiments show no immune or inflammatory cell infiltration in the subcutaneous tissue and no change in circulatory cytokines compared to sham ***,these SHHs present excellent burn dressing candidates to reduce the time of pain and time associated with dressing changes.

关键词： Supramolecular hybrid hydrogels Cationic copolymer On-demand dissoluble Self-healable Biocompatible Burn injury

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