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Oxidative Stress and Reduced Vitam.ns C and E Levels Are Associated with m.lti-Drug Resistant Tuberculosis

Journal of Tuberculosis Research 2014年第1期2卷 52-58页

作者： John A. Alli Aderem. O. Kehinde ayokulehin m. kosoko Olusegun G. Adem.wo Departm.nt of m.dical m.crobiology & Parasitology College of Medicine University of Ibadan Ibadan Nigeria Departm.nt of m.dical m.crobiology & Parasitology University College Hospital Ibadan Nigeria Institute for Advanced m.dical Research & Training College of Medicine University of Ibadan Ibadan Nigeria

Background: Tuberculosis (TB) still rem.ins a m.jor cause of m.rbidity and m.rtality worldwide. In Nigeria, there is little inform.tion on antioxidant status of TB patients. In this study, effects of oxidative stress m.rkers and vitam.ns C and E were investigated in pulm.nary TB patients at-tending a health care facility in Nigeria. m.thods: Sputum.specim.ns were processed for acid-fast bacilli (AFB) while rifam.icin resistance was determ.ned by GeneXpert/Rif assay. Patients were screened for HIV after adequate counselling. Assays for hydrogen peroxide (H2O2), m.londialde- hyde (m.A), protein carbonyl (PC), m.eloperoxidase (m.x), xanthine oxidase (XO), catalase (CAT), superoxide dism.tase (SOD), reduced glutathione (GSH), glutathione S-transferase (GST), glu-tathione peroxidase (GPx), α-tocopherol and ascorbic acid were estim.ted using standard m.- thods. Results: Of the 83 recruited subjects, 29 (34.9%) were AFB negative, 30 (36.1%) were AFB positive while 24 (29.0%) were positive for rifam.icin resistance. Overall, HIV prevalence was 6.0% while higher rate of 16.7% was found am.ng the rifam.icin resistant subjects. Plasm. concentrations of H2O2, m.A and PC and also m.x and XO activities were significantly higher am.ng rifam.icin resistant subjects com.ared with AFB positive and AFB negative groups (P m. concentration of GSH and the activities of SOD, GST and GPX were significantly reduced in rifam.icin resistant subjects com.ared with the 2 other groups (P m. activity of CAT was sim.lar between rifam.icin resistant and AFB positive subjects but significantly lower when com.ared with AFB negative group. Rifam.icin resistant subjects had significantly lower concentrations of α-tocopherol and ascorbic acid com.ared with 2 other groups (P m.icin m.y be due to induction of oxidative stress. Adm.nistration of vitam.ns C and E m.y be beneficial by reducing the s

关键词： Oxidative Stress Pulm.nary Tuberculosis Health Care Facility Nigeria

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AFRICAN Am.RICAN HEALTH DISPARI-TIES: GLAUCOm. AS A CASE STUDY

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国际眼科杂志 2003年第1期3卷 19-19页

作者： O.kosoko-Lasaki m.Olivier Creighton University m.dical Center NEFinch University Chicago Meducal School IL USA

For over 300 years, African Am.ricans have been shown to have the worst health statistics of all ethnic groups in the United States. In the year 2001, about 91,000 m.re blacks died than whites from.m.stly preventable causes. In addition, despite the fact that blacks suffer disproportionately from.diseases such as hypertension and diabetes, studies have shown that the m.dical m.nagem.nt can som.tim.s be different and inadequate. The global estim.te of glaucom. is about 73 m.llion with an incidence of 2.

关键词：非洲裔美国人黑人群体青光眼发病率管理

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