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The Effectiveness of Infection Control Practices among Health Care Workers Responding to the COVID-19 Pandemic in Nigeria

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Advances in Infectious Diseases 2021年第2期11卷 232-239页

作者： Fehintola A. Ige Aigbe G. Ohihoin Bosede O. Amuda Olufemi S. Amoo Chika K. Onwuamah Azuka P. Okwuraiwe Joseph O. Shaibu ebenezer O. Odewale Ayorinde B. James Adeleke Kayode Adefunke Adeshina Rosemary A. Audu Centre for Human Virology and Genomics Department of Microbiology Nigerian Institute of Medical Research Lagos Nigeria Clinical Science Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Tuberculosis Research Department of Microbiology Nigerian Institute of Medical Research Lagos Nigeria Biochemistry Department Nigerian Institute of Medical Research Lagos Nigeria Department of Community Health & Primary Health Care Lagos State University Teaching Hospital Lagos Nigeria Lagos State Ministry of Health Ikeja Lagos Nigeria

Background: The world is currently experiencing a healthcare crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Healthcare workers (HCWs) are at the forefront of controlling the spread of the disease;this response has resulted in a huge number of infections amongst HCWs and unfortunately some casualties. Infection prevention and control practices (IPC) are practical, proven methods that prevent avoidable harm to patients and protect health workers from contagious infection. This study was done to evaluate the effectiveness of IPC practices utilized in COVID-19 testing drive through facility in Lagos Nigeria. Method: The facility recruited 42 HCWs who were trained on IPC and use of Personal Protective Equipment (PPEs). Training on donning and doffing of PPEs, preparation of decontaminants and sample handling were done for relevant personnel. A daily log for monitoring COVID-19 symptoms was deployed to all HCWs;to help early detection of COVID-19 infection and prevent transmission amongst staff. Results: Of 42 personnel, 92.8% had a tertiary level of education while 71.4% had at least 5 years work experience. A total of 5 (11.9%) out of 42 HCWs were positive by week six of the study. All infected persons worked at the drive through centre. Most common symptom filled in the daily log tool was headache and fatigue. Conclusion: Despite all the measures introduced, 11.9% of HCWs became positive within 6 weeks, showing the highly infectious nature of the virus and the need to research into more effective measures in preventing the transmission of highly infectious pathogens to HCWs during outbreaks.

关键词： Healthcare Workers Infection Prevention and Control COVID-19 Pandemic

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一个常染色体隐性遗传性扁平角膜家族的临床和分子学特征

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 30-31页

作者： ebenezer N.D. Patel C.B. Hariprasad S.M. R.C. Allen 宋虎平 Department of Ophthalmology and Visual Sciences University of Iowa Hospitals and Clinics 200 Hawkins Dr Iowa City IA 52242 United States Dr

Background: Autosomal recessive cornea plana is characterized by a flattened corneal surface associated with hyperopia and various anterior segment abnormalities. Mutations have been detected in the keratocan gene (KERA), a member of the small leucine-rich proteoglycan family. Objective: To clinically and molecularly characterize a consanguineous family of Hispanic origin in which 3 individuals are affected with cornea plana. Methods: Clinical ophthalmic examination, including corneal topography and axial eye lengthmeasurement,was performed on 7 family members. Molecular analysis of KERA was performed on DNA from each family member who had been examined. Results: All 3 affected individuals showed extreme flattening of the cornea ( > 36 diopters ), normal axial eye lengths, and hyperopia greater than 6.25 D (spherical equivalent). Anterior segment abnormalities included scleralization of the cornea and central iris strands to the corneal endothelium. Affected individuals were homozygous for a novel mutation in KERA. The sequence change was found in exon 2, which results in an asparagine to aspartic acid change at codon 131. This amino acid change occurs within a highly conserved leucinerich repeat of keratocan. Conclusions: The cause of disease in this family is likely to be a mutation in exon 2 of KERA. Other mutations in KERA known to cause cornea plana also fall within the region encoding the leucine-rich repeat motifs and are predicted to affect the tertiary structure of the protein. Clinical Relevance: This is the first report of the identification of a mutation within KERA in a family of Hispanic origin with autosomal recessive cornea plana. Although the vast majority of cases of cornea plana are in individuals of Finnish descent, this report demonstrates the occurrence of the disease in other populations.

关键词：扁平角膜眼轴长度常染色体隐性遗传家族

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OJU Peyronie’s Disease in an Elderly Ghanaian Gentleman—A Case-Report and Literature Review

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Open Journal of Urology 2024年第10期14卷 519-531页

作者： Frank Obeng Aishah Fadila Adamu Samuel Edudzi Gavor Blessings Yao Setsoafia Sedem Atimpo ebenezer Antwi Enoch Kwaku Adjaho Nana Yaa Agyenim Boateng Merveille Adjin Anum-Laryea Gwendolyn Egyefi Armah Juliet Enyonam Dzivenu Frank Fosu Joel Kwame Kwao Alexander Kofi Quansah Pearl Esi Demawu Hussein Rachel Akosua Sogbe Kafui Kossi Kekessie Mawuenyo Attawa Oyortey Ali Mamudu Ayamba Faculty of Surgery School of Medicine University of Health and Allied Sciences Ho Ghana Department of Surgery Ho Teaching Hospital Ho Ghana School of Medicine University of Health and Allied Sciences Ho Ghana

Background: Peyronie’s disease is characterized by fibrous plaque formation in the tunica albuginea, leading to penile curvature and sexual dysfunction. Surgical correction is often required in cases of severe deformity or significant functional impairment. Aim: To present the case of a patient with severe Peyronie’s disease who underwent surgical correction using an autologous fascia lata graft. Case Presentation: We report the case of a 77-year-old Black-African gentleman with Peyronie’s disease, presenting with a self-reported penile curvature of 70 degrees and significant sexual frustration. He was managed surgically with plaque excision followed by a tunica albuginea patch using a subcutaneously harvested autologous fascia lata graft, all performed in a single surgical session. Conclusion: This case highlights the importance of individualized surgical planning and patient-specific considerations in achieving optimal outcomes in the management of Peyronie’s disease, particularly in cases requiring grafting for severe curvature.

关键词： Peyronie’s Disease Penile Trauma Tunica Albuginea Penile Deformity Sexual Frustration Careful Diagnosis Tailored-Surgical Therapy Calcific-Plaques Autologous Fascia Lata Graft Water-Tight Repair

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回顾性分析：免疫抑制剂治疗眼部炎症对死亡率的影响

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中国处方药 2009年第8期8卷 33-33页

作者： John H Kempen ebenezer Daniel James P Dunn

背景及目的：免疫抑制剂治疗是否会影响生存率目前尚未明确，本研究的目的是评估免疫抑制剂是否会增加死亡率。

关键词：免疫抑制剂死亡率眼部炎症治疗生存率

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COVID-19 Spread Patterns Is Unrelated to Malaria Co-Infections in Lagos, Nigeria

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Advances in Infectious Diseases 2020年第4期10卷 200-215页

作者： Olufemi Samuel Amoo Olugbenga Olanrewaju Aina Azuka Patrick Okwuraiwe Chika Kingsley Onwuamah Joseph Ojonugwa Shaibu Fehintola Ige Kelly Owaneze Hammed Olanrewaju Agboola Dorcas Njeri Kareithi Tochukwu Ifeanyi Onuigbo Amaka Stephanie Ikemefuna Joy Isioma Oraegbu ebenezer Olusoji Odewale Leona Chika Okoli Olusola Ajibaye Ayorinde Babatunde James Ganiyu Idris Greg Ohihoin Bosun Tijani Temmie Giwa-Tunbosun Richard Adegbola Babatunde Lawal Salako Rosemary Ajuma Audu Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Biochemistry Department Nigerian Institute of Medical Research Lagos Nigeria Co-Creation Hub Lagos Nigeria Lifebank Lagos Nigeria

Malaria and COVID-19, though caused by different organisms, share a significant number of symptoms like fever, headaches, difficulty in breathing and fatigue. Therefore, determining if a patient is positive for COVID-19 or Malaria based on symptoms alone, might be misleading, especially during pandemic response. It has been reported that an individual begins to manifest Malaria symptoms between 10 - 15 days after infection with malaria parasite, although some individuals may be asymptomatic. Some COVID-19 infected patients, like Malaria, are also asymptomatic but could contribute to transmission of SARS-CoV-2 virus. These similarities in symptoms have led to misconception about COVID-19 being real and misdiagnoses of both infections, especially in Nigeria. However, there are possibilities that Malaria and COVID-19 could co-exist in some individuals thereby leading to mismanagement and treatment of only one infection while neglecting the possibility of the patient being infected with both diseases. We aim to determine possible correlation between Malaria and COVID-19 in a Malaria endemic country like Nigeria. This study was carried out using the qPCR molecular testing approach, a gold standard for COVID-19 testing and rapid diagnostic test kits to detect Malaria parasites in 617 individuals residing in urban settings. We demonstrated that COVID-19 and Malaria infection amongst adults in urban settings are unrelated thereby focusing on symptoms alone may result in misdiagnosis. Our findings show that Malaria is not among the underlying medical conditions strongly associated with increased risk for severe COVID-19 illness amongst adults in urban settings.

关键词： Malaria COVID-19 Symptoms

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DETERMINATION OF GINSENOSIDES IN PLANT EXTRACTS FROM PANAX GINSENG AND PANAX QUINQUEFOLIUS L. BY LC/MS/MS

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质谱学报 1999年第Z1期 3-3页

作者： WANG Xiaomin, Takeo Sakuma, ebenezer Asafu-Adjaye,Gerald K. Shiu (Perkin-Elmer Sciex instruments, 71 Four Valley Drive, Concord, Ont.Canada L4K 4V8 FDA Product Quality Research Laboratory, 4 Research Court, Rockville, MD 20850, USA)

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父母患2型糖尿病的正常血糖者与静息能量消耗低相关

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英国医学杂志中文版 2018年第9期21卷 537-537页

作者：范丽君(译) 巩纯秀(校) 北京儿童医院

目的静息能量消耗（REE）与肥胖、胰岛素抵抗和2型糖尿病（T2DM）相关。REE和T2DM均为遗传性状。因此，我们研究父母T2DM对正常血糖子代的静息能量消耗的影响。方法将父母T2DM血糖正常的受试者87名，与父母无糖尿病的正常血糖受试者83... 详细信息

目的静息能量消耗（REE）与肥胖、胰岛素抵抗和2型糖尿病（T2DM）相关。REE和T2DM均为遗传性状。因此，我们研究父母T2DM对正常血糖子代的静息能量消耗的影响。方法将父母T2DM血糖正常的受试者87名，与父母无糖尿病的正常血糖受试者83名相比较，他们的年龄、性别、种族、体质指数（BMI）、体重和腰围进行匹配。研究他们的75g口服葡萄糖耐量试验；并使用间接测热法测定静息能量消耗，用双能x线吸收测定法评估体组分。使用Student t-检验、方差分析和回归分析进行统计分析。

关键词：糖尿病类型历史父母精力休息

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常染色体隐形遗传扁平角膜家族的临床和分子学特征

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美国医学会眼科杂志（中文版） 2006年第3期18卷 192-192页

作者： Neil D. ebenezer Chetankumar B. Patel Seenu M. Hariprasad Li L. Chen Reshma J. Patel Alison J. Hardcastle Richard C.Allen 扬帆（译）雷嘉启（校）

背景：常染色体隐形遗传扁平角膜特点是角膜表面扁平，伴远视和各种前节异常。突变定位在角膜基因（KERA），是一个小的富亮氨酸蛋白聚糖家族中的一员。

关键词：常染色体隐形遗传角膜表面分子学特征扁平家族临床前节异常蛋白聚糖

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