检索结果-南通市图书馆

The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

Advances in Breast Cancer Research 2016年第1期5卷 37-47页

作者： Mona Mohamed K. El-Deeb Heba G. El-Sheredy ayman farouk mohammed Department of Chemical Pathology Medical Research Institute Alexandria University Alexandria Egypt Department of Cancer Management and Research Medical Research Institute Alexandria University Alexandria Egypt Department of Surgery Medical Research Institute Alexandria University Alexandria Egypt

Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and anti-oxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female;the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.

关键词： Trace Elements Oxidative Capacity Breast Cancer Antioxidants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet

引用

Food Science and Human Wellness 2018年第4期7卷 252-259页

作者： ayman mohammed El-Anany Rehab farouk M.Ali Department of Special Food and Nutrition Researches Food Technology Research InstituteAgricultural Research CenterGizaEgypt Biochemistry Department Faculty of AgricultureCairo UniversityGizaEgypt Department of Food Science and Human Nutrition College of Agriculture and Veterinary MedicineAl-Qassum UniversityQassimSaudi Arab

The present study was conducted to evaluate the hypolipidemic effects of coffee silver skin(CSS)supplementation in rats fed a highfat diet(HFD).A total of 40 albino rats were used in the present *** groups were as follows:Rats fed a normal diet,N group;high fat diet,HFD group;high fat diet+10%CSS,HFD 10;HFD+15%CSS,HFD 15;HFD+20%CSS,HFD 20;the diets were followed for 8 *** samples were collected at the end of the *** the time of sacrifice,the weights of heart,liver,kidneys,epididymal fat and retroperitoneal fat of the experimental rats with respect to body weight were *** lipid parameter of the serum was recorded and liver and kidney function tests were ***,a histopathological assay was performed on the liver and kidney tissues of the rats fed the tested *** weight gain of the rats fed a HFD supplemented with 10,15 and 20%CSS was∼1.05,1.08 and 1.12 times lower than that of those rats fed HFD,*** incorporation of CSS at a level of 20%reduced the increase in liver,kidney,epididymal fat and retroperitoneal fat weight by 17.84,19.38,47.23 and 18.00%,respectively,compared with HFD *** administration induced considerable increases in alanine aminotransferase,aspartate aminotransferase and alkaline phosphatase activities compared with the control *** results also indicated that the HFD-fed rats exhibited increased levels of urea,uric acid and creatinine,by∼26.38,8.40 and 6.75%,respectively,compared with the control *** the exception of high-density lipoprotein cholesterol,all lipid fractions increased significantly in rats fed a *** administration of a HFD induced marked pathological changes in the liver and kidneys of the ***,the incorporation of various levels of CSS in to a HFD reduced these *** results of the present study illustrate that the incorporation of CSS into HFDs reduces the hyperlipidemia effect of these diets.

关键词： Hypolipidemic Coffee Fiber Biochemical Serum lipid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Nonlinear Optimal Control Approach for Bacterial Infections Under Antibiotics Resistance

引用

Journal of Systems Science & Complexity 2024年第6期37卷 2293-2317页

作者： RIGATOS Gerasimos ABBASZADEH Masoud SIANO Pierluigi AL-NUMAY mohammed ZOUARI farouk Unit of Industrial Automation Industrial Systems Institute26504Rion PatrasGreece Dept.of ECS Engineering Rensselaer Polytechnic Institute12065TroyNYUSA Dept.of Management and Innovation Systems University of Salerno84084FiscianoItaly Dept.of Electrical Eng. King Saud UniversityRiyadh 11421Saudi Arabia Laboratoire d'Automatique ENIT Tunisie1002 Tunis

The overuse and misuse of antibiotics has become a major problem for public *** become resistant to antibiotics and because of this the anticipated therapeutic effect is never ***-hospital infections are often aggravated and large amounts of money are spent for treating complications in the patients'*** this paper a nonlinear optimal(H-infinity)control method is developed for the dynamic model of bacterial infections exhibiting resistance to ***,differential flatness properties are proven for the associated state-space ***,the state-space description undergoes approximate linearization with the use of first-order Taylor series expansion and through the computation of the associated Jacobian *** linearization process takes place at each sampling instance around a time-varying operating point which is defined by the present value of the system's state vector and by the last sampled value of the control inputs *** the approximately linearized model of the system a stabilizing H-infinity feedback controller is *** compute the controller's gains an algebraic Riccati equation has to be repetitively solved at each time-step of the control *** global stability properties of the control scheme are proven through Lyapunov *** proposed method achieves stabilization and remedy for the bacterial infection under moderate use of antibiotics.

关键词： Bacterial infection differential flatness properties global stability Jacobian matrices nonlinear H-infinity control resistance to antibiotics Riccati equation Taylor series expansion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Incidence, clinical features and para-clinical findings of achalasia in Algeria: Experience of 25 years

引用

World Journal of Gastroenterology 2016年第38期22卷 8615-8623页

作者： Amar Tebaibia mohammed Amine Boudjella Djamel Boutarene farouk Benmediouni Hakim Brahimi Nadia Oumnia Internal Medicine Department Kouba HospitalUniversity of Algiers 1 Department of Epidemiology National Public Health InstituteEl BiarUniversity of Algiers 1

AIM To investigate the incidence of achalasia in Algeria and to determine its clinical and para-clinical profile. To evaluate the impact of continuing medical education(CME) on the incidence of this *** From 1990 to 2014, 1256 patients with achalasia were enrolled in this prospective study. A campaign of CME on diagnosis involving different regions of the country was conducted between 1999 and 2003. Annual incidence and prevalence were calculated by relating the number of diagnosed cases to 105 inhabitants. Each patient completed a standardized questionnaire, and underwent upper endoscopy, barium swallow and esophageal manometry. We systematically looked for Allgrove syndrome and familial *** The mean annual incidence raised from 0.04(95%CI: 0.028-0.052) during the 1990 s to 0.27/105 inhabitants/year(95%CI: 0.215-0.321) during the 2000 s. The incidence of the disease was two and half times higher in the north and the center compared to the south of the country. One-hundred-and-twenty-nine(10%) were children and 97(7.7%) had Allgrove syndrome. Familial achalasia was noted in 18 different families. Patients had dysphagia(99%), regurgitation(83%), chest pain(51%), heartburn 24.5% and weight loss(70%). The lower esophageal sphincter was hypertensive in 53% and hypotensive in 0.6%.CONCLUSION The mean incidence of achalasia in Algeria is at least 0.27/105 inhabitants. A good impact on the incidence of CME was noted. A gradient of incidence between different regions of the country was found. This variability is probably related to genetic and environmental factors. The discovery of an infantile achalasia must lead to looking for Allgrove syndrome and similar cases in the family.

关键词： Achalasia Incidence Allgrove syndrome Manometry Continuing medical education

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-nutritional characteristics and mechanism of soybean agglutinin

引用

BIOCELL 2021年第3期45卷 451-459页

作者： LI PAN JIAWEI LIU mohammed HAMDY farouk GUIXIN QIN NAN BAO YUAN ZHAO HUI SUN Key Laboratory of Animal Production Product Quality and SecurityMinistry of EducationKey Laboratory of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyJilin Agricultural UniversityChangchun130118China Animal Production Department Faculty of AgricultureAl-Azhar UniversityCairo11884Egypt

Soybean agglutinin(SBA)is an important anti-nutritional factor in *** can induce animal growth inhibition,cause pathological changes of intestinal tissue,and decrease in the immune system ***,a great deal of research has been done on the effects of SBA on cell morphology,division,apoptosis,autophagy,as well as the correlated signal transduction *** review mainly covers the chemical and biological characteristics of SBA,describes the multifaceted aspects of SBA anti-nutritional functions,and highlights the possible cellular and molecular mechanism of anti-nutritional effects of *** review has important implications for the prevention and treatment of SBA-induced diseases,drug development,processing techniques of plant products,prevention of food-borne toxins,as well as human and animal health protection.

关键词： Soybean agglutinin Autophagy Cell apoptosis Anti-nutritional functions Cell signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corneal topographic changes and surgically induced astigmatism following combined phacoemulsification and 25-gauge vitrectomy

引用

International Journal of Ophthalmology(English edition) 2017年第1期10卷 72-76页

作者： Khulood mohammed Sayed Mahmoud M.farouk Takashi Katome Toshihiko Nagasawa Takeshi Naito Yoshinori MitamurA Department of Ophthalmology and Visual Neuroscience Instituteof Health BiosciencesUniversity of Tokushima GraduateSchool3-18-15 Kuramoto-choTokushima 770-8503Japan Department of Ophthalmology Sohag Faculty of MedicineSohag University82524 SohagEgypt

AIM： To evaluate corneal topographic changes and surgically induced astigmatism （SIA） after combined phacoemulsification and 25-gauge transconjunctival sutureless vitrectomy （25-G TSV）.METHODS： A retrospective study on 96 eyes of 87 patients who underwent combined phacoemulsification and 25-G TSV. The different topographic parameters and SIA were analyzed pre- and ***： There was no significant changes in corneal topographic parameters at different follow up periods. Only surface regularity index changed significantly in the 2nd postoperative week and then returned to baseline values thereafter. Mean SIA gradually decreased to reach 0.12 D by the 6th postoperative ***： Corneal surface and astigmatic changes are insignificant in either early or late postoperative periods following combined phacoemulsification and 25-G TSV. The SIA was the minimum among previous reports on sutureless vitrectomy alone or combined with phacoemulsification. Improvement of SIA did not stop at the 3rd postoperative month but it continued till the 6th month postoperatively.

关键词： Corneal topographic indices surgicallyinduced astigmatism 25-gauge sutureless vitrectomy phacoemulsification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical outcomes of transepithelial photorefractive keratectomy versus femtosecond laser assisted keratomileusis for correction of high myopia in South Egyptian population

引用

International Journal of Ophthalmology(English edition) 2020年第1期13卷 129-134页

作者： Amr Mounir Engy Mohamed Mostafa Hatem Ammar Osama Ali mohammed Alahmady Hamad Alsmman Mahmoud Mohamed farouk Mohamed Gamal Elghobaier Department of Ophthalmology Sohag Faculty of MedicineSohag UniversitySohag 82524Egypt Egyptian Police Hospitals Cairo 11765Egypt

AIM: To evaluate the safety and efficacy of transepithelial photorefractive keratectomy(t-PRK) with adjuvant mitomycin C(MMC) versus femtosecond laser assisted keratomileusis(Femto-LASIK) in correction of high ***: Prospective randomized comparative study including 156 eyes of 156 patients with high myopia and a spherical equivalent refraction(SER) <-6.00 D. They were divided randomly into two groups: Group A included 72 eyes treated with t-PRK with adjuvant MMC and Group B included 84 eyes treated with Femto-LASIK. Visual acuity, SER, corneal topography, pachymetry and keratometry were assessed for 12 mo ***: The preoperative mean SER was-8.86±1.81 and-9.25±1.70 D in t-PRK MMC group and Femto-LASIK respectively(P=0.99) which improved to-0.65±0.43 D and-0.69±0.50 D at 12 mo follow up. Mean SER remained stable during the 12 mo of follow-up, with no statistically significant difference between the two groups(P=0.64). In t-PRK MMC group, only six eyes needed retreatment after six months of follow up. And two eyes showed haze(one reversible haze grade 2, while the other had dense irreversible haze grade 4).CONCLUSION: t-PRK MMC provides safe and satisfactory visual outcomes and acceptable risk as Femto-LASIK in patients with high myopia.

关键词： transepithelial photorefractive keratectomy femtosecond laser assisted keratomileusis high myopia corneal haze Egypt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dietary supplementation of some antioxidants against hypoxia

引用

World Journal of Gastroenterology 2012年第44期18卷 6379-6386页

作者： Sanaa Ahmed Ali Hanan farouk Aly Lilla mohammed Faddah Zeenat F Zaidi Department of Therapeutic Chemistry Division of Pharmaceutical and Drug IndustriesNational Research CenterCairo 12622Egypt Department of Pharmacology College of PharmacyKing Saud UniversityRiyadh 11495Saudi Arabia Department of Anatomy Faculty Of MedicineKing Saud UniversityRiyadh 11495Saudi Arabia

The present study aims to clarify the protective effect of supplementation with some antioxidants,such as idebenone(200 mg/kg,ip),melatonin(10 mg/kg,ip) and arginine(200 mg/kg,ip) and their combination,on liver function(***,albumin,alanine aminotransferase,aspartate aminotransferase and alkaline phosphatase),energetic parameters(adenosine triphosphate,adenosine diphosphate,adenosine monophosphate,inorganic phosphate,total adenylate,adenylate energy charge and potential phosphate).The effect on glycolytic and glycogenolytic enzymes(glucose,glycogen,glycogen phosphorylase,pyruvate kinase and phosphofructokinase against hypoxia) was also *** drugs were administered 24 and 1 h prior sodium nitrite *** biochemical parameters were estimated 1 h after sodium nitrite *** of sodium nitrite(75 mg/kg,sc) produced a significant disturbance in all biochemical parameters of liver function,energetic parameters and glycolytic and glycogenolytic *** damage was confirmed by histopathological examination of the liver as compared to *** marked changes in hepatic cells induced by sodium nitrite were completely abolished by pretreatment with the drug combination,suggesting potential protection against sodium nitrite-induced *** could be concluded that a combination of both idebenone and melatonin or idebenone and arginine provides potential protection against sodium nitrite-induced hypoxia by improving biochemical parameters and preserving liver histology.

关键词： Hypoxia Idebenone Melatonin Nitrate/ni-trite Adenosine triphosphate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Efficient Method for Epileptic Seizure Detection in Long-Term EEG Recordings

引用

Journal of Biomedical Science and Engineering 2014年第12期7卷 963-972页

作者： Alaa Eldeen Mahmoud Helal Ahmed Farag Seddik mohammed Ali Eldosoky Ayat Allah farouk Hussein Biomedical Engineering Department Faculty of Engineering Helwan University Cairo Egypt Clinical Neurophysiology Department Faculty of Medicine Cairo University Cairo Egypt

Epilepsy is one of the most prevalent neurological disorders with no age, racial, social class, and neither national nor geographic boundaries. There are 50 million sufferers in the world today with 2.4 million new cases occur each year. Electroencephalogram (EEG) has become a traditional procedure to investigate abnormal functioning of brain activity. Epileptic EEG is usually characterized by short transients and sharp waves as spikes. Identification of such event splays a crucial role in epilepsy diagnosis and treatment. The present study proposes a method to detect three epileptic spike types in EEG recordings based mainly on Template Matching Algorithm including multiple signal-processing approaches. The method was applied to real clinical EEG data of epileptic patients and evaluated according to sensitivity, specificity, selectivity and average detection rate. The promising results illuminate that hybrid processing approaches in temporal, frequency and spatial domains can be a real solution to identify fast EEG transients.

关键词： Electroencephalogram (EEG) Seizure Detection Epilepsy Diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Bilateral Ultrasound-Guided Quadratus Lumborum Block versus Lumbar Epidural Block on Postoperative Analgesia following Major Lower Abdominal Cancer Surgery

引用

Open Journal of Anesthesiology 2021年第12期11卷 335-346页

作者： Moaaz Mohamed Tohamy Samy Abdelrahman Amr Ashraf Amin mohammed Ahmad Mohamad Abd El-Rahman Basma Rezk farouk Mohamed Galal Mostafa El-Naggar Mahmoud Mostafa mohammed Montaser A. Mohamed Department of Anesthesia Intensive Care and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt Department of Biostatistics and Cancer Epidemiology South Egypt Cancer Institute Assiut University Assiut Egypt Department of Clinical Pathology South Egypt Cancer Institute Assiut University Assiut Egypt Department of Surgical Oncology South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Poor postoperative pain control leads to longer postoperative care, longer hospital stay and decreased patient overall satisfaction. Aim: To compare the efficacy and safety of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on the management of postoperative pain following major lower abdominal cancer surgery. Methods: The study was a double-blinded, and randomized study, conducted in South Egypt Cancer Institute, Assiut University, Egypt. It included cancer patients scheduled for major lower abdominal cancer surgery in the period from 2019 to 2020. They were divided into two groups: Group Ι received pre-emptive ultrasound-guided Quadratus Lumborum Block (QLB) with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of General Anesthesia (GA), and Group II received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA. VAS score, and time of the first analgesic request and postoperative total analgesic consumption were evaluated. Results: Sixty patients were included in our study. VAS score at rest was comparable between both studied groups in the first 6 h. At 8 and 10 h, Group II had a significantly higher VAS score at rest (P Limitation:

关键词： Quadratus Lumborum Block Lumbar Epidural Block Postoperative Pain Abdominal Cancer Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：