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Advances in clinical applications of bioceramics in the new regenerative medicine era

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World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： Noha elshazly Fayza Eid Nasr Ayat Hamdy Safa Saied Mohamed elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt Department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and *** new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic *** these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue *** clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass *** results were promising and opened new frontiers for utilizing these materials on a larger *** same results were mentioned when using different forms and formulas of bioceramics in hard defect *** bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical *** this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine Bioceramics Chronic wounds Bone defects Clinical applications

A Study of Linke Turbidity Factor over Qena / Egypt

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Advances in Atmospheric Sciences 1996年第4期13卷 519-532页

作者： Sayed M. elshazly Department of Physics Faculty of Science South Valley University Qena/A.R. Egypt

Data on instantaneous atmospheric Linke turbidity factor TL (m) are reported for clear days at Qena/Egypt in the period from June 1992 to May ***(m) is determined using the values of irradiance of direct solar radiation (I),which are calculated from global (G) and diffuse (D) - solar radiation *** and seasonally variations of both diurnal and daily average values of TL (m) increases steadily in the direction of sunset in the months from June to December 1992 as well as Summer and Autumn seasons,while it falls generally in this direction for the months from January to March and Winter *** April and May,TL (m) fluctuates obviously through the day hours,it is also shown that the average values of TL(m) are particularly large during Summer months compared to other months of the *** behavior of TL(m) is discussed in view of the variations of some weather elements,which affect the content of water vapor and dust particle in the atmosphere of the study *** seems t be of similar trends to that of other locations inside and outside *** virtual variation of TL(m) is eliminated by reducing its value to relative optical air mass m=2,according to Kasten *** resulting TL (2) is more representative for the content of dust particles and water vapor in the atmosphere.

关键词： Turbidity Linke turbidity factor Seasonal and diurnal variations Solar radiations components measurements Aerosol

Photopic negative response in diagnosis of glaucoma:an experimental study in glaucomatous rabbit model

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 459-464页

作者： Amal A.El Gohary Laila Hassan M.elshazly Department of Ocular Physiology Research Institute of Ophthalmology Department of Ophthalmology Memorial Institute of Ophthalmology

AIM: To determine whether the photopic negative response(Ph NR) elicited by transient white flash on white background is characterizing for glaucoma model in ***: Glaucoma was induced in twelve rabbits by subconjunctival injection of 0.05 m L of betamethasone in right eyes(each 1 m L contain betamethasone dipropionate5 mg and betamethasone sodium phosphate 2 mg).The intraocular pressure(IOP), electroretinogram(ERG) and visual evoked potential(VEP) were measured successively prior and on the 3, 7d, two weeks and four weeks postglaucoma induction. After four weeks, the animals were sacrificed and the globes were histopathologically ***: The IOP increased significantly after one week(P =0.0001), then it gradually returned to the control level. In ERG examination, the means of a and b wave amplitude and latency were not affected *** NR amplitude decreased significantly within one week(P =0.0001), but its latency was not affected significantly(P =0.132). The means of VEP latency and amplitude were significantly affected after two weeks and four weeks of glaucoma induction(P =0.0001 and 0.02,respectively). The histopathologic examination of the globes showed reduced number of cells in the retinal ganglion cell layer with multiple vacuoles in the retinal nerve fibre *** was significant positive correlation between ganglion cell layer cells and Ph NR amplitude( r =0.8, P =0.002).CONCLUSION: The rise in IOP resulted in irreversible changes or incomplete recovery of VEP and Ph NR amplitude. Both Ph NR and VEP represented good additional tools in early diagnosis of glaucoma.

关键词： glaucoma electrophysiology photopic negative response rabbits

A secure image steganography algorithm based on least significant bit and integer wavelet transform

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Journal of Systems Engineering and Electronics 2018年第3期29卷 639-649页

作者： elshazly Emad ABDELWAHAB Safey ABOUZAID Refaat ZAHRAN Osama ELARABY Sayed ELKORDY Mohamed Engineering Department Nuclear Research CenterAtomic Energy AuthorityCairo 11787Egypt Electronics and Electrical Communications Engineering Department Faculty of Electronic EngineeringMenoufia UniversityMenouf 32952Egypt

The rapid development of data communication in modern era demands secure exchange of information. Steganography is an established method for hiding secret data from an unauthorized access into a cover object in such a way that it is invisible to human eyes. The cover object can be image, text, audio,or video. This paper proposes a secure steganography algorithm that hides a bitstream of the secret text into the least significant bits（LSBs） of the approximation coefficients of the integer wavelet transform（IWT） of grayscale images as well as each component of color images to form stego-images. The embedding and extracting phases of the proposed steganography algorithms are performed using the MATLAB software. Invisibility, payload capacity, and security in terms of peak signal to noise ratio（PSNR） and robustness are the key challenges to steganography. The statistical distortion between the cover images and the stego-images is measured by using the mean square error（MSE） and the PSNR, while the degree of closeness between them is evaluated using the normalized cross correlation（NCC）. The experimental results show that, the proposed algorithms can hide the secret text with a large payload capacity with a high level of security and a higher invisibility. Furthermore, the proposed technique is computationally efficient and better results for both PSNR and NCC are achieved compared with the previous algorithms.

关键词： image steganography image processing integer wavelet transform

Yttria Tetragonal Zirconia Biomaterials:Kinetic Investigation

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Journal of Materials Science & Technology 2011年第4期27卷 332-337页

作者： Ezzat S.elshazly S.M.El-Hout M.El-Sayed Ali Department of Mechanical Engineering Virginia Commonwealth University Deptartment of Metallurgy Nuclear Research CenterAtomic Energy Authority

The low temperature aging behavior of polycrystalline tetragonal zirconia was investigated to explore the effects on phase transformation occurring during the process. XRD analysis was conducted for the phase identification and the tetragonal to monoclinic phase transformation was determined. The aging of tetragonal zirconia polycrystals doped with 3 mol% Y203 triggers tetragonal to monoclinic phase transformation on the surface of the specimen only, while the penetration inside the bulk of the specimen is very limited. A slight decrease in the mechanical properties was also observed after aging for 40 h. The transformation kinetics show a nucleation and growth mechanism on the specimen surface to be dominant in the low temperature aging in water environment.

关键词： Low temperature degradation 3Y-TZP Kinetics

An overview of resistance to Human epidermal growth factor receptor 2(Her2)targeted therapies in breast cancer

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Cancer Drug Resistance 2022年第2期5卷 472-486页

作者： Ahmed M.elshazly David A.Gewirtz Department of Pharmacology and Toxicology Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh 33516Egypt. Department of Pharmacology and Toxicology Virginia Commonwealth UniversityRichmondVA 23298USA.

Breast cancer(BC)is the second most common cause of cancer-related deaths and the most frequently diagnosed cancer in *** breast cancer types,HER2-positive breast cancer occurs in nearly 20%of human breast cancers and is associated with increased aggressiveness,poor prognosis,and shortened overall ***2+breast cancer is currently managed with multidisciplinary treatment strategies including surgery,radiation,chemotherapy,and targeted *** resistance remains a continuing challenge,especially to targeted therapy utilizing monoclonal antibodies and tyrosine kinase *** review discusses some of the recent molecular mechanisms that are involved in the development of resistance to Her2-targeted therapies including the PI3K/Akt/mTOR pathway,IGF-IR,Src,c-MET,the PP2A family,CD36,p27^(kip1),and miRNAs.

关键词： HER2+ Targeted therapy resistance IGF-IR Src c-MET PP2A CD36 miRNA

Alumina Effect on the Phase Transformation of 3Y-TZP Ceramics

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Journal of Materials Science & Technology 2008年第6期24卷 873-877页

作者： Ezzat S.elshazly M.El-Sayed Ali S.M.El-Hout Department of Metallurgy Nuclear Research CenterAtomic Energy AuthorityCairoEgypt

The isothermal tetragonal-to-monoclinic phase transformation of 3 mol fraction Y2O3-ZrO2 ceramics contain- ing different amounts of Al2O3 during ageing in water at 130℃ for periods of time up to 40 h was investigated to explore the effect of Al2O3 addition on this transformation. The propagation of the transformation into the specimen interiors was suppressed by the addition of Al2O3. The transformation kinetics showed a nucleation and growth mechanism on the specimen surface to be dominant in the low temperature ageing in water environment.

关键词： Phase transformation 3Y-TZP Al2O3 Kinetics

Is autophagy induction by PARP inhibitors a target for therapeutic benefit?

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Oncology Research 2022年第1期30卷 1-12页

作者： AHMED M.elshazly TUONG VI V.NGUYEN DAVID A.GEWIRTZ Department of Pharmacology and Toxicology Virginia Commonwealth UniversityMassey Cancer CenterRichmondVA23298USA Department of Pharmacology and Toxicology Faculty of PharmacyKafrelsheikh UniversityKafrelsheikh33516Egypt

PARP inhibitors have proven to be effective in conjunction with conventional therapeutics in the treatment of various solid as well as hematologic malignancies,particularly when the tumors are deﬁcient in DNA repair ***,as the case with other chemotherapeutic agents,their effectiveness is often compromised by the development of *** inhibitors have consistently been reported to promote autophagy,a process that maintains cellular homeostasis and acts as an energy source by the degradation and reutilization of damaged subcellular organelles and *** can exhibit different functional properties,the most prominent being *** addition,both cytotoxic and non-protective functions forms have also been identiﬁ*** this review,we explore the available literature regarding the different roles of autophagy in response to clinically-used PARP inhibitors,highlighting the possibility of targeting autophagy as an adjuvant therapy to potentially increase the effectiveness of PARP inhibition and to overcome the development of resistance.

关键词： Olaparib Niraparib Rucaparib Talazoparib Autophagy Cytoprotective Cytotoxic Non-protective

A Survey of SQL Injection Attack Detection and Prevention

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Journal of Computer and Communications 2014年第8期2卷 1-9页

作者： Khaled elshazly Yasser Fouad Mohamed Saleh Adel Sewisy Assistant Professor Head of Department of Mathematics Faculty of Science Suez University Suez Egypt Demonstrator of Computer Science Information System Institute Suez Egypt Lecturer of Computer Science Faculty of Science Suez University Suez Egypt Professor of Computer Science Faculty of Computers & Information Assiut University Assiut Egypt

Structured Query Language Injection Attack (SQLIA) is the most exposed to attack on the Internet. From this attack, the attacker can take control of the database therefore be able to interpolate the data from the database server for the website. Hence, the big challenge became to secure such website against attack via the Internet. We have presented different types of attack methods and prevention techniques of SQLIA which were used to aid the design and implementation of our model. In the paper, work is separated into two parts. The first aims to put SQLIA into perspective by outlining some of the materials and researches that have already been completed. The section suggesting methods of mitigating SQLIA aims to clarify some misconceptions about SQLIA prevention and provides some useful tips to software developers and database administrators. The second details the creation of a filtering proxy server used to prevent a SQL injection attack and analyses the performance impact of the filtering process on web application.

关键词： SQL Injection Database Security Attack Authentication