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聚乙二醇化干扰素及其联合病毒唑的不良反应

中华肝脏病杂志 2003年第11期11卷 686-687页

作者：斯崇文北京大学第一医院 100034

聚乙二醇化干扰素(pegylated interferon,peg干扰素)因其与聚乙二醇(PEG)结合成大分子物质,从肾脏排泄慢,半衰期明显延长,较标准干扰素延长约6～10倍.

关键词：聚乙二醇化干扰素联合用药病毒唑不良反应利巴韦林病毒性肝炎

基于地震观测的钢框架结构有限元模拟与易损性分析

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防灾科技学院学报 2018年第4期20卷 16-22页

作者：王飞康现栋马洁美 Kalkan erol 北京市地震局北京100080 中国地震局地球物理研究所北京100081 美国地质调查局门罗帕克94025

基于性能的抗震设计需要揭示准确有效的地震动参数以满足结构易损性研究的要求。选择开展结构观测的6层钢结构作为分析实例,建立结构有限元模型。以Northridge地震中结构反应记录作为输入开展结构模态和动力反应分析。利用地震记录识别... 详细信息

基于性能的抗震设计需要揭示准确有效的地震动参数以满足结构易损性研究的要求。选择开展结构观测的6层钢结构作为分析实例,建立结构有限元模型。以Northridge地震中结构反应记录作为输入开展结构模态和动力反应分析。利用地震记录识别结构的自振特性和位移反应,将识别结果与分析结果进行对比,直至模型分析结果与识别结果吻合,完成有限元模型的标定。选择20条地震动开展结构增量动力分析,将基于PGA和Sa(T1)的顶层位移角分布曲线与Pushover分析曲线进行对比。分析表明Sa(T1)较PGA更适合开展该结构易损性研究。建立Sa(T1)和层间位移角的关系曲线,确定达到某一层间位移角水平的地震动数量,并以此作为计算概率密度函数的依据,构造出Probit概率密度模型,得到该结构达到不同破坏状态的易损性曲线。分析表明钢结构具有良好的抗震性能,适用于地震高风险区的建设工程。

关键词：地震观测有限元模拟增量动力分析地震动特性易损性曲线

CSCR中盐皮质激素受体基因-2G/C的多态性及其与血浆皮质醇水平的关系（英文）

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国际眼科杂志 2016年第7期16卷 1203-1206页

作者： Alper Yazici Esin Sogutlu Sari Betul Eser Gozde Sahin Medine Alpdemir Adil Kilic Muhammet Kazim erol Sitki Samet Ermis 土耳其巴勒凯西尔巴勒凯西尔大学医学院眼科 10150 土耳其巴勒凯西尔巴勒凯西尔大学医学院遗传学系 10150 土耳其巴勒凯西尔比格达奇州医院生物化学系 10010 土耳其安塔利亚安塔利亚培训与研究医院眼科

目的:评估中心性浆液性脉络膜视网膜(CSCR)病变中盐皮质激素受体基因-2G/C单核苷酸多态性,以及基因多态性和血浆皮质醇水平的关系。方法:选取60例中心性浆液性脉络膜视网膜病变患者和50例正常人作为研究对象。患者皆患有急性中心性浆液... 详细信息

目的:评估中心性浆液性脉络膜视网膜(CSCR)病变中盐皮质激素受体基因-2G/C单核苷酸多态性,以及基因多态性和血浆皮质醇水平的关系。方法:选取60例中心性浆液性脉络膜视网膜病变患者和50例正常人作为研究对象。患者皆患有急性中心性浆液性脉络膜视网膜病变,即浆液性视网膜脱离和视网膜色素上皮脱离或功能障碍(排除其它可能导致渗出的疾病,比如脉络膜新生血管、炎症或浸润病变)。为避免皮质醇水平的昼夜变化,上午8时到10时之间采集外周血样,检测盐皮质激素受体基因多态性(rs2070951)和血浆皮质醇水平。结果:CSCR组的基因型频率分布为G/C(46.6%),G/G(26.7%)和C/C(26.7%)。两组间基因型分布无统计学差异(P=0.96)。研究结果显示,CSCR组的血浆皮质醇水平为401.2±162.1 nmol/L,对照组为296.8±130.1nmol/L,两组间差异有统计学意义(P<0.01)。血浆皮质醇水平在G/C(345.0±137.0 nmol/L),G/G(369.2±165.3 nmol/L)和C/C(395.3±188.8 nmol/L)基因型之间不存在差异(P=0.50)。结论:盐皮质激素受体基因多态性与中心性浆液性脉络膜视网膜病变和血浆皮质醇水平无关。

关键词：盐皮质激素黄斑中心性浆液性脉络膜视网膜病变多态性遗传学

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2014年8月24日纳帕南部6.0级地震

国际地震动态 2016年第2期37卷 22-23页

作者： erol Kalkan 徐文杰曹金名 U.S.Geological Survey 中国地震局工程力学研究所

2014年8月24日,美国加利福尼亚北部发生了MW6.0地震,震中位于纳帕（Napa）市西南-南9km处,纳帕市受此次地震影响较大。市中心记录的水平峰值地面加速度高达0.62g。继1989年洛马普列塔MW6.9地震后,此次地震是25年来加州北部遭受的最大地... 详细信息

2014年8月24日,美国加利福尼亚北部发生了MW6.0地震,震中位于纳帕（Napa）市西南-南9km处,纳帕市受此次地震影响较大。市中心记录的水平峰值地面加速度高达0.62g。继1989年洛马普列塔MW6.9地震后,此次地震是25年来加州北部遭受的最大地震。地震造成1人死亡,约200人受伤,

关键词：峰值地面加速度洛马强地面运动尼亚断层破裂反演方法波场大地测量学层应力重度损伤

老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系

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Asian Journal of Andrology 2013年第6期15卷 785-789,I0008页

作者： Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk erol Adil Esenx Department of Urology Dokuz Eylul University Faculty of Medicine Izmir 35340 Turkey Division of Urology Doc. Dr. Yasar Eryilmaz Dogubayazit State Hospital Agri 04900 Turkey Department of Urology Celal Bayar University Manisa 45040 Turkey Department of Urology Sifa University Izmir 35230 Turkey Clinic of Urology Ataturk Training and Research Hospital Izmir 35965 Turkey Division of Urology Adiyaman 82. Yll State Hospital Adiyaman 02040 Turkey Department of Urology Pamukkale University Faculty of Medicine Denizli 20020 Turkey Clinic of Urology Tepecik Training and Research Hospital Izmir 35120 Turkey Department of Urology Adnan Menderes University Faculty of Medicine Aydin 09100 Turkey

The aim of this study was to evaluate the relationship between lower urinary tract symptoms （LUTSs）, erectile dysfunction （ED） and symptomatic late-onset hypogonadism （SLOH） in ageing men in the Aegean region of Turkey. Five hundred consecutive patients 〉40 years old who had been in a steady sexual relationship for the past 6 months and were admitted to one of six urology clinics were included in the study. Serum prostate-specific antigen and testosterone levels and urinary flow rates were measured. All patients filled out the International Prostate Symptom Score and Quality of Life （IPSS-QoL）, International Index of Erectile Function （IIEF） and Aging Males＇ Symptoms （AMS） scale forms. Of the patients, 23.9% had mild LUTSs, 53.3% had moderate LUTSs and 22.8% had severe LUTSs. The total testosterone level did not differ between groups. Additionally, 69.6% had ED. The presence of impotence increased with increasing LUTS severity. Symptomatic late-onset hypogonadism （AMS 〉27） was observed in 71.2% of the patients. The prevalence of severe hypogonadism symptoms increased with the IPSS scores. A correlation analysis revealed that all three questionnaire scores were significantly correlated. In conclusion, LUTS severity is an age-independent risk factor for ED and SLOH. LUTS severity and SLOH symptoms appear to have a strong link that requires etiological and biological clarification in future studies.

关键词： ageing male erectile dysfunction lower urinary tract symptoms symptomatic late-onset hypogonadism symptom scores testosterone

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基因多态性与乙型和丙型肝炎病毒感染的关系

中华肝脏病杂志 2003年第11期11卷 698-700页

作者：张绪清第三军医大学西南医院全军感染病研究所重庆市400038

宿主在乙型肝炎病毒(hepatitis B virus,HBV)和丙型肝炎病毒(hepatitis C virus,HCV)感染后不同的临床发展过程,除了与病毒本身的因素有关外,更重要的是由于不同个体对HBV/HCV感染所发生的免疫反应的不同.

关键词：基因多态性乙型肝炎病毒感染丙型肝炎病毒感染肿瘤坏死因子α 白细胞介素10

Application of scoring systems with point-of-care ultrasonography for bedside diagnosis of appendicitis

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World Journal of Emergency Medicine 2016年第2期7卷 124-129页

作者： Erden erol Unluer Rifat Urnal Utku Eser Serkan Bilgin Mehmet Haciyanh Orhan Oyar Haldun Akoglu Arif Karagoz Department of Emergency Medicine Ataturk Training and Research Hospital Izmir Katip Celebi University Karabaglar Izmir 35150 Turkey Department of General Surgery Ataturk Training and Research Hospital Izmir Katip Celebi University Karabaglar Izmir 35150 Turkey Department of Radiology Ataturk Training and Research Hospital Izmir Katip Celebi University Karabaglar Izmir 35150 Turkey Department of Emergency Medicine Faculty of Medicine Marmara University Istanbul Istanbul 34890 Turkey Department of Emergency Medicine Karstyaka State Hospital Karstyaka Izmir 35520 Turkey

BACKGROUND: Appendicitis is a common disease requiring surgery. Bedside ultrasound(BUS) is a core technique for emergency medicine(EM). The Alvarado score is a well-studied diagnostic tool for appendicitis. This study aimed to investigate the relationship between patients' symptoms, Alvarado score and ultrasound(US) findings, as performed by emergency physicians(EPs) and radiologists, of patients with suspected ***: Three EM specialists underwent the BUS course and core course for appendicitis assessment. Patients suspected of having appendicitis were selected and their Alvarado and modif ied(m) Alvarado scores calculated. The specialists performed the BUS. Then, patients were given a formal US and surgery consultation if necessary. Preliminary diagnoses, admission or discharge from the emergency department(ED) and fi nal diagnosis were documented. The patients were also followed up after discharge from the ***: The determined cut-off value was 2 for Alvarado and 3 for m Alvarado scores. The sensitivities of the two scores were 100%. Each score was used to rule out appendicitis. The results of EP-performed BUS were as follows: accuracy 70%, sensitivity 0.733, specifi city 0.673, + LR 2.24, and – LR 0.40(95%CI). Radiologists were better than EPs at diagnosing appendicitis and radiologists and EPs were equally strong at ruling out appendicitis by US. When US was combined with Alvarado and m Alvarado scores, EP US+Alvarado/m Alvarado scores ≤3 and radiology US+Alvarado/m Alvarado scores ≤4 perfectly ruled out ***: BUS performed by EPs is moderately useful in detecting appendicitis. Combined with scoring systems, BUS may be a perfect tool for ruling out decisions in EDs.

关键词： Bedside ultrasound Alvarado score Appendicitis

硼氢化钠还原樟脑制备异冰片--国外本科生实验的介绍与讨论

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化学教育（中英文） 2020年第8期41卷 108-111页

作者：王志鹏蒋振雄杨雪梅 erol Can Vatansever 马新雨颜惠娟许兵 Department of Chemistry Texas A&M UniversityCollege StationTXUSA77840 Department of Biology Texas A&M UniversityCollege StationTXUnited States77840 Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTXUnited States77840

冰片作为一种自然界广泛存在的次级代谢产物,可以通过樟脑的还原反应制备。但由于冰片极易氧化为樟脑,实验室中常使用硼氢化钠还原樟脑制备冰片的方法。该法可能生成2种冰片异构体,可以通过动力学控制获得其中一个异冰片从而使其成为不... 详细信息

冰片作为一种自然界广泛存在的次级代谢产物,可以通过樟脑的还原反应制备。但由于冰片极易氧化为樟脑,实验室中常使用硼氢化钠还原樟脑制备冰片的方法。该法可能生成2种冰片异构体,可以通过动力学控制获得其中一个异冰片从而使其成为不可逆反应。该有机化学实验设计在美国与欧洲国家均有涉及,但在国内教材中只是单纯设计为环己酮等单分子的还原反应,缺乏体现化学在解决实际问题中的实用性以及课堂的趣味性。该实验的引进不失为改进国内有机化学实验设计的良好素材。

关键词：硼氢化还原樟脑硼氢化钠异冰片

Basis of Halal Lifestyle in Islamic Law

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Journal of Food Science and Engineering 2021年第1期11卷 23-32页

作者： Ayten erol The Department of Basic Islamic Sciences Faculty of Islamic SciencesUniversity of KırıkkaleKırıkkale 71450Turkey

The halal lifestyle in Islamic law is evaluated within the principles of makasidus-sharia,which aim to protect five principal vales of humanity,namely,life,reason,religion,generation and *** legitimacy of halal life is therefore based on the provisions of the Qur’an and Sunnah that aim to protect these values of all *** similarities between halal and other ethical practices in the context of universal values concerning both Muslims and non-Muslims will provide an opportunity for global recognition of halal *** this article we investigate how halal lifestyle is to be based according to Islamic *** first frame the halal life and later lay down its legal basis and finally conclude by illuminating on the halal lifestyle from a universal perspective.

关键词： Islamic law halal lifestyle halal earning production and consumption.