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Analyzing the Effects of Tool Holder Stiffness on Chatter Vibration Reduction in Turning

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Journal of Metallic Material Research 2023年第1期6卷 16-24页

作者： Kadir Gok erol Turkes Özler Karakas Arif Gok Department of Biomedical Engineering Engineering and Architecture FacultyIzmir Bakircay UniversityIzmir35000Turkey Department of Mechanical Engineering Engineering FacultyKırklareli UniversityKırklareli39010Turkey Department of Mechanical Engineering Engineering FacultyPamukkale UniversityDenizli20100Turkey Department of Industrial Design Architecture FacultyKutahya Dumlupinar UniversityKutahya43020Turkey

This paper investigates the effects of tool holder materials on chatter vibration in turning *** study uses a complex dynamic turning model with two degrees of freedom for the orthogonal cutting *** holders made from different materials,including Al 5083,Al 6082,Al 7012,and a standard 4140 material,were subjected to chatter vibration to investigate their process damping *** study found that the standard tool holder 4140 allows for higher stable depths of cut and produces similar process damping values compared to the other tool *** element analyses(FEA)were performed to verify the experimental results,and the modal and FEA analyses produced very similar *** study concludes that future research should investigate the effects of tool holders made from high alloy steel alloys on process ***,this paper provides important insights into the effects of tool hold-er materials on chatter vibration and process damping in turning operations,which can help in the design of more effi-cient and effective cutting systems.

关键词： Turning Tool holder Chatter Process damping Finite element analysis

伯氏疏螺旋体与嗜吞噬细胞无浆体感染抑制Th1型细胞因子产生

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中国热带医学 2007年第7期7卷 1061-1063,1070页

作者：宝福凯 erol Fikrig 昆明医学院微生物学与免疫学教研室 Department of Internal Medicine Yale University School of MedicineNew HavenCT06511USA.

目的应用动物模型探讨蜱传病原体伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染对Th1型细胞因子产生的影响。方法建立三种伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染小鼠模型和伯氏疏螺旋体单一感染小鼠模型。将小鼠分A组(同时感染组)、B组(伯... 详细信息

目的应用动物模型探讨蜱传病原体伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染对Th1型细胞因子产生的影响。方法建立三种伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染小鼠模型和伯氏疏螺旋体单一感染小鼠模型。将小鼠分A组(同时感染组)、B组(伯氏疏螺旋体先于嗜吞噬细胞无浆体感染组)、C组(嗜吞噬细胞无浆体先于伯氏疏螺旋体感染组)、D组(伯氏疏螺旋体单感染组)和E组(无感染对照组)等共5组,每组16只,在不同时间点测定各组小鼠血清Th1型细胞因子浓度,并对数据进行统计学分析。结果与单一感染组相比,在螺旋体感染后18d和30d,三种混合感染组小鼠血清中Th1型细胞因子显著偏低。结论伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染显著抑制Th1型细胞因子产生。

关键词：混合感染伯氏疏螺旋体嗜吞噬细胞无浆体莱姆病细胞因子

Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?

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Open Journal of Ophthalmology 2020年第1期10卷 10-20页

作者： Elcin Süren,Ersan Cetinkaya Mehmet Fatih Kücük Musatafa Kalayci Muhammet Kazim erol Antalya Training and Research Hospital Department of OphthalmologyAntalyaTurkey

Purpose: To investigate the effects of intravitreal anti-vascular endothelial growth factor (VEGF) for treatment of type-1 or aggressive posterior retinopathy of prematurity (ROP) on photoreceptor maturation in preterm infants using spectral domain optical coherence tomography (SD-OCT). Methods: A study group of 36 patients with ROP treated with anti-VEGF therapy was compared to a control group of 80 patients with ROP. All patients had undergone SD-OCT imaging at least once between 40 and 44 weeks post-menstrual age (PMA). Two imaging specialists evaluated the images for ellipsoid zone (EZ) development, cystoid macular edema (CME), sub-retinal fluid (SRF) at the fovea, and cone outer segment tips (COST). The outer nuclear layer thickness and the distance from the EZ to the central fovea was measured. Results: EZ development was observed in 18 (50%) patients in the study group and 68 (85%) in the control group (p = 0.002). CME was observed in 17 (47.2%) patients in the study group and 17 (21.2%) in the control group. The distance between the EZ and central fovea was 868 ± 440 μm in the study group and 725 ± 380 μm in the control group (p = 0.02). COST was not observed in any patient. Regression analysis indicated that anti-VEGF treatment and CME affect EZ development. Conclusions: Early photoreceptor maturation is correlated with preterm birth week but not ROP stage. Anti-VEGF treatment delays photoreceptor maturation in preterm infants.

关键词： Cystoid Macular Edema Photoreceptor Retinopathy of Prematurity Vascular Endothelial Growth Factor

An Unusual Paraneoplastic Syndrome of Synchronous Bladder Tumor and Prostate Cancer: Polymyositis

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Open Journal of Urology 2015年第10期5卷 179-181页

作者： Huseyin Badem Mehmet erol Yildirim Serife Badem Ozlem Sahin Balcik Sedat Tastemur Ersin Cimentepe Urology Department Turkey Yuksekİhtisas HospitalAnkaraTurkey Urology Department Turgut Ozal Universty HospitalAnkaraTurkey Radiology Department Turkey Yuksekİhtisas HospitalAnkaraTurkey Haematology Department Turgut Ozal Universty HospitalAnkaraTurkey

Introduction: Polymyositis (PM) is a type of inflammatory myopathy that is associated with a broad range of malignant disorders. An association of PM with synchronous carcinoma of the bladder and prostate is extremely rare. Case: A 65-year-old man admitted to hematology with complaints of severe progressive weakness of lower extremities, hematuria and irritative urinary symptoms lasting for a month. The hemogram and erythrocyte sedimentation rate were normal. ALT was normal but AST was 405.56 U/l. There was marked elevation of serum creatine kinase (CK) and lactate dehydrogenase, which were 14,065.15 U/l and 1267.50 U/l, respectively. PSA was 4.28 and DRE was positive. The abdominal ultrasound revealed a 24 × 20 mm soft tissue echogenicity lesion at the right wall and a 35 × 21 mm soft tissue echogenicity lesion at the left wall of the bladder. The rest of the abdominal viscera were normal. Computed tomography found, two 6 mm solid lesions at left anterolateral and a 18 × 12 mm solid lesion at inferoanterior bladder wall in addition to the above findings. Patient counseled to us. We resected all of the bladder masses with transurethral (TUR-BT) way and pathology revealed T2 high grade bladder tumor. Two days after TUR-BT, we performed a trans rectal ultrasonography guided prostate biopsy and pathology revealed a Gleason 3 + 4 prostate cancer. EMG showed sensorimotor polyneuropathy at the lower extremities, sustaining polymyozitis. Biopsy of the right peroneus brevis muscle showed no vasculitis with low grade neurologic changes. We offered to perform a radical cystoprostatectomy operation but the patient prefered chemotherapy. Two months after his initial presentation at the second cure of the chemotherapy all muscle weaknesses showed a dramatic regression. Conclusion: This case report indicates that both bladder carcinoma and prostate cancer should be kept in mind in elderly PM patients presenting with lower urinary tract symptoms and hematuria.

关键词： Polymyositis Bladder Tumor Prostate Cancer Emg

High pressure paint gun injury of the index finger:a case report

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Plastic and Aesthetic Research 2015年第1期2卷 350-352页

作者： Memet Yazar Zeliha Gül Ali Can Günenç Sevgi Kurt Yazar erol Kozanoğlu Plastic Reconstructive and Aesthetic Surgery ClinicSisli Etfal Training and Research Hospital34371 IstanbulTurkey Plastic Reconstructive and Aesthetic Surgery ClinicIstanbul Training and Research Hospital34098 IstanbulTurkey Plastic Reconstructive and Aesthetic Surgery ClinicIstanbul UniversityIstanbul Medicine Faculty34093 IstanbulTurkey

Injuries to the hand secondary to high pressure paint guns are considered to be true hand *** rare injuries may have serious outcomes,and a critical step in their management is extensive debridement performed within the first six hours following *** this reason,their diagnosis should not be delayed,and the hand surgeon should be informed immediately to initiate appropriate *** this report,the authors describe a patient who was injured with a chemical paint gun,and whose injury was not diagnosed in the emergency *** patient subsequently developed *** treatment is reported herein.

关键词： Finger injury high pressure injury trauma

YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams W.M.Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（LC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

Three Consecutive Monthly Intravitreal Ranibizumab for Choroidal Neovascularization in Central Serous Choriorethinopathy:A Case Report

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Open Journal of Ophthalmology 2012年第3期2卷 93-96页

作者： Kazim erol Esin Sogutlu Sari Arif Koytak A.Karacor D.T.Coban M.Bulut Ophthalmology Department Antalya Training and Research HospitalAntalyaTurkey Ophthalmology Department Kartal Training and Research HospitalIstanbulTurkey Ophthalmology Department Bezmialem Vakif UniversityIstanbulTurkey

Purpose: The author report the result of three consecutive monthly intravitreal ranibizumab injection for choroidal neovascularization (CNV) after bevacizumab injection for chronic central serous rethinopathy (CSR). Methods: A 48 year old man with chronic CSR was treated with intravitreal single dose 2.5 mg bevacizumab. One year after CNV was occurred, and three consecutive monthly intravitreal ranibizumab injections were performed. Results: Four weeks later the first ranibizumab dose, best corrected visual acuity was improved 20/80 to 20/20 and remained stable within one year. Conclusion: Repeat intravitreal ranibizumab injection in CNV after bevacizumab injection for chronic CSR appeared to be an effective treatment option.

关键词： Central Serous Choriorethinopathy Choroidal Neovascularization Ranibizumab

Pathological and immunohistochemical findings of lungs,heart,liver,and kidneys,and unexpected findings of fungi and parasites in lungs of deceased COVID-19 patients:A case series

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Journal of Acute Disease 2023年第5期12卷 204-212,I0001-I0003页

作者： Mehmet N.Yakar Bişar Ergün Aylin erol Özde Gökbayrak TekincanÇ.Aktaş Özlem Ulusan Bağcı Fırat Bayraktar Eyüp S.Uçan Begüm Ergan Bilgin Cömert Ayşe Caner Safiye Aktaş Ali N.Gökmen Division of Intensive Care Department of Anaesthesiology and ReanimationFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Division of Intensive Care Department of Internal MedicineFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Department of Basic Oncology Institute of OncologyDokuz Eylül UniversityİzmirTurkey Department of Basic Oncology Institute of Health SciencesEge UniversityİzmirTurkey Department of Parasitology Faculty of MedicineEge UniversityİzmirTurkey Division of Endocrinology and Metabolic Diseases Department of Internal MedicineFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Department of Chest Diseases Faculty of MedicineDokuz Eylül UniversityİzmirTurkey

Objective:To define histopathologic and immunohistochemical features of the lungs,heart,liver,and kidneys in patients who died from coronavirus disease 2019(COVID-19),and to determine the presence of SARS-CoV-2 in all tissues,as well as the presence of fungi and parasites in lung ***:This retrospective case study was conducted in the intensive care units of Dokuz Eylül University Hospital,and patients(≥18 years)who died due to COVID-19 between October 2020 and April 2021 were *** biopsy samples of the patient’s lung,heart,liver,and kidney tissues were ***:In the study,we enrolled 12 patients(mean age:70 years;50%male).Alveolar epithelial cell damage and diffuse alveolar damage were predominant in lung *** lymphocyte infiltration,centrilobular sinusoidal dilatation,and microvesicular steatosis in the liver,together with pigmented cast,non-isometric vacuolar degeneration,and capillary plugging in the kidneys,were commonly found among the ***-CoV-2 nucleocapsid protein antibodies were detected in three lung and two kidney tissues,and so did angiotensin-converting enzyme 2 receptor positivity in one lung and more than half of the kidney *** RT-PCR tests were positive in three lungs and one kidney *** DNA isolation from lung tissues,Pneumocystis jirovecii was detected in nine patients,Aspergillus fumigatus in two,Microsporidia in three,and Cryptosporidium in ***:SARS-CoV-2 is a multisystemic *** and parasites should be investigated in critically ill COVID-19 patients prescribed corticosteroids.

关键词： Biopsy COVID-19 Histopathology Immunohisto-chemistry Opportunistic infections SARS-CoV-2

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酒精性肝病的发病机制

中华肝脏病杂志 2003年第11期11卷 690-691页

作者：厉有名浙江大学医学院附属第一医院杭州310003

1.肝脏酒精代谢产物损伤:(1)乙醛的化学性损害:机体摄入的酒精90%以上在肝脏代谢,经过乙醇脱氢、肝微粒体乙醇氧化酶系统和过氧化氢酶氧化成乙醛,乙醛可损害各种细胞器和酶的结构功能;又能刺激免疫系统,诱发免疫反应性肝损害;损害线粒... 详细信息

1.肝脏酒精代谢产物损伤:(1)乙醛的化学性损害:机体摄入的酒精90%以上在肝脏代谢,经过乙醇脱氢、肝微粒体乙醇氧化酶系统和过氧化氢酶氧化成乙醛,乙醛可损害各种细胞器和酶的结构功能;又能刺激免疫系统,诱发免疫反应性肝损害;损害线粒体脂肪酸的β氧化,引起脂质过氧化反应,抑制谷胱甘肽(GSH)的生物合成,减弱超过氧化物酶等抗氧化功能.

关键词：酒精性肝病发病机制线粒体损害氧应激脂质过氧化