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Effects of granulocyte-colony stimulating factor on peritoneal defense mechanisms and bacterial translocation after administration of systemic chemotherapy in rats

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World Journal of Gastroenterology 2007年第18期13卷 2596-2599页

作者： Celal Cerci Cagri Ergin erol Eroglu Canan Agalar Fatih Agalar Sureyya Cerci Mahmut Bulbul Suleyman Demirel University School of Medicine General Surgery Department Isparta Turkey Pamukkale University School of Medicine Clinical Microbiology Department Denizli Turkey K■r■kkale University School of Medicine Infectious Diseases Department K■r■kkale Turkey K■r■kkale University School of Medicine General Surgery Department K■r■kkale Turkey Suleyman Demirel University School of Medicine Nuclear Medicine Department Isparta Turkey

AIM： To investigate the effects of granulocyte-colony stimulating factor （G-CSF） on peritoneal defense mechanisms and bacterial translocation after systemic 5-Fluorouracil （5-FU） administration. METHODS： Thirty Wistar albino rats were divided into three groups; the control, 5-FU and 5-FU ＋ G-CSF groups. We measured bactericidal activity of the peritoneal fluid, phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid, total peritoneal cell counts and cell types of peritoneal washing fluid. Bacterial translocation was quantified by mesenteric lymph node, liver and spleen tissue cultures. RESULTS： Systemic 5-FU reduced total peritoneal cell counts, neutrophUs and macrophage numbers. It also altered bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. 5-FU also caused significant increase in frequencies of bacterial translocation at the liver and mesenteric lymph nodes. G-CSF decreased bacterial translocation, it significantly enhanced bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. It also increased total peritoneal cell counts, neutrophils and macrophage numbers. CONCLUSION： Systemic 5-FU administration caused bacterial translocation, decreased the bactericidal activity of peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid. G-CSF increased both bactericidal activity of the peritoneal fluid and phagocytic activity of polymorphonuclear leucocytes in the peritoneal fluid, and prevented the bacterial translocation. We conclude that intraperitoneal GCSF administration protects the effects of systemic 5-FU on peritoneal defense mechanisms.

关键词： Granulocyte-colony stimulating factor 5-Fluorouracil Bacterial translocation Peritoneal defensemechanisms

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Gastric polypoid lesions:Analysis of 150 endoscopic polypectomy specimens from 91 patients

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World Journal of Gastroenterology 2003年第10期9卷 2236-2239页

作者： Rasim Gencosmanoglu Ebru Sen-Oran Ozlem Kurtkaya-Yapicier erol Avsar Aydin Sav Nurdan Tozun the Unit of Surgery Institute of GastroenterologySchool of MedicineMarmara UniversityIstanbulTurkey Department of Pathology School of MedicineMarmara UniversityIstanbulTurkey the Unit of Gastroenterology Institute of GastroenterologySchool of MedicineMarmara UniversityIstanbulTurkey

AIM:To analyze gastric polypoid lesions in our patient- population with respect to histopathologic features and demographic,clinical,and endoscopic characteristics of patients. METHODS:Clinical records and histopathologic reports of patients with gastric polypoid lesions were analyzed *** lesions had been totally removed by either endoscopic polypectomy or hot biopsy *** histopathologic slides were re-evaluated by the same histopathologist. RESULTS:One-hundred and fifty gastric polypoid lesions were identified in 91 *** were 53(58 %)women and 38(42 %)men with a median age of 53(range,31 to 82)*** most frequent presenting symptom was dyspepsia that was observed in 35(38.5 %)patients. Symptoms were mostly related to various associated gastric abnormalities such as chronic gastritis or H pylori infection rather than polypoid lesion *** lesions were commonly located in the antrum followed by *** of 150 lesions,80(53 %)had the largest dimensions less than or equal to 5 mm and only 7 were *** frequencies of hyperplastic polyps,foveolar hyperplasia,and fundic gland polyps were 46 %,18 %,and 14 % respectively. We also detected gastritis varioliformis in 12 specimens, lymphoid follicles in 9,4 adenomatous polyps in 4,polypoid lesions with edematous mucosa in 4,inflammatory polyps in 3,and carcinoid tumor in *** changes were observed within two hyperplastic polyps and low grade dysplasia in one *** evaluation of the surrounding gastric mucosa demonstrated chronic gastritis in 72(79 %)patients and H pylori infection in 45(49 %). CONCLUSION:Hyperplastic polyps are the mbst frequently encountered subtype of gastric polypoid *** are usually associated with chronic gastritis or H pylori *** to the previous belief,they may harbour adenomatous changes or dysplastic foci. Therefore,endoscopic polypectomy seems as a safe and fast procedure for both diagnosis a

关键词： Adult Aged Aged, 80 and over Dyspepsia Endoscopy, Digestive System Female Humans Hyperplasia Male Middle Aged Polyps Stomach Neoplasms

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Electron Microscopic Investigation of Anterior Lens Capsule and Epithelium in Patients with Diabetes Mellitus

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International Journal of Clinical Medicine 2018年第10期9卷 778-786页

作者： Yasemin Ozdamar erol Candan Ozogul Ufuk Elgin Fatma Helvacioglu Orhan Zilelioglu Department of Retinal Diseases and Vitreoretinal Surgery Ulucanlar Eye Educationand Research Hospital Ankara Turkey Department of Histology and Embryology Faculty of Medicine Gazi University Ankara Turkey Ulucanlar Eye Educationand Research Hospital Ankara Turkey

Purpose: To evaluate the histopathologic alterations of organelles in the epithelium of the anterior lens capsule. Methods: The interventional study included 26 eyes;of which 11 had non-proliferative diabetic retinopathy (diabetic group) and cataract, and 15 had age-related cataract (control group). We investigated the anterior lens capsule in patients with diabetes mellitus by using electron microscopy and to compare it between diabetic eyes and healthy eyes. Anterior capsule samples were obtained by circular continuous capsulorhexis during phacoemulsification procedures. All the samples were fixed and conventionally processed for electron microscopy analysis. Results: Demographic characteristics of the diabetic group and the control group were similar (p > 0.05). In the diabetic group, electron dense cells with an apoptotic appearance were seen and these cells had an apoptotic nucleus and prominent mitochondrial crystalysis. In addition, there was dilatation of the endoplasmic reticulum cistern. In the control group, lens epithelial cells and all their elements had a normal pattern. Neither cells with an apoptotic appearance nor mitochondrial crystalysis was seen, but there was dilatation of the endoplasmic reticulum cistern. Conclusions: Diabetes mellitus can engender structural abnormalities of organelles in the epithelium of the anterior lens capsule including mitochondrial crystalysis, dilatation of the endoplasmic reticulum cistern and apoptotic dense nucleus. It can be suggested that diabetes mellitus affects organelles of anterior lens epithelium in eyes with cataracts, while it causes non-proliferative changes in the retina.

关键词： Anterior Lens Epithelium Cataract Diabetes Mellitus Endoplasmic Reticulum Mitochondria

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Coagulation of a giant hemangioma in glans penis with holmium laser

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Asian Journal of Andrology 2008年第5期10卷 819-821页

作者： Emin Aydur Bulent erol Lutfi Tahmaz Hasan Cem Irkilata Cenker Eken Ahmet Fuat Peker Department of Urology Gulhane Military Medical Academy Etlik Ankara 06018Turkey Department of Emergency Medicine Gulhane Military Medical Academy Etlik Ankara 06018 Turkey

A 21-year-old man presented with an enlarged giant hemangioma on glans penis which also causes an erectile dysfunction （ED） that partially responded to the intracavernous injection stimulation test. Although the findings in magnetic resonance imaging （MRI） indicated a glandular hemangioma, penile colored Doppler ultrasound revealed an invaded cavernausal hemangioma to the glans. Surgical excision was avoided according to the broad extension of the gland lesion. Holmium laser coagulation was applied to the lesion due to the cosmetically concerns. However, the cosmetic results after holmium laser application was not impressive as expected without an improvement in intracavernous injection stimulation test. In conclusion, holmium laser application should not be used to the hemangiomas of glans penis related to the corpus cavernosum, but further studies are needed to reveal the effects of holmium laser application in small hemangiomas restricted to the glans penis.

关键词： lasers, penis, erectile dysfunction hemangioma holmium laser

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Is External Ventricular Drainage Life-Saving in Cerebellar Hemorrhages?

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Open Journal of Modern Neurosurgery 2019年第2期9卷 154-163页

作者： Suat erol Celik Ajlan Uzunkol Buse Sarigul Halil Olgun Peker Yunus Kurtulus Department of Neurosurgery Okmeydani Training and Research HospitalIstanbulTurkey

Background: The treatment of cerebellar hemorrhage (CH) may be different surgery or conservative according to the hematoma volume, compression of vital structures or hydrocephalus existence. In the present study, the authors investigated the risk factors, the indications and the situation of external ventricular drainage (EVD) on the treatment line. Methods: 63 pure cerebellar hemorrhage patients were enrolled in the study. 36 cases underwent surgery;the other 27 were received conservative treatment. 15 and 13 cases received EVD in both groups. Hospital stay and mortality rates were investigated. Results: 4 cases in the conservative group underwent surgery secondary to treatment failure. Both of the groups had equal rates of morbidity and mortality. On the other hand, the group that received surgical intervention had shorter median hospital stay. The EVD does not seem to be life-saving at first but it gives time for preparing for surgery. Conclusions: We found that CH was strongly associated with early hydrocephalus and mortality. The early diagnosis and surgical evacuation of the mass are mandatory and life-saving if hematoma is larger than 10 ml. The EVD may not being a life-saving instrument but majorly it may be a time earning device if acute hydrocephalus present.

关键词： Cerebellar Hemorrhage External Ventricular Drainage Hydrocephalus Hypertension

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The Impact of Aggressive Behaviour, Sleeping, and Fatigue on Road Traffic Crashes as Comparison between Minibus/Van/Pick-up and Commercial Taxi Drivers

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Journal of Traffic and Transportation Engineering 2017年第1期5卷 21-31页

作者： Abdulbari Bener Timo Lajunen Turker Ozkan erol Yildirim Khair S. Jadaan Department of Biostatistics and Medical Informatics Cerrahpasa Faculty of Medicine Istanbul University Istanbul 34098Turkey Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences University of ManchesterManchester M13 9PL UK Department of Psychology Istanbul Medipol University Kavacik 34810 Beykoz istanbul Turkey Safety Research Unit Department of Psychology Middle East Technical University Ankara 06800 Turkey Department of Civil Engineering Faculty of Engineering University of Jordan Amman 11942 Jordan Department of Transportation Engineering University of Illinois at Urbana-Champaign IL 61820-6983 USA

No study has been conducted to determine the relationship between RTC （road traffic crashes） and depression, anxiety and stress scale （DASS-21）, tiredness, fatigues and sleeping. The aim of the present study was to examine the effect of aggressive driver behaviour, fatigue and sleeping on RTC comparison between commercial taxi and minibus/van/pick-up cars drivers. A cross-sectional study included a representative sample of 2,300 drivers of which 1,786 drivers （77.6%） agreed to participate. The Manchester DBQ （Driver Behaviour Questionnaire） was used to measure the aberrant driving behaviours leading to accidents. The study is based on the measurement using the depression anxiety stress scales （DASS-21）. Participants completed a DASS-21 questionnaire with items related to socio-demographic information, BMI （body mass index）, driving experience, fatigue, sleeping, adherence to traffic laws （including speed limits and wearing seat belt）, and drivers＇ driving records. Univariate and multivariate statistical analyses were performed. In a representative sampling, the age distribution of the participants ranged from 25 to 65 years with the mean age 38.3±10.2 and the mean annual mileage （km） per month was 14,587±1,741 （p 〈 0.001）. There was a significant difference found between both group minibus/van/pick-up and commercial taxi drivers regarding of their age group （p 〈 0.001）, education （p = 0.003）, history of accident （p = 0.003）, seat belt use （p = 0.022） time of accident （p = 0.005）; crossing red light （p 〈 0.001）, excessive speed limits （p = 0.002）, BMI group （p = 0.022）, physical activity （p = 0.003）, annual mileage in km （p 〈 0.001）, number of working days （p = 0.010） and hours （p = 0.030）; number of sleeping hours （p = 0.025）, CD music listening （p = 0.010）, mobile phone use （p = 0.001）, soft drinking （p = 0.002） and cigarette smoking habit （p 〈 0.001）. When the history of RTC was assessed, minibus/van/pick-ups were more likely to be involved in accidents compared t

关键词： Aggressive behavior sleeping fatigue violation driving accident.

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建筑拆除废弃物再生骨料颗粒破碎与压缩特性

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Journal of Central South University 2023年第10期30卷 3499-3516页

作者：孔坤锋陈锋肖源杰李昀博姜钰王萌 TUTUMLUER erol 陈宇亮李志勇 Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing 100081China School of Civil Engineering Central South UniversityChangsha 410075China Key Laboratory of Engineering Structures of Heavy-haul Railway of Ministry of Education(Central South University) Changsha 410075China Department of Civil&Environmental Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801U.S.A. Hunan Communications Research Institute Corporation Limited Changsha 410015China

使用回收的建筑拆除废弃物作为无黏结骨料是路面基层/底基层施工的资源节约型、经济型和生态友好型替代方法之一。单个粗集料颗粒的细观强度和压碎特性会对此类再生无黏结集料的宏观强度和变形行为产生重大影响。本文通过单颗粒压碎试... 详细信息

使用回收的建筑拆除废弃物作为无黏结骨料是路面基层/底基层施工的资源节约型、经济型和生态友好型替代方法之一。单个粗集料颗粒的细观强度和压碎特性会对此类再生无黏结集料的宏观强度和变形行为产生重大影响。本文通过单颗粒压碎试验和侧限压缩试验系统地研究了不同粒径和成分的再生骨料的压碎强度和压缩变形特性。试验结果表明,单颗粒破碎强度具有显著的尺寸效应,对于同种类型的再生骨料,破碎应力峰值随颗粒尺寸的增大而减小。此外,采用双曲线函数可以很好地描述侧限压缩过程的应力-应变关系。在相同的垂直应力水平下,随着粒径的增大,垂直应变和屈服应力值分别逐渐增大和减小。最后,采用颗粒破碎指标B_(r)量化了不同垂直应力水平下各粒度范围的颗粒破碎情况。根据破碎指标Br的预测公式的极限值,可得出各粒度范围的极限破碎状态。

关键词：建筑拆除废弃物再生骨料颗粒破碎永久变形单颗粒破碎试验侧限压缩试验

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伯氏螺旋体在小鼠宿主中的关节特异性转录谱(英文)

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科技通报 2008年第6期24卷 832-838,846页

作者：宝福凯 erol Fikerig 昆明医学院微生物学与免疫学教研室昆明650031 Department of Internal Medicine Yale University School of Medicine

目的建立伯氏疏螺旋体感染的小鼠模型,研究伯氏疏螺旋体在小鼠关节组织中的关节特异性基因表达谱。方法首先,建立伯氏疏螺旋体感染小鼠模型,在不同时间点处死小鼠,收集小鼠关节、心脏、皮肤和膀胱组织,从四种组织中分别提取总RNA;随后,... 详细信息

目的建立伯氏疏螺旋体感染的小鼠模型,研究伯氏疏螺旋体在小鼠关节组织中的关节特异性基因表达谱。方法首先,建立伯氏疏螺旋体感染小鼠模型,在不同时间点处死小鼠,收集小鼠关节、心脏、皮肤和膀胱组织,从四种组织中分别提取总RNA;随后,用DECAL技术和微阵列技术分析不同时间点伯氏疏螺旋体在四种组织中的转录组;最后,将伯氏疏螺旋体在关节中的转录组依次与其他三种组织中的转录组进行比较,找出仅在关节中表达的伯氏疏螺旋体基因,从而获得伯氏疏螺旋体不同时间点的关节特异性基因表达谱。结果与其他组织相比,在感染后第15天,伯氏疏螺旋体在小鼠关节组织特异地表达21个基因,其中13个基因位于伯氏疏螺旋体染色体上,8个基因位于质粒上;在感染后的第105天,伯氏疏螺旋体在小鼠关节组织特异地表达24个基因,其中13个基因位于伯氏疏螺旋体染色体上,11个基因位于质粒上。结论伯氏疏螺旋体在小鼠关节组织中存在独特的基因表达谱,这些在关节中特异表达的基因可能与莱姆关节炎的发生、发展有关。

关键词：伯氏疏螺旋体莱姆病 DECAL技术微阵列基因转录组表达谱

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A FAST,HIGH SENSITIVITY AND HIGH MASS ACCURACY API TIME-OF-FLIGHT MASS SPECTROMETER AND ITS APPLICATIONS

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质谱学报 1999年第Z1期 11-12页

作者： SHEN Shida, erol Gulcicek, Bruce Andrien, Craig Whitehouse (Analytica of Branford inc., 29 Business Park Dr., Branford, Connecticut 06405, USA)

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伯氏疏螺旋体与嗜吞噬细胞无浆体混合感染的实验研究

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热带医学杂志 2007年第3期7卷 195-200,204页

作者：宝福凯 erol Fikrig 昆明医学院微生物学与免疫学教研室 Department of Internal Medicine Yale University School of MedicineNew HavenCT 06511USA

目的应用动物模型探讨蜱传病原体伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染对组织螺旋体载量、莱姆关节炎严重性、宿主免疫功能的影响。方法建立伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染和伯氏疏螺旋体单一感染小鼠模型,在不同时间点研... 详细信息

目的应用动物模型探讨蜱传病原体伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染对组织螺旋体载量、莱姆关节炎严重性、宿主免疫功能的影响。方法建立伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染和伯氏疏螺旋体单一感染小鼠模型,在不同时间点研究各组小鼠组织中的螺旋体载量、关节炎严重性和血清IgG效价,并对数据进行统计学分析。结果与单一感染组相比,在螺旋体感染后18d和30d,混合感染组小鼠组织螺旋体载量显著增高,关节炎明显严重,血清IgG效价显著偏低。结论伯氏疏螺旋体和嗜吞噬细胞无浆体混合感染显著增加小鼠组织螺旋体载量、加重关节炎症状和病理改变,且抑制体液免疫功能。

关键词：混合感染伯氏螺旋体嗜吞噬细胞无浆体莱姆病实时荧光定量PCR

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