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A transferred regulator that contributes to Xanthomonas oryzae *** oxidative stress adaptation and virulence by regulating the expression of cytochrome bd oxidase genes

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Journal of Integrative Agriculture 2022年第6期21卷 1673-1682页

作者： WANG Pei-hong WANG Sai NIE Wen-han WU Yan Iftikhar AHMAD ayizekeranmu yiming HUANG Jin CHEN Gong-you ZHU Bo Shanghai Yangtze River Delta Eco-Environmental Change and Management Observation and Research Station/Shanghai Cooperative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240P.R.China Department of Environmental Sciences COMSATS University IslamabadVehari-CampusVehari 61100Pakistan

Horizontal gene transfer(HGT)has been well documented as a driving force in the evolution of *** has been shown that a horizontally acquired gene,xoc_2868,involved in the global response against oxidative stress and pathogenicity of Xanthomonas oryzae *** strain ***,as a transcriptional factor(TF),the regulatory mechanism of XOC_2868 has not yet been ***,evolutionary analysis suggested XOC_2868 might be co-transferred with its physically proximate downstream genes from a Burkholderiaceae ***,RNA-seq data of wild-type(BLS256)andΔxoc_2868 strains under oxidative stress showed that XOC_2868 did not regulate the expression of its adjacent genes,but remarkably influenced the expression of several genes involved in the extracellular polysaccharide(EPS)production and xanthan *** immunoprecipitation-sequence(ChIP-seq)combined with transcriptome analysis revealed that XOC_2868 directly regulates a cydAB operon,encoding two subunits of cytochrome bd oxidase and involved in redox *** withΔxoc_2868 strain,cydA-and cydAB-knockout mutants also showed a higher sensitivity to H_(2)O_(2)along with a reduced bacterial virulence compared with the wild-type ***,our findings raise the possibility of regulatory circuit evolution shaped by HGT and driven by selection and reveal a novel regulatory pathway that regulates the expression of cytochrome bd oxidase and thus contributes to the virulence of BLS256.

关键词： HGT transcriptional factor Xanthomonas oryzae pv.oryzicola oxidative stress adaptation and virulence

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Horizontal gene transfer of a syp homolog contributes to the virulence of Burkholderia glumae

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Journal of Integrative Agriculture 2021年第12期20卷 3222-3229页

作者： WANG Sai WANG Pei-hong NIE Wen-han CUI Zhou-qi LI Hong-yu WU Yan ayizekeranmu yiming FU Luo-yi Iftikhar AHMAD CHEN Gong-you ZHU Bo School of Agriculture and Biology Shanghai Jiao Tong University/Key Laboratory of Urban Agriculture of the Ministry of Agriculture and Rural AffairsShanghai 200240P.R.China Department of Plant Pathology&Ecology the Connecticut Agricultural Experiment StationNew Haven 06504CTUSA Department of Environmental Sciences COMSATS University IslamabadVehari-CampusVehari 61100Pakistan

Horizontal gene transfer(HGT)has been proved a major driving force in prokaryotic ***,the molecular functions of these transferred genes in pathogenic bacteria especially plant pathogenic bacteria are still not fully *** this study,the whole-genome in silico analysis was performed and found a syringopeptin synthetase(syp)homolog in Burkholderia glumae,which can cause bacterial panicle blight in rice,was predicted to be horizontally transferred from Pseudomonas ancestor with solid confidence by phylogenetic *** comprehensive molecular experiments were performed to study the potential role of this gene in *** of rice panicles with the syp mutant resulted in 60%lower disease index compared with the wild type(WT)parent strain,suggesting the requirement of syp for the full virulence of *** analysis of exudates from *** showed suppression of synthesis of metabolites analogous to syringopeptin in the *** these data raise the possibility of HGT phenomenon in shaping the virulence and adaptation of *** over evolutionary time.

关键词： horizontal gene transfer burkholderia glumae syringopeptin synthetase

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基于质谱的肿瘤标志物筛选研究进展

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中国细胞生物学学报 2023年第12期45卷 1793-1803页

作者：阿衣则克然木·依明黄琳钱昆上海交通大学生物医学工程学院上海200030 上海市胸科医院/上海交通大学医学院附属胸科医院检验科上海200030 上海市胸科医院/上海交通大学医学院附属胸科医院胸部肿瘤研究所上海200030

随质谱技术的飞速发展,其在肿瘤标志物研究领域的应用日益扩大。该文从样品预处理、质谱检测和临床应用这三个方面详细介绍了质谱技术在核酸、蛋白质和代谢物层面筛选肿瘤标志物的最新研究进展,总结了不同质谱方法的优势与挑战。最后对... 详细信息

随质谱技术的飞速发展,其在肿瘤标志物研究领域的应用日益扩大。该文从样品预处理、质谱检测和临床应用这三个方面详细介绍了质谱技术在核酸、蛋白质和代谢物层面筛选肿瘤标志物的最新研究进展,总结了不同质谱方法的优势与挑战。最后对基于质谱技术的肿瘤标志物筛选的未来发展方向进行了系统性展望,预期为相关领域研究提供可靠依据。

关键词：质谱技术肿瘤生物标志物

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