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Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice

Asian Journal of Andrology 2020年第6期22卷 590-601页

作者： Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru ayhan kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Genetics Reproduction and Development Laboratory CNRS UMR 6293-INSERM U1103-Universite Clermont AuvergneClermont-Ferrand 63001France Institute of Neuroscience State Key Laboratory of NeuroscieneeShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key Laboratory of Agricultural Animal Genetics Breedingand Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of AgricultureHuazhong Agricultural UniversityWuhan 430070China Department of Cellular and Molecular Medicine University of CaliforniaSan DiegoLa JollaCA 92093-0651USA Department of Anatomy Histology and EmbryologyShanghai Jiao long University School of MedicineShanghai Key Laboratory of Reproductive MedicineShanghai 200025China department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Priority Research Centre for Reproductive Sciences School of Environmental and Life SciencesThe University of NewcastleCallaghanNSW 2308Australia.

The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various *** foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic *** mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal ***,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 *** explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m *** analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-*** agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and *** absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-***,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses.

关键词： epididymis GPX5 oxidative stress piRNA PIWI-interacting RNA small noncoding RNA

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Redox active polymer metal chelates for use in flexible symmetrical supercapacitors:Cobalt-containing poly(acrylic acid)polymer electrolytes

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Journal of Energy Chemistry 2021年第4期30卷 145-153页

作者： Emre Cevik ayhan Bozkurt Department of Genetics Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

The novel polymer metal chelate electrolytes(polychelates)were prepared by incorporation of cobalt sulfate(Co)into poly(acrylic acid)(PAA)host ***-solid state supercapacitor devices were fabricated using polychelates,PAA-Co X(X:3,5,7,and 10)where X represents the doping fraction(w/w)of Co in *** polymer metal electrolytes were showed excellent bending-stretching properties,thermal stability and electrochemical durability with an optimum ionic conductivity of 3.15×10^(-4) S cm^(-1).Hierarchically porous activated carbon and nano-sized conductive carbon were used to form carbon composite symmetrical device *** electric double-layer capacitor(EDLC)and redox reactions of Co-incorporated polychelates at the interfaces of porous activated carbon provided an optimum specific capacitance of 341.33 F g^(-1) with a device of PAA-Co7,which is at least 15 times enhancement compared to the device of pristine *** PAA-Co7 device also provided energy density of 21.25 Wh kg^(-1) at a power density of 117.69 W kg^(-1).A prolonged cyclic stability of the device exhibited superior capacitive performance after 10,000 charge-discharge cycles and the maintained 90%of its initial *** addition,the supercapacitor with a dimension of 1.5 cm×3 cm containing PAA-Co7 successfully operated the red-blue-green(RGB)LED light.

关键词： Supercapacitor Redox active supercapacitor Cobalt Poly(acrylic acid) Polymer electrolyte

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RELAXED ELASTIC LINES OF SECOND KIND ON ORIENTED SURFACE IN MINKOWSKI SPACE

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Applied Mathematics and Mechanics(English Edition) 2006年第11期27卷 1481-1489页

作者： ayhan TUTAR ayhan SARIO■LUG■L Ondokuz Mayis University Faculty of Science and ArtsDepartment of MathematicsKurupelit-Samsun55139Turkey

The relaxed elastic line of second kind on an oriented surface in the Minkowski space was defined and for the relaxed elastic line of second kind which is lying on an oriented surface the Euler-Lagrange equations were derived. Furthermore, whether these curves lie on a curvature line or not was investigated and some applications were given.

关键词： elastic line geodesic Minkowski space Euler-Lagrange equations

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On Weighted Estimates of High-Order Riesz-Bessel Transformations Generated by the Generalized Shift Operator

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Acta Mathematica Sinica,English Series 2005年第1期21卷 53-64页

作者： Isman EKINCIOGLU ayhan SERBETCI Department Department of Mathematics Ankara University06100 Tandogan-AnkaraTurkey

In this paper, we establish sufficient conditions on weights which ensurethat high-order Riesz-Bessel transformations generated by the generalized shift operator actboundedly from one weighted L_p-space into another.

关键词： Generalized shift operator Riesz-Bessel transformations

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Effect of thermal treatment on the swelling and surface roughness of common alder and wych elm wood

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Journal of Forestry Research 2016年第1期27卷 225-229页

作者： ayhan Aytin Suleyman Korkul Program of Furniture and Decoration Duzce Vocational School Duzce University Diizce Turkey Department of Forest Industry Engineering Faculty of Forestry Duzce University Diizce Turkey

Wood heat treatment has increased signifi- cantly in recent years and is still growing as an industrial process to improve some wood properties. We studied the change of swellingand surface roughness of common alder （Alnus glutinosa （L.） Gaertn. ***） and wych elm （Ulmus glabra Huds.） woods after heat treatment at two different temperatures and durations. The temperatures were 180 and 200 ℃ and the durations were 2 and 4 h. A stylus method was employed to evaluate the surface char- acteristics of the samples. Roughness measurements by the stylus method were made in the direction perpendicular to the fiber on the wood surface. Four main roughness parameters, mean arithmetic deviation of profile （Ra）, mean peak-to-valley height （Rz）, root mean square roughness （Rq）, and maximum roughness （Ry） were used to evaluate the effect of heat treatment on the surface characteristics of the specimens. Swelling and surface roughness parameters （Ra, Rz, Ry, and Rq） differed significantly for two temper- atures and two durations of heat treatment. Swelling and surface roughness values decreased with increasing treat- ment temperature and treatment times.

关键词： Heat treatment Swelling Surfaceroughness. Common alder Wych elm

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A comparative assessment of rock mass deformation modulus

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International Journal of Mining Science and Technology 2015年第5期25卷 735-740页

作者： Kadir Karaman Ferdi Cihangir ayhan Kesimal Department of Mining Engineering Karadeniz Technical University

Deformation modulus of a rock mass(E_m) is one of the most important design parameters in construction of rock engineering projects such as underground ***,difficulties are frequently encountered during in-situ tests which are also time-consuming and expensive for determining this *** E_m is often estimated indirectly from proposed equations by different researchers,many of these equations cannot be used in case of problematic rock conditions(thinly bedded,highly jointed rock masses,etc.) as high quality core samples are *** study aims to explore more practical and useful equation for E_m estimation using Rock Quality Designation(RQD) and point load index *** were made between available empirical equations and the proposed E_m equation in terms of the estimation *** comparison tests(ANOVA) showed that E_m can be reliably estimated using proposed equation especially at the preliminary stages of projects.

关键词： Rock mass deformation modulus RQD RMR Q RMi Point load index

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Does crossover innervation really affect the clinical outcome？ A comparison of outcome between unilateral and bilateral digital nerve repair

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Neural Regeneration Research 2016年第9期11卷 1499-1505页

作者： Melike Oruc Kadri Ozer Ozlem Colak Yüksel Kankaya Ugur kocer Ankara Training and Research Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Ankara Turkey Aydin State Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Aydin Turkey Istanbul Okmeydani Training and Research Hospital Plastic Reconstructive and Aesthetic Surgery Clinic Istanbul Turkey

Digital nerve injuries are the mostly detected nerve injury in the upper extremity. However, since the clinical phenomenon of crossover innervation at some degree from uninjured digital nerve to the in- jured side occurs after digital nerve injuries is sustained, one could argue that this concept might even result in the overestimation of the outcome of the digital nerve repair. With this knowledge in mind, this study aimed to present novel, pure, focused and valuable clinical data by comparing the outcomes of bilateral and unilateral digital nerve repair. A retrospective review of 28 fingers with unilateral or bilateral digital nerve repair using end-to-end technique in 19 patients within 2 years was performed. Weber＇s two-point discrimination, sharp/dull discrimination, warm/cold sensation and Visual Analog Scale scoring were measured at final 12-month follow ups in all patients. There was no significant difference in recovery of sensibility after unilateral and bilateral digital nerve repairs. Though there is crossover innervation microscopically, it is not important in the clinical evaluation period. According to clinical findings from this study, crossover innervations appear to be negligible in the estimation of outcomes of digital neurorrhaphy.

关键词： nerve regeneration digital nerve repair unilateral bilateral crossover innervation sensibility neurorrhaphy nerve sprouting neural regeneration

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Evaluation of Two-center One- and Two-electron Integrals over Slater Type Orbitals

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Chinese Journal of Chemistry 2006年第5期24卷 603-608页

作者： YAKAR, Yusuf OZMEN, ayhan ATAV, Ulfet Department of Physics Faculty of Arts and Science at Aksaray Nigde University Aksaray Turkey Department of Physics Faculty of Arts and Science Selcuk University Konya Turkey

A formulation previously presented by the authors for coulomb integrals was generalized to other two-center integrals, except exchange integral. Within this frame, molecular integrals were expressed in terms of some new functions closely related to the well-known incomplete gamma functions and these functions recursively evaluated. Special issues arising in the case of hybrid integrals were addressed, and the results were compared with the ones found in the literature.

关键词： overlap integral hybrid integral coulomb integral Slater type orbital elliptical coordinate

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Explicit solutions of nonlinear wave equation systems

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Chinese Physics B 2013年第1期22卷 39-45页

作者： Ahmet Bekir Burcu ayhan M. Naci zer Mathematics and Computer Science Department Eskisehir Osmangazi University

We apply the （G＇/G）-expansion method to solve two systems of nonlinear differential equations and construct traveling wave solutions expressed in terms of hyperbolic functions, trigonometric functions, and rational functions with arbitrary parameters. We highlight the power of the （G＇/G）-expansion method in providing generalized solitary wave solutions of different physical structures. It is shown that the （G＇/G）-expansion method is very effective and provides a powerful mathematical tool to solve nonlinear differential equation systems in mathematical physics.

关键词： (G'/G)-expansion method long-short-wave interaction system coupled integrable dispersionless system

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Impact of central venous port implantation method and access choice on outcomes

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World Journal of Clinical Cases 2023年第1期11卷 116-126页

作者： ayhan Erdemir Huseyin Kemal Rasa Department of General Surgery Anadolu Medical CenterKocaeli 41400Turkey Department of General Surgery Anadolu Medical Center HospitalKocaeli 41400Turkey

BACKGROUND Although the number of patients who need central venous ports for permanent vascular access is increasing,there is still no“gold standard”for the implantation *** To identify the implantation technique that should be *** Two hundred central venous port-implanted patients in a tertiary hospital were retrospectively *** were assigned into two groups according to the access *** first group comprised patients whose jugular veins were used,and the second group comprised patients whose subclavian veins were *** were evaluated regarding age,sex,application side,primary diagnosis,active follow-up period in the hospital,chemotherapy agents administered,number of complications,and the Clavien-Dindo severity *** distribution of the variables was tested with the Kolmogorov-Smirnov test and the Mann-Whitney U ***χ^(2) test was used to analyze the *** There was no statistically significant difference between the groups regarding age,sex,side,number of chemotherapy drugs,and duration of port usage(P>0.05).Only 2 patients in group 1 had complications,whereas in group 2 we observed 19 patients with complications(P<0.05).No port occlusion was found in group 1,but the catheters of 4 patients were occluded in group *** port was infected in group 1 compared to three infected ports in group *** port ruptures,two pneumothorax,one revision due to a mechanical problem,one tachyarrhythmia during implantation,and four suture line problems were also recorded in group 2 *** also showed that it would be sufficient to evaluate and wash ports once every 2 *** Our results robustly confirm that the jugular vein route is safer than the subclavian vein approach for central venous port implantation.

关键词： Permanent vascular access Central venous ports Central venous port implantation methods Jugular vein route Subclavian vein approach Impact of implantation method on outcomes

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