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Vaccination coverage in children with juvenile idiopathic arthritis,inflammatory bowel diseases,and healthy peers:Cross-sectional electronic survey data

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World Journal of Clinical Pediatrics 2023年第2期12卷 45-56页

作者： Elizaveta Makarova aygul khabirova Natalia Volkova Tatiana Gabrusskaya Natalia Ulanova Larisa Sakhno Maria Revnova Mikhail Kostik Department of Polyclinic Pediatrics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Hospital Pediatrics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Pediatric GI Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia

BACKGROUND Patients with immune-mediated diseases,such as juvenile idiopathic arthritis(JIA)and inflammatory bowel disease(IBD)are at increased risk of developing infections,due to disease-related immune dysfunction and applying of immunosuppressive *** To evaluate vaccine coverage in patients with IBD and JIA,and compare it with healthy *** In the cross-sectional study we included the data from a questionnaire survey of 190 Legal representatives of children with JIA(n=81),IBD(n=51),and healthy children(HC,n=58).An electronic online questionnaire was created for the *** There were female predominance in JIA patients and younger onset *** of JIA had higher education *** level and family status were similar in the three studied *** with JIA and IBD had lower vaccine coverage,without parental rejection of vaccinations in IBD,compare to JIA and healthy *** main reason for incomplete vaccination was medical conditions in IBD and *** patients had a lower rate of normal vaccine-associated reactions compared to JIA and *** encouraging role of physicians for vaccinations was the lowest in JIA *** patients had more possibilities to check antibodies before immune-suppressive therapy and had more supplementary vaccinations compared to JIA and *** JIA and IBD patients had lower vaccine coverage compared to ***'encouragement of vaccination and the impossibility of discus about future vaccinations and their outcomes seemed the main factors for patients with immune-mediated diseases,influencing vaccine *** investigations are required to understand the reasons for incomplete vaccinations and improve vaccine coverage in both groups,especially in rheumatic disease *** approaches that stimulate vaccination in healthy children are not always optimal in children with immunemediated *** is necessary to provide personalized vaccine-encouraging strategie

关键词： Vaccines Juvenile idiopathic arthritis Inflammatory bowel diseases Vaccine coverage Immune-mediated diseases

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