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Danlu Tongdu tablets treat lumbar spinal stenosis through reducing reactive oxygen species and apoptosis by regulating CDK2/CDK4/CDKN1A expression

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Traditional Medicine Research 2023年第7期8卷 47-55页

作者： Xue Bai ayesha tasleem tahir Zheng-Heng Yu Wen-Bo Cheng Bo Zhang Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Breast Disease Center Peking University First HospitalBeijing 100034China Tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China Beijing Intelligent Medicine and Network Pharmacology Co. Ltd.Beijing 100020China

Lumbar spinal stenosis is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen,and is manifested as chronic low back and leg *** Tongdu(DLTD)tablets can relieve chronic pain caused by lumbar spinal stenosis,but the molecular mechanism remains largely *** this study,the potential molecular mechanism of DLTD tablets in the treatment of lumbar spinal stenosis was first predicted by the network pharmacology *** showed that DLTD functions in regulating anti-oxidative,apoptosis,and inflammation signaling ***,the flow cytometry results showed that DLTD tablets efficiently reduced reactive oxygen species content and inhibited rat neural stem cell apoptosis induced by hydrogen *** also inhibited the mitochondrial membrane potential damage induced by hydrogen *** analysis showed that DLTD induced cell cycle-related protein,CDK2 and CDK4,and reduced CDKN1A protein expression *** together,our study provided new insights of DLTD in treating lumbar spinal stenosis through reducing reactive oxygen species content,decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.

关键词： Danlu Tongdu lumbar spinal stenosis reactive oxygen species cell apoptosis

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Recent advances in titanium carbide MXene-based nanotextures with influential effect of synthesis parameters for solar CO_(2)reduction and H_(2)production:A critical review

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Journal of Energy Chemistry 2023年第1期76卷 295-331,I0008页

作者： Muhammad tahir Azmat Ali Khan Sehar tasleem Rehan Mansoor Areen Sherryna Beenish tahir Chemical and Petroleum Engineering Department UAE UniversityP.0.Box 15551Al AinUnited Arab Emirates Balochistan University of Information Technology Engineering and Management Sciences(BUITEMS)QuttaBalochistanPakistan Department of Chemical Engineering School of Chemical and Energy EngineeringUniversiti Teknologi Malaysia81310UTM.Johor BahruJohorMalaysia Civil and Environmental Engineering Department UAE UniversityP.o.Box 15551Al AinUnited Arab Emirates

Photocatalytic solar to energy conversion is considered an attractive approach for overcoming energy crises and environmental ***,titanium carbide(Ti_(3)C_(2))MXenes have been recognized as promising cocatalysts based on their metallic conductivity,excessive active reaction sites,and enlarged surface *** current review focuses on the properties and applications of Ti_(3)C_(2)MXenes useful in the field of *** specifically,surface modification of Ti_(3)C_(2)MXenes by varying synthesis parameters to get pure materials and also composites with the role of functional groups towards solar energy conversion applications is highlighted in this *** effect of etching and oxidizing pathways to get an efficient cocatalyst has been discussed in *** the significant effect of parameters,optimum synthesis conditions such as etchant type,concentration,time and type of intercalant in both the Ti_(3)C_(2)synthesis approaches for improved photoactivity are ***,the surface modification of Ti_(3)C_(2)through oxidation for TiO2growth on its surface is deliberated with a detailed discussion on etchant type,concentration,etching time,and environmental *** optimum oxidation condition,including temperature,time,and environment for thermal treatment of Ti_(3)C_(2),were also ***,the review summarizes the conclusion and future perspectives for solar energy conversion applications.

关键词： Solar to energy conversion Ti_(3)C_(2)nanomaterials Termination groups MXene cocatalyst Synthesis parameters

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