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Network pharmacology analysis combined with experimental verification of the molecular mechanism of Xihuang pill in treating liver cancer

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traditional Medicine Research 2023年第6期8卷 24-32页

作者： Meng-Xin He ayesha t.tahir Saba Waris Wen-Bo Cheng Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Gynacology Allama Iqbal Medical CollegeLahore 54000Pakistan tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China

Background:Xihuang pill is a kind of traditional Chinese medicine,which has been widely used in the treatment of kinds of ***,there is still a lack of systematic understanding of the molecular mechanism of Xihuang pill in the treatment of liver *** this work,we aim to explore the molecular mechanism of Xihuang pill in treating liver ***:the functional components in Xihuang pill were collected from traditional Chinese Medicine Database and Analysis *** target genes of these components were also collected using traditional Chinese Medicine Database and Analysis *** target genes of liver cancer were predicted using GeneCards *** intersecting genes were then analyzed with Venn *** Encyclopedia of Genes and Genomes and Database for Annotation,Visualization,and Integrated Discovery were used to analyze the ***,cell counting kit-8 was used to measure the half-maximal inhibitory concentration of Xihuang *** living dead cell staining method was used to observe the survival of ***2 cell apoptosis was tested by flow cytometry with fluorescein isothiocyanate/propidium iodide double staining method,and then the mitochondrial damage was also detected by flow *** expression of target genes was detected by quantitative real-time polymerase chain ***:A total of 130 compounds and 198 genes were identified as potential active ingredients and putative liver cancer‑related *** obtained 1,899 disease targets and 297 transcriptome targets from the *** drug-disease intersecting genes,CCNB1,BIRC5,tOP2A,ESR1,IGF2 and IGFBP3 were *** are enrichment in apoptosis,PI3K-AKt signaling pathway,MAPK signaling pathway,pathways in cancer and p53 signaling ***,it was found that the apoptosis rate of the HepG2 cells in Xihuang pill treated group was significantly higher than that of the control *** the apoptosis rate gradually increased in a dose depe

关键词： Xihuang pill liver cancer network pharmacology p53 signal pathway apoptosis-multiple species pathway

Prediction and validation of molecular biological mechanism of Fuzheng Huayu capsule in the treatment of liver cancer

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Cancer Advances 2023年第7期6卷 1-9页

作者： Zi-Ning Wang ayesha t.tahir Saba Waris Wen-Bo Cheng Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Gynacology Allama Lqbal Medical CollegeLahore 54000Pakistan tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China

Background:Fuzheng Huayu capsule(FZHY)combined with antiviral treatment has been shown to significantly reduce the risk of liver cancer in patients with hepatitis B ***,the potential of FZHY to directly treat liver cancer remains largely *** study aims to investigate the molecular mechanism underlying the potential of FZHY in treating liver ***:A network pharmacological analysis was performed using the traditional Chinese Medicine Systems Pharmacology database to identify FZHY compounds and *** targets were searched using the Genecards database,and transcriptome data was downloaded from the NCBI *** Ontology analysis was conducted using the DAVID database,and Kyoto Encyclopedia of Genes and Genomes analysis was based on KOBAS and bioinformatics *** Swissdock database was used for molecular *** cell experiments,the half inhibitory concentration(IC50)of FZHY was determined using the CCK8 *** effects of FZHY on cell viability,apoptosis,and mitochondrial membrane potential were evaluated using a fluorescence microscope and flow *** molecular mechanism of FZHY in treating liver cancer was verified using quantitative polymerase chain ***:A total of 127 compounds and 184 proteins were identified as potential active ingredients and putative liver cancer-related ***,1,899 liver cancer targets,279 transcriptome targets,and 3 pathways(p53 signaling pathway,apoptosis and PI3K-Akt pathway)were *** FZHY-targets-liver cancer interaction network was ***50 of FZHY lyophilized powder solution to liver cancer was 5.13 mg/mL(IC50=5.13 mg/mL).FZHY treatment led to an increase in the ratio of cell apoptosis and induced mitochondrial membrane potential damage,resulting in an increase in the number of dead *** expression levels of CCNB1 and BIRC5 were induced with FZHY treatment,while the expression levels of AKR1C3 and IGF2 were ***

关键词： liver cancer Fuzheng Huayu capsule traditional Chinese medicine CCNB1 BIRC5 AKR1C3 IGF2

An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative,anti-inflammatory and anti-apoptosis activities

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Chinese Herbal Medicines 2023年第3期15卷 407-420页

作者： Huan Zhang Jun Kang Wuyan Guo Fujie Wang Mengjiao Guo Shanshan Feng Wuai Zhou Jinnan Li ayesha t.tahir Shaoshan Wang Xinjun Du Hui Zhao Weihua Wang Hong Zhu Bo Zhang tCM Network Pharmacology Department Tianjin Key Laboratory of Early Druggability Evaluation of Innovative DrugsTianjin International Joint Academy of BiomedicineTianjin 300457China School of Life Sciences Tianjin UniversityTianjin 300072China Chunfeng(Beijing)Health technology Co. Ltd.Beijing 100176China Institute for tCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China Department of Biosciences COMSAS University IslamabadIslamabad 44000Pakistan tianjin Binhai New Area Han Gu traditional Chinese Medical Hospitals Tianjin 300480China Key Laboratory of Food Nutrition and Safety Ministry of EducationTianjin University of Science and TechnologyTianjin 300457China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China Center of Pharmaceutical technology Tsinghua UniversityBeijing 100084China Beijing Intelligent Medicine and Network Pharmacology Co. LtdBeijng 100020China

Objective:Identifying novel strategies to prevent particulate matter(PM)-induced lung injury is crucial for the reduction of the morbidity of chronic respiratory *** combined intervention represented by herbal formulae for simultaneously targeting multiple pathological processes can provide a more beneficial effect than the single *** aim of this paper is therefore to design a safe and effective medicinal and edible Chinese herbs(MECHs)formula against PM-induced lung ***:PM-induced oxidative stress,inflammatory response and apoptosis A549 cell model were used to screen anti-oxidant,anti-inflammatory and anti-apoptotic MECHs,respectively.A network pharmacology method was utilized to rationally design a novel herbal *** performance liquid chromatography-mass spectrometer was utilized to assess the quality control of MECHs *** excretion of magnetic iron oxide nanospheres of the MECHs formula was estimated in *** MECH formula against PM-induced lung injury was investigated with mice ***:Five selected herbs were rationally designed to form a new MECH formula,including Citri Exocarpium Rubrum(Juhong),Lablab Semen Album(Baibiandou),Atractylodis Macrocephalae Rhizoma(Baizhu),Mori Folium(Sangye)and Polygonati Odorati Rhizoma(Yuzhu).the formula effectively promoted the magnetic iron oxide nanospheres excretion in *** mid/high dose formula significantly prevented PM-induced lung damage in mice by enhancing the activity of SOD and GSH-Px,reducing the MDA and ROS level and attenuating the upregulation of pro-inflammatory cytokine(IL-6,IL-8,IL-1βand tNFa),down regulating the protein expression of NF-κB,StAt3 and ***:Our findings suggest that the effective MECHs formula will become a novel strategy for preventing PM-induced lung injury and provide a paradigm for the development of functional foods using MECHs.

关键词： apoptosis inflammatory response lung injury medicinal and edible Chinese herbs oxidative stress particulate matter

Plant phosphate nutrition:sensing the stress

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Stress Biology 2022年第1期2卷 496-509页

作者： Viswanathan Satheesh ayesha tahir Jinkai Li Mingguang Lei Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Biosciences COMSATS University IslamabadPark RoadIslamabadPakistan University of Chinese Academy of Sciences Beijing 100049China

Phosphorus(P)is obtained by plants as phosphate(Pi)from the soil and low Pi levels affects plant growth and *** to low Pi condition entails sensing internal and external Pi levels and translating those signals to molecular and morphophysiological changes in the *** this review,we present findings related to local and systemin Pi sensing with focus the molecular mechanisms behind root system architectural changes and the impact of hormones and epigenetic mechanisms affecting those *** also present some of the recent advances in the Pi sensing and signaling mechanisms focusing on inositol pyrophosphate InsP8 and its interaction with SPX domain proteins to regulate the activity of the central regulator of the Pi starvation response,PHR.

关键词： Phosphate signaling Root system architecture Inositol pyrophosphates InsP8 SPX domain Plant Human

Constructing S-scheme 2D/0D g-C_(3)N_(4)/tiO_(2) NPs/MPs heterojunction with 2D-ti3AlC2 MAX cocatalyst for photocatalytic CO_(2) reduction to CO/CH_(4) in fixed-bed and monolith photoreactors

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Journal of Materials Science & technology 2022年第11期106卷 195-210页

作者： Muhammad tahir Beenish tahir Department of Chemical Engineering School of Chemical and Energy EngineeringUniversiti Teknologi Malaysia81310UTM Johor BahruMalaysia Chemical and Petroleum Engineering Department UAE UniversityP.O.Box 15551Al AinUnited Arab Emirates

Exfoliated 2D MAX ti_(3) AlC_(2) conductive cocatalyst anchored with g-C_(3)N_(4)/tiO_(2) to construct 2D/0D/2D het-erojunction has been explored for enhanced CO_(2) photoreduction in a fixed-bed and monolith *** tiO_(2) particle sizes(NPs and MPs)were systematically investigated to determine effective metal-support interaction with faster charge carrier separation among the composite *** tiO_(2) NPs were anchored with 2D ti_(3) AlC_(2) MAX structure,10.44 folds higher CH_(4) production was observed com-pared to anchoring tiO_(2) *** CH_(4) yield rate of 2103.5μmol g^(−1) h^(−1) achieved at selectivity 96.59%using ternary g-C_(3)N_(4)/tiO_(2)/ti_(3) AlC_(2)2D/0D/2D composite which is 2.73 and 7.45 folds higher than using binary g-C_(3)N_(4)/ti_(3) AlC_(2) MAX and tiO_(2) NPs/ti_(3)AlC_(2) samples,respectively.A step-scheme(S-scheme)photocatalytic mechanism operates in this composite,suppressed the recombination of useful electron and holes and provides higher reduction potential for efficient CO_(2) conversion to CO and CH_(4).More im-portantly,when light intensity was increased by 5 folds,CH_(4) production rate was increased by 3.59 folds under visible *** performance of composite catalyst was further investigated in a fixed-bed and monolith photoreactor and found monolithic support increased CO production by 2.64 folds,whereas,53.99 times lower CH_(4) production was *** lower photocatalytic activity in a monolith photore-actor was due to lower visible light penetration into the ***,2D MAX ti_(3) AlC_(2) composite catalyst can be constructed for selective photocatalytic CO_(2) methanation under visible light in a fixed-bed photoreactor.

关键词： Photocatalytic CO_(2)methanation Exfoliated 2D MAX ti_(3)AlC_(2) g-C_(3)N_(4)/tiO_(2) Fixed-bed reactor,Monolith photoreactor Solar energy

Danlu tongdu tablets treat lumbar spinal stenosis through reducing reactive oxygen species and apoptosis by regulating CDK2/CDK4/CDKN1A expression

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traditional Medicine Research 2023年第7期8卷 47-55页

作者： Xue Bai ayesha tasleem tahir Zheng-Heng Yu Wen-Bo Cheng Bo Zhang Jun Kang School of Life Sciences Tianjin UniversityTianjin 300072China Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Breast Disease Center Peking University First HospitalBeijing 100034China tianjin Key Laboratory of Medical Mass Spectrometry for Accurate Diagnosis Tianjin 300399China Institute for tCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRistDepartment of AutomationTsinghua UniversityBeijing 100084China Beijing Intelligent Medicine and Network Pharmacology Co. Ltd.Beijing 100020China

Lumbar spinal stenosis is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen,and is manifested as chronic low back and leg *** tongdu(DLtD)tablets can relieve chronic pain caused by lumbar spinal stenosis,but the molecular mechanism remains largely *** this study,the potential molecular mechanism of DLtD tablets in the treatment of lumbar spinal stenosis was first predicted by the network pharmacology *** showed that DLtD functions in regulating anti-oxidative,apoptosis,and inflammation signaling ***,the flow cytometry results showed that DLtD tablets efficiently reduced reactive oxygen species content and inhibited rat neural stem cell apoptosis induced by hydrogen *** also inhibited the mitochondrial membrane potential damage induced by hydrogen *** analysis showed that DLtD induced cell cycle-related protein,CDK2 and CDK4,and reduced CDKN1A protein expression *** together,our study provided new insights of DLtD in treating lumbar spinal stenosis through reducing reactive oxygen species content,decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.

关键词： Danlu tongdu lumbar spinal stenosis reactive oxygen species cell apoptosis

Characterization of ion irradiated silicon surfaces ablated by laser-induced breakdown spectroscopy

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Chinese Physics B 2018年第8期27卷 505-510页

作者： t Iqbal M Abrar M B tahir M Seemab A Majid S Rafique Department of Physics Faculty of Sciences University of Gujrat Hafiz Hayat Campus Department of Physics Hazara University Mansehra Department of Physics University of Engineering and Technology (UET)Lahore Pakistan

Low energy metallic ions, generated by a Q-switched Nd：YAG laser （1064-nm wavelength, 10-mJ energy, 9-nm 12-ns-pulse width, 1011 W/cm2 intensity） irradiated on a silicon substrate to modify various properties, such as electrical, morphological, and structural modifications. thomson parabola technique is used to calculate the energy of these metallic ions whereas the electrical conductivity is calculated with the help of Four-point probe. Interestingly circular tracks forming chain like damage trails are produced via these energetic ions which are carefully examined by optical microscopy. It is observed that excitation, ionization, and cascade collisions are responsible for surface modifications of irradiated samples. Four-point probe analysis revealed that the electrical conductivity of substrate has reduced with increasing trend of atomic number of irradiated metallic ions （A1, ti, Cu, and Au）. the x-ray diffraction analysis elucidated the crystallographic changes leading to reduction of grain size of N-type silicon substrate, which is also associated with the metallic ions used. the decreasing trend of conductivity and grain size is due to thermal stresses, scattering effect, structural imperfections, and non-uniform conduction of energy absorbed by substrate atoms after the ion irradiation.

关键词： ablation thomson parabola technique four-point probe

Emergency Prioritized and Congestion Handling Protocol for Medical Internet of things

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Computers, Materials & Continua 2021年第1期66卷 733-749页

作者： Sabeen tahir Sheikh tahir Bakhsh Rayed AlGhamdi Information technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia

Medical Internet of things(MIots)is a collection of small and energyefficient wireless sensor devices that monitor the patient’s *** healthcare networks transmit continuous data monitoring for the patients to survive them *** are many improvements in MIots,but still,there are critical issues that might affect the Quality of Service(QoS)of a *** handling is one of the critical factors that directly affect the QoS of the *** congestion in MIot can cause more energy consumption,delay,and important data *** a patient has an emergency,then the life-critical signals must transmit with minimum *** emergencies,the MIots have to monitor the patients continuously and transmit data(e.g.,ECG,BP,heart rate,etc.)with minimum ***,there is an efficient technique required that can transmit emergency data of high-risk patients to the medical staff on time with maximum *** main objective of this research is to monitor and transmit the patient’s real-time data efficiently and to prioritize the emergency *** this paper,Emergency Prioritized and Congestion Handling Protocol for Medical Iots(EPCP_MIot)is proposed that efficiently monitors the patients and overcome the congestion by enabling different monitoring *** the emergency data transmissions are prioritized and transmit at SIFS *** proposed technique is implemented and compared with the previous technique,the comparison results show that the proposed technique outperforms the previous techniques in terms of network throughput,end to end delay,energy consumption,and packet loss ratio.

关键词： Congestion control MIots emergency prioritization energy-efficient

Liquid Phase Bonding of 316L Stainless Steel to AZ31 Magnesium Alloy

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Journal of Materials Science & technology 2011年第1期27卷 22-28页

作者： Waled Elthalabawy tahir Khan Department of Mechanical and Manufacturing Engineering University of Calgary

the excellent corrosion resistance,formability and strength make stainless steels versatile for diverse ***,its high specific strength and good crashworthiness make it suitable for transportation and aerospace *** the other hand,the need to reduce the weight of vehicle and aerospace components has created renewed interest in the use of magnesium *** to their differences in physical and metallurgical properties,bonding of the 316L steel and AZ31 magnesium alloy using conventional fusion welding methods encountered many ***,the use of liquid phase forming interlayers is required to overcome the differences in their properties,eliminates the need for a high bonding pressure to achieve intimate contact between the bonded *** Cu and Ni interlayers successively formed a eutectic phase with *** formation of intermetallics and Mg diffusion caused the eutectic phase to isothermally solidify with increasing bonding *** formation of ternary intermetallic phases（λ1 and B2） impaired the bond shear strength particularly at the end of the isothermal solidification stage where no eutectic phase was ***,the joints showed a higher shear strength value of 57 MPa when bonding with Cu interlayer at 530℃ for 30 min compared to 32 MPa when Ni interlayer was used at 510℃ for 20 min.

关键词： Magnesium alloy Stainless steel Eutectic bonding Microstructure Shear strength