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Aloe barbadensis Miller peptide/polypeptide fraction alleviates inflammation through inhibition of proinflammatory cytokines and mediators in vitro and in rats with Freund’s adjuvant-induced hind paw edema

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 524-530页

作者： Spoorthy N.Babu ayesha noor Centre for Bio Separation Technology Vellore Institute of TechnologyVelloreIndia

Objective:To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo ***:The peptide/polypeptide fraction from Aloe vera was obtained through trichloroacetic acid *** anti-inflammatory property of the peptide/polypeptide fraction was tested by protein denaturation,membrane stabilization *** effect of the fraction on RAW 264.7 cell viability was examined by MTT *** nitric oxide level was determined through Griess ***-αand IL-6 levels were estimated using ELISA *** vivo studies were carried out in male Wistar rats through injection of Freund’s adjuvant in the hind *** edema was measured through the Vernier scale and levels of alanine aminotransferase,aspartate transaminase,TNF-α,IL-6,and secretory phospholipase A2 were estimated through their respective kits after fourteen days of *** Pad Prism6 was used for analyzing the ***:The peptide/polypeptide extract inhibited protein denaturation with an IC50 value of(218.9±15.6)μg/m L and stabilized the membrane of red blood cells with an IC50 value of(275.9±19.1)μg/m *** extract showed no changes in cell morphology or cytotoxicity up to the concentration of 20μg/mL in MTT *** peptide/polypeptide fraction markedly reduced the levels of proinflammatory markers and mediators in both in vitro and in vivo ***:The results indicate that the peptide/polypeptide fraction of Aloe vera has antiinflammatory property through inhibition of inflammatory markers and mediators responsible for NF-κB and mitogen-activated protein kinase pathways.

关键词： Aloe vera Peptide/Polypeptide Inflammation Proinflammatory cytokines

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Task sharing: situation analysis about capacity and resources for management of diabetic retinopathy in Pakistan

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 809-814页

作者： Mufarriq Shah ayesha noor C Alex Harper Jill Elizabeth Keeffe Pakistan Institute of Community Ophthalmology Hayatabad Medical Complex Vision and Dental Care Clinic Centre for Eye Research Australia Department of OphthalmologyUniversity of Melbourneand Royal Victorian Eye and Ear Hospital LV Prasad Eye Institute

AIM: To assess the capacity and resources of eye care facilities, using the WHO Health Systems Framework, to manage diabetic retinopathy(DR) through task ***: Using purposive sampling, four participants(administrators) from four selected hospitals in two provinces in Pakistan were recruited for this cross-sectional study. A survey, to assess the capacity and resources of the selected eye care facilities for the feasibility to adopt task sharing in management of DR to prevent vision loss, was emailed to participants who were asked to complete. Responses to open-ended questions were entered into a Microsoft Excel spread sheet and inductive approach was applied for ***: All the surveyed eye care facilities offer eye care services for people with diabetes and DR. All surveyed eye care facilities have a shortage in the number of human resources across all cadres. Optometrists and mid-level eye care workers did not have active roles in DR screening and management in all four hospitals. All the hospitals surveyed did not have a computerized record management system for patients who visit ophthalmologists for eye examinations. Equipment for detection and management of DR were short in number and main users were ophthalmologists. There was no policy for population-based screening program for detection of DR in any of the surveyed ***: A system-based approach to manage DR is needed. The capacity of eye care facilities and the potential to improve access of people with diabetes to eyecare services can be enhanced through implementation of task sharing.

关键词： task sharing capacity diabetes diabetic retinopathy Pakistan

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Alginate based encapsulation of polyphenols ofPiper betelleaves:Development,stability,bio-accessibility and biological activities

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Food Bioscience 2022年第3期47卷 998-1006页

作者： ayesha noor Musa Al Murad A.Jaya Chitra Spoorthy N.Babu S.Govindarajan Centre for Bio Separation Technology (CBST) Vellore Institute of Technology (VIT)Vellore632014Tamil NaduIndia

Plant polyphenols have recently gained attention in nutraceutical and pharmaceutical industries due to their various therapeutic ***,the polyphenols are prone to oxidation,unstable towards heat,light,pH and their unpleasant taste also limits their *** usage of encapsulated polyphenols can alleviate these drawbacks and hence,efficient encapsulation methods have been *** present study focused on the synthesis of microspheres of Piper betle polyphenols by extrusion method using alginate and assesses the impact of alginate encapsulation on stability,bioavailability and therapeutic *** of Piper betle were studied for their stability,yield,size,characterized by using SEM for surface morphology and FTIR and evaluated for their bioavailability using in vitro simulated gastrointestinal digestion and therapeutic properties for a period of 24 *** results showed that encapsulation was successful using extrusion technique and the stability was improved as it protected the polyphenols and antioxidant from degradation for a period of 24 *** addition,bioavailability was also increased in small intestine and the antioxidant and antidiabetic properties were better retained after ***,this study showed that encapsulation of polyphenols of Piper betle leaves with alginate improved stability and can be a promising technique for food supplementation/nutraceutical with natural antioxidants.

关键词： Polyphenols Stability Encapsulation Alginate Antioxidant Antidiabetic

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Roles of the eye care workforce for task sharing in management of diabetic retinopathy in Cambodia

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 101-107页

作者： Mufarriq Shah Gail M.Ormsby ayesha noor Rahul Chakrabarti Manfred Morchen Fakir MAmirul Islam CAlex Harper Jill E Keeffe Pakistan Institute of Community Ophthalmology Hayatabad Medical Complex Peshawar 25000Pakistan Centre for Eye Research Australia Department of Ophthal-mologyUniversity of MelbourneRoyal Victorian Eye and Ear HospitalMelbourneVIC 302Australia Faculty of Education Science and BusinessLifestyle Research CentreAvondale College of Higher EducationCooranbongNSW 2265Australia Vision and Dental Care Clinic Peshawar 25000Pakistan CARITAS Takeo Eye Hospital Krong Doun Kaev 21151Cambodia Regional office Asia South East CBM International Unit 604 Alabang Business Tower 1216 Acacia AveMuntinlupa City 1799Philippines Statistics Data Science and EpidemiologySwinburne University of TechnologyHawthornVIC 3122Australia LV Prasad Eye Institute Hyderabad 500034India

AIM： To identify the current roles of eye and health care workers in eye care delivery and investigate their potential roles in screening and detection for management of diabetic retinopathy（DR） through task ***： Purposive sampling of 24 participants including health administrators, members from non-government organizations and all available eye care workers in Takeo province were recruited. This cross sectional mixed method study comprised a survey and in-depth interviews. Data were collected from medical records at Caritas Takeo Eye Hospital（CTEH） and Kiri Vong District Referral Hospital Vision Centre, and a survey and interviews with participants were done to explore the potential roles for task sharing in DR management. Qualitative data were transcribed into a text program and then entered into N-Vivo（version 10） software for data management and analysis. RESULTS： From 2009 to 2012, a total of 105 178 patients were examined and 14 030 eye surgeries were performed in CTEH by three ophthalmologists supported by ophthalmic nurses in operating and eye examination for patients. Between January 2011 and September 2012, 151 patients（72 males） with retinal pathology including 125（83%） with DR visited CTEH. In addition 170 patients with diabetes were referred to CTEH for eye examinations from Mo Po Tsyo screening programs for people with diabetes. Factors favouring task sharing included high demand for eye care services and scarcity of ***： Task sharing and team work for eye care services is functional. Participants favor the potential role of ophthalmic nurses in screening for DR through task sharing.

关键词： task sharing diabetes diabetic retinopathy human resources Cambodia

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Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 123-153页

作者： Muhammad Qasim Khan Fazal Malik Fahad Alturise noor Rahman Department of Computer Science Iqra National UniversityPeshawar25000Pakistan Department of Cybersecurity College of ComputerQassim UniversityBuraydah52555Saudi Arabia Department of Computer Science and Engineering Al-Fayha CollegeAl Jubayl31961Saudi Arabia

Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband ***,they consume important and scarce network resources such as bandwidth and processing *** have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial *** paper draws its motivation from such real network disaster incidents attributed to signaling *** this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and *** provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding *** important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a *** paper presents an update and an extension of our earlier conference *** our knowledge,no similar survey study exists on the subject.

关键词： Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication

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Unveiling the impact:COVID-19's influence on bacterial resistance in the Kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin K Saeed Safiya K Almusawi noor A Albalooshi Mohammed Al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

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Milk phospholipids-based nanostructures functionalized with rhamnolipids and bacteriocin:Intrinsic and synergistic antimicrobial activity for cheese preservation

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Food Bioscience 2022年第3期47卷 371-382页

作者： ayesha Sardar Khalid Taskeen Niaz Bina Zarif Saima Shabbir Tayyaba noor Ramla Shahid Muhammad Imran Department of Biosciences Faculty of SciencesCOMSATS University IslamabadPark RoadIslamabad45550Pakistan Department of Materials Science and Engineering Institute of Space TechnologyIslamabad44000Pakistan School of Chemical and Materials Engineering (SCME) National University of Science and Technology (NUST)IslamabadPakistan

Milk fat globule membrane (MFGM) phospholipids-based nanostructures were developed and their functionalization with rhamnolipids (RLs) was carried out to enhance the preservation of cheese against resistant foodborne pathogens i.e.,Listeria monocytogenes and Escherichia coli .Void (without nisin) and nisin-loaded RLs functionalized MFGM nanostructures (RLs-MFGM-NS) were fabricated by ultrasonication-assisted self-assembly *** morphology of void and loaded RLs-MFGM-NS and pristine MFGM nanostructures (MFGM-NS) was observed under scanning electron microscopy (SEM),which indicated uniform size ranging from 43 nm (void RLs-MFGM-NS) to 194 nm (loaded RLs-MFGM-NS).FTIR analyses confirmed the electrostatic interaction,predominantly H-bonding and linkage of carboxyl ester group of MFGM with C–H group in RLs after functionalization of ***,quantitative antimicrobial assay on cheese slices confirmed the broad-spectrum potential of intrinsically active nanostructures (due to RLs) having synergistic activity with nisin against *** and *** .Hence,nisin-loaded RLs-MFGM-NS can be applied as promising bioactive additives for sustained preservation of cheese.

关键词： Rhamnolipids Nisin MFGM Functionalized nanostructures Foodborne pathogens

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Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan M Isa Marwa J Abdulnabi Nawra S Naser Fatema N Lahmda noor M AlAnsari Zahra H Isa Afaf M Mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the Mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(P<0.001);and presented with more cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(P<0.001)],and positive physical findings(P=0.002)than non-IgE-mediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 mo

关键词： Children Milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

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Radiative Blood-Based Hybrid Copper-Graphene Nanoliquid Flows along a Source-Heated Leaning Cylinder

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1017-1037页

作者： Siti Nur Ainsyah Ghani noor Fadiya Mohd noor Institute of Mathematical Sciences Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia Center for Data Analytics Consultancy&Services(UM-CDACS) Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia

Variant graphene,graphene oxides(GO),and graphene nanoplatelets(GNP)dispersed in blood-based copper(Cu)nanoliquids over a leaning permeable cylinder are the focus of this *** forms of graphene are highly beneficial in the biological and medical fields for cancer therapy,anti-infection measures,and drug *** non-Newtonian Sutterby(blood-based)hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating *** governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational *** equations are then transformed into boundary value problems through a shooting technique,followed by the implementation of the bvp4c tool in *** influences of various parameters on the model’s nondimensional velocity and temperature profiles,reduced skin friction,and reduced Nusselt number are presented for detailed *** results indicated that Cu-GNP/blood and Cu-GO/blood hybrid nanofluids exhibit the lowest and highest velocity distributions,respectively,for increased nanoparticles volume fraction,curvature parameter,Sutterby fluid parameter,Hartmann number,and wall permeability ***,opposite trends are observed for the temperature distribution for all considered parameters,except the mixed convection *** in the reduced skin friction magnitude and the reduced Nusselt number with higher values of graphene/GO/GNP nanoparticle volume fraction are also ***,GNP is identified as the superior heat conductor,with an average increase of approximately 5%and a peak of 7.8%in the reduced Nusselt number compared to graphene and GO nanoparticles in the Cu/blood nanofluids.

关键词： Hybrid nanofluid sutterby fluid tiwari-das model thermal radiation graphene graphene oxides graphene nanoplatelets

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Effects of bismuth on structural and dielectric properties of cobalt-cadmium spinel ferrites fabricated via micro-emulsion route

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Chinese Physics B 2019年第8期28卷 408-416页

作者： Furhaj Ahmed Sheikh Muhammad Khalid Muhammad Shahzad Shifa H M noor ul Huda Khan Asghar Sameen Aslam ayesha Perveen Jalil ur Rehman Muhammad Azhar Khan Zaheer Abbas Gilani Department of Physics Balochistan University of Information TechnologyEngineering & Management SciencesQuetta 87300Pakistan Department of Physics Government College UniversityFaisalabad 38000Pakistan Department of Physics The Islamia University of Bahawalpur 63100Pakistan

Spinel ferrites have a significant role in high-tech *** the present work nano-crystalline ferrites having general formula Co0.5Cd0.5BixFe2-xO4 with(x=0.0,0.05,0.1,0.15,0.2,and 0.25)are synthesized via micro-emulsion *** x-ray diffraction(XRD)studies discover the FCC spinel *** size is calculated in a range of 11 nm-15 *** parameter calculations are reduced due to its substitution which leads to the exchange of large ionic radius of Fe^3+for small ionic radius of Bi^3+.The x-ray density is analyzed to increase with *** transform infrared spectroscopy(FTIR)is performed to analyze absorption band *** two absorption bands are observed in a range of 400 cm^-1-600 cm^-1,and they are the characteristic feature of spinel ***-gravimetric analysis(TGA)reveals the total weight loss of nearly 1.98%.Dielectric analysis is carried out by impedance analyzer in a frequency span from 1 MHz to 3 GHz by using the Maxwell Wagner *** studies reveal the decrease of dielectric *** alternating current(AC)conductivity exhibits a plane behavior in a low frequency range and it increases with the applied frequency *** is attributed to the grain effects in a high frequency range or may be due to the reduction of *** and imaginary part of impedance show the decreasing trend which corresponds to the grain boundary *** imaginary modulus shows the occurrence of peak that helps to understand the interfacial ***-Cole graph shows a single semicircle which confirms that the conduction mechanism is due to the grain boundaries at low *** studies reveal the applicability of these ferrites in high frequency equipment,microwave applications,high storage media,and semiconductor devices.

关键词： Co-ferrite nanocrystalline ferrites XRD microemulsion dielectric properties

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