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Angiotensin Ⅱ receptor blockers and gastrointestinal adverse events of resembling sprue-like enteropathy:a systematic review

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Gastroenterology Report 2019年第3期7卷 162-167,I0001页

作者： ayesha kamal Christopher Fain Angela Park Peiqi Wang Eduardo Gonzalez-Velez Daniel A.Leffler Susan M.Hutfless Department of Medicine Division of GastroenterologyJohns Hopkins UniversityBaltimoreMDUSA Johns Hopkins Department of Surgery and Surgical SciencesJohns Hopkins UniversityBaltimoreMDUSA Division of Gastroenterology Beth Israel Deaconess Medical CenterBostonMAUSA Department of Epidemiology Johns Hopkins Bloomberg School of Public HealthBaltimoreMDUSA

Background:Olmesartan,an angiotensin Ⅱ receptor blocker(ARB),is associated with gastrointestinal symptoms resembling sprue-like *** have proposed that enteropathy may be a class effect rather than *** performed a systematic review to identify literature of sprue-like enteropathy for all ***:Case reports,case series and comparative studies of ARBs were searched on PubMed and Embase databases through 21 November 2018 and then ***:A total of 82 case reports and case series as well as 5 comparative studies,including 248 cases,were selected and *** ARBs listed in the case reports were olmesartan(233 users;94.0%),telmisartan(5 users;2.0%),irbesartan(4 users;1.6%),valsartan(3 users;1.2%),losartan(2 users;0.8%)and eprosartan(1 user;0.4%).The periods between ARB initiation and onset of symptoms ranged from 2 weeks to 13 *** results were reported in 218 cases,in which 201 cases(92.2%)were villous atrophy and 131 cases(60.1%)were intraepithelial *** leucocyte antigen(HLA)testing was performed in 147 patients,among whom 105(71.4%)had HLA-DQ2 or HLA-DQ8 *** antibodies were tested in 169 patients,among whom 167(98.8%)showed negative *** exclusion from the diet failed to relieve symptoms of enteropathy in 127(97.7%)of 130 patients with *** remission of symptoms after discontinuation of ARB was reported in 233(97.4%)of the 239 patients with *** cases(2.8%)reported recurrence of symptoms after restarting olmesartan;rechallenge was not reported for the non-olmesartan *** retrospective studies conducted worldwide had inconsistent study designs(*** in periods of study and case definition)and ***:Although enteropathy is rare,clinicians should remain vigilant of this potential adverse event even years after medication initiation.

关键词： angiotensinⅡreceptor blockers olmesartan enteropathy diarrhea

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Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis:Systematic review and meta-analysis

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World Journal of Hepatology 2024年第11期16卷 1331-1338页

作者： Nirav Agrawal Scarlet Louis-Jean Zoya Ladiwala Harsha Adnani ayesha kamal Mitchell Karpman Albert Steven Fleisher Sanmeet Singh Department of Internal Medicine Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Biostatistics Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Gastroenterology Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Acute kidney injury(AKI)in cirrhosis is *** diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum ***,urine biomarkers could also be used to assess the type of AKI and the severity of the *** performed a systematic review with metaanalysis to evaluate the association with urine neutrophil gelatinase-associated lipocalin(NGAL)marker in identifying acute tubular necrosis(ATN)in patients with *** To assess the reliability of urine NGAL in the detection of ATN in patients with *** We systematically searched MEDLINE and PubMed using keywords including“urine biomarkers”,“NGAL”,“kidney dysfunction”,and“cirrhosis”to identify relevant *** was screened and *** studies assessed hospitalized cirrhosis patients with AKI using the urine NGAL *** synthesized the data using diagnostic odds ratio(DOR),comparative and descriptive analyses,and Cochran Mantel-Haenszel(CMH)statistics to evaluate *** Three thousand seven hundred and one patients with cirrhosis were analyzed from a total of 21 cohort *** DOR of 14 of those studies[pooled DOR:22.150,(95%CI:17.58-27.89),P<0.0001]demonstrated a significant association between urine NGAL levels and its identification of *** stratification by cirrhosis status,heterogeneity was analyzed and showed a significant non-zero correlation between NGAL and AKI(CMH statistic=702.19,P<0.0001).CONCLUSION In patients with cirrhosis,the use of urine NGAL is a reliable biomarker for detecting ATN and identifying the etiology of AKI.

关键词： Neutrophil gelatinase-associated lipocalin Acute tubular necrosis Acute kidney injury Cirrhosis Biomarker Severe liver dysfunction

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Human Pose Estimation and Object Interaction for Sports Behaviour

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Computers, Materials & Continua 2022年第7期72卷 1-18页

作者： ayesha Arif Yazeed Yasin Ghadi Mohammed Alarfaj Ahmad Jalal Shaharyar kamal Dong-Seong Kim Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain15551UAE Department of Electrical Engineering College of EngineeringKing Faisal UniversityAl-AhsaSaudi Arabia Department of IT Convergence Engineering Kumoh National Institute of TechnologyGumiKorea

In the new era of technology,daily human activities are becoming more challenging in terms of monitoring complex scenes and *** understand the scenes and activities from human life logs,human-object interaction(HOI)is important in terms of visual relationship detection and human pose *** understanding and interaction recognition between human and object along with the pose estimation and interaction modeling have been *** existing algorithms and feature extraction procedures are complicated including accurate detection of rare human postures,occluded regions,and unsatisfactory detection of objects,especially small-sized *** existing HOI detection techniques are instancecentric(object-based)where interaction is predicted between all the *** estimation depends on appearance features and spatial ***,we propose a novel approach to demonstrate that the appearance features alone are not sufficient to predict the ***,we detect the human body parts by using the Gaussian Matric Model(GMM)followed by object detection using *** predict the interaction points which directly classify the interaction and pair them with densely predicted HOI vectors by using the interaction *** interactions are linked with the human and object to predict the *** experiments have been performed on two benchmark HOI datasets demonstrating the proposed approach.

关键词： Human object interaction human pose estimation object detection sports estimation sports prediction

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Synthesis and Properties of Melt Processed Poly(thiourea-azo-sulfone)/Carbon Nanotubes Nanocomposites

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Chinese Journal of Polymer Science 2014年第1期32卷 64-72页

作者： ayesha Kausar Nanosciences and Catalysis Division National Centre for Physics Quaid-i-Azam University Campus

An aromatic azo-polymer, poly（thiourea-azo-sulfone）（PTAS）, has been prepared using 4-（4- aminophenylsulfonyl）benzenamine and diazonium salt solution of 2,6odiaminopyridine. PTAS was easily processable using polar solvents and had high molar mass 63 × 103 ***1-1 according to GPC. Mechanically and thermally stable and electrically conducting polymer/CNTs nano-composites were obtained via melt processing technique. Fine distribution of CNTs in a polymer matrix performed an essential role in the preparation of polymer/CNTs nano-composites based on interfacial interaction between CNTs and polymer matrix. Scanning electron micrographs showed good dispersion of filler and adhesion of matrix on the surface of nanotubes. Accordingly, increasing the amount of CNTs from 0.1 wt% to 5 wt% increased the electrical conductivity from 2.99 ***-1 to 3.56 ***-1. Mechanical strength of functional nanotubes-based hybrids was enhanced from 43.22 MPa to 65.02 MPa compared with that of hybrids with non-functional filler in matrix 37.21 MPa. A rapport between nanotube loading and thermal stability of the materials was also observed. 10% gravimetric loss temperature was increased from 528 ~C to 578 ~C, while glass transition was improved from 241 ℃ to 271 ℃. Adding up of small quantity of functional CNTs strongly affected the tensile, electrical and thermal properties of materials. Improvement of the physical properties of CNT-reinforced polymer nano-composites was ascribed to the melt processing technique.

关键词： Poly(thiourea-azo-sulfone) Melt processing Tensile strength Thermal stability Electrical conductivity.

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Properties of Phosphoric Acid Doped Poly(benzimidazole/sulfone/siloxane/amide)/Sulfonated Polystyrene/Silica Nanoparticle-based Proton Exchange Membranes for Fuel Cells

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Chinese Journal of Polymer Science 2014年第10期32卷 1319-1328页

作者： ayesha Kausar Muhammad Siddiq Nanosciences and Catalysis Division National Centre For Physics Quaid-i-Azam University CampusIslamabad 44000 Pakistan Department of Chemistry Quaid-i-Azam University Islamabad Pakistan

New siloxane and sulfone containing poly（benzimidazole/sulfone/siloxane/amide）（PBSSA） has been prepared for the formation of hybrid membranes （PBSSA/PS-S/SiNPs） with sulfonated polystyrene （PS-S） and 0.1 wt%-2 wt% silica nanoparticles （SiNPs）. Field emission scanning electron micrographs showed good dispersion of filler, formation of dense nanoporous honeycomb like structure and uniform ionic pathway in these hybrids. The porous membrane structure was responsible for the fine water retention capability and higher proton conductivity of the new hybrids. Increasing the amount of nanoparticles from 0.1 wt% to 2 wt% increased the tensile stress of acid doped PBSSA/PS-S/SiNPs nanocomposites from 65.7 MPa to 68.5 MPa. A relationship between nanofiller loading and thermal stability of the membranes was also experientially studied, as the glass transition temperature of phosphoric acid doped PBSSAJPS-S/SiNPs nanocomposites increased from 207℃ to 215 ℃. The membranes also had higher ion exchange capacity （IEC） around 2.01 mmol/g to 3.01 mmol/g. The novel membranes with high IEC value achieved high proton conductivity of 1.10-2.34 S/cm in a wide range of humidity values at 80 ~C which was higher than that of perfluorinated Nafion 117 membrane （1.1 × 10^-1 S/cm） at 80 ~C （94% RH）. A H2/O2 fuel cell using the PBSSA/PS-S/SiNP 2 （IEC 3.01 retool/g） showed better performance than that of Nation 117 at 40 ℃ and 30% RH.

关键词： Poly(benzimidazole/sulfone/siloxane/amide) Sulfonated polystyrene Silica nanoparticles Ion exchange capacity Proton conductivity.

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Indispensable Hibi Relations and Grobner Bases

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Algebra Colloquium 2015年第4期22卷 567-580页

作者： ayesha Asloob Qureshi ] Abdus Salam School of Mathematical Sciences GC University Lahore. 68-B New Muslim "Ibwn Lahore 54600 Pakistan

In this paper we consider Hibi rings and Rees rings attached to a poset. We classify the ideal lattices of posets whose Hibi relations are indispensable and the ideal lattices of posets whose Hibi relations form a quadratic Grobner basis with respect to the rank lexicographic order. Similar classifications are obtained for Rees rings of Hibi ideals.

关键词： Hibi rings Hibi relations Gr5bner bases lattices

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MECHANICALLY AND THERMALLY STABLE BLENDS OF POLY(STYRENE-BUTADIENE-STYRENE) WITH CONDUCTING POLY(THIOUREA-AZO-NAPHTHYL)

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Chinese Journal of Polymer Science 2013年第12期31卷 1623-1631页

作者： ayesha Kausar Syed Tajammul Hussain Nanosciences and Catalysis Division National Centre for PhysicsQuaid-i-Azam University Campus

A new aromatic azo-polymer, poly（thiourea-azo-naphthyl）（PTAN）, has been synthesized using 1-（5- thiocarbamoylaminonaphthyl）thiourea and diazonium salt solution of 2,6-diaminopyridine. PTAN was easily processable using polar solvents and had high molar mass 57 × 10^3 g/mol. Electrically conducting, mechanically and thermally stable rubbery blends of poly（styrene-butadiene-styrene）（SBS） triblock copolymer and PTAN were produced by solution blending technique. FESEM of SBS/PTAN blends revealed nano-scale dispersion of the conducting filler showing good adhesion between the matrix and PTAN. Remarkable effects of azo-content on the conductivity of SBS-based blends have been observed. Accordingly, PTAN loading from 10 to 60 wt% increased the conductivity from 1.24 to 1.66 S/cm. Relationship between PTAN loading and thermal stability of the materials was also investigated. With increasing the PTAN content, 10% gravimetric loss was increased from 484 to 500 ℃, while glass transition was enhanced from 119 to 126 ℃. Thermal and conducting data of the blend showed better results relative to pure elastomer but were lower than those of the conducting filler. Similarly, the tensile strength （57.35-62.33 MPa） of SBS/PTAN was improved relative to there of SBS. Fine balance of properties renders new materials fairly better than the existing elastomeric blends used in a number of applications.

关键词： Poly(thiourea-azo-naphthyl) SBS Electrical conduction Thermal stability Tensile strength.

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Prospects and limitations of soil amendment and irrigation techniques for the water-saving public urban greenery and ephemeral weed management in the sandy soils of the United Arab Emirates

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Journal of Arid Land 2024年第9期16卷 1288-1302页

作者： ayesha ALAM Elke GABRIEL-NEUMANN Department of Integrative Agriculture College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates ASPIRE Research Institute of Food Security in Drylands College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates

Public urban greenery greatly contributes to the residential and tourist value of cities in the Gulf Region,but due to the hyper-arid climatic conditions,the cost of irrigation and plant maintenance is very *** strategies to reduce the monetary and ecological costs involve the cultivation of native xerophytic plantations,and/or the use of soil improvers to increase water-and nutrient-holding capacity of the sandy *** soil improvers based on mineral,organic,or synthetic materials have entered the United Arab Emirates(UAE)market in recent years,but there is considerable uncertainty about how they should best be used in combination with ornamental plant stands involving xerophytic native *** present study investigated the effect of soil amendment and deep pipe irrigation on perennial ornamental plant stands involving native plants(Tephrosia appolinea(Gel.)Link in combination with Aerva javanica(Burm.f.)*** Schult.)and native-exotic plants(*** in combination with Ruelia simplex ***)either or not topsoil and subsoil amendment with bentonite and hydrophobic sand under the irrigation water supply of less than 50%of reference evapotranspiration(ET0).After one year of cultivation,*** and ***(native ***)produced high biomass and exhibited high water use efficiency(WUE)as compared with *** and ***(native ***)combination given that no significant differences were found under the soil amendment *** stands thrived under irrigation water supply far below what is usually supplied to exotic ornamental stands in public parks of the Al Ain City,the ***,subsoil amendment in combination with deep pipe irrigation reduced the occurrence of weeds and increased the overall plant rooting *** results suggest that subsoil amendment and irrigation up to 60-80 cm depth can potentially control ephemeral weed infestation,which is a great challenge in various plant production systems of the

关键词： native and exotic plant communities competitive strength soil improvers urban plantation subsoil amendment weed management

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Thermal, Mechanical and Electrical Studies of Novel Shape Memory Polyurethane/Polyaniline Blends

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Chinese Journal of Polymer Science 2015年第9期33卷 1313-1324页

作者： Rabia Sattar ayesha Kausar Muhammad Siddiq Department of Chemistry Quaid-i-Azam University Nanosciences and Catalysis Division National Centre for Physics Quaid-i-Azam University Campus

Shape memory polymer （SMP） blends based on polyurethane （PU） and polyaniline （PANI） were prepared via chemical in situ polymerization process. The thermal, mechanical, electrical and shape memory properties were investigated. The structural characterization and morphology of the polymer blends were inspected by Fourier transform infrared （FTIR） and scanning electron microscopy （SEM）, respectively. The 1 wt% of PANI loading enhanced the thermal stability of the system up to 339 ~C. According to differential scanning calorimetry （DSC）, the glass transition temperature （Tg） and melting temperature （Tm） of PU/PANI blends increased with the polyaniline loading （0.1 wt%-l wt%）. Improved mechanical properties such as tensile strength and Young＇s modulus of PU matrix were also observed with PANI. Moreover, the electrical conductivity of PU/PANI blends was also found to be a function of PANI loading. Remarkable recoverability of thermally triggered shape memory （SM） behavior to the extent of 96% was achieved for 1 wt% PANI blend.

关键词： Shape memory Polyurethane Polyaniline Blends Conductivity.

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Parameter Estimation Based on Censored Data under Partially Accelerated Life Testing for Hybrid Systems due to Unknown Failure Causes

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Computer Modeling in Engineering & Sciences 2022年第3期130卷 1239-1269页

作者： Mustafa kamal Department of Basic Sciences College of Science and Theoretical StudiesSaudi Electronic UniversityDammam32256Saudi Arabia

In general,simple subsystems like series or parallel are integrated to produce a complex hybrid *** reliability of a system is determined by the reliability of its constituent *** is often extremely difficult or impossible to get specific information about the component that caused the system to *** failure causes are instances in which the actual cause of systemfailure is *** the other side,thanks to current advanced technology based on computers,automation,and simulation,products have become incredibly dependable and trustworthy,and as a result,obtaining failure data for testing such exceptionally reliable items have become a very costly and time-consuming ***,because of its capacity to produce rapid and adequate failure data in a short period of time,accelerated life testing(ALT)is the most utilized approach in the field of product reliability and life *** on progressively hybrid censored(PrHC)data froma three-component parallel series hybrid system that failed to owe to unknown causes,this paper investigates a challenging problem of parameter estimation and reliability assessment under a step stress partially accelerated life-test(SSPALT).Failures of components are considered to follow a power linear hazard rate(PLHR),which can be used when the failure rate displays linear,decreasing,increasing or bathtub failure *** Tempered random variable(TRV)model is considered to reflect the effect of the high stress level used to induce early failure *** maximum likelihood estimation(MLE)approach is used to estimate the parameters of the PLHR distribution and the acceleration factor.A variance covariance matrix(VCM)is then obtained to construct the approximate confidence intervals(ACIs).In addition,studentized bootstrap confidence intervals(ST-B CIs)are also constructed and compared with ACIs in terms of their respective interval lengths(ILs).Moreover,a simulation study is conducted to demonstrate the

关键词： Step stress partially accelerated life test progressive hybrid censoring data masking power linear hazard rate distribution hybrid system

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