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Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

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World Journal of Gastroenterology 2008年第43期14卷 6704-6710页

作者： Aliye Soylu Can Dolapcioglu Kemal Dolay aydin ciltas Nurgul Yasar Mustafa kalayci Halil Alis Nurten Sever Gastroenterology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Gastroenterology Dr.Lutfi Kirdar Kartal Research and Training HospitalIstanbul 34865Turkey General Surgery Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Internal Medicine Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey Pathology Bakirkoy Dr Sadi Konuk Research and Training HospitalIstanbul 34147Turkey

AIM： To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs （NSAIDs） with respect to some risk factors and patient characteristics. METHODS： The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion （group Ⅰ ） with suicidal intent. Thirty patients with or without mild complaints of dyspepsia （group Ⅱ） were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score （LS）, expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS： Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ （P 〈 0.01）. The LS was similar in both groups Ⅰ a and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs （group Ⅰ c） compared to other patients （P 〈 0.01）. The LS was correlated to age （P 〈 0.01） and total amount of drug ingested （P 〈 0.05） in group Ⅰ ; but it was not correlated with Helicobacter pylori （H pylori） infection or duration of exposure （P 〉 0.05）. The biopsy score （BS） was higher in group Ⅰ than group Ⅱ （P 〈 0.01）, and higher in group Ⅰb than group Ⅰa （P 〈 0.05）. CONCLUSION： The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.

关键词： Acute gastric injury Nonsteroidal anti-inflammatory drug Acetaminophen Endoscopic lesion Gastroscopy

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Determination of diclofenac in pharmaceutical preparations by voltammetry and gas chromatography methods

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Journal of Pharmaceutical Analysis 2015年第3期5卷 153-160页

作者： Bilal Yilmaz Ulvihan ciltas Department of Analytical Chemistry Faculty of PharmacyAtaturk University

Rapid, sensitive and specific methods were developed for the determination of diclofenac in pharmaceutical preparations by linear sweep voltammetry （LSV） and gas chromatography （GC） with mass spectrometry （MS） detection. The linearity was established over the concentration range of 5- 35 μg/mL for LSV and 0.25-5 μg/mL for GC-MS method. The intra- and inter-day relative standard deviation （RSD） was less than 4.39% and 4.62% for LSV and GC-MS, respectively. Limits of quantification （LOQ） were determined as 4.8 and 0.15 μg/mL for LSV and GC-MS, respectively. No interference was found from tablet excipients at the selected assay conditions. The methods were applied for the quality control of commercial diclofenac dosage forms to quantify the drug and to check the formulation content uniformity.

关键词： Diclofenac Sweep voltammetry Chromatography-massspectrometry Pharmaceutical preparation

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Surgical intervention may not always be required in gossypiboma with intraluminal migration

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World Journal of Gastroenterology 2007年第48期13卷 6605-6607页

作者： H Alis A Soylu K Dolay M Kalaycl A ciltas General Surgery Department Endoscopy Unit Bakirkoy Research and Training Hospital Istanbul Turkey Department of Gastroenterology Bakirkoy Research and Training Hospital Istanbul Turkey

Gossypiboma is the technical term for a retained surgical sponge. Because of legal-ethical concerns, there have not been many publications on this topic. Delays in diagnosis and treatment might increase mortality and morbidity. Radiological imaging is used in diagnosis. We present a case of gossypiboma that had fistulized to bulbous following hydatic cyst surgery. We established the diagnosis with endoscopy and followed its migration endoscopically.

关键词： Gossypiboma Retained surgical sponge Endoscopy

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