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A novel t(3;12)(q21;p13) translocation in a patient with accelerated chronic myeloid leukemia after imatinib and nilotinib therapy

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Cancer Biology & Medicine 2013年第1期10卷 47-51页

作者： ayda bennour Ikram Tabka Yosra Ben Youssef Zahra Kmeira Abderrahim Khelif Ali Saad Halima Sennana Department of Cytogenetics Molecular Genetics and Reproductive Biology Farhat Hached University Teaching Hospital Department of Clinical Hematology Farhat Hached Hospital

The acquisition of secondary chromosomal aberrations in chronic myeloid leukemia (CML) patients with Philadelphia chromosome-positive (Ph+) karyotype signifies clonal evolution associated with the progression of the disease to its accelerated or blastic phase. Therefore, these aberrations have clinical and biological significance. T(3;12)(q26;p13), which is a recurrent chromosomal aberration observed in myeloid malignancies, is typically associated with dysplasia of megakaryocytes, multilineage involvement, short duration of any blastic phase, and extremely poor prognosis. We have identified a recurrent reciprocal translocation between chromosomes 3 and 12 with different breakpoint at bands 3q21 in the malignant cells from a 28-year-old man. The patient was initially diagnosed as having Ph+ CML in the chronic phase. The t(3;12)(q21;p13) translocation occurred 4 years after the patient was first diagnosed with CML while undergoing tyrosine kinase inhibitor therapy. We confirmed the t(3;12)(q21;p13) translocation via fluorescence in situ hybridization assay by using whole-chromosome paint probes for chromosomes 3 and 12. Our findings demonstrate that, similar to other recurrent translocations involving 3q26 such as t(3;3) and t(3;21), the t(3;12)(q21;p13) translocation is implicated not only in myelodysplastic syndrome and acute myeloid leukemia but also in the progression of CML. These findings extend the disease spectrum of this cytogenetic aberration.

关键词： Philadelphia chromosome t(3 12)(q21 p13) chronic myeloid leukemia accelerated phase fluorescence in situhybridization

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A Hybrid Coordinated Design Method for Power System Stabilizer and FACTS Device Based on Synchrosqueezed Wavelet Transform and Stochastic Subspace Identification

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Journal of Modern Power Systems and Clean Energy 2021年第4期9卷 910-918页

作者： ayda Faraji Ali Hesami Naghshbandy Arman Ghaderi Baayeh Department of Electrical Engineering Faculty of EngineeringUniversity of KurdistanSanandajKurdistanIran

The occurrence of low-frequency electromechanical oscillations is a major problem in the effective operation of power systems. The scrutiny of these oscillations provides substantial information about power system stability and security. In this paper, a new method is introduced based on a combination of synchrosqueezed wavelet transform and the stochastic subspace identification (SSI) algorithm to investigate the low-frequency electromechanical oscillations of large-scale power systems. Then, the estimated modes of the power system are used for the design of the power system stabilizer and the flexible alternating current transmission system (FACTS) device. In this optimization problem, the control parameters are set using a hybrid approach composed of the Prony and residual methods and the modified fruit fly optimization algorithm. The proposed mode estimation method and the controller design are simulated in MATLAB using two test case systems, namely IEEE 2-area 4-generator and New England-New York 68-bus 16-generator systems. The simulation results demonstrate the high performance of the proposed method in estimation of local and inter-area modes, and indicate the improvements in oscillation damping and power system stability.

关键词： Low‐frequency oscillation modified fruit fly optimization algorithm Prony analysis stochastic subspace identification(SSI)algorithm synchrosqueezed wavelet transform(SSWT)

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Comparison of Essential Oil Composition,Phenolic Compound and Biological Activities of Salvia microphylla and Teucrium polium(Lamiaceae)

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Journal of Renewable Materials 2022年第6期10卷 1607-1621页

作者： ayda Khadhri Chedia Aouadhi Eric Masson Antonio Pizzi Plant Soil and Environment Interactions LaboratoryFaculty of SciencesUniversity of El-Manar IITunisTunisia Bacteriology and Biotechnology Development Groups Epidemiology Laboratory and Veterinary MicrobiologyPasteur Institute of TunisUniversity of El-Manar IITunisTunisia CRITTBois EpinalFrance LERMAB University of LorraineEpinalFrance Department of Physics King Abdulaziz UniversityJeddahSaudi Arabia

Salvia microphylla and Teucrium polium are medicinal and aromatic plants with ethnobotanical *** present study was conducted to investigate the chemical composition of Salvia microphylla and Teucrium polium essential oils,the secondary metabolites,and the biological activities of their infusion and methanolic(MeOH)*** oils were extracted by hydrodistillation from shoots Salvia microphylla and Teucrium *** content,antioxidant and antimicrobial activities were *** chromatography-mass spectrometry(GCMS)results showed the presence of significant qualitative and quantitative variations for the composition of the both essential oils(EO).Salvia microphylla EO were most complex and present 70 compounds with the major components wereβ-caryophyllene(13.32%),1,8 cineole(11.25%),Cis p-Menthane-3-one(10.74%),andβ-Selinenol(9.71%).Where in the Teucrium polium EO,45 compounds were identified with the important components areβ-cadinene(10%),β-citronellol(8.5%),Carvacrol(7.63%),and Eugenol(7.15%).Obtained results showed that both plant are very rich in secondary *** isolated from Salvia microphylla presented the highest contents in the phenolic compound than extracted from Teucrium *** antioxidant activity data demonstrated that all extracts showed strong antioxidant and radical scavenging *** oil and methanol extracts presented a potential for antimicrobial activities against all tested *** obtained results highlight the potential use of Salvia microphylla and Teucrium polium as possible natural antioxidant substances and sources of bioactive molecules.

关键词： Salvia microphylla Teucrium polium phenolic compounds antioxidant antimicrobial activity essential oil

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Design Study of a Cable-based Gait Training Machine

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Journal of Bionic Engineering 2017年第2期14卷 232-244页

作者： Houssein Lamine Med Amine Laribi Sami bennour Lotfi Romdhane Said Zeghloul Mechanical Laboratory of Sousse (LMS) National Engineering School of Sousse University of Sousse Sousse 4000 Tunisia Department of GMSC Pprime Institute CNRS ENSMA University of Poitiers UPR 3346 France Mechanical Engineering Department American University of Sharjah PO Box 26666 Sharjah United Arab Emirates

This paper deals with a design approach of a gait training machine based on a quantitative gait analysis. The proposed training machine is composed of a body weight support device and a cable-driven parallel robot. This paper is focused on the cable-driven robot, which controls the pose of the lower limb through an orthosis placed on the patient＇s leg. The cable robot reproduces a normal gait movement through the motion of the orthosis. A motion capture system is used to perform the quantitative analysis of a normal gait, which will be used as an input to the inverse dynamic model of the cable robot. By means of an optimization algorithm, the optimal design parameters, which minimize the tensions in the cables, are determined. Two constraints are considered, i.e., a non-negative tension in the cables at all times, and a free cable/end-effector collision. Once the optimal solution is computed, a power analysis is carried out in order to size the robot actuators. The proposed approach can be easily extended for the design study of a similar type of cable robots.

关键词： gait rehabilitation cable-driven robots body weight support system design optimization

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Synthesis, Surface Characterization and Photocatalytic Activity of TiO_2 Supported on Almond Shell Activated Carbon

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Journal of Materials Science & Technology 2014年第9期30卷 894-902页

作者： A.Omri S.D.Lambert J.Geens F.bennour M.Benzina Laboratory of Water-Energy-Environment (LR35 Code: AD-10-02 National School of Engineers of SfaxUniversity of SfaxBP W 3038 Sfax Tunisia Laboratory of Chemical Engineering B6a University of LiègeB-4000 Liège Belgium Tunisian Chemical Group Sfax -Tunisia B.P 393/3018 Tunisia

Three types of photocatalysts were synthesized by metal organic chemical vapor deposition and impregnation methods using the almond shell activated carbon as support. These photocatalysts denoted by （TiO2/ASAC （V）, TiO2/ASAC （11） and TiO2/ASAC （12）） were characterized by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, diffuse reflectance spectroscopy （DRS） and nitrogen adsorption-desorption isotherms. SEM observation shows that TiO2 was deposited on activated carbon surface. XRD results confirm that TiO2 existed in a mixture of anatase and rutile phases. The DRS spectra show the characteristic absorption edge of TiO2 at approximate 380 nm corresponding to the optical band gap of 3.26 eV. Besides, FTIR spectrum indicated the presence of （Ti-O） groups. The specific surface area of photocatalysts decreased drastically in comparison with the original activated carbon. The catalysts were very efficient for the photodegradation of total organic carbon （TOC） from industrial phosphoric acid solution under UV irradiation. The kinetics of photocatalytic TOC degradation was found to follow a pseudo- first-order model. The prepared TiO2/ASAC showed high photoactivity for the photodegradation of TOC in the following order： TiO2/ASAC （V）〉 TiO2/ASAC （11）〉 TiO2/ASAC （12）〉 ASAC 〉 TiO2 （P25）.

关键词： Almond shell activated carbon Photocatalyst Vapor deposition Impregnation Total organic carbon

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Use of complementary and alternative medicine in pregnant women:A cross-sectional survey in the south of Iran

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Journal of Integrative Medicine 2019年第6期17卷 392-395页

作者： Naghmeh Yazdi Alireza Salehi Mina Vojoud Mohammad Hossein Sharifi ayda Hoseinkhani Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences71348-14336 ShirazIran Student Research Committee Shiraz University of Medical Sciences71348-14336 ShirazIran

Objective: The use of traditional medicine and complementary alternative medicine(TM/CAM) derived from herbal remedies or natural supplements is increasing worldwide, but there are limited data on the use of TM/CAM during pregnancy. Iran has various ethnic populations, and the usage of TM/CAM by the different ethnic groups has not been researched. The aim of this study is to understand the use of TM/CAM modalities in pregnant women of different ethnic groups in southern ***: This study was conducted in primary health care centers in Khuzestan Province, Iran, from May to August, 2016. A semi-structured valid questionnaire was used to gather information in pregnant women(n = 170).Results: About 46.5% of women in this study used TM/CAM during previous pregnancies. The majority(67%) of study participants were Arab. The Arab population showed increased use of TM/CAM during pregnancy(P = 0.014). Women with complications in former pregnancies had significantly higher incidence rate of TM/CAM use(65.8%) compared to the other group(39.6%)(P = 0.001).Conclusion: Understanding TM/CAM use and the associated factors in different ethnic groups of pregnant women will benefit the evaluation of the proper health policies and mother-infant health programs. This study contributes to the growing literature on TM/CAM, ethnic diversity and pregnant women.

关键词： Pregnancy Complementary medicine Traditional medicine Alternative medicine

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Fragrant Microcapsules Based onβ-Cyclodextrin for Cosmetotextile Application

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Journal of Renewable Materials 2019年第12期7卷 1347-1362页

作者： Maroua Ben Abdelkader Nedra Azizi ayda Baffoun Yves Chevalier Mustapha Majdoub Laboratoire des Interfaces et Matériaux Avancés(LIMA) Facultédes SciencesUniversitéde Monastirbd de l’Environnement5019 MonastirTunisia Laboratoire d’Automatique de Génie des Procédés et de Génie Pharmaceutique(LAGEPP)UniversitéClaude Bernard Lyon 1UMR CNRS 500743 bd du 11 Novembre 191869622 Villeurbanne CedexFrance Unitéde Recherche Matériaux et Procédés Textiles Universitéde MonastirÉcole Nationale d’Ingénieurs de Monastirav.Ibn Eljazzar5019 MonastirTunisia

Microencapsulation of neroline inside microcapsules having a polyurethane shell based onβ-cyclodextrin(β-CD)and hexane diisocyanate was performed by interfacial *** polyol nature ofβ-CD caused tight crosslinking of microcapsules *** of neroline were characterized for their chemical composition and structure of the polyurethane shell by FTIR spectroscopy,thermogravimetric analysis,optical and electron microscopy,light scattering and electrophoresis *** content and encapsulation yield were 15%and 60%,*** microcapsules of mean diameter 29μm were slightly cationic with an isoelectric point of ***-loaded microcapsules were fixed on cotton fabric using an impregnation *** functionalized fabric showed improved resistance to washing cycles in comparison with previously reported diol-based *** microcapsules display great potential for the long-lasting release of fragrance in the framework of cosmetotextile.

关键词： Microcapsules interfacial polycondensation β-cyclodextrin neroline cosmetotextile

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Cable-Driven Parallel Robot Workspace Identification and Optimal Design Based on the Upper Limb Functional Rehabilitation

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Journal of Bionic Engineering 2022年第2期19卷 390-402页

作者： Ferdaws Ennaiem Abdelbadia Chaker Juan Sandoval Sami bennour Abdelfattah Mlika Lotfi Romdhane Said Zeghloul Med Amine Laribi Department of GMSC Pprime Institute CNRSENSMAUniversity of PoitiersUPR 3346PoitiersFrance Mechanical Laboratory of Sousse(LMS) National Engineering School of SousseUniversity of Sousse4000 SousseTunisia American University of Sharjah PO Box 26666SharjahUnited Arab Emirates

An assessment of the human motion repeatability for three selected Activities of Daily Living(ADL)is performed in this *** exercises were prescribed by an occupational therapist for the upper limb *** movement patterns of five participants,recorded using a Qualisys motion capture system,are compared based on the Analysis of Variance(ANOVA)*** survey is motivated by the need to find the appropriate task workspace of a 6-degrees of freedom cable-driven parallel robot for upper limb rehabilitation,which is able to reproduce the three selected *** comparison is performed to justify,whether or not,there is enough similarity between the participants’gestures,and so a single reference trajectory can be adopted as the robot-prescribed *** the results of the comparative study,an optimization process of the sought robot design is carried out,where the structure size and the cable tensions simultaneously minimized.

关键词： Human motion repeatability Activities of Daily Living(ADL) Analysis of Variance(ANOVA) Task workspace Cable-driven parallel robot Upper limb rehabilitation Optimization

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A review on the mechanisms of low salinity water/surfactant/nanoparticles and the potential synergistic application for c-EOR

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Petroleum Research 2023年第3期8卷 324-337页

作者： Stanley Sim Sze Lim Henry Elochukwu Jobrun Nandong Ziad bennour Mohamed Ali Hamid Chemical and Energy Department Faculty of Engineering and ScienceCurtin University MalaysiaMalaysia School of Engineering and Physical Sciences Heriot Watt UniversityMalaysia

Chemical enhanced oil recovery(c-EOR)is a conventional and promising strategy to recover oil from reservoir techniques such as low salinity water flooding(LSWF),surfactant flooding,alkaline flooding,polymers flooding,and nanofluid *** use of various types of chemical materials for c-EOR method has recently attracted the attention of the oil and gas *** primary objective of this review work is to explore the synergy of low salinity water/surfactant/nanoparticle flooding for effective c-EOR method and investigate the mechanism behind these *** advantages of combining these chemical materials for c-EOR methods is also *** and limitations of this synergy and their economic feasibility for additional oil recovery and potential return on investment are *** have been successfully used in various applications in several industries and have also shown good application for EOR in terms of wettability *** contributes to wettability alteration,while surfactant contributes to wettability alteration and interfacial tension(IFT)***,fines migration caused by LSWF and nanoparticle agglomeration can cause formation damage,while excessive surfactant adsorption can lead to cost overrun on surfactant *** the characteristics of reservoir formation mineralogy and appropriate nanoparticle type,size,and concentration can be used to resolve this *** synergy of LSWF and nanoparticles in alkaline medium can serve as sacrificial agent to reduce excessive surfactant ***,the appropriate synergistic formulation of LSFW/surfactant/nanoparticle can improve additional oil recovery and support return on investment for c-EOR projects.

关键词： Surfactant Low salinity water Nanoparticles Nanofluid Enhanced oil recovery

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Identification of Secondary Metabolites in Tunisian Tilia platyphyllos *** MALDI-TOF and GC-MS

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Journal of Renewable Materials 2024年第4期12卷 827-842页

作者： ayda Khadhri Mohamed Mendili Marwa Bannour-Scharinger Eric Masson Antonio Pizzi University of El-Manar II Faculty of SciencesPlantSoilEnvironment Interactions LaboratoryCampus AcademiaTunis2092Tunisia LERMAB University of Lorraine27 Rue Philippe SeguinEpinal88000France

This study is the first to evaluate the phytochemical content and biological properties of Tunisian *** Scop.A total of 23 compounds of essential oils were identified by gas chromatography-mass spectrometry(GC-MS)analysis of bracts and fruit *** results show that oxygenated monoterpenes were the dominant class of essential *** phenolic composition was investigated by matrix-assisted laser desorption/ionizationtime of flight(MALDI-TOF).The analysis showed that the chemical profiles of the ethanolic extracts of bracts and fruits are substantially *** highest polyphenol content was found in the ethanolic extracts of the fruits(7.65 mg gallic acid equivalents(GAE).g−1 on dry weight(DW).As for the antioxidant capacity,it was recorded in the essential oils of the fruits(IC_(50)=0.91 ***^(−1)).The results obtained showed that the antioxidant activity of the fruit essential oil was higher than that of the ethanol *** fruit essential oil was also found to have the highest reducing power(IC_(50)=0.67 ***^(−1)).In terms of iron-chelating power,fruit essential oil has the highest chelating power(IC_(50)=2.03 ***^(−1)).Compared to the ethanolic extract,the essential oil had the maximum antioxidant *** enzymatic activity of acetylcholinesterase(AChE)inhibition of the essential oil from *** bracts had the most potent inhibitory effect(IC_(50)=0.77 ***^(−1)),followed by the essential oil from the fruits(IC_(50)=0.95 ***^(−1)).The results suggest that *** can be used as a potential source of naturally occurring bioactive compounds and antioxidants.

关键词： T.platyphyllos antioxidant activity acetylcholinesterase inhibition essential oil MALDI-TOF GC-MS

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