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Effectiveness of Oral Health Education Program on Prevention of Periodontal Disease in Japanese Pregnant Women

Open Journal of Nursing 2016年第4期6卷 282-293页

作者： Mayumi Noguchi Akira Tagaya ayako sakoda Hitoshi Komatsuzawa Natsumi Fujiwara Motoyuki Sugai Japanese Red Cross Hiroshima College of Nursing Hatsukaichi Japan Japanese Red Cross Toyota College of Nursing Toyota Japan (Current) Nagano College of Nursing Komagane Japan Department of Bacteriology Hiroshima University Graduate School of Biomedical & Health Sciences Hiroshima Japan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan (Current) Department of Oral Health Care Promotion Tokushima University Graduate School of Biomedical Sciences Tokushima Japan (Current)

The prevalence of periodontal disease among pregnant women increases with gestational age. Therefore, oral health education in the early stage of pregnancy should prevent periodontal disease and decrease the risk of an adverse pregnancy outcome such as preterm delivery and low birth weight. However, there has been no study on oral health care intervention for prevention of periodontal disease during pregnancy. The purpose of this study was to examine the efficiency of an oral health education program on periodontal disease among Japanese low-risk pregnant women. A total of 207 pregnant women before 20 weeks of gestation were recruited. The first 131 of them were assigned to the control group and the remaining 76 to the experimental group. The experiment participants received an oral health education program including the toothpick brushing method in their early stage of pregnancy. Improvement of the self-assessment score of periodontal symptoms was used as a binary outcome variable. A logistic regression analysis indicated that the intervention (OR = 3.83) and proficiency of the toothpick brushing method (OR = 24.93) were statistically significant predictors of the outcome in the late stage of pregnancy. The positive outcome appeared after practice of the toothpick method brushing for 20 or more weeks, and was associated with the decrease in the log-transformed proportion of the count of Candida species in salivary microbiota (p = 0.026).

关键词： Periodontal Disease Pregnancy Oral Health Educational Intervention Toothpick Brushing Method

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An extended computational approach for point-defect equilibria in semiconductor materials

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npj Computational Materials 2022年第1期8卷 746-756页

作者： Takafumi Ogawa ayako Taguchi Akihide Kuwabara Nanostructures Research Laboratory Japan Fine Ceramics Center2-4-1 MutsunoAtsuta-kuNagoya456-8587Japan

Concentrations of intrinsic and extrinsic point defects in crystalline materials with a bandgap are typically calculated in a constant-μapproach from defect formation energies based on density functional *** this work,calculations of thermal and charge equilibria among point defects are extended to a constant-N *** two approaches for point-defect equilibria are comparatively demonstrated in the application to Mg_(2)Si doped with Li,Na,and Ag,which is a lightweight and environmentally friendly thermoelectric candidate *** results reveal the systematic behavior of defect and carrier *** dopant atoms form interstitial defects at similar concentrations to substitutional defects at the Mg sites,resulting in significantly reduced free-carrier concentrations compared to the expected *** developed procedures could be utilized to find an optimal avenue for achieving higher carrier concentrations,e.g.,with regard to annealing temperature and the concentration of dopant atoms,in various semiconductors and insulators.

关键词： defect equilibria point

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Anticancer effect of adenosine on gastric cancer via diverse signaling pathways

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World Journal of Gastroenterology 2015年第39期21卷 10931-10935页

作者： ayako Tsuchiya Tomoyuki Nishizaki Division of Bioin- formation Department of Physiology Hyogo College of Medicine

Extracellular adenosine induces apoptosis in a variety of cancer cells via intrinsic and extrinsic pathways. In the former pathway, adenosine uptake into cells triggers apoptosis, and in the latter pathway, adenosine receptors mediate apoptosis. Extracellular adenosine also inducesapoptosis of gastric cancer cells. Extracellular adenosine is transported into cells through an adenosine transporter and converted to AMP by adenosine kinase. In turn, AMP activates AMP-activated protein kinase(AMPK). AMPK is the factor responsible for caspase-independent apoptosis of GT3-TKB gastric cancer cells. Extracellular adenosine, on the other hand, induces caspase-dependent apoptosis of MKN28 and MKN45 gastric cancer cells by two mechanisms. Firstly, AMP, converted from intracellularly transported adenosine, initiates apoptosis, regardless of AMPK. Secondly, the A3 adenosine receptor, linked to Gi/Gq proteins, mediates apoptosis by activating the Gq protein effector, phospholipase Cγ, to produce inositol 1,4,5-trisphosphate and diacylglycerol, which activate protein kinase C. Consequently, the mechanisms underlying adenosine-induced apoptosis vary, depending upon gastric cancer cell types. Understand the contribution of each downstream target molecule of adenosine to apoptosis induction may aid the establishment of tailor-made chemotherapy for gastric cancer.

关键词： Adenosine Apoptosis Intrinsic pathway Extrinsic pa

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HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea

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Neural Regeneration Research 2016年第11期11卷 1758-1759页

作者： Yoshiki Koriyama ayako Furukawa Graduate School and Faculty of Pharmaceutical Sciences Suzuka University of Medical Science

Retinal degenerative diseases （RDs） such as retinitis pigmentosa （RP） are characterized by slowly progressive photoreceptor cell death, but the molecular mechanism underlying RP remains unclear. Animal models for RP have led to a better understand- ing of the disease pathological mechanisms, yet it remains difficult to identify an appropriate genetic model for RDs in general because there are many causative genes （Rossmiller et al., 2012）.

关键词： HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea cell MNU

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Nonalcoholic fatty liver disease: does sex matter?

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 164-166页

作者： Amedeo Lonardo ayako Suzuki Azienda Ospedalero-Universitaria di Modena Operating Unit of Internal MedicineOspedale Civile di BaggiovaraModenaItaly Division of Gastroenterology Duke UniversityDurhamNorth CarolinaUSA

Introduction The hallmark of nonalcoholic fatty liver disease(NAFLD)is the intrahepatocyte accumulation of lipids with or without necro-inflammatory changes and ballooning[i.e.,steatohepatitis or nonalcoholic steatohepatitis(NASH)],fibrosis,cirrhosis and hepatocellular carcinoma(HCC),which is observed in dysmetabolic individuals in the absence of competing causes of chronic liver disease such as excess alcohol consumption,viral infections,autoimmune or hereditary conditions and steatogenic medications(1).NAFLD represents an example of lipotoxicity caused by ectopic lipid *** relatively modest amounts of ectopic lipid accumulation in normally lean organs(e.g.,liver,pancreas,heart,kidney and muscle)can trigger functional disturbance in the affected organs and a subsequent vicious circle of adverse metabolic consequences in predisposed individuals(1);this will eventually result in those hepatic and extra-hepatic manifestations and co-morbid conditions which are frequently observed in NAFLD *** this perspective,NAFLD should be viewed as one of the systemic manifestations and consequences resulting from lipid overflow.

关键词： organs balloon consequences

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Multiseptate gallbladder with anomalous pancreaticobiliary ductal union: A case report

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World Journal of Gastroenterology 2005年第38期11卷 6066-6068页

作者： Takafumi Yamamoto Jun Matsumoto Shinya Hashiguchi Atsumasa Yamaguchi Koro sakoda Chiaki Taki Department of Endoscopy Departments of Internal Medicine Surgeryand Pathology Kagoshima Medical Association Hospital Kagoshima 890-0081 Japan

Multiseptate gallbladder, characterized by the presence of multiple septa dividing the gallbladder lumen, is a very extremely rare congenital anomaly of the gallbladder. On the other hand, anomalous pancreaticobiliary ductal union is also one of the congenital anomalous biliary diseases and thought to be related with choledochal cyst or biliary tract malignancies. In this paper, we describe a unique and first patient of multiseptate gallbladder with anomalous pancreaticobiliary ductal union and a review of the literature. To clarify more characters of the multiseptate gallbladder, examination of a larger patient population will be needed and further studies will be required.

关键词： Multiseptate gallbladder Anomalous pancreaticobiliary ductal union Congenital anomaly

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Characterization of Hydroxyapatite Film on Titanium Substrate by Sputtering Technique

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 260-262页

作者：万涛 AOKI Hideki KATOH ayako Frontier Research and Development Center Tokyo Denki University Saitama 350-0394 JapanBiomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070China Frontier Research and Development Center Tokyo Denki University Saitama 350-0394 JapanInternational Apatite Co. Ltd.Kyobashi Bldg2-8-3Kyobashi Chuo-KuTokyo104-0032Japan International Apatite Co. Ltd. Kyobashi Bldg2-8-3Kyobashi Chuo-KuTokyo104-0032Japan

Radiofrequeut magnetron sputtering technique was used to produce calcium phosphate coated on the titurdum substrates, and the sputtered coating films were crystallized in an autoclave at 110℃ using a low temperature hydrothermal technique. The crystallization of as-sputtered coating film on the titanium substrates were amorphous calcium phosphate film. However, after the hydrothermal technique, calcium phosphate crystals grew and these were cohumnar crystal. The Ca/P ratio of sputtered coating films in 1.6 to 2.0.

关键词： sputtering crystallization hydroxyapatite

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Phylogeography of Potentilla fruticosa,an alpine shrub on the Qinghai-Tibetan Plateau

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Journal of Plant Ecology 2010年第1期3卷 9-15页

作者： Cui Li ayako Shimono Haihua Shen Yanhong Tang Environmental Biology Division National Institute for Environmental StudiesOnogawa 16-2Tsukuba 305-8506Japan Faculty of Environment and Economics Shanxi University of Finance and EconomicsTaiyuan 030006ShanxiChina

Aims Our objectives were(i)to elucidate the phylogeography of chloroplast DNA(cpDNA)in Potentilla fruticosa in relation to Quaternary climate change and postglacial colonization,(ii)to infer historical population range expansion using mismatch distribution analyses and(iii)to locate the refugia of this alpine species on the Qinghai-Tibetan plateau during glacial-interglacial *** Potentilla fruticosa is a widespread species distributed on the Qinghai-Tibetan *** sampled leaves of *** from 10 locations along a route of;1300 km from the northeastern plateau(Haibei,Qinghai)to the southern plateau(Dangxiong,Tibet).We examined the cpDNA of 15 haplotypes for 87 individuals from the 10 populations based on the sequence data from;1000 base pairs of the trnS-trnG and *** relationship of haplotypes was analyzed using the Phylip software package and the program *** diversity of populations indices was obtained using the program *** Findings With the limited samples,we found that(i)higher nucleotide diversity often occurs in high-altitude populations,(ii)the ancestral haplotypes distribute in the populations with higher nucleotide diversity than recent haplotypes,(iii)the expansion time of population in the high altitudes was estimated to be approximately at 52-25 ka BP(1000 years Before Present,where"Present"is AD 1950)and that in the low altitudes to be;5.1-2.5 ka BPand(iv)the source location of *** is at the high altitudes,which might provide refugia for the species during the interglacial warm *** species expanded from the high-elevated locations on the Tanggula Mountains during the Holocene.

关键词： alpine plants climatic changes cpDNA Qinghai Tibet

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