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A new diagnostic feasibility for cardiomyopathy utilizing acoustic microscopy

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World Journal of Cardiovascular Diseases 2013年第1期3卷 22-30页

作者： Yoichi Nakamura Kengo fukushima Kusano Kazufumi Nakamura Kazuto Kobayashi Naohiro Hozumi Yoshifumi Saijo Tohru Ohe Biomedical Imaging Laboratory Graduate School of Biomedical Engineering Tohoku University Sendai Japan Department of Cardiology Sakakibara Heart Institute of Okayama Okayama Japan Department of Cardiovascular Medicine Matsuyama Shimin Hospital Matsuyama Japan Department of Research and Development Honda Electronics Co. Ltd. Toyohashi Japan epartment of Cardiovascular Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Toyohashi University of Technology International Cooperation Center for Engineering Education Development Toyohashi Japan

Aims: Dilated cardiomyopathy often shows left ventricular systolic dysfunction, although histologically it always exhibits non-specific abnormality. We hypothesized that myocyte sound speed might be altered due to incomplete protein accumulation in cells. Methods and Results: Ninety eight biopsied samples were obtained from 49 patients comprising 43 with clinical dilated cardiomyopathy and 6 with hypertrophic cardiomyopathy. Sound speed was evaluated in deparaffinized 10 μm thick sections using an acoustic microscope (frequency range: 50 - 105 MHz). Conventional histology revealed 7 cases of persistent myocarditis derived from clinical dilated cardio- myopathy samples. Histology of the remaining dilated cardiomyopathy patients indicated non-specific abnormality. All hypertrophic cardiomyopathy cases exhibited myocardial disarray. Ten normal autopsied hearts were compared as controls. The sound speed of controls was 1627 ± 30m/sec. The sound speed in dilated cardiomyopathy samples (1700 ±51m/sec) was 1.045-fold faster compared to controls. The sound speed in hypertrophic cardiomyopathy samples (1734 ±51m/sec, 1.066-fold compared to controls) was faster than that of the myocarditis group (1672 ±30m/sec, 1.028-fold) (P = 0.0218). Furtheremore, desmin expression was evaluated as extent of emergence (grading 0 - 4). The desmin expression score in hypertrophic cardiomyopathy samples (2.7 ± 0.8) was significantly higher than in other groups (dilated 2.0 ± 1.4, myocarditis 1.6 ± 1.5 vs., controls 0, P ≤ 0.0001, 0.0001, 0.0129, respectively). Conclusion: Cardio-myopathy enhanced the sound speed, which correlated with the elasticity of myocytes, following the impaired compliance of left ventricle, despite the absence of histological changes. The elevation of sound speed of myocytes may be linked to cytoskeletal changes. Myocyte sound speed may be a new diagnostic tool for diagnosis of idiopathic cardiomyopathy independently of conventional histological diagnosis.

关键词： Cardiomyopathy Acoustic Microscopy Heart Failure Myocytes Sound Speed Diagnosis

Design of Evolvable Hardware for Robotic Navigation

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 547-554页

作者： Yong Liu 1,Tetsuya Higuchi 2,Masaya lwata 2 1.The University of Aizu, fukushima 965 8580,Japan 2.Evolvable Systems Laboratory, Electrotechnical Laboratory, Lbaraki 305 8568,Japan The University of Aizu Fukushima Japan Evolvable Systems Laboratory Electrotechnical Laboratory Lbaraki Japan

This paper presents an integrated on line learning system to evolve programmable logic array (PLA) controllers for navigating an autonomous robot in a two dimensional environment. The integrated on line learning system consists of two learning modules: one is the module of reinforcement learning based on temporal difference learning based on genetic algorithms, and the other is the module of evolutionary learning based on genetic algorithms. The control rules extracted from the module of reinforcement learning can be used as input to the module of evolutionary learning, and quickly implemented by the PLA through on line evolution. The on line evolution has shown promise as a method of learning systems in complex environment. The evolved PLA controllers can successfully navigate the robot to a target in the two dimensional environment while avoiding collisions with randomly positioned obstacles.

关键词： evolvable hardware robotic navigation reinforcement learning evolutionary learning reconfigurable hardware device

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从生药中寻找化妆品有效成分的研究

国外医药（植物药分册） 1991年第4期6卷 164-165页

作者： fukushima M 韩淑萍

我们研究了用于治疗痤疮、疹、皮肤干燥和脂溢性脱发的中国药剂中的某些生药对皮脂分泌的影响,采用一种新的成熟的方法,即测定仓鼠耳皮脂腺的大小。采用这种方法,对选自中国中医处方的16种生药,进行了对皮脂腺激活作用的研究。在被试生... 详细信息

我们研究了用于治疗痤疮、疹、皮肤干燥和脂溢性脱发的中国药剂中的某些生药对皮脂分泌的影响,采用一种新的成熟的方法,即测定仓鼠耳皮脂腺的大小。采用这种方法,对选自中国中医处方的16种生药,进行了对皮脂腺激活作用的研究。在被试生药中,其中三种生药即人参、鱼腥草和陈皮分别能使皮脂腺大小减少30％、20％和29％(P<0.01)。为了寻找化妆品的有效成分,我们一直在进行生药的研究,本工作中,我们研究了生药对皮脂的影响作用,而皮脂一直被认为对皮肤的状态有影响。虽然皮脂是由皮脂腺和表皮细胞分泌。

关键词：生药化妆品有效成分

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发电电动机通风系统的模拟研究

东方电机 1992年第1期20卷 115-121页

作者： fukushima,N 戴庆忠

What factors are associated with premature death among professional baseball players in Japan?

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Health 2013年第4期5卷 757-760页

作者： Hideyuki Kanda Satoshi Tsuboi Masayoshi Tsuji Takeyasu Kakamu Yayoi Mori Takehito Hayakawa Tetsuhito fukushima Department of Epidemiology and Public Health School of Medicine Yokohama City University Yokohama Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan

The aim of this study is to clarify factors related to premature death among Japanese professional baseball players by a case-control analysis. The subjects are two matching groups of 622 Japan Professional Baseball (JPB) league players, those deceased and those surviving. Cases and controls are matched by birth year. All players debuted on the first string between 1934 and 2003, and are listed in The Official Baseball Encyclopedia of Japan. To compare means and frequencies of characteristics between deceased and surviving groups, t-tests and chi-square tests were used. A logistic regression analysis was assessed contributions of each independent variable on death. Significant differences between deceased and surviving players were observed in this study;deceased players had higher body mass indexes and longer careers. Furthermore, logistic regression analysis confirmed that body mass index and career length were statistically significant determinants of death for baseball players. This is the first report to examine factors of death for professional baseball players except employing data attained from Major League Baseball.

关键词： Factors of Death Professional Baseball Player Body Mass Index Career Length

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严重的死后枪弹创变形的判定

严重的死后枪弹创变形的判定

第十五届国际法庭科学大会

作者： Hideki Asamura Kayoko Takayanagi Cunyan liu Michael Ota Hirofumi fukushima 李健 Department of Legal Medicine Shinshu University School of Medicine3-1-1 AsahiMatumoto390-8621Japan Department of Legal Medicine Shinshu University School of Medicine3-1-1 AsahiMatumoto390-8621Japan Department of Legal Medicine Shinshu University School of Medicine3-1-1 AsahiMatumoto390-8621Japan Department of Legal Medicine Shinshu University School of Medicine3-1-1 AsahiMatumoto390-8621Japan Department of Legal Medicine Shinshu University School of Medicine3-1-1 AsahiMatumoto390-8621Japan

＜正＞1、判断变形枪伤的困难性;2、在这类案件中 X 射线检查的必要性;3、不常见枪伤的特征。在日本,枪伤的尸检占所有合法尸检的1%,因为枪的拥有者一般都是合法的。但一些日本的歹徒邦帮派成员和杀手也拥有枪。

关键词：枪创变形 X-线检查

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实验脉冲核磁共振

实验脉冲核磁共振

Effects of Cholestasis on Whole Blood Concentration of Tacrolimus, an Immunosuppressant, in Living-Related Liver Transplant Recipients

1995年

作者：（美）Eiichi fukushima （美）Stephen B.W.Roeder 童瑜晔等译

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International Journal of Clinical Medicine 2013年第10期4卷 432-439页

作者： Shinji Kobuchi Keizo fukushima Yuta Maeda Takatoshi Kokuhu Hidetaka Ushigome Norio Yoshimura Nobuyuki Sugioka Kanji Takada 4Department of Transplantation and Regenerative Surgery Kyoto Prefectural University of Medicine Kyoto Japan. Department of Clinical Pharmacokinetics Fac- ulty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan Department of Clinical Pharmacokinetics Fac- ulty of Pharmaceutical Sciences Kobe Gakuin University Kobe Japan Department of Hospital Pharmacy Kyoto Prefectural Uni- versity of Medicine Kyoto Japan Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan

Background: To explore the effects of cholestasis on whole blood concentration of tacrolimus (TAC), an immunosup-pressant, we investigated the relationship among blood TAC concentration, bile flow, and TAC metabolites in bile, as well as the relationship between total bilirubin (T-Bil), an index of cholestasis, and blood TAC concentration, in liver transplant recipients. Methods: Data were collected retrospectively from 16 male and 19 female patients (mean age: 38 years;range: 12 -59 years) who had undergone a living-related liver transplantation at Kyoto Prefectural University of Medicine from 2004 through 2008. Analysis of TAC, demethyl-TAC, and hydroxy-TAC in bile was performed by LC-MS/MS. Results: There was no correlation between the ratio of TAC metabolite to TAC in bile (M/P) of demethyl-TAC and post operation days (POD), whereas a weak linear correlation was demonstrated between M/P of hydroxy-TAC and POD (r = -0.345). Moreover, linear correlations were not observed between M/P and the TAC trough level normalized dose (TLTAC/dose), and between TLTAC/dose and POD. A negative linear correlation was demonstrated between bile flow and T-Bil in blood (r = -0.495). Furthermore, a positive linear correlation was observed between TLTAC/dose and T-Bil (r = 0.598), whereas there was no correlation between bile flow and TLTAC/dose. Conclusions: Improvement of hepatic function and the increase of TAC clearance after postoperative day 7 did not significantly contribute to hepatic TAC metabolism, bile excretion, and TLTAC/dose. Postoperative biliary stricture from liver transplantation with/without biliary drainage caused inter-and intra-patient variability in TLTAC/dose after liver transplantation, which could be assessed by T-Bil. T-Bil in blood might be a predictive biomarker for determining the degree of bile duct stricture and TAC dose in liver transplantation patients. Along with an appropriate dosing regimen, therapeutic drug monitoring including T-Bil would be ben

关键词： Pharmacokinetics Bile Duct Stricture Tacrolimus Drug Metabolism Total Bilirubin Therapeutic Drug Monitoring

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