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Journal of Diabetes Mellitus 2016年第3期6卷 197-203页

作者： Kenji D. Furukawa Naoto Yamaaki aya fujimoto Kiminori Ohyama Hiroaki Muramoto Department of Internal Medicine Japan Community Health care Organization (JCHO) Kanazawa Hospital Kanazawa Japan

We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.

关键词： Glargine Self-Titration BOT T2DM Insulin 3-3-1 Algorithm

Appropriate Heart Rate in a Patient with Repaired Tetralogy of Fallot

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Congenital Heart Disease 2022年第6期17卷 647-652页

作者： aya Miyazaki Hideki Uemura Yasuyo Takeuchi Junya Tomida Yasuo Ono Yoshifumi fujimoto Norie Mitsushita Akio Ikai Department of Transitional Medicine Division of Congenital Heart DiseaseShizuoka General HospitalShizuokaJapan Congenital Heart Disease Center Nara Medical UniversityKashiharaJapan Department of Cardiology Shizuoka General HospitalShizuokaJapan Department of Clinical Engineering Shizuoka General HospitalShizuokaJapan

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart diseasewith unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinusnode dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changingthe pacemaker’s lower rate from 60 to 75 bpm, New York Heart Association classification improved from III to II,and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart ratecould be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioningLV.

关键词： Heart rate repaired tetralogy of Fallot failing right ventricle pacemaker lower rate the right-left ventricular interaction

Joint input–output identiﬁcation of unstable systems with kernel regularization

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Control Theory and Technology 2024年第2期22卷 195-202页

作者： Yusuke fujimoto Toshiharu Sugie Department of Environmental Engineering the University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushu 8080135FukuokaJapan Professor Emeritus Kyoto UniversityYoshida-HonmachiSakyo-kuKyoto 6068501KyotoJapan

This paper discusses closed-loop identiﬁcation of unstable *** particular,weﬁrst apply the joint input–output identiﬁcation method and then convert the identiﬁcation problem of unstable systems into that of stable systems,which can be tackled by using kernel-based regularization *** propose to identify two transfer functions by kernel regularization,the one from the reference signal to the input,and the one from the reference signal to the *** these transfer functions are stable,kernel regularization methods can construct their accurate *** the model of unstable system is constructed by ratio of these *** effectiveness of the proposed method is demonstrated by a numerical example and a practical experiment with a DC motor.

关键词： Closed-loop identification Kernel regularization Joint input-output identification

Approximate Solutions to the Hamilton-Jacobi Equations for Generating Functions

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Journal of Systems Science & Complexity 2020年第2期33卷 261-288页

作者： HAO Zhiwei fujimoto Kenji ZHANG Qiuhua Department of Astronautical Science and Mechanics Harbin Institute of TechnologyHarbin 150001China Department of Aeronautics and Astronautics Kyoto UniversityC3 Bldg.Kyotodaigaku-katsuraNishikyo-kuKyoto 615-8540Japan

For a nonlinear finite time optimal control problem,a systematic numerical algorithm to solve the Hamilton-Jacobi equation for a generating function is proposed in this *** algorithm allows one to obtain the Taylor series expansion of the generating function up to any prescribed order by solving a sequence of first order ordinary differential equations ***,the coefficients of the Taylor series expansion of the generating function can be computed exactly under a certain technical *** a generating function is found,it can be used to generate a family of optimal control for different boundary *** the generating function is computed off-line,the on-demand computational effort for different boundary conditions decreases a lot compared with the conventional *** is useful to online optimal trajectory generation *** examples illustrate the effectiveness of the proposed algorithm.

关键词： Generating functions Hamilton-Jacobi equations optimal control Taylor series expansion two-point boundary-value problems

Molecular dynamics simulation of the A-DNA to B-DNA transition in aqueous RbCl solution

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Science China Chemistry 2013年第4期56卷 524-532页

作者： YU YangXin fujimoto Shintaro Laboratory of Chemical Engineering Thermodynamics Department of Chemical Engineering Tsinghua University

Unrestrained molecular dynamics （MD） simulations have been carded out to characterize the stability of DNA conformations and the dynamics of A-DNA^B-DNA conformational transitions in aqueous RbC1 solutions. The PARM99 force field in the AMBER8 package was used to investigate the effect of RbC1 concentration on the dynamics of the A^B conformational tran- sition in the DNA duplex d（CGCGAATTCGCG）2. Canonical A- and B-form DNA were assumed for the initial conformation and the final conformation had a length per complete turn that matched the canonical B-DNA. The DNA structure was moni- tored for 3.0 ns and the distances between the C5＇ atoms were obtained from the simulations. It was found that all of the double stranded DNA strands of A-DNA converged to the structure of B-form DNA within 1.0 ns during the unrestrained MD simula- tions. In addition, increasing the RbC1 concentration in aqueous solution hindered the A^B conformational transition and the transition in aqueous RbC1 solution was faster than that in aqueous NaC1 solution for the same electrolyte strength. The effects of the types and concentrations of counterions on the dynamics of the A^B conformational transition can be understood in terms of the variation in water activity and the number of accumulated counterions in the major grooves of A-DNA. The ru- bidium ion distributions around both fixed A-DNA and B-DNA were obtained using the restrained MD simulations to help ex- plain the effect of RbC1 concentration on the dynamics of the A^B conformational transition.

关键词： DNA conformational transition molecular dynamics aqueous RbCI solution

Simulation study on dynamics of A- to B-form transition in aqueous DNA solution:Effect of alkali metal counterions

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Science China Chemistry 2013年第12期56卷 1735-1742页

作者： YU YangXin fujimoto Shintaro Laboratory of Chemical Engineering Thermodynamics Department of Chemical EngineeringTsinghua University

DNA and its conformational transition can be used to design nanometer-scale structures, nano-tweezers and nanomechanical devices. Experiments and molecular simulations have been used to study the concentration effect on the A-DNA→B-DNA conformational transition, but a systematical investigation on counterion effect on the dynamics of this transition has not been reported up to now. In present work, restrained and unrestrained molecular dynamics （MD） simulations have been performed to characterize the stability of DNA conformations and the dynamics of A-DNA→B-DNA transitions in aqueous solutions with different alkali metal counterions. The DNA duplex d（CGCGAATTCGCG）2, coion Cl- and counterions Li＋, Na＋, K＋, Rb＋ and Cs~ as well as water molecule were considered using the PARM99 force field in the AMBER8 package. It was found that B-form DNA is more stable than A-form DNA in aqueous electrolyte solutions with different alkali metal counterions. In- creasing KCI concentration in solution hinders the A-DNA^B-DNA transition and the transition times for different alkali metal counterions conform to neither the simple sequence related to naked ion size nor to hydrated diameter, but an apparently abnormal sequence of K＋〈 Rb＋〈 Cs＋〈 Na＋〈 Li＋. This abnormal sequence can be well understood in terms of an electrostatic model based on the effective cation diameters and the modified mean-spherical approximation （MMSA）. The present results provide valuable information for the design of DNA-based nanomaterials and nanodevices.

关键词： A-DNA B-DNA conformational transition alkali metal ion molecular dynamics

Large Eddy Simulation of Swirling Jet in a Bluff-Body Burner

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Journal of Thermal Science 2005年第1期14卷 28-33页

作者： Yohei fujimoto Yuzo INOKUCHI Nobuhiko YAMASAKI Department of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581Japan

The large eddy simulation (LES) is applied to an unconfined swirling flow of an air surrounding a bluff-body having a central jet of air, and the complicated flowfield that involves the recirculation and vortex breakdown is investigated. The Smagorinsky model is used as the sub-grid scale model. The results of the present numerical simulation are compared with the experimental data of the mean and stochastic root mean square (RMS) variations of two velocity components. Although the inflow conditions are specified in a simple manner, the obtained numerical results are in reasonable agreement with the experiments, except for a part of RMS variation values near downstream of the bluff body. The present numerical calculations can successfully reproduce the two characteristics of the flow, i.e., an upstream recirculation zone established just downstream of the burner plane and the additional recirculation zone established at the more downstream location.

关键词： large eddy simulation swirl bluff-body recirculation.

FRACTURE MODES OF C/C COMPOSITES AT ELEVATED TEMPERATURE

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FRACTURE MODES OF C/C COMPOSITES AT ELEVATED TEMPERATURE

Vaccine therapy for dysbiosis-related diseases

作者： Tadashi Shioya Koji fujimoto aya Kanai Department of Aeronautics and Astronautics University of TokyoTokyo 1138656Japan Department of Aeronautics and Astronautics University of TokyoTokyo 1138656Japan All Nippon Airways Co. Japan

＜正＞Fracture modes of Carbon/Carbon（ C/C） composites are examined experimentally and analysed both in macroscopically and microscopically. C/C composite that is a composite of carbon fibres and carbon matrix can maintain strength and stiffness at elevated temperature higher than 200℃. The purpose of this study is to investigate mechanical properties of C/C composites at high temperature by means of the tensile test. In this paper, the creep properties and the relation between the tensile modulus and temperature were described. Silicon impregnated C/C composite material is also examined. The fracture mode of this material is discussed comparing with that of the conventional C/C composite material

关键词： C/C Composites Compression Failure Interlaminar Matrix Compression

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World Journal of Gastroenterology 2020年第21期26卷 2758-2767页

作者： Kosuke fujimoto Satoshi Uematsu Department of Immunology and Genomics Osaka City University Graduate School of MedicineOsaka 545-8585Japan Division of Innate Immune Regulation International Research and Development Center for Mucosal VaccinesThe Institute of Medical ScienceThe University of TokyoTokyo 113-8654Japan Division of Metagenome Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyo 113-8654Japan Collaborative Research Institute for Innovative Microbiology The University of TokyoTokyo 113-8654Japan

Progress in genomic analysis has resulted in the proposal that the intestinal microbiota is a crucial environmental factor in the development of multifactorial diseases,such as obesity,diabetes,rheumatoid arthritis,and inflammatory bowel diseases represented by Crohn’s disease and ulcerative *** gut microbiome contributes to the pathogenesis of such disorders;however,there are few effective treatments for controlling only disease-mediating ***,we review current knowledge about the intestinal microbiome in health and disease,and discuss a regulatory strategy using a parenteral vaccine with emulsified curdlan and CpG oligodeoxynucleotides,which we have recently *** other conventional injectable immunizations,our vaccine contributes to the induction of antigen-specific systemic and mucosal *** vaccine strategy can prevent infectious diseases such as Streptococcus pneumoniae infection,and control metabolic symptoms mediated by intestinal bacteria(*** ramosum)by induction of high titers of antigen-specific IgA at target mucosal *** the future,our vaccination approach could be an effective therapy for common infectious diseases and dysbiosis-related disorders that have been difficult to control so far.

关键词： Dysbiosis IgA Microbiome Mucosal immunity Pathobiont Vaccine

HYDROTHERMAL CRACKING OF RESIDUAL OILS

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石油学报（石油加工） 2001年第1期17卷 42-46页

作者： Noritatsu TSUBAKI Jie CHANG Kaoru fujimoto Department of Applied Chemistry School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo kuTokyo113 8656Japan

The hydrothermal cracking of heavy oils, such as Canadian oil sand bitumen and Arabian heavy vacuum residue, as well as their model compound were performed over sulfided Ni/Al 2O 3 and NiMo/Al 2O 3 catalysts under 663～703 K and 6.0～8.0 MPa of hydrogen pressure in a batch autoclave reactor. According to the reaction mechanism of hydrothermal cracking, a small amount of free redical initiators, such as di tert peroxide, sulfur, etc., was added into the feed to generate free redicals at lower temperature, and obviously showed promotional effect on the conversion of hydrocarbons. The reaction mechanisms of hydrothermal cracking as well as the enhancing effect of initiators were studied by a probe reaction with 1 phenyldodecane as a model compound. The hydrothermal cracking of hydrocarbon proceeded via free redical mechanism and hydrogenating quench. The initiators might easily generate free redicals under reaction temperature, these redicals might abstract H from hydrocarbon molecule and reasonably initiate the chain reactions, therefore, promote the conversion of hydrocarbon even at lower reaction temperature.

关键词： Cracking (chemical)