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Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 411-416页

作者： Saad Bin Dajem Sara Bayoumi Ali Omar Ghanem Abdelrady Nouraldin Mahmoud Salahaldin Ahmed Muhammed Soliman Yasmin mohamed Kamal Ammar Yasser Abdelazim aya fadi mohamed Kareem Morsy Ayman Saber mohamed Sohair Ramadan Fahmy Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Zoology Faculty of ScienceCairo UniversityCairoEgypt

Objective:To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in ***:The animals were divided randomly into three groups(n=6 per group):control,gentamicin,and Allolobophora caliginosa coelomic fluid-treated *** was established after injection of gentamicin daily for 8 days at a dose of 100 mg/*** aminotransferase,alanine aminotransferase,alkaline phosphatase,total proteins,albumin,creatinine,urea,uric acid,malondialdehyde,glutathione,catalase and histopathology of tissues were investigated in the ***:Allolobophora caliginosa coelomic fluid significantly decreased urea,creatinine,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and malondialdehyde levels while significantly increasing levels of total proteins,albumin,glutathione and *** histopathological investigation showed partial restoration of renal and hepatic ***:This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.

关键词： Allolobophora caliginosa Coelomic fluid Gentamicin Hepatorenal toxicity Earthworm

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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic fadi Murad Sarah-Lilly Hassan Youssef Haikel Mossaad Megahed Matthias Hannig mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

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Microstructure and texture evolution of AZ31 Mg alloy after uniaxial compression and annealing

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Journal of Magnesium and Alloys 2019年第1期7卷 124-133页

作者： fadi Abouhilou Abdelkader Hanna Hiba Azzeddine Djamel Bradai Faculty of Physics USTHBBP32 El-AliaDar El-BeidaAlgiersAlgeria Physics and Chemistry of Materials Laboratory Department of PhysicsUniversity Mohamed BoudiafM’Sila 28000Algeria Department of Physics University Mohamed BoudiafM’sila 28000Algeria

The effect of initial texture on the microstructure and texture evolution of as extruded AZ31 alloy after hot uniaxial compression at 430°C and subsequent annealing at 450°C for 72h has been investigated using electron backscatter *** were machined from the extruded block in such orientations that the compression axis,CD,was parallel(CD0ED)or perpendicular(CD90ED)to the initial extrusion direction,ED,*** show that the deformation microstructure for both samples was characterized by equiaxed grains that resulted from dynamic *** at 450°C for 72 h led to the increase of grains size to 28 and 25μm for CD0ED and CD90ED samples,respectively.A random deformation texture was developed in CD0ED sample while the deformation of CD90ED developed typical(0002)basal *** deformation textures of both samples were retained after subsequent annealing at 450°C for 72 *** flow behavior was affected by the initial *** CD0ED sample showed the highest work *** evolutions were explained in term of the activation and suppression of basal,non-basal slip and mechanical twinning.©2018 Published by Elsevier *** behalf of Chongqing *** is an open access article under the CC BY-NC-ND license.

关键词： Magnesium alloys Schmid factor Texture Deformation Annealing Microstructure

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Artificial Chiral Nanostructure at Oblique Incidence

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Journal of Electrical Engineering 2017年第1期5卷 20-26页

作者： mohamed Boutria Rachid Oussaid Daniel Van Labeke fadi Issam Baida Universite des Sciences et de la Technologie Houari Boumediene Alger Algerie Departement d'Optique P.M. Duffieux Institut FEMTO-ST Universite de Franche-Comte France Ecole Normale Superieure Kouba Alger Algerie

We propose in this paper the design of artificial nanostructure chirality obtained by oblique illumination. This structure is based on anisotropic metamaterial having an optical activity induced by the special geometry of the pattern and the incident beam. Starting from a non-chiral material, the artificial chirality is obtained thanks to the rectangular apertures which form the periodic perfect metal nanostructure （one layer） and the oblique incidence of the light beam. An extraordinary light transmission （93%） through the metal nanostructure is achieved by exciting the cavity modes. The extrinsic chirality obtained can be granted to the desired value by appropriately adjusting the geometric parameters and the angle of incidence.

关键词： Nanostructure optical activity extrinsic chirality metamaterial.

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